The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis
Open accessAbstract
Summary Long chain fatty acid (LCFA) oxidation has been shown to play an important role in IL-4-mediated macrophage polarization [M(IL-4)]. However, many of these conclusions are based on the inhibition of carnitine palmitoyltransferase-1 with high concentrations of etomoxir that far exceed what is required to inhibit enzyme activity (EC90 < 3 μM). We employ genetic and pharmacologic models to demonstrate that LCFA oxidation is largely dispensable for IL-4-driven polarization. Unexpectedly, high concentrations of etomoxir retained the ability to disrupt M(IL-4) polarization in the absence of Cpt1a or Cpt2 expression. Although excess etomoxir inhibits the adenine nucleotide translocase, oxidative phosphorylation is surprisingly dispensable for M(IL-4). Instead, the block in polarization was traced to depletion of intracellular free CoA, likely resulting from conversion of the pro-drug etomoxir into active etomoxiryl-CoA. These studies help explain the effect(s) of excess etomoxir on immune cells, and reveal an unappreciated role for CoA metabolism in macrophage polarization.
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Cites
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Metadata
- Authors
- Divakaruni, A. S., Hsieh, W. Y., Minarrieta, L., Duong, T. N., Kim, K. K. O., Desousa, B. R., Andreyev, A. Y., Bowman, C. E., Caradonna, K., Dranka, B. P., Ferrick, D. A., Liesa, M., Stiles, L., Rogers, G. W., Braas, D., Ciaraldi, T. P., Wolfgang, M. J., Sparwasser, T., Berod, L., Bensinger, S. J., & Murphy, A. N.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 28
- Issue
- 3
- Pages
- 490-503.e7
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2810749981
- Cited by
- 361
- References
- 64
- FWCI
- 14.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Divakaruni, A. S., Hsieh, W. Y., Minarrieta, L., Duong, T. N., Kim, K. K. O., Desousa, B. R., Andreyev, A. Y., Bowman, C. E., Caradonna, K., Dranka, B. P., Ferrick, D. A., Liesa, M., Stiles, L., Rogers, G. W., Braas, D., Ciaraldi, T. P., Wolfgang, M. J., Sparwasser, T., Berod, L., . . . Murphy, A. N. (2018). Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metabolism. https://doi.org/10.1016/j.cmet.2018.06.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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