As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid

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Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability

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Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression

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Targeting Pulmonary Fibrosis by SLC1A5-Dependent Glutamine Transport Blockade

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The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade

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Thymidine phosphorylase promotes malignant progression in hepatocellular carcinoma through pentose Warburg effect

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Activated amino acid response pathway generates apatinib resistance by reprograming glutamine metabolism in non-small-cell lung cancer

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Amino acids in cancer: Understanding metabolic plasticity and divergence for better therapeutic approaches

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L-asparaginase anti-tumor activity in pancreatic cancer is dependent on its glutaminase activity and resistance is mediated by glutamine synthetase

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Inorganic Phosphate as “Bioenergetic Messenger” Triggers M2‐Type Macrophage Polarization

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Evaluating Metabolite-Based Biomarkers for Early Diagnosis of Pancreatic Cancer: A Systematic Review

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Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on KRAS-mutant colorectal cancer

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Cysteine is a limiting factor for glioma proliferation and survival

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Adaptive Protein Translation by the Integrated Stress Response Maintains the Proliferative and Migratory Capacity of Lung Adenocarcinoma Cells

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Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells

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SNAT7 regulates mTORC1 via macropinocytosis

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Lipid Metabolism Heterogeneity and Crosstalk with Mitochondria Functions Drive Breast Cancer Progression and Drug Resistance

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Metabolic Reprogramming of Cancer Cells and Therapeutics Targeting Cancer Metabolism

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CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism

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Targeting Nutrient Dependency in Cancer Treatment

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Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis

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Dietary Manipulation of Amino Acids for Cancer Therapy

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Co-inhibition of glutaminolysis and one-carbon metabolism promotes ROS accumulation leading to enhancement of chemotherapeutic efficacy in anaplastic thyroid cancer

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Metabolomic Profile of Abdominal Aortic Aneurysm

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Cancer-Induced Metabolic Rewiring of Tumor Endothelial Cells

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Alone and Together: Current Approaches to Targeting Glutaminase Enzymes As Part of Anti-Cancer Therapies

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Asparagine, a critical limiting metabolite during glutamine starvation

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GCN4 Regulates Secondary Metabolism through Activation of Antioxidant Gene Expression under Nitrogen Limitation Conditions in Ganoderma lucidum

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Anticancer Properties of N,N-dibenzylasparagine as an Asparagine (Asp) analog, Using Colon Cancer Caco-2 Cell Line

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Targeting the Metabolic Adaptation of Metastatic Cancer

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Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma

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Metabolic Reprogramming Underlying Brain Metastasis of Breast Cancer

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Asparagine bioavailability regulates the translation of MYC oncogene

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Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents

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Beyond Genetics: Metastasis as an Adaptive Response in Breast Cancer

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Mechanical forces and metabolic changes cooperate to drive cellular memory and endothelial phenotypes

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Targeting Asparagine Synthetase in Tumorgenicity Using Patient-Derived Tumor-Initiating Cells

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Glutamine protects mouse spermatogonial stem cells against NOX1-derived ROS for sustaining self-renewal divisionin vitro

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Enzyme Engineering Strategies for the Bioenhancement of l-Asparaginase Used as a Biopharmaceutical

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Immunometabolism: a new dimension in immunotherapy resistance

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Exploring the potential of asparagine restriction in solid cancer treatment: recent discoveries, therapeutic implications, and challenges

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Cancer knocks you out by fasting: Cachexia as a consequence of metabolic alterations in cancer

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mTORC1 senses glutamine and other amino acids through GCN2

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Metabolomics-based phenotypic screens for evaluation of drug synergy via direct-infusion mass spectrometry

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Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation

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Dual asparagine-depriving nanoparticles against solid tumors

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Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling

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The MEMIC is an ex vivo system to model the complexity of the tumor microenvironment

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l-asparaginase and 6-diazo-5-oxo-l-norleucine synergistically inhibit the growth of glioblastoma cells

Ohba, S., & Hirose, Y. (2020) · Journal of Neuro-Oncology · doi:10.1007/s11060-019-03351-4 · Cited by 14

Rapid serum‐free /suspension adaptation: Medium development using a definitive screening design for Chinese hamster ovary cells

Wu, S., Rish, A. J., Skomo, A., Zhao, Y., Drennen, J. K., & Anderson, C. A. (2021) · Biotechnology Progress · doi:10.1002/btpr.3154 · Cited by 14

Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress

Okuda, K., Umemura, A., Kataoka, S., Yano, K., Takahashi, A., Okishio, S., Taketani, H., Seko, Y., Nishikawa, T., Yamaguchi, K., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.758549 · Cited by 11

Antimetabolic cooperativity with the clinically approved l-asparaginase and tyrosine kinase inhibitors to eradicate CML stem cells

Trinh, A., Khamari, R., Fovez, Q., Mahon, F., Turcq, B., Bouscary, D., Maboudou, P., Curt, M. J.-C., Coiteux, V., Germain, N., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101410 · Cited by 14

Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity

Rattigan, K. M., Zarou, M. M., & Helgason, G. V. (2023) · Blood · doi:10.1182/blood.2022018258 · Cited by 16

Glycan/Protein-Stable Isotope Labeling in Cell Culture for Enabling Concurrent Quantitative Glycomics/Proteomics/Glycoproteomics

Jiang, P., Peng, W., Zhao, J., Goli, M., Huang, Y., Li, Y., & Mechref, Y. S. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c00247 · Cited by 13

