The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism

R: A Language and Environment for Statistical Computing

R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,893

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106

Fiji: an open-source platform for biological-image analysis

Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890

The Sequence Alignment/Map format and SAMtools

Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709

<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data

Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364

limma powers differential expression analyses for RNA-sequencing and microarray studies

Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458

QIIME allows analysis of high-throughput community sequencing data

Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887

Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities

Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 21,481

An integrated encyclopedia of DNA elements in the human genome

The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072

Bayes factors

Kass, R. E., & Raftery, A. E. (1995) · Journal of the American Statistical Association · doi:10.1080/01621459.1995.10476572 · Cited by 12,558

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Kuleshov, M. V., Jones, M. R., Rouillard, A. D., Fernandez, N. F., Duan, Q., Wang, Z., Koplev, S., Jenkins, S. L., Jagodnik, K. M., Lachmann, A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw377 · Cited by 10,799

Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms

Caporaso, J. G., Lauber, C. L., Walters, W. A., Berg-Lyons, D., Huntley, J., Fierer, N., Owens, S. M., Betley, J., Fraser, L., Bauer, M., et al. (2012) · The ISME Journal · doi:10.1038/ismej.2012.8 · Cited by 8,839

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479

UniFrac: a New Phylogenetic Method for Comparing Microbial Communities

Lozupone, C., & Knight, R. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8228-8235.2005 · Cited by 8,227

Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform

Kozich, J. J., Westcott, S. L., Baxter, N. T., Highlander, S. K., & Schloss, P. D. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.01043-13 · Cited by 7,246

The gut microbiota as an environmental factor that regulates fat storage

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245

Obesity alters gut microbial ecology

Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

Durinck, S., Spellman, P. T., Birney, E., & Huber, W. K. (2009) · Nature Protocols · doi:10.1038/nprot.2009.97 · Cited by 4,226

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615

Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22

Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614

UpSet: Visualization of Intersecting Sets

Lex, A., Gehlenborg, N., Strobelt, H., Vuillemot, R., & Pfister, H. (2014) · IEEE Transactions on Visualization and Computer Graphics · doi:10.1109/tvcg.2014.2346248 · Cited by 2,340

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280

Circulating Ghrelin Levels Are Decreased in Human Obesity

Tschöp, M. H., Weyer, C., Tataranni, P. A., Devanarayan, V., Ravussin, É., & Heiman, M. L. (2001) · Diabetes · doi:10.2337/diabetes.50.4.707 · Cited by 2,031

Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity

Markle, J. G. M., Frank, D. N., Mortin-Toth, S., Robertson, C. E., Feazel, L. M., Rolle-Kampczyk, U., von Bergen, M., McCoy, K. D., Macpherson, A. J., & Danska, J. S. (2013) · Science · doi:10.1126/science.1233521 · Cited by 2,025

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990

Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences

Cox, L. M., Yamanishi, S., Sohn, J., Alekseyenko, A. V., Leung, J. M., Cho, I., Kim, S. G., Li, H., Gao, Z., Mahana, D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.052 · Cited by 1,859

Bacteria as vitamin suppliers to their host: A gut microbiota perspective

LeBlanc, J. G., Milani, C., de Giori, G. S., Sesma, F., van Sinderen, D., & Ventura, M. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2012.08.005 · Cited by 1,613 · cited 1×

High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity

Hildebrandt, M. A., Hoffmann, C., Sherrill–Mix, S. A., Keilbaugh, S. A., Hamady, M., Chen, Y., Knight, R., Ahima, R. S., Bushman, F., & Wu, G. D. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.042 · Cited by 1,576 · cited 11×

High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice

Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00050-2 · Cited by 1,487

Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis

Thaiss, C. A., Zeevi, D., Levy, M., Zilberman-Schapira, G., Suez, J., Tengeler, A. C., Abramson, L., Katz, M. N., Korem, T., Zmora, N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.048 · Cited by 1,449

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

Staudinger, J. L., Goodwin, B. J., Jones, S. A., Hawkins‐Brown, D., MacKenzie, K. I., Latour, A. M., Liu, Y., Klaassen, C. D., Brown, K. K., Reinhard, J. F., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051551698 · Cited by 1,378

A map of the cis-regulatory sequences in the mouse genome

Shen, Y., Yue, F., McCleary, D. F., Ye, Z., Edsall, L., Kuan, S., Wagner, U., Dixon, J., Lee, L., Lobanenkov, V. V., et al. (2012) · Nature · doi:10.1038/nature11243 · Cited by 1,361 · cited 1×

Integrated, Nontargeted Ultrahigh Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry Platform for the Identification and Relative Quantification of the Small-Molecule Complement of Biological Systems

Evans, A. M., DeHaven, C. D., Barrett, T., Mitchell, M. W., & Milgram, K. E. (2009) · Analytical Chemistry · doi:10.1021/ac901536h · Cited by 1,317

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

Perry, R. J., Peng, L., Barry, N. A., Cline, G. W., Zhang, D., Cardone, R. L., Petersen, K. F., Kibbey, R. G., Goodman, A. L., & Shulman, G. I. (2016) · Nature · doi:10.1038/nature18309 · Cited by 1,299

DAVID-WS: a stateful web service to facilitate gene/protein list analysis

Jiao, X., Sherman, B. T., Huang, D. W., Stephens, R. M., Baseler, M., Lane, H. C., & Lempicki, R. A. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts251 · Cited by 1,066

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4

Venkatesh, M., Mukherjee, S., Wang, H., Li, H., Sun, K., Benechet, A. P., Qiu, Z., Maher, L., Redinbo, M. R., Phillips, R. S., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.014 · Cited by 1,066

Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

Spruijt, C. G., Gnerlich, F., Smits, A. H., Pfaffeneder, T., Jansen, P. W. T. C., Bauer, C., Münzel, M., Wagner, M., Müller, M., Khan, F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.02.004 · Cited by 973

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

Caesar, R., Tremaroli, V., Kovatcheva-Datchary, P., Cani, P. D., & Bäckhed, F. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.026 · Cited by 960

