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Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota
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“Furthermore, gut microbiota has been described in the past two decades as a very important player in the regulation of whole‐body energy homeostasis, in response to diverse stimuli such as cold 165, 166, nutrition 167, 168, or fasting/feeding cycles 168, 169, 170, through the production of mediators such as short chain fatty acids (SCFAs) and secondary BAs 167, 169.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [170]
Citations
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Fast and sensitive protein alignment using DIAMOND
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Self-citationPredictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Langille, M. G. I., Zaneveld, J., Caporaso, J. G., McDonald, D., Knights, D., Reyes, J. A., Clemente, J. C., Burkepile, D. E., Vega Thurber, R. L., Knight, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2676 · Cited by 9,116 · cited 1×
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“In addition, both BAT and WAT express protonlinked monocarboxylate transporter 1 (MCT1) encoded by Mct1, which drives acetate and lactate transport across the plasma membrane of adipocytes (den Besten et al., 2013; Iwanaga et al., 2009).”
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760 · cited 2×
“Gut Microbiota Orchestrates EODF-Induced WAT Beiging Recently, correlative evidence revealed a metabolic interaction between the gut microbial communities and the host, and gut bacteria have an important role in the regulation of brown and beige adipose tissues (Chevalier et al., 2015; Holmes et al., 2012; Mestdagh et…”
Gut microbiota, metabolites and host immunity
Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409 · cited 2×
“Gut Microbiota Orchestrates EODF-Induced WAT Beiging Recently, correlative evidence revealed a metabolic interaction between the gut microbial communities and the host, and gut bacteria have an important role in the regulation of brown and beige adipose tissues (Chevalier et al., 2015; Holmes et al., 2012; Mestdagh et…”
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,406 · cited 2×
“…or EODF/MT (EODF versus AL or EODF/MT versus AL/MT drunk with the same water), and red letters show the effects of microbiota depletion (AB versus CV within the same feeding regimen). promote thermogenesis and suppresses obesity (Ishibashi and Seale, 2010; Shabalina et al., 2013; Wu et al., 2012).”
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Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615
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Items 101–144 of 144
Qu, Y., Wang, P., Wang, D., Li, B., & Yang, F. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116447 · Cited by 4
Endocrine Regulation of Brown and Beige Adipose Tissue
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“Li et al. [33] demonstrated for the first time that intermittent fasting (IF) increases the total energy expenditure and selectively induces WAT browning by re-shaping gut microbiota, which led to the elevation of browning stimuli via increased short-chain fatty acid (SCFA) release, such as acetate…”
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“IF has been gaining increased attention as an effective approach for weight loss and improvement of insulin sensitivity [6–11 , 14 ].”
InfluentialMarko, D. M., Conn, M. O., Cavallari, J. F., Neudorf, H., Steele, A. P., Duggan, B. M., McAlpin, B. T., Barra, N. G., Hawke, T., Little, J., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117023 · Cited by 1
Effects of Intermittent Fasting on Weight Loss and Cardiometabolic Health
Gerboğa, R., & Bekar, C. (2023) · Current Perspectives on Health Sciences · doi:10.58208/cphs.1218650 · Cited by 2
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Cai, Y., Xu, J., & Wang, B. (2025) · Phytotherapy Research · doi:10.1002/ptr.70068 · Cited by 6
“Li et al. (2017) demonstrated that every- other-day fasting reshapes GM composition, stimulating microbial secretion of acetate and lactate to selectively activate brown adipose tissue, offering therapeutic potential for obesity-related metabolic disorders.”
Adipose tissue as a plastic organ to management obesity and diabetes mellitus
Павловна, М. А., & As, A. (2022) · Endocrinology News Opinions Training · doi:10.33029/2304-9529-2022-11-2-64-70 · Cited by 2
Li, X., Chen, P., Zhang, P., Chang, Y. E., Cui, M., & Duan, J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/375584 · Cited by 2
Zou, Y., Song, D., Cai, Y., Liang, K., Fu, J., & Zhang, H. (2024) · Research Square · doi:10.21203/rs.3.rs-4649887/v1 · Cited by 2
Oh, S., Park, S., & Kim, E. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01613-y · Cited by 1
Natarajan, D., Milan, M., Reyff, Z., Negri, S., Ekambaram, S., Varshney, R., Rudolph, M. C., Tarantini, S., & Balasubramanian, P. (2026) · The Journals of Gerontology Series A · doi:10.1093/gerona/glag085 · Cited by 1
“Other studies have also reported a similar phenomenon in response to intermittent fasting, 24,36,37 and our results suggest that fasting-mediated WAT beiging is also preserved in aged mice.”