Animal Models of Retinopathy of Prematurity: Advances and Metabolic Regulators

Maurya, M., Liu, C., Bora, K., Kushwah, N., Pavlovich, M. C., Wang, Z., & Chen, J. (2024) · Biomedicines · doi:10.3390/biomedicines12091937 · Cited by 13

Recent advances in nanomedicine for metabolism-targeted cancer therapy

Da, J., Di, X., Xie, Y., Li, J., Zhang, L., & Liu, Y. (2024) · Chemical Communications · doi:10.1039/d3cc05858a · Cited by 12

Induction of CTH expression in response to amino acid starvation confers resistance to anti-LAT1 therapy in MDA-MB-231 cells

Yamaga, T., Suehiro, J., Wada, Y., & Sakurai, H. (2022) · Scientific Reports · doi:10.1038/s41598-022-04987-5 · Cited by 12

Druggable Metabolic Vulnerabilities Are Exposed and Masked during Progression to Castration Resistant Prostate Cancer

Choi, S. Y. C., Ribeiro, C. F., Wang, Y. Z., Loda, M. F., Plymate, S. R., & Uo, T. (2022) · Biomolecules · doi:10.3390/biom12111590 · Cited by 13

The regulation of amino acid metabolism in tumor cell death: from the perspective of physiological functions

Wang, J., Wang, H., Gao, M., Zhang, Y., Zhang, L., Huang, D., Tu, K., & Xu, Q. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01875-9 · Cited by 14

Breast cancers as ecosystems: a metabolic perspective

Martino, F., Lupi, M., Giraudo, E., & Lanzetti, L. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04902-9 · Cited by 14

Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival

Goswami, M. T., Weh, E., Subramanya, S., Weh, K. M., Durumutla, H. B., Hager, H. M., Miller, N., Chaudhury, S., Andren, A. C., Sajjakulnukit, P., et al. (2025) · eLife · doi:10.7554/elife.100747.3 · Cited by 11

Metabolism in the tumor microenvironment: implications for pathogenesis and therapeutics

Wik, J. A., Berge, E. R., Stromsnes, K., & Skålhegg, B. S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1610255 · Cited by 13

The Role of Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer

Vadlakonda, L., Indracanti, M., Kalangi, S. K., Gayatri, B. M., Gajula, N. N., & Reddy, A. B. M. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00566-5 · Cited by 11

Effectiveness of a bacteriophage YZU_PF006 in controlling dairy spoilage caused by Pseudomonas fluorescens

Yuan, L., Ma, L., Liu, Y., Yuan, X., Wang, S., Zhou, W., Xu, Z., & Yang, Z. (2024) · Journal of Dairy Science · doi:10.3168/jds.2024-25567 · Cited by 11

Endogenous glutamine is rate-limiting for anti-CD3 and anti-CD28 induced CD4+ T-cell proliferation and glycolytic activity under hypoxia and normoxia

Wik, J. A., Chowdhury, A. I., Kolan, S. S., Bastani, N. E., Li, G., Alam, K., Grimolizzi, F., & Skålhegg, B. S. (2022) · Biochemical Journal · doi:10.1042/bcj20220144 · Cited by 13

Enzymatic depletion of circulating glutamine is immunosuppressive in cancers

Kumar, M., Leekha, A., Nandy, S., Kulkarni, R. S., Martinez-Paniagua, M. A., Sefat, K. M. S. R., Willson, R. C., & Varadarajan, N. (2024) · iScience · doi:10.1016/j.isci.2024.109817 · Cited by 10

Novel Therapeutics Affecting Metabolic Pathways

Punekar, S. R., & Cho, D. C. (2019) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_238499 · Cited by 11

The lncRNA DAMER selectively guides m6A-dependent regulation of ATF4 and asparagine metabolism under nutrient stress in cancer

Tao, T., Feng, X., Yang, Y., Liu, B., Liang, J., Chen, Z., Wang, S., Zhao, J., Yang, X., Huo, L., et al. (2026) · Nature Cell Biology · doi:10.1038/s41556-026-01905-z · Cited by 11

Integrated transcriptomics and metabolomics analysis reveals the biomolecular mechanisms associated to the antitumoral potential of a novel silver-based core@shell nanosystem

Aragoneses-Cazorla, G., Vallet‐Regí, M., Gómez-Gómez, M. M., González, B., & Luque-Garcia, J. L. (2023) · Microchimica Acta · doi:10.1007/s00604-023-05712-3 · Cited by 10

Asparagine as a signal for glutamine sufficiency via asparagine synthetase: a fresh evidence-based framework in physiology and oncology

Olawuni, B., & Bode, B. P. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00316.2024 · Cited by 10

Abstract B39: Asparagine drives translational adaptation of cancer cells to glutamine deficit

Pavlova, N. N., Zhang, J., & Thompson, C. B. (2017) · Cancer Research · doi:10.1158/1538-7445.transcontrol16-b39

Asparagine Protects Tumor Cells from Glutamine Depletion–Induced Cell Death

(2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2014-205 · Cited by 2

Abstract A09: The role of asparagine in glutamine-independent proliferation of breast cancer cells

Pavlova, N. N., & Thompson, C. B. (2016) · Molecular Cancer Research · doi:10.1158/1557-3125.metca15-a09

Asparagine as a signal for glutamine sufficiency via asparagine synthetase: a fresh evidence-based framework in physiology and oncology

Olawuni, B., & Bode, B. P. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00316.2024 · Cited by 10

The Population-dependent Requirement by Cultured Mammalian Cells for Metabolites Which They Can Synthesize

Eagle, H., Washington, C. L., Levy, M., & Cohen, L. A. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99661-4 · Cited by 42