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Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial
Open accessAbstract
Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade.
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In the citing paper
“Obese adults receiving tocilizumab, subjected to 12 weeks of endurance exercise, showed a blunted exercise-induced loss of visceral fat mass compared with controls, as measured by DEXA [78].”
In the citing paper
“Conversely, blocking IL-6 signaling with tocilizumab during exercise blunts this metabolic effect and prevents the reduction in fat, underscoring the key role of IL-6 in exercise-induced fat mobilization [46].”
From Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging (2025) · cites this paper as [46]
In the citing paper
“another study has shown that the intravenous administration of IL-6 at higher concentrations (>100 pg/mL, comparable to those used during strenuous exercise) stimulates lipolysis.”
From Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging (2025) · cites this paper as [46]
In the citing paper
“The myokine IL-6 mediates the exercise-associated anti-inflammatory effects both acutely with each bout of exercise and as a consequence of training adaptation, including reduction in abdominal adiposity.”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [136]
In the citing paper
“Exercise training will lead to a decrease in visceral and cardiac fat mass (136, 138, 221) and hence a decrease in circulating inflammatory molecules via a mechanism that involves exercise-induced increase in IL-6 (136), as described above.”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [136]
In the citing paper
“acute exercise in humans also releases additional molecules79, such as growth and differentiation factor 15 (GDF15)80 and IL-6 (REF.81), which also affect lipolysis”
From Exerkines in health, resilience and disease (2022) · cites this paper as [81]
In the citing paper
“Notably, this effect appears specific to high-intensity exercise, as IL-6R blockade does not influence perceived exertion during moderate-intensity exercise [ 34 , 44 ].”
From IL-6 Activity is Required for Maximal Catecholamine Release During High-Intensity Exercise in Men (2026) · cites this paper as [44]
Citations
Cites
A guideline of selecting and reporting intraclass correlation coefficients for reliability research
Koo, T. K., & Li, M. Y. (2016) · Journal of Chiropractic Medicine · doi:10.1016/j.jcm.2016.02.012 · Cited by 31,709
Garber, C. E., Blissmer, B., Deschenes, M. R., Franklin, B. A., Lamonte, M. J., Lee, I.-M., Nieman, D. C., & Swain, D. P. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318213fefb · Cited by 9,319
Ference, B. A., Ginsberg, H. N., Graham, I., Ray, K. K., Packard, C. J., Bruckert, E., Hegele, R. A., Krauss, R. M., Raal, F. J., Schunkert, H., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx144 · Cited by 3,962
Sedentary Behavior Research Network (SBRN)—Terminology Consensus Project process and outcome
on behalf of SBRN Terminology Consensus Project Participants, Tremblay, M. S., Aubert, S., Barnes, J. D., Saunders, T. J., Carson, V., Latimer-Cheung, A. E., Chastin, S. F. M., Altenburg, T. M., & Chinapaw, M. J. M. (2017) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-017-0525-8 · Cited by 3,793
The anti-inflammatory effect of exercise
Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100
Fox, C. S., Massaro, J. M., Hoffmann, U., Pou, K. M., Maurovich-Horvat, P., Liu, C.-Y., Vasan, R. S., Murabito, J. M., Meigs, J. B., Cupples, L. A., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.675355 · Cited by 2,882
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
General and abdominal adiposity and risk of death in Europe
Pischon, T., Boeing, H., Hoffmann, K., Bergmann, M., Schulze, M. B., Overvad, K., van der Schouw, Y. T., Spencer, E., Moons, K. G. M., Tjønneland, A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0801891 · Cited by 2,155
Analysing controlled trials with baseline and follow up measurements
Vickers, A. J., & Altman, D. G. (2001) · BMJ · doi:10.1136/bmj.323.7321.1123 · Cited by 2,116
Waist circumference as a measure for indicating need for weight management
Lean, M. E. J., Han, T. S., & Morrison, C. E. (1995) · BMJ · doi:10.1136/bmj.311.6998.158 · Cited by 1,869
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Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226
“Exercise training will lead to a decrease in visceral and cardiac fat mass (136, 138, 221) and hence a decrease in circulating inflammatory molecules via a mechanism that involves exercise-induced increase in IL-6 (136), as described above.”
BackgroundMethodExerkines in health, resilience and disease
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927
Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs
Scheffer, D. D. L., & Latini, A. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165823 · Cited by 535
Exercise and metabolic health: beyond skeletal muscle
Thyfault, J. P., & Bergouignan, A. (2020) · Diabetologia · doi:10.1007/s00125-020-05177-6 · Cited by 455
Obesity paradox in cardiovascular disease: where do we stand?