InfluentialGuan, Z., Li, X., Chen, Y., Sheng, Z., Wen, J., Zhou, H., Chen, C., Liu, J., Zhu, G., Pang, Z., et al. (2026) · Bone Research · doi:10.1038/s41413-026-00541-5 · Cited by 4
“36 After Abx treatment, IVDD was induced using the widely used tail disc needle puncture model, followed by oral gavage of vehicle (PBS), Akk , or Escherichia coli ( E. coli , a commensal control strain), with non-punctured Abx-treated mice serving as baseline controls (Fig.”
Traditional Chinese Medicine Herbs and Gut Microbiota
Su, Z. (2019) · Annals of Advanced Biomedical Sciences · doi:10.23880/aabsc-16000133 · Cited by 1
Lin, S., Wu, C., Li, X., Wang, Y., Lang, D.-Q., & Shen, C. (2023) · doi:10.22541/au.168112301.11759524/v1 · Cited by 1
RUOLO DEL DIGIUNO E DELLA RESTRIZIONE CALORICA NELLA TERAPIA DEL DIABETE TIPO 2
Cioffi, I., Ponzo, V., & Bo, S. (2018) · il Diabete · doi:10.30682/ildia1804b
Yeni Bir Yaklaşım Olan Aralıklı Açlık Yöntemleri ve Sağlık Üzerine Etkileri
Yıldırım, A., & Erge, S. (2020) · Journal of Nutrition and Dietetics · doi:10.33076/2020.bdd.1291
“Yapılan bir çalışmada, aralıklı açlığın, adipoz dokuda kahverengi yağ dokusunu arttırdığı ve bağırsak mikrobiyotasını değiştirerek obezite oranını azalttığı gösterilmiştir (20).”
Yang, F., Liu, C., Liu, X., Pan, X.-D., Li, X.-Y., Tian, L., Sun, J.-H., Yang, S.-J., Zhao, R., An, N., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-214009/v1 · Cited by 1
“…trial 25:25 Men and women with overweight and obesity ADF: repeatedly alternate between consuming 25% of energy needs over 24- hour Consumed 100% of energy needs every day 24w 46 ± 10 22:3 FM Fi HO Li et al. (2017)[49] Germany A randomized controlled clinical pilot study 23:23 Persons with a…”
Stimuler les tissus adipeux bruns et beiges : un levier thérapeutique ?
Lagarde, D., Montané, R., Ader, I., Casteilla, L., & Carrière, A. (2021) · Médecine des Maladies Métaboliques · doi:10.1016/j.mmm.2021.10.017 · Cited by 2
Irani, H., Khodami, B., Abiri, B., & Saidpour, A. (2021) · Research Square · doi:10.21203/rs.3.rs-837137/v1
JEJUM INTERMITENTE: UMA VISÃO SOBRE A DIABETES E A OBESIDADE
Romero, R. B., Jorge, L. F., Neto, S. A. M., Rocha, C. M., Alvarenga, G. H. F., & Silvério, A. C. P. (2022) · RECIMA21 - Revista Científica Multidisciplinar · doi:10.47820/recima21.v3i2.1096
Systems-wide effects of short-term feed deprivation in obese micePreprint
Andersen, D., Roager, H. M., Zhang, L., Moll, J. M., Frandsen, H. L., Danneskiold‐Samsøe, N. B., Hansen, A. K., Kristiansen, K., Licht, T. R., & Brix, S. (2020) · Research Square · doi:10.21203/rs.3.rs-44356/v1
Systems-wide effects of short-term feed deprivation in obese micePreprint
Andersen, D., Roager, H. M., Zhang, L., Moll, J. M., Frandsen, H. L., Danneskiold‐Samsøe, N. B., Hansen, A. K., Kristiansen, K., Licht, T. R., & Brix, S. (2020) · Research Square · doi:10.21203/rs.3.rs-44356/v2
Irani, H., Khodami, B., Abiri, B., & Saidpour, A. (2022) · Research Square · doi:10.21203/rs.3.rs-837137/v2
Erfan, O. S., Eldesoqui, M. B., & El‐kader, M. A. (2022) · Egyptian Academic Journal of Biological Sciences. D, Histology and Histochemistry · doi:10.21608/eajbsd.2022.239711
“Previous work shows that IF increases both basal and glucose-stimulated insulin secretion in mice with diet-induced obesity (Liu et al., 2017).”