Gender Bias in Autoimmunity Is Influenced by Microbiota

Yurkovetskiy, L., Burrows, M. P., Khan, A. A., Graham, L., Volchkov, P., Becker, L., Antonopoulos, D. A., Umesaki, Y., & Chervonsky, A. V. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.013 · Cited by 943

Diet and feeding pattern affect the diurnal dynamics of the gut microbiome

Zarrinpar, A., Chaix, A., Yooseph, S., & Panda, S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.008 · Cited by 926

Tissue-specific expression and regulation of sexually dimorphic genes in mice

Yang, X., Schadt, E. E., Wang, S., Wang, H., Arnold, A. P., Ingram-Drake, L., Drake, T. A., & Lusis, A. J. (2006) · Genome Research · doi:10.1101/gr.5217506 · Cited by 922

Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism

Leone, V., Gibbons, S. M., Martinez, K., Hutchison, A. L., Huang, E. Y., Cham, C. M., Pierre, J. F., Heneghan, A. F., Nadimpalli, A., Hubert, N., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.006 · Cited by 921

Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations

Thaiss, C. A., Levy, M., Korem, T., Dohnalová, L., Shapiro, H., Jaitin, D. A., David, E., Winter, D. R., Gury-BenAri, M., Tatirovsky, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.003 · Cited by 870

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

Li, Y., Innocentin, S., Withers, D. R., Roberts, N. A., Gallagher, A., Grigorieva, E. F., Wilhelm, C., & Veldhoen, M. (2011) · Cell · doi:10.1016/j.cell.2011.09.025 · Cited by 837

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Ben-Sahra, I., Hoxhaj, G., Ricoult, S. J. H., Asara, J. M., & Manning, B. D. (2016) · Science · doi:10.1126/science.aad0489 · Cited by 795

Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- N -Oxide

Romano, K. A., Vivas, E. I., Amador-Noguez, D., & Rey, F. E. (2015) · mBio · doi:10.1128/mbio.02481-14 · Cited by 777

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

Tremaroli, V., Karlsson, F., Werling, M., Ståhlman, M., Kovatcheva-Datchary, P., Olbers, T., Fändriks, L., le Roux, C. W., Nielsen, J., & Bäckhed, F. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.009 · Cited by 757

Gut microbiota induce IGF-1 and promote bone formation and growth

Yan, J., Herzog, J. W., Tsang, K., Brennan, C. A., Bower, M. A., Garrett, W. S., Sartor, B. R., Aliprantis, A. O., & Charles, J. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607235113 · Cited by 750

Sexual Dimorphism in the Control of Growth Hormone Secretion*

Jansson, J., Edén, S., & Isaksson, O. G. P. (1985) · Endocrine Reviews · doi:10.1210/edrv-6-2-128 · Cited by 746

Visualization of a Correlation Matrix [R package corrplot version 0.84]

Wei, T., & Šimko, V. (2017) · Cited by 726

Sex differences in metabolic homeostasis, diabetes, and obesity

Mauvais-Jarvis, F. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0033-y · Cited by 626 · cited 2×

Testosterone: a metabolic hormone in health and disease

Kelly, D. M., & Jones, T. H. (2013) · Journal of Endocrinology · doi:10.1530/joe-12-0455 · Cited by 612

Germ‐free C57BL/6J mice are resistant to high‐fat‐diet‐induced insulin resistance and have altered cholesterol metabolism

Rabot, S., Membrez, M., Bruneau, A., Gérard, P., Harach, T., Moser, M., Raymond, F., Mansourian, R., & Chou, C. J. (2010) · The FASEB Journal · doi:10.1096/fj.10.164921 · Cited by 610 · cited 11×

Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens

Garsin, D. A., Villanueva, J. M., Begun, J., Kim, D. H., Sifri, C. D., Calderwood, S. B., Ruvkun, G., & Ausubel, F. M. (2003) · Science · doi:10.1126/science.1080147 · Cited by 610

Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut

Joyce, S. A., MacSharry, J., Casey, P. G., Kinsella, M., Murphy, E. F., Shanahan, F., Hill, C., & Gahan, C. G. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323599111 · Cited by 604

Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock

Liang, X., Bushman, F. D., & FitzGerald, G. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501305112 · Cited by 578

Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs

Mukherji, A., Kobiita, A., Ye, T., & Chambon, P. (2013) · Cell · doi:10.1016/j.cell.2013.04.020 · Cited by 560

Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions

Li, L., Dong, J., Yan, L., Yong, J., Liu, X., Hu, Y., Fan, X., Wu, X., Guo, H., Wang, X., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.03.007 · Cited by 558

The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification

Gachon, F., Fleury-Olela, F., Schaad, O., Descombes, P., & Schibler, U. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.015 · Cited by 513

Competition between DNA methylation and transcription factors determines binding of NRF1

Domcke, S., Bardet, A. F., Adrian Ginno, P., Hartl, D., Burger, L., & Schübeler, D. (2015) · Nature · doi:10.1038/nature16462 · Cited by 508

Carnitine and Acylcarnitines

Reuter, S. E., & Evans, A. M. (2012) · Clinical Pharmacokinetics · doi:10.1007/bf03261931 · Cited by 507

The Intestinal Immune System in Obesity and Insulin Resistance

Winer, D. A., Luck, H., Tsai, S. J., & Winer, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.003 · Cited by 493

Chronic sleep disruption alters gut microbiota, induces systemic and adipose tissue inflammation and insulin resistance in mice

Poroyko, V. A., Carreras, A., Khalyfa, A., Khalyfa, A. A., Leone, V., Peris, E., Almendros, I., Gileles-Hillel, A., Qiao, Z., Hubert, N., et al. (2016) · Scientific Reports · doi:10.1038/srep35405 · Cited by 480 · cited 1×

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis

Martelot, G. L., Claudel, T., Gatfield, D., Schaad, O., Kornmann, B., Sasso, G. L., Moschetta, A., & Schibler, U. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000181 · Cited by 463

corrplot: Visualization of a Correlation Matrix

Wei, T., & Šimko, V. (2010) · doi:10.32614/cran.package.corrplot · Cited by 453

LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis.

