Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair
Open accessAbstract
During wound injury, efferocytosis fills the macrophage with a metabolite load nearly equal to the phagocyte itself. A timely question pertains to how metabolic phagocytic signaling regulates the signature anti-inflammatory macrophage response. Here we report the metabolome of activated macrophages during efferocytosis to reveal an interleukin-10 (IL-10) cytokine escalation that was independent of glycolysis yet bolstered by apoptotic cell fatty acids and mitochondrial β-oxidation, the electron transport chain, and heightened coenzyme NAD+. Loss of IL-10 due to mitochondrial complex III defects was remarkably rescued by adding NAD+ precursors. This activated a SIRTUIN1 signaling cascade, largely independent of ATP, that culminated in activation of IL-10 transcription factor PBX1. Il-10 activation by the respiratory chain was also important in vivo, as efferocyte mitochondrial dysfunction led to cardiac rupture after myocardial injury. These findings highlight a new paradigm whereby macrophages leverage efferocytic metabolites and electron transport for anti-inflammatory reprogramming that culminates in organ repair.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Efferocytosis leads to IL-10 induction in macrophages through signaling pathways activated by apoptotic cell cargo, including fatty acids and tryptophan.
“Efferocytosis leads to IL-10 induction in macrophages through signaling pathways activated by apoptotic cell cargo, including fatty acids and tryptophan (30, 40).”
From Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction–associated steatohepatitis (2025) · cites this paper as [40]
The Results sections on mitochondrial bias and fatty acid oxidation report that efferocytosis induces macrophage IL-10 and that fatty acids in apoptotic cells increase its production. The NAD-Dependent IL-10 Acts through Sirtuins section describes a signaling route to IL-10 expression. These passages do not support the claim that apoptotic-cell tryptophan activates an IL-10-inducing pathway. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIL-10 is among the proresolving molecules known to be induced by efferocytosis.
“Among the proresolving molecules known to be induced by efferocytosis is interleukin-10 (IL-10) (30, 40)”
From Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction–associated steatohepatitis (2025) · cites this paper as [40]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713 · see citing works
Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166 · cited 3× · see citing works
“This approach confirmed that apoptotic cells (Annexin V+, PI−) specifically and reproducibly induced macrophages to produce the canonical antiinflammatory cytokine IL-10 (Fadok et al., 1998) (Figures 1D and 1E).”
BackgroundMethodResolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552 · see citing works
Jha, A. K., Huang, S. C.-C., Sergushichev, A., Lampropoulou, V., Ivanova, Y., Loginicheva, E., Chmielewski, K., Stewart, K. M., Ashall, J., Everts, B., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.005 · Cited by 2,066 · see citing works
Chandel, N. S., McClintock, D. S., Feliciano, C. E., Wood, T. M., Melendez, J. A., Rodriguez, A. M., & Schumacker, P. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001914200 · Cited by 2,000 · see citing works
Self-citationLampropoulou, V., Sergushichev, A., Bambousková, M., Nair, S., Vincent, E. E., Loginicheva, E., Cervantes‐Barragán, L., Ma, X., Huang, S. C., Griss, T., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.004 · Cited by 1,547 · see citing works
Palsson-McDermott, E. M., Curtis, A. M., Goel, G., Lauterbach, M. A. R., Sheedy, F. J., Gleeson, L. E., van den Bosch, M. W. M., Quinn, S. R., Domingo-Fernandez, R., Johnston, D. G. W., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.005 · Cited by 1,397 · see citing works
Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation
Vats, D., Mukundan, L., Odegaard, J. I., Zhang, L., Smith, K. L., Morel, C. R., Greaves, D. R., Murray, P. J., & Chawla, A. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.011 · Cited by 1,369 · cited 1× · see citing works
“In skeletal cells, SIRT1 controls the transcription of peroxisome proliferator-activated receptor-gamma co-acti-vator-1α (PGC-1α) (Amat et al., 2009), which separately has been linked to IL-10 induction (Morari et al., 2010) and oxidative metabolism in macrophages (Vats et al., 2006).”
