Cited by 403Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismExercise and Physiological Responses

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Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial

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Wedell-Neergaard, Anne-Sophie, Lang Lehrskov, Louise, Christensen, Regitse Højgaard, Legaard, Grit Elster, Dorph, Emma, Larsen, Monica Korsager, Launbo, Natja, Fagerlind, Sabrina Ravn, Seide, Sidsel Kofoed, Nymand, Stine, Ball, Maria, Vinum, Nicole, Dahl, Camilla Noerfelt, Henneberg, Marie, Ried-Larsen, Mathias, Nybing, Janus Damm, Christensen, Robin, Rosenmeier, Jaya Birgitte, Karstoft, Kristian, Pedersen, Bente Klarlund, Ellingsgaard, Helga, Krogh-Madsen, Rikke·2019·Cell Metabolism

DOI 10.1016/j.cmet.2018.12.007

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Abstract

Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade.

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Additional file 7 of The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the “DOSE-EX” multi-arm parallel-group randomised clinical trial
Lyngbæk, M. P. P., Legaard, G. E., Bennetsen, S. L., Feineis, C. S., Rasmussen, V., Moegelberg, N., Brinkløv, C. F., Nielsen, A. B., Kofoed, K. S., Lauridsen, C. A., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14361947
Additional file 3 of The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the “DOSE-EX” multi-arm parallel-group randomised clinical trial
Lyngbæk, M. P. P., Legaard, G. E., Bennetsen, S. L., Feineis, C. S., Rasmussen, V., Moegelberg, N., Brinkløv, C. F., Nielsen, A. B., Kofoed, K. S., Lauridsen, C. A., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14361935
Additional file 2 of The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the “DOSE-EX” multi-arm parallel-group randomised clinical trial
Lyngbæk, M. P. P., Legaard, G. E., Bennetsen, S. L., Feineis, C. S., Rasmussen, V., Moegelberg, N., Brinkløv, C. F., Nielsen, A. B., Kofoed, K. S., Lauridsen, C. A., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14361932
Additional file 6 of The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the “DOSE-EX” multi-arm parallel-group randomised clinical trial
Lyngbæk, M. P. P., Legaard, G. E., Bennetsen, S. L., Feineis, C. S., Rasmussen, V., Moegelberg, N., Brinkløv, C. F., Nielsen, A. B., Kofoed, K. S., Lauridsen, C. A., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14361944
Additional file 1 of The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the “DOSE-EX” multi-arm parallel-group randomised clinical trial
Lyngbæk, M. P. P., Legaard, G. E., Bennetsen, S. L., Feineis, C. S., Rasmussen, V., Moegelberg, N., Brinkløv, C. F., Nielsen, A. B., Kofoed, K. S., Lauridsen, C. A., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14361929
Additional file 3 of Prehabilitative resistance exercise reduces neuroinflammation and improves mitochondrial health in aged mice with perioperative neurocognitive disorders
Liu, Y., Chu, J. M. T., Ran, Y., Zhang, Y., Chang, R. C.-C., & Wong, G. T. C. (2022) · Figshare · doi:10.6084/m9.figshare.20081199
Additional file 5 of The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the “DOSE-EX” multi-arm parallel-group randomised clinical trial
Lyngbæk, M. P. P., Legaard, G. E., Bennetsen, S. L., Feineis, C. S., Rasmussen, V., Moegelberg, N., Brinkløv, C. F., Nielsen, A. B., Kofoed, K. S., Lauridsen, C. A., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14361941
Additional file 2 of Prehabilitative resistance exercise reduces neuroinflammation and improves mitochondrial health in aged mice with perioperative neurocognitive disorders
Liu, Y., Chu, J. M. T., Ran, Y., Zhang, Y., Chang, R. C.-C., & Wong, G. T. C. (2022) · Figshare · doi:10.6084/m9.figshare.20081196
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de Melo, D. G., Ramos, C. O., Rodrigues, V. C. D. C., Pereira, G. J. D. S., Brícola, R. S., Cintra, D. E., & de Moura, L. P. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124546
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Authors: Wedell-Neergaard, A.-S., Lang Lehrskov, L., Christensen, R. H., Legaard, G. E., Dorph, E., Larsen, M. K., Launbo, N., Fagerlind, S. R., Seide, S. K., Nymand, S., Ball, M., Vinum, N., Dahl, C. N., Henneberg, M., Ried-Larsen, M., Nybing, J. D., Christensen, R., Rosenmeier, J. B., Karstoft, K., Pedersen, B. K., Ellingsgaard, H., & Krogh-Madsen, R.
Affiliations: University of Copenhagen (DK)
Bispebjerg Hospital (DK)
Corresponding author: Ellingsgaard, Helga
ORCID: Christensen, Regitse Højgaard
Legaard, Grit Elster
Launbo, Natja
Nymand, Stine
Nybing, Janus Damm
Christensen, Robin
Rosenmeier, Jaya Birgitte
Karstoft, Kristian
Pedersen, Bente Klarlund
Ellingsgaard, Helga
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2019-04
Volume: 29
Issue: 4
Pages: 844-855.e3
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2018.12.007
OpenAlex: W2906928401
Cited by: 403
References: 54
Citations by year: 2026: 38 · 2025: 54 · 2024: 56 · 2023: 56 · 2022: 64 · 2021: 59 · 2020: 42 · 2019: 33
FWCI: 26.13
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
Locations: Cell Metabolism (publishedVersion)
SSRN Electronic Journal (acceptedVersion)
PubMed (publishedVersion)
University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Danish Diabetes Academy
TrygFonden
Novo Nordisk Fonden
Oak Foundation (OCAY-13-309)
Hjerteforeningen (16-R107-A6704-22970)
Strategiske Forskningsråd (09-067009, 09-075724)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: visceral adipose tissue, interleukin-6, exercise training, tocilizumab, IL-6 receptor inhibition, abdominal obesity, lipolysis, skeletal muscle, cholesterol, body weight, lean body mass, adipose tissue mass
MeSH terms: Adult, Double-Blind Method, Female, Humans, Male, Middle Aged, Organ Size, Signal Transduction, Exercise, Interleukin-6, Intra-Abdominal Fat

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Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial

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