Fayard, E., Auwerx, J., & Schoonjans, K. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.03.008 · Cited by 445

Circadian disorganization alters intestinal microbiota

Voigt, R. M., Forsyth, C. B., Green, S. J., Mutlu, E., Engen, P., Vitaterna, M. H., Turek, F. W., & Keshavarzian, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097500 · Cited by 439

Role of the Microbiome in Energy Regulation and Metabolism

Nieuwdorp, M., Gilijamse, P. W., Pai, N., & Kaplan, L. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.008 · Cited by 421

Structural Analyses Reveal Phosphatidyl Inositols as Ligands for the NR5 Orphan Receptors SF-1 and LRH-1

Krylova, I. N., Sablin, E. P., Moore, J. M. R., Xu, R. X., Waitt, G. M., MacKay, J. A., JUZUMIENE, D. I., Bynum, J. M., Madauss, K. P., Montana, V. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.01.024 · Cited by 409

Microbiota depletion promotes browning of white adipose tissue and reduces obesity

Suárez-Zamorano, N., Fabbiano, S., Chevalier, C., Stojanović, O., Colin, D. J., Stevanović, A., Veyrat-Durebex, C., Tarallo, V., Rigo, D., Germain, S., et al. (2015) · Nature Medicine · doi:10.1038/nm.3994 · Cited by 403

The gut microbiota modulates host amino acid and glutathione metabolism in mice

Mardinoglu, A., Shoaie, S., Bergentall, M., Ghaffari, P., Zhang, C., Larsson, E., Bäckhed, F., & Nielsen, J. (2015) · Molecular Systems Biology · doi:10.15252/msb.20156487 · Cited by 383

AhR sensing of bacterial pigments regulates antibacterial defence

Moura‐Alves, P., Fae, K. C., Houthuys, E., Dorhoi, A., Kreuchwig, A., Furkert, J., Barison, N., Diehl, A., Munder, A., Constant, P., et al. (2014) · Nature · doi:10.1038/nature13684 · Cited by 380

Circadian Clock Mutation Disrupts Estrous Cyclicity and Maintenance of Pregnancy

Miller, B. H., Olson, S. L., Turek, F. W., Levine, J. E., Horton, T. H., & Takahashi, J. S. (2004) · Current Biology · doi:10.1016/j.cub.2004.07.055 · Cited by 377

An Insulin-like Signaling Pathway Affects Both Longevity and Reproduction in Caenorhabditis elegans

Tissenbaum, H. A., & Ruvkun, G. (1998) · Genetics · doi:10.1093/genetics/148.2.703 · Cited by 357

Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries

Tijet, N., Boutros, P. C., Moffat, I. D., Okey, A. B., Tuomisto, J., & Pohjanvirta, R. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.018705 · Cited by 342

Transcriptional targets shared by estrogen receptor‐related receptors (ERRs) and estrogen receptor (ER) α, but not by ERβ

Vanacker, J.-M., Pettersson, K., Gustafsson, J.-Α., & Laudet, V. (1999) · The EMBO Journal · doi:10.1093/emboj/18.15.4270 · Cited by 340

Analysis of intronic and exonic reads in RNA-seq data characterizes transcriptional and post-transcriptional regulation

Gaidatzis, D., Burger, L., Florescu, M., & Stadler, M. B. (2015) · Nature Biotechnology · doi:10.1038/nbt.3269 · Cited by 313

Persistent Organic Pollutants Modify Gut Microbiota–Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation

Zhang, L., Nichols, R. G., Correll, J. B., Murray, I. A., Tanaka, N., Smith, P. B. W., Hubbard, T. D., Sebastian, A., Albert, I. U., Hatzakis, E., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1409055 · Cited by 307

ISMARA: automated modeling of genomic signals as a democracy of regulatory motifsPreprint

Balwierz, P. J., Pachkov, M. V., Arnold, P., Gruber, A. J., Zavolan, M., & van Nimwegen, E. (2014) · Genome Research · doi:10.1101/gr.169508.113 · Cited by 306

Gender-specific pathway differences in the human serum metabolome

Krumsiek, J., Mittelstraß, K., Do, K. T., Stückler, F., Ried, J. S., Adamski, J., Peters, A., Illig, T., Kronenberg, F., Friedrich, N., et al. (2015) · Metabolomics · doi:10.1007/s11306-015-0829-0 · Cited by 293

The Circadian Clock Protein BMAL1 Is Necessary for Fertility and Proper Testosterone Production in Mice

Alvarez, J. D., Hansen, A. G., Ord, T. S., Bębas, P., Chappell, P. E., Giebultowicz, J. M., Williams, C. J., Moss, S., & Sehgal, A. (2008) · Journal of Biological Rhythms · doi:10.1177/0748730407311254 · Cited by 287

Estradiol-Dependent Decrease in the Orexigenic Potency of Ghrelin in Female Rats

Clegg, D. J., Brown, L. M., Zigman, J. M., Kemp, C. J., Strader, A. D., Benoit, S. C., Woods, S. C., Mangiaracina, M., & Geary, N. (2007) · Diabetes · doi:10.2337/db06-0015 · Cited by 284

Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics

Carmody, R. N., & Turnbaugh, P. J. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72335 · Cited by 268 · cited 1×

Manipulation of the microbiota of mass-reared Mediterranean fruit flies Ceratitis capitata (Diptera: Tephritidae) improves sterile male sexual performance

Ami, E. B., Yuval, B., & Jurkevitch, É. (2009) · The ISME Journal · doi:10.1038/ismej.2009.82 · Cited by 267

Laron Dwarfism and Non-Insulin-Dependent Diabetes Mellitus in theHnf-1α Knockout Mouse

Lee, Y., Sauer, B., & Gonzalez, F. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.3059 · Cited by 262

Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver

Atger, F., Gobet, C., Marquis, J., Martín, E., Wang, J., Weger, B. D., Lefebvre, G. C., Descombes, P., Naef, F., & Gachon, F. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515308112 · Cited by 254

Intestinal Microbiota Regulate Xenobiotic Metabolism in the Liver

Björkholm, B., Bok, C. M., Lundin, A., Rafter, J., Hibberd, M. L., & Pettersson, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006958 · Cited by 249

Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles

Sinturel, F., Gerber, A., Mauvoisin, D., Wang, J., Gatfield, D., Stubblefield, J. J., Green, C. B., Gachon, F., & Schibler, U. (2017) · Cell · doi:10.1016/j.cell.2017.04.015 · Cited by 228

Dietary fat and gut microbiota interactions determine diet-induced obesity in mice

Kübeck, R., Bonet-Ripoll, C., Hoffmann, C., Walker, A., Müller, V. M., Schüppel, V. L., Lagkouvardos, I., Scholz, B., Engel, K.-H., Daniel, H., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.10.001 · Cited by 211

Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver

Wang, J., Mauvoisin, D., Martín, E., Atger, F., Galindo, A. N., Dayon, L., Sizzano, F., Palini, A. G., Kussmann, M., Waridel, P., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.003 · Cited by 190

Mechanisms for Initiating Cellular DNA Replication

Costa, A., Hood, I. V., & Berger, J. M. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052610-094414 · Cited by 186

Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner

Myronovych, A., Kirby, M., Ryan, K. K., Zhang, W., Jha, P., Setchell, K. D. R., Dexheimer, P. J., Aronow, B. J., Seeley, R. J., & Kohli, R. (2013) · Obesity · doi:10.1002/oby.20548 · Cited by 182

Depressed Liver Regeneration After Partial Hepatectomy of Germ–Free, Athymic and Lipopolysaccharide–Resistant Mice

Cornell, R. P., Liljequist, B. L., & Bartizal, K. F. (1990) · Hepatology · doi:10.1002/hep.1840110603 · Cited by 178

The Circadian Clock Mutation Promotes Intestinal Dysbiosis

Voigt, R. M., Summa, K. C., Forsyth, C. B., Green, S. J., Engen, P. A., Naqib, A. D., Vitaterna, M. H., Turek, F. W., & Keshavarzian, A. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12943 · Cited by 172

Impairment of Peripheral Circadian Clocks Precedes Metabolic Abnormalities in ob/ob Mice

Ando, H., Kumazaki, M., Motosugi, Y., Ushijima, K., Maekawa, T., Ishikawa, E., & Fujimura, A. (2011) · Endocrinology · doi:10.1210/en.2010-1068 · Cited by 166

Dynamic, Sex-Differential STAT5 and BCL6 Binding to Sex-Biased, Growth Hormone-Regulated Genes in Adult Mouse Liver

Zhang, Y., Laz, E. V., & Waxman, D. J. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06312-11 · Cited by 163

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

Coste, A., Dubuquoy, L., Barnouin, R., Annicotte, J., Magnier, B. C., Noti, M., Corazza, N., Antal, M. C., METZGER, D., Desreumaux, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702440104 · Cited by 161

Insect Sex Determination Manipulated by Their Endosymbionts: Incidences, Mechanisms and Implications

Kageyama, D., Narita, S., & Watanabe, M. (2012) · Insects · doi:10.3390/insects3010161 · Cited by 159

Development of a Method for the Determination of Pulsatile Growth Hormone Secretion in Mice

Steyn, F. J., Huang, L., Ngo, S. T., Leong, J. W., Tan, H. Y., Xie, T. Y., Parlow, A. F., Veldhuis, J. D., Waters, M. J., & Chen, C. (2011) · Endocrinology · doi:10.1210/en.2011-0253 · Cited by 154

SwissRegulon, a database of genome-wide annotations of regulatory sites: recent updates

Pachkov, M. V., Balwierz, P. J., Arnold, P., Ozonov, E. A., & van Nimwegen, E. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1145 · Cited by 153

Microbial Regulation of Glucose Metabolism and Cell-Cycle Progression in Mammalian Colonocytes

Donohoe, D. R., Wali, A., Brylawski, B. P., & Bultman, S. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046589 · Cited by 145

AHR Function in Lymphocytes: Emerging Concepts

Zhou, L. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.11.007 · Cited by 145

The AH Receptor in Biology and Toxicology

Pohjanvirta, R. (2011) · Wiley eBooks · doi:10.1002/9781118140574 · Cited by 141

nhr-25, the Caenorhabditis elegans Ortholog of ftz-f1, Is Required for Epidermal and Somatic Gonad Development

Gissendanner, C. R., & Sluder, A. E. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9679 · Cited by 140

Genome-Wide Analysis of Chromatin States Reveals Distinct Mechanisms of Sex-Dependent Gene Regulation in Male and Female Mouse Liver

Sugathan, A., & Waxman, D. J. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00280-13 · Cited by 140

Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals

Montagner, A., Korecka, A., Polizzi, A., Lippi, Y., Blum, Y., Canlet, C., Tremblay-Franco, M., Gautier-Stein, A., Burcelin, R., Yen, Y.-C., et al. (2016) · Scientific Reports · doi:10.1038/srep20127 · Cited by 137 · cited 2×

Gender dimorphism in rat liver mitochondrial oxidative metabolism and biogenesis

Justo, R., Boada, J., Frontera, M., Oliver, J., Bermúdez, J., & Gianotti, M. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00035.2005 · Cited by 133

Chronobesity: role of the circadian system in the obesity epidemic

Laermans, J., & Depoortere, I. (2015) · Obesity Reviews · doi:10.1111/obr.12351 · Cited by 129

How growth hormone controls growth, obesity and sexual dimorphism

Lichanska, A. M., & Waters, M. J. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.10.006 · Cited by 128

Methods for analyzing deep sequencing expression data: constructing the human and mouse promoterome with deepCAGE data

