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Cited by 26PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and TherapyMetabolism, Diabetes, and Cancer

SNAT7 regulates mTORC1 via macropinocytosis

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Meng, Delong, Yang, Qianmei, Jeong, Mi-Hyeon, Curukovic, Adna, Tiwary, Shweta, Melick, Chase H., Lama-Sherpa, Tshering D., Wang, Huanyu +6 more·2022·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.2123261119PMC PMC9171778
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Abstract

Significance: The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway is frequently elevated in human disease, including cancer, type 2 diabetes, metabolic disorders, and neurodegeneration. We identify SNAT7 as an important regulator of mTORC1. We believe this research will provide valuable insight about mTORC1 biology and may uncover novel therapeutic targets for patients.

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Crossref · 10.1073/pnas.2123261119

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  • Abrogating expression of lysosomal glutamine and asparagine transporter SNAT7 regulates mTORC1-dependent macropinocytosis and pancreatic cancer cell proliferation.

    “A recent study showed that abrogating the expression of lysosomal glutamine and asparagine transporter SNAT7 regulates mTORC1-dependent macropinocytosis and pancreatic cancer cell proliferation, suggesting nutrients uptake through macropinocytosis is critical for SNAT7-mTORC1 signaling [36].”

    From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [36]

  • Nutrients uptake through macropinocytosis is critical for SNAT7-mTORC1 signaling.

    “suggesting nutrients uptake through macropinocytosis is critical for SNAT7-mTORC1 signaling [36].”

    From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [36]

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Cited by

Sorted by citations

  • Insights of Endocytosis Signaling in Health and Disease

    Pathak, C., Vaidya, F. U., Waghela, B. N., Jaiswara, P. K., Gupta, V. K., Kumar, A., Rajendran, B. K., & Ranjan, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032971 · Cited by 59 · see citing works

    “A recent study showed that abrogating the expression of lysosomal glutamine and asparagine transporter SNAT7 regulates mTORC1-dependent macropinocytosis and pancreatic cancer cell proliferation, suggesting nutrients uptake through macropinocytosis is critical for SNAT7-mTORC1 signaling [36].”
    Background

Authors
Meng, D., Yang, Q., Jeong, M.-H., Curukovic, A., Tiwary, S., Melick, C. H., Lama-Sherpa, T. D., Wang, H., Huerta-Rosario, M., Urquhart, G., Zacharias, L. G., Lewis, C., DeBerardinis, R. J., & Jewell, J. L.
Affiliations
  • Harold C. Simmons Comprehensive Cancer Center (US)
  • Children's Medical Center (US)
Corresponding author
Jewell, Jenna L.
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2022-05-13
Volume
119
Issue
20
Pages
e2123261119-e2123261119
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.2123261119
PMC
PMC9171778
OpenAlex
W4280568518
Cited by
26
References
21
Citations by year
2026: 8 · 2025: 5 · 2024: 6 · 2023: 6 · 2022: 1
FWCI
1.47
Type
journal article
Language
en
Open access
Licence
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Cancer Prevention and Research Institute of Texas (RR150032, RP160713, RP180778)
  • The Welch Foundation (I-1927-20170325, I-1927-20200401, I-1733)
  • 2017 UT Southwestern President''''s Research Council Distinguished Researcher Award (N/A)
  • American Cancer Society (133894-RSG-19-162-01-TBE)
  • HHS | NIH | National Institute of General Medical Sciences (R01GM129097-01, T32GM008203)
  • HHS | NIH | National Cancer Institute (R35CA22044901)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
mTORC1, macropinocytosis, albumin, amino acid sensing
MeSH terms
Mechanistic Target of Rapamycin Complex 1, Asparagine, Glutamine, Humans, Lysosomes, Pancreatic Neoplasms, Pinocytosis, Signal Transduction, Amino Acid Transport Systems, Neutral

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