BackgroundEvans, A. M., DeHaven, C. D., Barrett, T., Mitchell, M. W., & Milgram, K. E. (2009) · Analytical Chemistry · doi:10.1021/ac901536h · Cited by 1,315 · see citing works
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
Liu, P.-S., Wang, H., Li, X., Chao, T., Teav, T., Christen, S., Di Conza, G., Cheng, W.-C., Chou, C.-H., Vavakova, M., et al. (2017) · Nature Immunology · doi:10.1038/ni.3796 · Cited by 1,264 · see citing works
Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation
Krawczyk, C. M., Holowka, T., Sun, J., Blagih, J., Amiel, E., DeBerardinis, R. J., Cross, J. R., Jung, E., Thompson, C. B., Jones, R. G., et al. (2010) · Blood · doi:10.1182/blood-2009-10-249540 · Cited by 1,246 · see citing works
Metabolic Instruction of Immunity
Buck, M. D., Sowell, R., Kaech, S. M., & Pearce, E. L. (2017) · Cell · doi:10.1016/j.cell.2017.04.004 · Cited by 1,232 · see citing works
Apoptotic cell clearance: basic biology and therapeutic potential
Poon, I. K. H., Lucas, C. D., Rossi, A. G., & Ravichandran, K. S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3607 · Cited by 1,223 · see citing works
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
Huang, S. C., Everts, B., Ivanova, Y., O’Sullivan, D., Nascimento, M., Smith, A. M., Beatty, W. L., Love-Gregory, L. D., Lam, W. Y., O’Neill, C. M., et al. (2014) · Nature Immunology · doi:10.1038/ni.2956 · Cited by 1,215 · see citing works
Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities
Tabas, I., & Glass, C. K. (2013) · Science · doi:10.1126/science.1230720 · Cited by 1,093 · see citing works
Inflammation and plaque vulnerability
Hansson, G. K., Libby, P., & Tabas, I. A. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12406 · Cited by 809 · see citing works
Jose, P. J., Griffiths-Johnson, D. A., COLLINS, P. D., Walsh, D. T., Moqbel, R., Totty, N. F., Truong, O., Hsuan, J. J., & Williams, T. J. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.3.881 · Cited by 806 · see citing works
Kim, H.-S., Patel, K., Muldoon-Jacobs, K., Bisht, K. S., Aykin-Burns, N., Pennington, J. D., van der Meer, R., Nguyen, P., Savage, J., Owens, K. M., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.11.023 · Cited by 785 · see citing works
Self-citationA-González, N., Bensinger, S. J., Hong, C., Beceiro, S., Bradley, M. N., Zelcer, N., Deniz, J. M., Ramírez, C. M., Díaz, M., Gallardo, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.018 · Cited by 679 · see citing works
The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism
Haschemi, A., Kosma, P., Gille, L., Evans, C. R., Burant, C. F., Starkl, P., Knapp, B., Haas, R., Schmid, J. A., Jandl, C., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.023 · Cited by 635 · see citing works
SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
Li, X., Zhang, S., Blander, G., Tse, J. G., Krieger, M., & Guarente, L. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.032 · Cited by 631 · see citing works
Self-citationmTORC2-IRF4 mediated metabolic reprograming is essential for macrophage alternative activation
Huang, S., Smith, A., Everts, B., Colonna, M., Pearce, E. L., Schilling, J., & Pearce, E. J. (2016) · Immunity · doi:10.1016/j.immuni.2016.09.016 · Cited by 579 · see citing works
Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells
Bosurgi, L., Cao, Y. G., Cabeza-Cabrerizo, M., Tucci, A., Hughes, L. D., Kong, Y., Weinstein, J. S., Licona-Limon, P., Schmid, E. T., Pelorosso, F., et al. (2017) · Science · doi:10.1126/science.aai8132 · Cited by 560 · see citing works
Tanner, K. G., Landry, J. W., Sternglanz, R., & Denu, J. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250422697 · Cited by 557 · see citing works
Titov, D. V., Cracan, V., Goodman, R. P., Peng, J., Grabarek, Z., & Mootha, V. K. (2016) · Science · doi:10.1126/science.aad4017 · Cited by 518 · see citing works
METABOLIC PATTERNS IN THREE TYPES OF PHAGOCYTIZING CELLS
Oren, R., Farnham, A. E., Saito, K., Milofsky, E. S., & Karnovsky, M. L. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.3.487 · Cited by 504 · see citing works
Screening large-scale association study data: exploiting interactions using random forests
Lunetta, K. L., Hayward, B., Segal, J., & Eerdewegh, P. V. (2004) · BMC Genetics · doi:10.1186/1471-2156-5-32 · Cited by 464 · see citing works
Mitochondria and cell signalling
Tait, S. W. G., & Green, D. R. (2012) · Journal of Cell Science · doi:10.1242/jcs.099234 · Cited by 453 · see citing works
Krishnamurthy, P., Rajasingh, J., Lambers, E., Qin, G., Losordo, D. W., & Kishore, R. (2008) · Circulation Research · doi:10.1161/circresaha.108.188243 · Cited by 423 · see citing works
Wan, E. Y., Yeap, X. Y., Dehn, S., Terry, R. L., Novak, M. L., Zhang, S., Iwata, S., Han, X., Homma, S., Drosatos, K., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.301198 · Cited by 384 · see citing works
Self-citationMitochondrial fission promotes the continued clearance of apoptotic cells by macrophages
Wang, Y., Subramanian, M., Yurdagul, A., Barbosa-Lorenzi, V. C., Cai, B., de Juan-Sanz, J., Ryan, T. A., Nomura, M., Maxfield, F. R., & Tabas, I. (2017) · Cell · doi:10.1016/j.cell.2017.08.041 · Cited by 364 · see citing works
Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis
Divakaruni, A. S., Hsieh, W. Y., Minarrieta, L., Duong, T., Kim, K. K. O., Desousa, B. R., Andreyev, A. Y., Bowman, C. E., Caradonna, K. L., Dranka, B. P., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.06.001 · Cited by 364 · see citing works
Alternatively activated macrophages determine repair of the infarcted adult murine heart
Shiraishi, M., Shintani, Y., Shintani, Y., Ishida, H., Saba, R., Yamaguchi, A., Adachi, H., Yashiro, K., & Suzuki, K. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85782 · Cited by 344 · see citing works
Varia, M. A., Calkins-Adams, D. P., Rinker, L. H., Kennedy, A. S., Novotny, D. B., Fowler, W. C., & Raleigh, J. A. (1998) · Gynecologic Oncology · doi:10.1006/gyno.1998.5163 · Cited by 342 · see citing works
Hartl, F. U., Schmidt, B., Wächter, E., Weiss, H., & Neupert, W. (1986) · Cell · doi:10.1016/0092-8674(86)90809-3 · Cited by 334 · see citing works
The mitochondrial respiratory chain is essential for haematopoietic stem cell function
Ansó, E., Weinberg, S. E., Diebold, L. P., Thompson, B. J., Malinge, S., Schumacker, P. T., Liu, X., Zhang, Y., Shao, Z., Steadman, M., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3529 · Cited by 310 · see citing works
Self-citationYamamoto, T., Byun, J., Zhai, P., Ikeda, Y., Oka, S., & Sadoshima, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098972 · Cited by 305 · see citing works
Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation
Riffelmacher, T., Clarke, A. J., Richter, F. C., Stranks, A. J., Pandey, S., Danielli, S., Hublitz, P., Yu, Z., Johnson, E., Schwerd, T., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.005 · Cited by 301 · see citing works
Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism
Masri, S., Rigor, P., Cervantes, M., Ceglia, N., Sebastian, C., Xiao, C., Roqueta-Rivera, M., Deng, C., Osborne, T. F., Mostoslavsky, R., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.050 · Cited by 292 · see citing works
CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
Chatterjee, S., Daenthanasanmak, A., Chakraborty, P., Wyatt, M. W., Dhar, P., Selvam, S. P., Fu, J., Zhang, J., Nguyen, H., Kang, I., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.006 · Cited by 270 · see citing works
Chung, E. Y., Liu, J., Homma, Y., Zhang, Y., Brendolan, A., Saggese, M., Han, J., Silverstein, R. L., Selleri, L., & Ma, X. (2007) · Immunity · doi:10.1016/j.immuni.2007.11.014 · Cited by 249 · see citing works
Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein
Park, D., Han, C. Z., Elliott, M. R., Kinchen, J. M., Trampont, P. C., Das, S., Collins, S., Lysiak, J. J., Hoehn, K. L., & Ravichandran, K. S. (2011) · Nature · doi:10.1038/nature10340 · Cited by 248 · see citing works
Self-citationDeBerge, M., Yeap, X. Y., Dehn, S., Zhang, S., Grigoryeva, L. S., Misener, S., Procissi, D., Zhou, X., Lee, D. C., Müller, W. A., et al. (2017) · Circulation Research · doi:10.1161/circresaha.117.311327 · Cited by 241 · see citing works
Self-citationAmat, R., Planavila, A., Chen, S. L., Iglesias, R., Giralt, M., & Villarroya, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.022749 · Cited by 218 · see citing works
The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes
Anzai, A., Choi, J. L., He, S., Fenn, A. M., Nairz, M., Rattik, S., McAlpine, C. S., Mindur, J. E., Chan, C. T., Iwamoto, Y., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170689 · Cited by 210 · see citing works
Studies on the Biosynthesis of Nicotinamide Adenine Dinucleotide
Ikeda, M., Tsuji, H., Nakamura, S., Ichiyama, A., Nishizuka, Y., & Hayaishi, O. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)97589-7 · Cited by 203 · see citing works
Eller, K., Wolf, D. G. F., Huber, J., Metz, M., Mayer, G. J., McKenzie, A. N. J., Maurer, M., Rosenkranz, A. R., & Wolf, A. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001183 · Cited by 182 · see citing works
Wang, Y., Mohsen, A.-W. A., Mihalik, S. J., Goetzman, E. S., & Vockley, J. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.139493 · Cited by 169 · see citing works
Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling.
Quirós, M., Nishio, H., Neumann, P., Siuda, D., Brazil, J., Azcutia, V., Hilgarth, R., O'Leary, M. N., Garcia-Hernandez, V., Leoni, G., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90229 · Cited by 169 · see citing works
HoWangYin, K.-Y., Zlatanova, I., Pinto, C., Ngkelo, A., Cochain, C., Rouanet, M., Vilar, J., Lemitre, M., Stockmann, C., Fleischmann, B. K., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.020857 · Cited by 165 · see citing works
Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase
Chandak, P. G., Radović, B., Aflaki, E., Kolb, D., Buchebner, M., Fröhlich, E., Magnes, C., Sinner, F., Haemmerle, G., Zechner, R., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.107854 · Cited by 163 · see citing works
Inhibition of NADP dependent oxidoreductases by the 6‐aminonicotinamide analogue of NADP
Köhler, E., Barrach, H.-J., & Neubert, D. (1970) · FEBS Letters · doi:10.1016/0014-5793(70)80063-1 · Cited by 163 · see citing works
Waypa, G. B., Marks, J. D., Guzy, R. D., Mungai, P. T., Schriewer, J. M., Đokić, D., Ball, M. K., & Schumacker, P. T. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201207-1294oc · Cited by 154 · see citing works
Self-citationModification of the fatty acid composition of cultured human fibroblasts.