Balwierz, P. J., Carninci, P., Daub, C. O., Kawai, J., Hayashizaki, Y., Belle, W. V., Beisel, C., & van Nimwegen, E. (2009) · Genome biology · doi:10.1186/gb-2009-10-7-r79 · Cited by 127

Testosterone Replacement Therapy Restores Normal Ghrelin in Hypogonadal Men

Pagotto, U., Gambineri, A., Pelusi, C., Genghini, S., Cacciari, M., Otto, B., Castañeda, T., Tschöp, M., & Pasquali, R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030554 · Cited by 120

Gut bacteria–host metabolic interplay during conventionalisation of the mouse germfree colon

Aidy, S. E., Derrien, M., Merrifield, C. A., Levenez, F., Dore, J. M., Boekschoten, M. V., Dekker, J. P., Holmes, E. C., Zoetendal, E. G., van Baarlen, P., et al. (2012) · The ISME Journal · doi:10.1038/ismej.2012.142 · Cited by 116

Sex Differences in the Circadian Variation of Cytochrome P450 Genes and Corresponding Nuclear Receptors in Mouse Liver

Lu, Y., Jin, T., Xu, Y.-S., Zhang, D., Wu, Q., Zhang, Y.-K. J., & Liu, J. (2013) · Chronobiology International · doi:10.3109/07420528.2013.805762 · Cited by 112

Effects of probiotic administration on zebrafish development and reproduction.

Carnevali, O., Avella, M., & Gioacchini, G. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.02.022 · Cited by 111

Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity

Kriebs, A., Jordan, S. D., Soto, E., Henriksson, E., Sandate, C. R., Vaughan, M. E., Chan, A. B., Duglan, D., Papp, S. J., Huber, A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704955114 · Cited by 108

Microbial metabolites regulate host lipid metabolism through NR5A–Hedgehog signalling

Lin, C.-C., & Wang, M. C. (2017) · Nature Cell Biology · doi:10.1038/ncb3515 · Cited by 106

The striking similarities in the metabolic associations of female androgen excess and male androgen deficiency

Escobar-Morreale, H. F., Alvarez-Blasco, F., Botella-Carretero, J. I., & Luque‐Ramírez, M. (2014) · Human Reproduction · doi:10.1093/humrep/deu198 · Cited by 105

The Circadian Clock Components CRY1 and CRY2 Are Necessary to Sustain Sex Dimorphism in Mouse Liver Metabolism

Bur, I. M., Cohen-Solal, A., Carmignac, D. F., Abécassis, P.-Y., Chauvet, N., Martin, A., van der Horst, G. T. J., Robinson, I. C. A. F., Maurel, P., Mollard, P., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808360200 · Cited by 103

Appetite‐regulating hormones from the upper gut: disrupted control of xenin and ghrelin in night workers

Schiavo‐Cardozo, D., Lima, M. M. O., Pareja, J. C., & Geloneze, B. (2013) · Clinical Endocrinology · doi:10.1111/cen.12114 · Cited by 96

Gender-specific postnatal demethylation and establishment of epigenetic memoryPreprint

Reizel, Y., Spiro, A., Sabag, O., Skversky‐Blocq, Y., Hecht, M., Keshet, I., Berman, B. P., & Cedar, H. (2015) · Genes & Development · doi:10.1101/gad.259309.115 · Cited by 95

Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid

Ijssennagger, N., Janssen, A. W. F., Milona, A., Pittol, J. M. R., Hollman, D. A. A., Mokrý, M., Betzel, B., Berends, F. J., Janssen, I. M. C., van Mil, S. W. C., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.01.016 · Cited by 94

Characterization of germ cell differentiation in the male mouse through single-cell RNA sequencing

Lukassen, S., Bosch, E., Ekici, A. B., & Winterpacht, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-24725-0 · Cited by 94

Hormonal appetite control is altered by shift work: a preliminary study

Crispim, C. A., Waterhouse, J. M., Dâmaso, A. R., Zimberg, I. Z., Padilha, H. G., Oyama, L. M., Tufik, S. B., & de Mello, M. T. (2011) · Metabolism · doi:10.1016/j.metabol.2011.04.014 · Cited by 92

Developmental Regulation of Drug-Processing Genes in Livers of Germ-Free Mice

Selwyn, F. P., Cheng, S. L., Bammler, T. K., Prasad, B., Vrana, M., Klaassen, C. D., & Cui, J. Y. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv110 · Cited by 92

MotEvo: integrated Bayesian probabilistic methods for inferring regulatory sites and motifs on multiple alignments of DNA sequences

Arnold, P., Erb, I., Pachkov, M. V., Molina, N., & van Nimwegen, E. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr695 · Cited by 90

Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood

Conforto, T. L., & Waxman, D. J. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-9 · Cited by 88

A DNA Methylation Site in the Male-Specific P450 ( Cyp 2d-9) Promoter and Binding of the Heteromeric Transcription Factor GABP

Yokomori, N., Kobayashi, R., Moore, R., Sueyoshi, T., & Negishi, M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5355 · Cited by 88

The nature of the sex-linked differences in glutathione peroxidase activity and aerobic oxidation of glutathione in male and female rat liver

Pinto, R. E., & Bartley, W. (1969) · Biochemical Journal · doi:10.1042/bj1150449 · Cited by 86

Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system

Ohtake, F., Fujii‐Kuriyama, Y., Kawajiri, K., & Kato, S. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.03.007 · Cited by 86

Biallelic mutations in CAD, impair de novo pyrimidine biosynthesis and decrease glycosylation precursors

Ng, B. G., Wolfe, L. A., Ichikawa, M., Markello, T. C., He, M., Tifft, C. J., Gahl, W. A., & Freeze, H. H. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv057 · Cited by 86

Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice

Murray, I. A., Nichols, R. G., Zhang, L., Patterson, A. D., & Perdew, G. H. (2016) · Scientific Reports · doi:10.1038/srep33969 · Cited by 84

Impact of Growth Hormone Resistance on Female Reproductive Function: New Insights from Growth Hormone Receptor Knockout Mice1

Zaczek, D., Hammond, J. M., Suen, L., Wandji, S., Service, D., Bartke, A., Chandrashekar, V., Coschigano, K. T., & Kopchick, J. J. (2002) · Biology of Reproduction · doi:10.1095/biolreprod67.4.1115 · Cited by 82

Male-Specific Hepatic Bcl6: Growth Hormone-Induced Block of Transcription Elongation in Females and Binding to Target Genes Inversely Coordinated with STAT5

Meyer, R., Laz, E. V., Su, T., & Waxman, D. J. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0242 · Cited by 82

Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes

Uyama, T., Jin, X.-H., Tsuboi, K., Tonai, T., & Ueda, N. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.07.001 · Cited by 80

Two main groups of mouse major urinary protein genes, both largely located on chromosome 4.