The etiology of gut dysbiosis and its role in chronic disease
Danenberg, A. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822238-6.00020-0
O QUE O JEJUM INTERMITENTE TEM A DIZER SOBRE CÂNCER, SAÚDE CARDIOVASCULAR E SAÚDE CÉREBRO-MENTAL
Romero, R. B., Rocha, C. M., Neto, S. A. M., Alvarenga, G. H. F., Cruz, R. B., Jorge, L. F., & Silvério, A. C. P. (2023) · RECIMA21 - Revista Científica Multidisciplinar · doi:10.47820/recima21.v4i1.2638
Gut Microbiome and Brown Adipose Tissue
Moreno‐Navarrete, J. M. (2023) · Endocrinology · doi:10.1007/978-3-031-08115-6_6-1
Forlano, R., & Sigon, G. (2023) · Digestive and Liver Disease · doi:10.1016/j.dld.2023.07.029
Gut Microbiome and Brown Adipose Tissue
Moreno‐Navarrete, J. M. (2024) · Endocrinology · doi:10.1007/978-3-031-35064-1_6
Wildes, M. P., Fernando, D. G., Grobe, C. C., Reho, J. J., Grobe, J. L., Kidambi, S., Kindel, T. L., Kwitek, A. E., Segar, J. L., Williams, J. S., et al. (2024) · Endocrinology · doi:10.1210/endocr/bqae117 · Cited by 1
Insulin Prevents Fat Loss and Promotes Muscle Loss During Intermittent Fasting in ObesityPreprint
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“In mice that undergo ADF or 5:2 IF there is hyperphagia during re-278 feeding days post-IF which equilibrates the weekly caloric intake (10, 39).”
Epigenetically Mediated Health Effects of Intermittent Fasting
Işık, T. (2025) · İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi · doi:10.38079/igusabder.1529934
Hendesi, H., Godfrey, D. A., Ruble, A. F., Tran, A. M., Villani, D. A., Landgrave, S. H., Hasan, N. A., Adams, D. J., & Zuscik, M. J. (2025) · Bone Reports · doi:10.1016/j.bonr.2025.101876 · Cited by 1
“Several studies have linked the health benefits of IF to shifts in gut microbiota composition and function (Li et al., 2017; Liu et al., 2020b; Beli et al., 2018; Cignarella et al., 2018).”
Guo, F., Liu, X., Liu, X., et al. (2025) · Lipids · doi:10.1002/lipd.70023
“In addition, the gut microbiota plays an essential role in promoting adipose tissue browning, and thus alleviating metabolic diseases (Li et al. 2017).”
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Tissus adipeux brun et beige : exploration et rôle dans la physiologie humaine
Montané, R., de Souza, R. A., Cros, A., Gras, E., Jeanson, Y., Portais, J., Yart, A., Dray, C., Casteilla, L., Ader, I., et al. (2026) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2026.01.002
An exploratory serum metabolomics study for screening and staging of breast cancer
Zou, Y., Song, D., Cai, Y., Liang, K., Fu, J., & Zhang, H. (2026) · Gynecological Endocrinology · doi:10.1080/09513590.2026.2637977 · Cited by 2
Külahlıoğlu, N., Teker, H. T., Kabayer, S., et al. (2026) · OSMANGAZİ JOURNAL OF MEDICINE · doi:10.20515/otd.1727767
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“Although chronic IF has been associated with adverse outcomes like impaired beta cell maturation [ 34 ] and suppressed hair follicle regeneration [ 35 ], short-term IF regimens have demonstrated compelling benefits [ 36, 37 ].”
Metadata
- Authors
- Li, G., Xie, C., Lu, S., Nichols, R. G., Tian, Y., Li, L., Patel, D., Ma, Y., Brocker, C. N., Yan, T., Krausz, K. W., Xiang, R., Gavrilova, O., Patterson, A. D., & Gonzalez, F. J.
- Corresponding author
- Li, Guolin
- Gonzalez, Frank J.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 26
- Issue
- 5
- Pages
- 801
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC5695033
- OpenAlex
- W4253137490
- Cited by
- 144
- References
- 67
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 16 · 2023: 15 · 2022: 19 · 2021: 21 · 2020: 17 · 2019: 15 · 2018: 16
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (Z01BC005561)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- intermittent fasting, white adipose tissue browning, brown adipose tissue, obesity, gut microbiota, gut microbiota transplantation, antibiotic therapy, caloric restriction, metabolic disorders
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