Spector, A. A., Kiser, R. E., Denning, G. M., Koh, S. W., & DeBault, L. E. (1979) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40609-1 · Cited by 138 · see citing works
Transcriptional and Translational Regulation of TGF-β Production in Response to Apoptotic Cells
Xiao, Y. Q., Freire-de-Lima, C. G., Schiemann, W. P., Bratton, D. L., Vandivier, R. W., & Henson, P. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3575 · Cited by 130 · see citing works
Alvey, C. M., Spinler, K. R., Irianto, J., Pfeifer, C. R., Hayes, B. H., Xia, Y., Cho, S., Dingal, P. C. D. P., Hsu, J., Smith, L., et al. (2017) · Current Biology · doi:10.1016/j.cub.2017.06.005 · Cited by 116 · see citing works
Schönfeld, P., Wieckowski, M. R., Lebiedzińska, M., & Wojtczak, L. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.010 · Cited by 100 · see citing works
Dehn, S., & Thorp, E. B. (2017) · The FASEB Journal · doi:10.1096/fj.201700450r · Cited by 67 · see citing works
Self-citationCiarlo, E., Heinonen, T., Théroude, C., Herderschee, J., Mombelli, M., Lugrin, J., Pfefferlé, M., Tyrrell, B. E., Lensch, S., Acha‐Orbea, H., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01037 · Cited by 59 · see citing works
Biochemical and physiologic consequences of carnitine palmityltransferase deficiency
Carroll, J. E., Brooke, M. H., Vivo, D. C. D., Kaiser, K. K., & Hagberg, J. M. (1978) · Muscle & Nerve · doi:10.1002/mus.880010203 · Cited by 56 · see citing works
NAMPT-Mediated Salvage Synthesis of NAD+ Controls Morphofunctional Changes of Macrophages
Venter, G., Oerlemans, F. T. J. J., Willemse, M. P., Wijers, M., Fransen, J. A. M., & Wieringa, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097378 · Cited by 51 · see citing works
Cardiomyocytes induce macrophage receptor shedding to suppress phagocytosis
Zhang, S., Yeap, X., Grigoryeva, L. S., Dehn, S., DeBerge, M., Tye, M. Y., Rostlund, E., Schrijvers, D. M., Zhang, Z. J., Sumagin, R., et al. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.08.009 · Cited by 38 · see citing works
Self-citationElectron transfer through the isolated mitochondrial cytochrome b-c1 complex
Rich, P. R. (1983) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(83)90073-7 · Cited by 37 · see citing works
Morari, J., Torsoni, A. S., Anhê, G. F., Roman, E. A., Cintra, D. E., Ward, L. S., Bordin, S. A., & Velloso, L. A. (2009) · Metabolism · doi:10.1016/j.metabol.2009.07.020 · Cited by 19 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Biology and therapeutic potential of interleukin-10
Saraiva, M., Vieira, P., & O’Garra, A. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190418 · Cited by 1,123 · see citing works
Efferocytosis in health and disease
Doran, A. C., Yurdagul, A., & Tabas, I. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0240-6 · Cited by 1,066 · see citing works
The role of macrophages in the resolution of inflammation
Watanabe, S., Alexander, M., Misharin, A. V., & Budinger, G. R. S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124615 · Cited by 925 · see citing works
The clearance of dead cells by efferocytosis
Boada-Romero, E., Martinez, J., Heckmann, B. L., & Green, D. R. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0232-1 · Cited by 893 · see citing works
Obesity, Hypertension, and Cardiac Dysfunction
Mouton, A. J., Li, X., Hall, M. E., & Hall, J. E. (2020) · Circulation Research · doi:10.1161/circresaha.119.312321 · Cited by 549 · see citing works
Yurdagul, A., Subramanian, M., Wang, X., Crown, S. B., Ilkayeva, O. R., Darville, L., Kolluru, G. K., Rymond, C. C., Gerlach, B. D., Zheng, Z., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.001 · Cited by 525 · see citing works
Metabolism of tissue macrophages in homeostasis and pathology
Wculek, S. K., Dunphy, G., Heras-Murillo, I., Mastrangelo, A., & Sancho, D. (2022) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00791-9 · Cited by 501 · see citing works
Drugging the efferocytosis process: concepts and opportunities
Mehrotra, P., & Ravichandran, K. S. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00470-y · Cited by 459 · see citing works
CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate
Chen, Y., Zhang, J., Cui, W., & Silverstein, R. L. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20211314 · Cited by 466 · see citing works
Macrophages: The Good, the Bad, and the Gluttony
Ross, E. A., Devitt, A., & Johnson, J. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708186 · Cited by 436 · see citing works
Macrophages at the interface of the co-evolving cancer ecosystem
Kloosterman, D. J., & Akkari, L. (2023) · Cell · doi:10.1016/j.cell.2023.02.020 · Cited by 436 · see citing works
Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair
Lafuse, W. P., Wozniak, D. J., & Rajaram, M. V. S. (2020) · Cells · doi:10.3390/cells10010051 · Cited by 400 · see citing works
Inflammation and Skeletal Muscle Regeneration: Leave It to the Macrophages!