Bishop, J. O., Clark, A. J., Clissold, P. M., Hainey, S., & Francke, U. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01217.x · Cited by 79

Normalization of reproductive function in germfree mice following bacterial contamination

SHIMIZU, K., MURANAKA, Y., FUJIMURA, R., ISHIDA, H., TAZUME, S., & SHIMAMURA, T. (1998) · Experimental Animals · doi:10.1538/expanim.47.151 · Cited by 77

The Aryl Hydrocarbon Receptor Affects Mouse Ovarian Follicle Growth via Mechanisms Involving Estradiol Regulation and Responsiveness1

Barnett-Ringgold, K., Tomic, D., Gupta, R. K., Miller, K. P., Meachum, S., Paulose, T., & Flaws, J. A. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.106.057687 · Cited by 77

Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice

Baptissart, M., Vega, A., Martinot, E., Pommier, A., Houten, S. M., Marceau, G., Haze, A. D., Baron, S., Schoonjans, K., Lobaccaro, J. A., et al. (2014) · Hepatology · doi:10.1002/hep.27204 · Cited by 77

Puberty Is Delayed in Male Growth Hormone Receptor Gene—Disrupted Mice

KEENE, D. E., Suescun, M. O., BOSTWICK, M. G., Chandrashekar, V., Bartke, A., & Kopchick, J. J. (2002) · Journal of Andrology · doi:10.1002/j.1939-4640.2002.tb02308.x · Cited by 75

Impact of CUX2 on the Female Mouse Liver Transcriptome: Activation of Female-Biased Genes and Repression of Male-Biased Genes

Conforto, T. L., Zhang, Y., Sherman, J., & Waxman, D. J. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00886-12 · Cited by 75

Growth hormone and bile acid synthesis. Key role for the activity of hepatic microsomal cholesterol 7alpha-hydroxylase in the rat.

Rudling, M. J., Parini, P., & Angelin, B. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119398 · Cited by 74

Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features

Rocca, C. L., Tait, S., Guerranti, C., Busani, L., Ciardo, F., Bergamasco, B., Perra, G., Mancini, F. R., Marci, R., Bordi, G., et al. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph121012426 · Cited by 67

Behavioral Sexual Dimorphism in School-Age Children and Early Developmental Exposure to Dioxins and PCBs: A Follow-Up Study of the Duisburg Cohort

Winneke, G., Ranft, U., Wittsiepe, J., Kasper-Sonnenberg, M., Fürst, P., Krämer, U., Seitner-Sorge, G., & Wilhelm, M. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306533 · Cited by 64

Role of the clock gene Bmal1 and the gastric ghrelin-secreting cell in the circadian regulation of the ghrelin-GOAT system

Laermans, J., Vancleef, L., Tack, J. F., & Depoortere, I. (2015) · Scientific Reports · doi:10.1038/srep16748 · Cited by 60

SLC22A5/OCTN2 expression in breast cancer is induced by estrogen via a novel intronic estrogen-response element (ERE)

Wang, C., Uray, I. P., Mazumdar, A., Mayer, J. A., & Brown, P. H. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1925-0 · Cited by 59

Mice Fed a High-Fat Diet Supplemented with Resistant Starch Display Marked Shifts in the Liver Metabolome Concurrent with Altered Gut Bacteria

Kieffer, D. A., Piccolo, B. D., Marco, M. L., Kim, E. B., Goodson, M. L., Keenan, M. J., Dunn, T. N., Knudsen, K. E. B., Martin, R. J., & Adams, S. H. (2016) · Journal of Nutrition · doi:10.3945/jn.116.238931 · Cited by 58

Pregnane X Receptor as a Therapeutic Target to Inhibit Androgen Activity

Zhang, B., Cheng, Q., Ou, Z., Lee, J. H., Xu, M., Kochhar, U., Ren, S., Huang, M., Pflug, B. R., & Xie, W. (2010) · Endocrinology · doi:10.1210/en.2010-0708 · Cited by 57

Exposure to Endocrine Disrupters and Nuclear Receptor Gene Expression in Infertile and Fertile Women from Different Italian Areas

Rocca, C. L., Tait, S., Guerranti, C., Busani, L., Ciardo, F., Bergamasco, B., Stecca, L., Perra, G., Mancini, F. R., Marci, R., et al. (2014) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph111010146 · Cited by 56

Growth Hormone Secretion in Night Workers

Weibel, L., FOLLENIUS, M., Spiegel, K., Gronfier, C., & BRANDENBERGER, G. (1997) · Chronobiology International · doi:10.3109/07420529709040541 · Cited by 56

Aryl hydrocarbon receptor-mediated Cyp1a1 expression is modulated in a CLOCK-dependent circadian manner

Tanimura, N., Kusunose, N., Matsunaga, N., Koyanagi, S., & Ohdo, S. (2011) · Toxicology · doi:10.1016/j.tox.2011.09.007 · Cited by 56

Unexpected gender difference in sensitivity to the acute toxicity of dioxin in mice

Pohjanvirta, R., Miettinen, H., Sankari, S., Hegde, N., & Lindén, J. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.04.032 · Cited by 55

