Cited by 273Gut microbiota and healthCircadian rhythm and melatoninAnimal Nutrition and Physiology

The DOI matches its Crossref record; 192 of the 193 references it cites were found in a registry or an index.

The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism

Open access
Weger, Benjamin D., Gobet, Cédric, Yeung, Jake, Martin, Eva, Jimenez, Sonia, Betrisey, Bertrand, Foata, Francis, Berger, Bernard, Balvay, Aurélie, Foussier, Anne, Charpagne, Aline, Boizet-Bonhoure, Brigitte, Chou, Chieh Jason, Naef, Felix, Gachon, Frédéric·2019·Cell Metabolism

Abstract

The circadian clock and associated feeding rhythms have a profound impact on metabolism and the gut microbiome. To what extent microbiota reciprocally affect daily rhythms of physiology in the host remains elusive. Here, we analyzed transcriptome and metabolome profiles of male and female germ-free mice. While mRNA expression of circadian clock genes revealed subtle changes in liver, intestine, and white adipose tissue, germ-free mice showed considerably altered expression of genes associated with rhythmic physiology. Strikingly, the absence of the microbiome attenuated liver sexual dimorphism and sex-specific rhythmicity. The resulting feminization of male and masculinization of female germ-free animals is likely caused by altered sexual development and growth hormone secretion, associated with differential activation of xenobiotic receptors. This defines a novel mechanism by which the microbiome regulates host metabolism.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2018.09.023

Cites

192 of 192 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 193 references

1 of the 193 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Items 201–273 of 273

Metadata

Authors
Weger, B. D., Gobet, C., Yeung, J., Martin, E., Jimenez, S., Betrisey, B., Foata, F., Berger, B., Balvay, A., Foussier, A., Charpagne, A., Boizet-Bonhoure, B., Chou, C. J., Naef, F., & Gachon, F.
Affiliations
  • Centre Hospitalier Universitaire Vaudois (CH)
  • École Polytechnique Fédérale de Lausanne (CH)
  • Nestlé (Switzerland) (CH)
  • AgroParisTech (FR)
Corresponding author
Gachon, Frédéric
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2019-02
Volume
29
Issue
2
Pages
362-382.e8
ISSN
1550-4131 (ISSN-L)
OpenAlex
W2897926834
Cited by
269
References
193
Citations by year
2026: 23 · 2025: 32 · 2024: 33 · 2023: 37 · 2022: 31 · 2021: 44 · 2020: 39 · 2019: 26
FWCI
10.14
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
  • HAL (submittedVersion, cc-by-nc-nd)
Funders
  • European Research Council (ERC-2010-StG-260988)
  • Swiss National Science Foundation (310030_173079)
  • Natural Sciences and Engineering Research Council of Canada
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords
gut microbiota, circadian clock, sex differences, germ-free mice, growth hormone secretion, xenobiotic receptors, sexual development, metabolism, transcriptome, metabolome
MeSH terms
Gastrointestinal Microbiome, Animals, Circadian Rhythm, Female, Intestines, Liver, Male, Mice, Inbred C57BL, Sex Characteristics, Mice, Adipose Tissue, White, Ghrelin, Circadian Clocks, Transcriptome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review