Chazaud, B. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.04.006 · Cited by 378 · see citing works
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371 · see citing works
Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets
Chen, R., Zhang, H., Tang, B., Luo, Y., Yang, Y., Zhong, X., Chen, S., Xu, X., Huang, S., & Liu, C. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01840-1 · Cited by 387 · see citing works
Efferocytosis induces macrophage proliferation to help resolve tissue injury
Gerlach, B. D., Ampomah, P. B., Yurdagul, A., Liu, C., Lauring, M. C., Wang, X., Kasikara, C., Kong, N., Shi, J., Tao, W., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.10.015 · Cited by 360 · see citing works
Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis
Rodríguez-Morales, P., & Franklin, R. A. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.10.004 · Cited by 327 · see citing works
Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis
Wculek, S. K., Heras‐Murillo, I., Mastrangelo, A., Mañanes, D., Galán, M. Á., Miguel, V., Curtabbi, A., Barbas, C., Chandel, N. S., Enrı́quez, J. A., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.01.011 · Cited by 312 · see citing works
Self-citationPhagocytosis of Apoptotic Cells in Resolution of Inflammation
Kourtzelis, I., Hajishengallis, G., & Chavakis, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00553 · Cited by 301 · see citing works
Cai, S., Zhao, M., Zhou, B., Yoshii, A., Bugg, D., Villet, O. M., Sahu, A., Olson, G. S., Davis, J., & Tian, R. (2022) · Journal of Clinical Investigation · doi:10.1172/jci159498 · Cited by 287 · see citing works
Mitochondrial metabolism regulates macrophage biology
Wang, Y., Li, N., Zhang, X., & Horng, T. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100904 · Cited by 278 · see citing works
TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer
Park, M. D., Reyes-Torres, I., LeBerichel, J., Hamon, P., LaMarche, N. M., Hegde, S., Belabed, M., Troncoso, L., Grout, J. A., Magen, A., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01475-4 · Cited by 251 · see citing works
Ritterhoff, J., & Tian, R. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00887-x · Cited by 264 · see citing works
Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis
Tabas, I. A., & Bornfeldt, K. (2020) · Circulation Research · doi:10.1161/circresaha.119.315939 · Cited by 249 · see citing works
Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes
Zheng, C., Sui, B., Zhang, X., Hu, J.-C. E., Chen, J., Liu, J., Wu, D., Ye, Q., Xiang, L., Qiu, X., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12109 · Cited by 239 · see citing works
The role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation
Schilperoort, M., Ngai, D., Sukka, S. R., Avrampou, K., Shi, H., & Tabas, I. A. (2023) · Immunological Reviews · doi:10.1111/imr.13214 · Cited by 181 · see citing works
Metabolic adaptations of tissue-resident immune cells
Caputa, G., Castoldi, Â., & Pearce, E. J. (2019) · Nature Immunology · doi:10.1038/s41590-019-0407-0 · Cited by 176 · see citing works
Ampomah, P. B., Cai, B., Sukka, S. R., Gerlach, B. D., Yurdagul, A., Wang, X., Kuriakose, G., Darville, L. N. F., Sun, Y., Sidoli, S., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00551-7 · Cited by 176 · see citing works
Inflammation Resolution: Implications for Atherosclerosis
Doran, A. C. (2022) · Circulation Research · doi:10.1161/circresaha.121.319822 · Cited by 177 · see citing works
Efferocytosis in atherosclerosis
Adkar, S. S., & Leeper, N. J. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01037-7 · Cited by 166 · see citing works
Foam Cells: One Size Doesn’t Fit All
Guerrini, V., & Gennaro, M. L. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.10.002 · Cited by 155 · see citing works
Francisco, J. J., & Re, D. P. D. (2023) · Antioxidants · doi:10.3390/antiox12111944 · Cited by 160 · see citing works
Dynamics of monocyte-derived macrophage diversity in experimental myocardial infarction
Rizzo, G., Gropper, J., Piollet, M., Vafadarnejad, E., Rizakou, A., Bandi, S. R., Arampatzi, P., Krammer, T., DiFabion, N., Dietrich, O., et al. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvac113 · Cited by 165 · see citing works
The immunologic Warburg effect: Evidence and therapeutic opportunities in autoimmunity
Kornberg, M. (2020) · Wiley Interdisciplinary Reviews: Systems Biology and Medicine · doi:10.1002/wsbm.1486 · Cited by 118 · see citing works
Extracellular vesicles arising from apoptosis: forms, functions, and applications
Gregory, C. D., & Rimmer, M. P. (2023) · The Journal of Pathology · doi:10.1002/path.6138 · Cited by 140 · see citing works
Crosstalk Between Macrophages and Vascular Smooth Muscle Cells in Atherosclerotic Plaque Stability
Yurdagul, A. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316233 · Cited by 137 · see citing works
Immunometabolic mechanisms of heart failure with preserved ejection fraction
Schiattarella, G. G., Alcaide, P., Condorelli, G., Gillette, T. G., Heymans, S. R. B., Jones, E. A. V., Kallikourdis, M., Lichtman, A. H., Marelli‐Berg, F. M., Shah, S. J., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00032-w · Cited by 131 · see citing works