Male and female mice show significant differences in hepatic transcriptomic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Lee, J., Prokopec, S. D., Watson, J. D., Sun, R., Pohjanvirta, R., & Boutros, P. C. (2015) · BMC Genomics · doi:10.1186/s12864-015-1840-6 · Cited by 53

Antisense transcription‐dependent chromatin signature modulates sense transcript dynamics

Brown, T., Howe, F. S., Murray, S. C., Wouters, M., Lorenz, P., Seward, E., Rata, S., Angel, A., & Mellor, J. (2018) · Molecular Systems Biology · doi:10.15252/msb.20178007 · Cited by 52

Bangladeshi children with acute diarrhoea show faecal microbiomes with increased Streptococcus abundance, irrespective of diarrhoea aetiology

Kieser, S., Sarker, S. A., Sakwińska, O., Foata, F., Sultana, S., Khan, Z. A., Islam, S., Porta, N., Combremont, S., Bétrisey, B., et al. (2018) · Environmental Microbiology · doi:10.1111/1462-2920.14274 · Cited by 52

Growth Hormone and Prolactin Secretion in Genetically Obese Zucker Rats*

Finkelstein, J. A., Jervois, P. M., Menadue, M. F., & Willoughby, J. O. (1986) · Endocrinology · doi:10.1210/endo-118-3-1233 · Cited by 52

Butyrate increases intracellular calcium levels and enhances growth hormone release from rat anterior pituitary cells via the G-protein-coupled receptors GPR41 and 43

Miletta, M. C., Petkovic, V., Eblé, A., Ammann, R. A., Flück, C. E., & Mullis, P.-E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107388 · Cited by 51

Disruption of Aryl Hydrocarbon Receptor (AhR) Induces Regression of the Seminal Vesicle in Aged Male Mice

Baba, T., Shima, Y., Owaki, A., Mimura, J., Oshima, M., Fujii-Kuriyama, Y., & Morohashi, K. (2008) · Sexual Development · doi:10.1159/000117714 · Cited by 50

The Aryl Hydrocarbon Receptor Pathway and Sexual Differentiation of Neuroendocrine Functions

Petersen, S. L., Krishnan, S., & Hudgens, E. D. (2006) · Endocrinology · doi:10.1210/en.2005-1157 · Cited by 50

Interaction of a Novel Sex-dependent, Growth Hormone-regulated Liver Nuclear Factor with CYP2C12 Promoter

Waxman, D. J., Zhao, S., & Choi, H. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.29978 · Cited by 48

Long-lasting effects of early barbiturates on central nervous system and behavior

Fishman, R. H., & Yanai, J. (1983) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(83)90004-0 · Cited by 47

Dysregulation of Notch and ERα signaling in AhR −/− male mice

Huang, B., Butler, R., Miao, Y., Dai, Y., Wu, W., Su, W., Fujii‐Kuriyama, Y., Warner, M. N., & Gustafsson, J.-Α. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613269113 · Cited by 47

Deterministic construct of amplifying actions of ghrelin on pulsatile growth hormone secretion

Farhy, L. S., & Veldhuis, J. D. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00451.2004 · Cited by 44

The clock genes period 1 and period 2 mediate diurnal rhythms in dioxin-induced Cyp1A1 expression in the mouse mammary gland and liver

Qu, X., Metz, R. P., Porter, W. W., Neuendorff, N., Earnest, B. J., & Earnest, D. J. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.03.020 · Cited by 39

Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver

Conforto, T. L., Steinhardt, G. F., & Waxman, D. J. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1028 · Cited by 39

Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice

Brown‐Borg, H. M., Rakoczy, S. G., Wonderlich, J. A., Armstrong, V., & Rojanathammanee, L. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-10 · Cited by 37

Sex differences in the activity of mice: Modulation by postnatal gonadal hormones

Broida, J. P., & Svare, B. B. (1984) · Hormones and Behavior · doi:10.1016/0018-506x(84)90051-5 · Cited by 36

Modified expression of cytochrome P450 mRNAs by growth hormone in mouse liver

Jarukamjorn, K., Sakuma, T., Jaruchotikamol, A., Ishino, Y., Oguro, M., & Nemoto, N. (2005) · Toxicology · doi:10.1016/j.tox.2005.11.014 · Cited by 36

Partial Hepatectomy Induced Long Noncoding RNA Inhibits Hepatocyte Proliferation during Liver Regeneration

Huang, L., Damle, S. S., Booten, S. L., Singh, P., Sabripour, M., Hsu, J., Jo, M., Katz, M., Watt, A., Hart, C. E., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132798 · Cited by 32

Genome-Wide Analysis of Germline Signaling Genes Regulating Longevity and Innate Immunity in the Nematode Pristionchus pacificus

Rae, R. G., Sinha, A., & Sommer, R. J. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002864 · Cited by 31

Hepatic Long Intergenic Noncoding RNAs: High Promoter Conservation and Dynamic, Sex-Dependent Transcriptional Regulation by Growth Hormone

Melia, T., Hao, P., Yilmaz, F., & Waxman, D. J. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00861-15 · Cited by 29

Metformin Inhibits Growth Hormone–Mediated Hepatic PDK4 Gene Expression Through Induction of Orphan Nuclear Receptor Small Heterodimer Partner

Kim, Y. D., Kim, Y., Tadi, S., Yu, J. H., Yim, Y., Jeoung, N. H., Shong, M., Hennighausen, L. G., Harris, R. A., Lee, I., et al. (2012) · Diabetes · doi:10.2337/db11-1665 · Cited by 28

Gender Dictates the Nuclear Receptor-Mediated Regulation of CYP3A44

Anakk, S., Huang, W., Staudinger, J. L., Tan, K. H., Cole, T. J., Moore, D. D., & Strobel, H. W. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.011270 · Cited by 28

Aryl hydrocarbon receptor‐mediated suppression of GH receptor and Janus kinase 2 expression in mice

Nukaya, M., Takahashi, Y., Gonzalez, F. J., & Kamataki, T. (2004) · FEBS Letters · doi:10.1016/s0014-5793(03)01528-x · Cited by 27

