12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake
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12,13-diHOME is secreted from brown adipose tissue and increases skeletal muscle oxidative capacity.
“12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME), which is secreted from BAT and increases skeletal muscle oxidative capacity91.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [91]
In humans and mouse models, exercise facilitates BAT secretion of 12,13-diHOME, which enhances skeletal muscle free fatty acid uptake and oxidation.
“In both humans and mouse models, exercise facilitates BAT secretion of 12,13-diHOME, which enhances skeletal muscle FFA uptake and oxidation91.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [91]
Levels of a lipokine produced from brown adipose tissue increase with acute and chronic training and affect white adipose tissue lipolysis.
“This paper demonstrated that levels of a lipokine produced from brown adipose tissue increase with acute and chronic training to affect white adipose tissue lipolysis.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [91]
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“, 2018), as well as the lipokine 12,13-diHOME (Lynes et al., 2017; Stanford et al., 2018).”
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“In addition, acute exercise elevates circulating 12,13-diHOME in humans and mice 10 .”
- Authors
- Stanford, K. I., Lynes, M. D., Takahashi, H., Baer, L. A., Arts, P. J., May, F. J., Lehnig, A. C., Middelbeek, R. J. W., Richard, J. J., So, K., Chen, E. Y., Gao, F., Narain, N. R., Distefano, G., Shettigar, V. K., Hirshman, M. F., Ziolo, M. T., Kiebish, M. A., Tseng, Y.-H., Coen, P. M., & Goodyear, L. J.
- Corresponding author
- Stanford, Kristin I.
- Goodyear, Laurie J.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 27
- Issue
- 6
- Pages
- 1357
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC5993199
- OpenAlex
- W4251642920
- Cited by
- 73
- References
- 0
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 10 · 2023: 15 · 2022: 8 · 2021: 11 · 2020: 8 · 2019: 6 · 2018: 1
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL138738)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK112283, R01DK077097, R01DK102898, K01DK105109, K23DK114550, P30DK036836, R01DK099511)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- 12,13-diHOME, lipokines, physical activity, brown adipose tissue, lipidomics, circulating lipids, adipokines
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