Self-citationGranulopoiesis and Neutrophil Homeostasis: A Metabolic, Daily Balancing Act
Yvan‐Charvet, L., & Ng, L. G. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.05.004 · Cited by 130 · see citing works
Self-citationWang, Y., Wang, J., Zhang, J., Wang, Y., Wang, Y., Kang, H., Zhao, W., Bai, W., Miao, N., & Wang, J. (2024) · Science Advances · doi:10.1126/sciadv.adj3289 · Cited by 131 · see citing works
Metabolic reprogramming in skin wound healing
Wang, Z., Zhao, F., Xu, C., Zhang, Q., Ren, H., Huang, X., He, C., Ma, J., & Wang, Z. (2024) · Burns & Trauma · doi:10.1093/burnst/tkad047 · Cited by 124 · see citing works
TREM2 protects from atherosclerosis by limiting necrotic core formation
Piollet, M., Porsch, F., Rizzo, G., Kapser, F., Schulz, D., Kiss, M. G., Schlepckow, K., Morenas‐Rodríguez, E., Sen, M. O., Gropper, J., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00429-9 · Cited by 130 · see citing works
The Role of Macrophages in the Infarcted Myocardium: Orchestrators of ECM Remodeling
O’Rourke, S. A., Dunne, A., & Monaghan, M. G. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00101 · Cited by 120 · see citing works
The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials
Mata, R., Yao, Y., Cao, W., Ding, J., Zhou, T., Zhai, Z., & Gao, C.-Y. (2021) · Research · doi:10.34133/2021/4189516 · Cited by 112 · see citing works
Immunology of chronic low-grade inflammation: relationship with metabolic function
van de Vyver, M. (2023) · Journal of Endocrinology · doi:10.1530/joe-22-0271 · Cited by 112 · see citing works
Macrophages in Heart Failure with Reduced versus Preserved Ejection Fraction
DeBerge, M., Shah, S. J., Wilsbacher, L. D., & Thorp, E. B. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.01.002 · Cited by 107 · see citing works
Self-citationChakraborty, S., Singh, A., Wang, L. X., Wang, X., Sanborn, M. A., Ye, Z., Maienschein‐Cline, M., Mukhopadhyay, A., Ganesh, B. B., Malik, A. B., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20221388 · Cited by 111 · see citing works
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments
Wang, Y., Trzeciak, A. J., Rojas, W. S., Saavedra, P. H. V., Chen, Y., Chirayil, R., Etchegaray, J. I., Lucas, C. D., Puleston, D. J., Keshari, K. R., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.12.005 · Cited by 107 · see citing works
First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis
Trzeciak, A. J., Wang, Y., & Perry, J. S. A. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.001 · Cited by 107 · see citing works
Intercellular Adhesion Molecule 1 Functions as an Efferocytosis Receptor in Inflammatory Macrophages
Wiesolek, H. L., Bui, T. M., Lee, J. J., Dalal, P., Finkielsztein, A., Batra, A., Thorp, E. B., & Sumagin, R. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2019.12.006 · Cited by 102 · see citing works
Self-citationMerlin, J., Ivanov, S., Dumont, A., Sergushichev, A., Gall, J., Stunault, M. I., Ayrault, M., Vaillant, N., Castiglione, A., Swain, A., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00471-y · Cited by 101 · see citing works
Self-citationNgai, D., Schilperoort, M., & Tabas, I. A. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00921-9 · Cited by 99 · see citing works
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction
DeBerge, M., Glinton, K. E., Subramanian, M., Wilsbacher, L. D., Rothlin, C. V., Tabas, I. A., & Thorp, E. B. (2021) · Journal of Clinical Investigation · doi:10.1172/jci139576 · Cited by 98 · see citing works
Self-citationMitochondrial metabolism mediated macrophage polarization in chronic lung diseases
Dong, T., Chen, X., Xu, H., Song, Y., Wang, H., Gao, Y., Wang, J., Du, R., Lou, H., & Dong, T. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108208 · Cited by 101 · see citing works
Utility of monocyte HLA-DR and rationale for therapeutic GM-CSF in sepsis immunoparalysis
Joshi, I., Carney, W. P., & Rock, E. P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1130214 · Cited by 102 · see citing works
Ryan, E. M., Sadiku, P., Coelho, P., Watts, E., Zhang, A., Howden, A. J. M., Sánchez-García, M. A., Bewley, M. A., Cole, J., McHugh, B. J., et al. (2023) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202203-0482oc · Cited by 94 · see citing works
Targeting Efferocytosis in Inflammaging
Poon, I. K. H., & Ravichandran, K. S. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-032723-110507 · Cited by 92 · see citing works
Cellular Responses to the Efferocytosis of Apoptotic Cells
Yin, C., & Heit, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.631714 · Cited by 92 · see citing works
Zhao, X., Huffman, L. D., Hafner, H., Athaiya, M., Finneran, M. C., Kalinski, A. L., Kohen, R., Flynn, C. G. K., Passino, R., Johnson, C. N., et al. (2022) · eLife · doi:10.7554/elife.80881 · Cited by 91 · see citing works
Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice
Jha, M. K., Passero, J. V., Rawat, A. K., Ament, X. H., Yang, F. W., Vidensky, S., Collins, S. L., Horton, M. R., Höke, A., Rutter, G. A., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci141964 · Cited by 89 · see citing works
Basophils balance healing after myocardial infarction via IL-4/IL-13