Effect of Deletion of Ghrelin‐O‐Acyltransferase on the Pulsatile Release of Growth Hormone in Mice

Xie, T. Y., Ngo, S. T., Veldhuis, P. P., Jeffery, P. L., Chopin, L. K., Tschöp, M. H., Waters, M. J., Tolle, V., Epelbaum, J., Chen, C., et al. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12327 · Cited by 26

Changes in Glucose Transporters, Gluconeogenesis, and Circadian Clock after Duodenal–Jejunal Bypass Surgery

Kim, M. K., Son, Y. G., Kang, Y. N., Ha, T. K., & Ha, E. (2014) · Obesity Surgery · doi:10.1007/s11695-014-1434-4 · Cited by 25

Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Hormones of Energy Balance in a TCDD-Sensitive and a TCDD-Resistant Rat Strain

Lindén, J., Lensu, S., & Pohjanvirta, R. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150813938 · Cited by 25

Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalpha

Martinot, E., Baptissart, M., Vega, A., Sèdes, L., Rouaisnel, B., Vaz, F. M., Saru, J., Haze, A. D., Baron, S., Caira, F., et al. (2017) · Scientific Reports · doi:10.1038/srep42182 · Cited by 25

Certain Aspects of Hepatocarcinogenesis in the Infant Mouse Model

Vesselinovitch, S. D. (1987) · Toxicologic Pathology · doi:10.1177/019262338701500216 · Cited by 25

Dioxin-induced retardation of development through a reduction in the expression of pituitary hormones and possible involvement of an aryl hydrocarbon receptor in this defect: A comparative study using two strains of mice with different sensitivities to dioxin

Takeda, T., Taura, J., Hattori, Y., Ishii, Y., & Yamada, H. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.04.022 · Cited by 23

Cafeteria diet-induced obesity is associated with a low spontaneous growth hormone secretion and normal plasma insulin-like growth factor-I concentrations

Schepper, J. A. D., Smitz, J. P., Zhou, X.-L., Louis, G. M. B., Velkeniers, B., & Vanhaelst, L. (1998) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(98)80310-9 · Cited by 21

Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3

Lin, G., LaPensee, C. R., Qin, Z. S., & Schwartz, J. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.07.020 · Cited by 20

Neonatal phenobarbital-induced defects in age- and sex-specific growth hormone profiles regulating monooxygenases

Agrawal, A. K., Pampori, N. A., & Shapiro, B. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.268.3.e439 · Cited by 20

Involvement of the AHR in Development and Functioning of the Female and Male Reproductive Systems

Karman, B. N., Hernández‐Ochoa, I., Ziv‐Gal, A., & Flaws, J. A. (2011) · doi:10.1002/9781118140574.ch31 · Cited by 18

Effects of growth hormone on respiration and ATPase activity of rat liver and heart mitochondria

Katkocin, D. M., Gupta, K. M., Collipp, P. J., & Maddaiah, V. T. (1979) · Biochemical Medicine · doi:10.1016/0006-2944(79)90046-2 · Cited by 17

Effects of neonatal and adult castration on the in vitro metabolism of steroids and xenobiotics in rat liver.

Blanck, A., Åström, A., & Hansson, T. (1986) · PubMed · Cited by 12

Influence of Germ-free Status on Hepatoma Induction by 7,12-Dimethylbenz(a)anthracene in C3H Mice

Grant, G. A., & Roe, F. J. C. (1969) · Nature · doi:10.1038/2221282a0 · Cited by 10

Effects of testosterone on the metabolism of folate coenzymes in the rat

Rovinetti, C., Bovina, C., Tolomelli, B., & Marchetti, M. (1972) · Biochemical Journal · doi:10.1042/bj1260291 · Cited by 9

Rates of lipogenesis and plasma insulin concentrations in inbred lines of mice differing in fatness

Harrison, L. M., & Sinnett‐Smith, P. A. (1990) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(90)90190-9 · Cited by 3

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286

Sex differences in metabolic regulation and diabetes susceptibility

Tramunt, B., Smati, S., Grandgeorge, N., Lenfant, F., Arnal, J.-F., Montagner, A., & Gourdy, P. (2020) · Diabetologia · doi:10.1007/s00125-019-05040-3 · Cited by 923

The circadian regulation of food intake

Challet, E. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0210-x · Cited by 428

Mechanisms of sex differences in Alzheimer’s disease

Lopez-Lee, C., Torres, E. R. S., Carling, G., & Gan, L. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.024 · Cited by 376

Sex disparities matter in cancer development and therapy

Haupt, S., Caramia, F., Klein, S. L., Rubin, J. B., & Haupt, Y. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00348-y · Cited by 350

Circadian rhythms in the gut microbiota shape sex differences in host gene expression and metabolismPreprint

Munyoki, S. K., Goff, J. P., Kolobaric, A., Long, A., Mullett, S. J., Burns, J. K., Jenkins, A. K., DePoy, L. M., Wendell, S. G., McClung, C. A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.15.508006 · Cited by 3

Microbiota drives sex-specific differences

Morris, A. W. J. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0127-9 · Cited by 10

Intestinal microbial circadian rhythms drive sex differences in host immunity and metabolism

Munyoki, S. K., Goff, J. P., Kolobaric, A., Long, A., Mullett, S. J., Burns, J. K., Jenkins, A. K., DePoy, L. M., Wendell, S. G., McClung, C. A., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107999 · Cited by 32

Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism

Leone, V., Gibbons, S. M., Martinez, K., Hutchison, A. L., Huang, E. Y., Cham, C. M., Pierre, J. F., Heneghan, A. F., Nadimpalli, A., Hubert, N., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.006 · Cited by 921

Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals

Montagner, A., Korecka, A., Polizzi, A., Lippi, Y., Blum, Y., Canlet, C., Tremblay-Franco, M., Gautier-Stein, A., Burcelin, R., Yen, Y.-C., et al. (2016) · Scientific Reports · doi:10.1038/srep20127 · Cited by 137