Sicklinger, F., Meyer, I. S., Li, X., Radtke, D., Dicks, S., Kornadt, M. P., Mertens, C., Meier, J. K., Lavine, K. J., Zhang, Y., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci136778 · Cited by 88 · see citing works
Anti-Inflammatory Neutrophil Functions in the Resolution of Inflammation and Tissue Repair
Loh, W., & Vermeren, S. (2022) · Cells · doi:10.3390/cells11244076 · Cited by 87 · see citing works
Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells
McCubbrey, A. L., McManus, S. A., McClendon, J. D., Thomas, S. M., Chatwin, H. B., Reisz, J. A., D’Alessandro, A., Mould, K. J., Bratton, D. L., Henson, P. M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110222 · Cited by 81 · see citing works
Hosseini, Z., Marinello, M., Decker, C., Sansbury, B. E., Sadhu, S., Gerlach, B. D., Ramos, R. B., Adam, A. P., Spite, M. R., & Fredman, G. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315758 · Cited by 79 · see citing works
After cell death: the molecular machinery of efferocytosis
Moon, B., Yang, S., Moon, H., Lee, J., & Park, D. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01070-5 · Cited by 78 · see citing works
Immune cells in cardiac homeostasis and disease: emerging insights from novel technologies
Steffens, S., Nahrendorf, M., & Madonna, R. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab842 · Cited by 77 · see citing works
Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution
Sukka, S. R., Ampomah, P. B., Darville, L. N. F., Ngai, D., Wang, X., Kuriakose, G., Xiao, Y., Shi, J., Koomen, J. M., McCusker, R. H., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01115-7 · Cited by 82 · see citing works
Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages
Gonzalez, M. A., Lu, D., Yousefi, M., Kroll, A. V., Lo, C. H., Briseño, C. G., Watson, J. E. V., Novitskiy, S. V., Arias, V., Zhou, H., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20221472 · Cited by 74 · see citing works
Wang, H., Zhang, Y., Zhang, Y., Li, C., Zhang, M., Wang, J., Zhang, Y., Du, Y., Cui, W., & Chen, W. (2024) · Advanced Materials · doi:10.1002/adma.202402968 · Cited by 76 · see citing works
Innate Immunity Effector Cells as Inflammatory Drivers of Cardiac Fibrosis
Baci, D., Bosi, A., Parisi, L., Buono, G., Mortara, L., Ambrosio, G., & Bruno, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197165 · Cited by 77 · see citing works
Macrophage Responses to Environmental Stimuli During Homeostasis and Disease
Rasheed, A., & Rayner, K. J. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab004 · Cited by 79 · see citing works
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses
Lesbats, J., Brillac, A., Reisz, J. A., Mukherjee, P., Lhuissier, C., Fernández-Monreal, M., Dupuy, J.-W., Sequeira, A., Tioli, G., De La Calle Arregui, C., et al. (2025) · Nature · doi:10.1038/s41586-025-08629-4 · Cited by 74 · see citing works
Lantz, C. W., Radmanesh, B., Liu, E., Thorp, E. B., & Lin, J. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-70353-y · Cited by 69 · see citing works
Self-citationNąckiewicz, D., Dan, M., Speck, M., Chow, S., Chen, Y., Pospisilik, J. A., Verchere, C. B., & Ehses, J. A. (2019) · iScience · doi:10.1016/j.isci.2019.100775 · Cited by 71 · see citing works
COVID-19: Proposing a Ketone-Based Metabolic Therapy as a Treatment to Blunt the Cytokine Storm
Bradshaw, P. C., Seeds, W. A., Miller, A. C., Mahajan, V. R., & Curtis, W. M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6401341 · Cited by 68 · see citing works
Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities
Stroope, C., Nettersheim, F. S., Coon, B. G., Finney, A. C., Schwartz, M. A., Ley, K. F., Rom, O., & Yurdagul, A. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01015-w · Cited by 72 · see citing works
Pervizaj-Oruqaj, L., Ferrero, M. R., Matt, U., & Herold, S. (2024) · European Respiratory Review · doi:10.1183/16000617.0263-2023 · Cited by 72 · see citing works
DeBerge, M., Lantz, C. W., Dehn, S., Sullivan, D. P., van der Laan, A. M., Niessen, H. W. M., Flanagan, M. E., Brat, D. J., Feinstein, M. J., Kaushal, S., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20200667 · Cited by 68 · see citing works
Self-citationChuang, S. T., Stein, J. B., Nevins, S., Bektas, C. K., Choi, H. K., Ko, W., Jang, H., Ha, J., & Lee, K. (2024) · Advanced Materials · doi:10.1002/adma.202308377 · Cited by 68 · see citing works
Zuo, S., Wang, Y., Bao, H., Zhang, Z., Yang, N.-F., Jia, M., Zhang, Q., Jian, A., Ji, R., Zhang, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51736-5 · Cited by 73 · see citing works
Lee, J., Park, B., Park, J.-H., Lim, S., Kwon, S. P., Hwang, J., Kim, H., Park, H., & Kim, B. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.08.028 · Cited by 66 · see citing works
Macrophage fatty acid metabolism and atherosclerosis: The rise of PUFAs
Ménégaut, L., Jalil, A., Thomas, C., & Masson, D. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.10.002 · Cited by 65 · see citing works
Immunometabolism in heart failure
Andreadou, I., Ghigo, A., Nikolaou, P., Świrski, F. K., Thackeray, J. T., Heusch, G., & Vilahur, G. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01165-8 · Cited by 69 · see citing works
Recruited atypical Ly6G + macrophages license alveolar regeneration after lung injury
Ruscitti, C., Abinet, J., Maréchal, P., Meunier, M., meeûs, C. D., Vanneste, D., Janssen, P., Dourcy, M., Thiry, M., Bureau, F., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.ado1227 · Cited by 63 · see citing works
Zhang, G., Li, Q., Tao, W., Qin, P., Chen, J., Yang, H., Chen, J., Liu, H., Dai, Q., & Zhen, X. (2023) · Theranostics · doi:10.7150/thno.77088 · Cited by 62 · see citing works
Cardiac macrophages and emerging roles for their metabolism after myocardial infarction
Thorp, E. B. (2023) · Journal of Clinical Investigation · doi:10.1172/jci171953 · Cited by 64 · see citing works
Self-citationBakker, N. V. T., & Pearce, E. J. (2020) · Immunological Reviews · doi:10.1111/imr.12848 · Cited by 62 · see citing works
Cai, W., Cheng, J., Zong, S.-Y., Yu, Y., Wang, Y., Song, Y., He, R., Yuan, S., Chen, T., Hu, M., et al. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.10.007 · Cited by 60 · see citing works
Glycolysis in Innate Immune Cells Contributes to Autoimmunity
Xu, Y., Chen, Y., Zhang, X., Ma, J., Liu, Y., Cui, L., & Wang, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.920029 · Cited by 62 · see citing works
Cao, D., Khan, Z., Li, X., Saito, S., Bernstein, E. A., Victor, A. R., Ahmed, F., Hoshi, A., Veiras, L. C., Shibata, T., et al. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad082 · Cited by 60 · see citing works
SIRT3 Regulates Clearance of Apoptotic Cardiomyocytes by Deacetylating Frataxin
Gao, J., Huang, C., Kong, L., Zhou, W., Sun, M., Wei, T., & Shen, W. (2023) · Circulation Research · doi:10.1161/circresaha.123.323160 · Cited by 60 · see citing works
Catanzaro, E., Féron, O., Skirtach, A. G., & Krysko, D. V. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.925290 · Cited by 59 · see citing works
Mitochondria orchestrate macrophage effector functions in atherosclerosis
Dumont, A., Lee, M., Barouillet, T., Murphy, A. J., & Yvan‐Charvet, L. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100922 · Cited by 59 · see citing works
Self-citationEfferocytosis in the Central Nervous System
Zhao, J., Zhang, W., Wu, T., Wang, H., Mao, J., Liu, J., Zhou, Z., Lin, X., Yan, H., & Wang, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.773344 · Cited by 56 · see citing works
Immunometabolism at the Heart of Cardiovascular Disease
DeBerge, M., Chaudhary, R. K., Schroth, S. L., & Thorp, E. B. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2022.12.010 · Cited by 57 · see citing works
Self-citationRole of Damage-Associated Molecular Patterns in Septic Acute Kidney Injury, From Injury to Recovery
Ludes, P., de Roquetaillade, C., Chousterman, B. G., Pottecher, J., & Mebazaa, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.606622 · Cited by 54 · see citing works
Efferocytosis: An accomplice of cancer immune escape
Qiu, H., Shao, Z., Wen, X., Liu, Z., Chen, Z., Qu, D., Ding, X., & Zhang, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115540 · Cited by 55 · see citing works
Myocardial fibrosis from the perspective of the extracellular matrix: Mechanisms to clinical impact
Lunde, I. G., Rypdal, K. B., Linthout, S. V., Dı́ez, J., & González, A. (2024) · Matrix Biology · doi:10.1016/j.matbio.2024.08.008 · Cited by 54 · see citing works
Comparative Review of Microglia and Monocytes in CNS Phagocytosis
Andoh, M., & Koyama, R. (2021) · Cells · doi:10.3390/cells10102555 · Cited by 52 · see citing works
Immunometabolism of Phagocytes and Relationships to Cardiac Repair
Zhang, S., Bories, G. F. P., Lantz, C. W., Emmons, R., Becker, A., Liu, E., Abecassis, M. M., Yvan‐Charvet, L., & Thorp, E. B. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00042 · Cited by 52 · see citing works
Self-citationER-Mitochondria Communication in Cells of the Innate Immune System
Namgaladze, D., Khodzhaeva, V., & Brüne, B. (2019) · Cells · doi:10.3390/cells8091088 · Cited by 51 · see citing works
- Authors
- Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N. S., Schumacker, P. T., & Thorp, E. B.
- Affiliations
- Northwestern University (US)
- ITMO University (RU)
- Metabolon (United States) (US)
- Corresponding author
- Thorp, Edward B.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 29
- Issue
- 2
- Pages
- 443-456.e5
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC6471613
- OpenAlex
- W2907223756
- Cited by
- 485
- References
- 65
- Citations by year
- 2026: 82 · 2025: 90 · 2024: 84 · 2023: 71 · 2022: 45 · 2021: 62 · 2020: 31 · 2019: 20
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NHLBI (F32HL127958, HL122309, HL139812)
- Chicago Biomedical Consortium
- Sidney Bess Memorial Fund (2R01CA152601-A1, 1R01CA152799-01A1, 1R01CA168292-01A1, 1R01CA214025-01)
- Avon Foundation
- Lynn Sage Cancer Research Foundation
- Chicago Community Trust
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- efferocytosis, macrophage polarization, IL-10, mitochondrial beta-oxidation, electron transport chain, NAD+, SIRT1, PBX1, mitochondrial complex III, wound healing, myocardial injury, cardiac rupture, anti-inflammatory macrophages, tissue repair
- MeSH terms
- Animals, Electron Transport, Fatty Acids, Humans, Inflammation, Macrophages, Mice, Inbred C57BL, Mitochondria, NAD, Oxidation-Reduction, Wound Healing, Interleukin-10, Jurkat Cells, Mice, Cytophagocytosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review