Carbone, S., Canada, J. M., Billingsley, H., Siddiqui, M. S., Elagizi, A., & Lavie, C. J. (2019) · Vascular Health and Risk Management · doi:10.2147/vhrm.s168946 · Cited by 410
Regulation of Adipose Tissue Inflammation by Interleukin 6
Han, M. S., White, A., Perry, R. J., Camporez, J.-P., Hidalgo, J., Shulman, G. I., & Davis, R. J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920004117 · Cited by 344
Laddu, D., Lavie, C. J., Phillips, S. A., & Arena, R. A. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.04.006 · Cited by 310
Interleukin 6 as an Energy Allocator in Muscle Tissue
Kistner, T. M., Pedersen, B. K., & Lieberman, D. E. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00538-4 · Cited by 295
The effect of exercise on cytokines: implications for musculoskeletal health: a narrative review
Docherty, S., Harley, R., McAuley, J. J., Crowe, L. A. N., Pedret, C., Kirwan, P., Siebert, S., & Millar, N. L. (2022) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-022-00397-2 · Cited by 344
Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278
“Abbreviations ADAM A disintegrin and metalloproteinase AMPK AMP-activated protein kinase AE Acute exercise ANGPTL4 Angiopoietin-like 4 AP-1 Activator protein-1 AT Adipose tissue BAIBA Beta-aminoisobutyric acid BAT Brown or beige adipose tissue BMR Basal metabolic rate CE Chronic exercise CIDEA Cell-death inducing DNA…”
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He, L., Meng, Y., He, S., Tan, X., Zhang, Y., Zhang, X., Wang, L., & Zheng, W. (2022) · Cells · doi:10.3390/cells11193001 · Cited by 286
Egan, B., & Sharples, A. P. (2023) · Physiological Reviews · doi:10.1152/physrev.00054.2021 · Cited by 278
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Molecular mechanisms of exercise contributing to tissue regeneration
Chen, J., Zhou, R. J., Ye, F., & Cheng, L. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01233-2 · Cited by 185
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Role of Interleukin-6 in Vascular Health and Disease
Villar-Fincheira, P., Sanhueza-Olivares, F., Norambuena-Soto, I., Cancino-Arenas, N., Hernandez-Vargas, F., Troncoso, R., Gabrielli, L., & Chiong, M. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.641734 · Cited by 154
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Noone, J., Mucinski, J. M., DeLany, J. P., Sparks, L. M., & Goodpaster, B. H. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.025 · Cited by 128
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Lyu, Y.-X., Fu, Q., Wilczok, D., Ying, K., King, A., Antebi, A., Vojta, A., Stolzing, A., Moskalev, A., Georgievskaya, A., et al. (2024) · Aging · doi:10.18632/aging.206135 · Cited by 48
Wood, G., Taylor, E., Ng, V., Murrell, A., Patil, A., van der Touw, T., Sigal, R., Wolden, M., & Smart, N. (2022) · British Journal of Sports Medicine · doi:10.1136/bjsports-2021-103999 · Cited by 45
de Lima, N. S., Sousa, R. A. L. D., Amorim, F. T., Gripp, F., Magalhães, C. O. D. E., Pinto, S. H., Dias‐Peixoto, M. F., Monteiro-Júnior, R. S., Bourbeau, K., & Cassilhas, R. C. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00859-5 · Cited by 44
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Dalton, B., Leppänen, J., Campbell, I. C., Chung, R., Breen, G. D., Schmidt, U. H., & Himmerich, H. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.05.012 · Cited by 43
Zamboni, M. M., Mazzali, G., Brunelli, A., Saatchi, T., Urbani, S., Giani, A., Rossi, A. P., Zoico, E., & Fantin, F. (2022) · Cells · doi:10.3390/cells11213361 · Cited by 47
Trinh, B., Peletier, M. C., Simonsen, C., Plomgaard, P., Karstoft, K., Pedersen, B. K., van Hall, G., & Ellingsgaard, H. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100396 · Cited by 42
Tero-Vescan, A., Degens, H., Matsakas, A., Ștefănescu, R., Ősz, B. E., & Slevin, M. (2025) · Pharmaceuticals · doi:10.3390/ph18081222 · Cited by 44
Tan, L. F., Chan, Y. H., Seetharaman, S. K., Anbarasan, D., Au, L. S. Y., Kwek, S. C., Chen, M. Z., Ng, S. E., Hui, R. J. Y., & Merchant, R. A. (2023) · The journal of nutrition health & aging · doi:10.1007/s12603-023-1928-7 · Cited by 48
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Mølmen, K. S., Hammarström, D., Pedersen, K. K., Lie, A. C. L., Steile, R. B., Nygaard, H., Khan, Y., Hamarsland, H., Koll, L., Hanestadhaugen, M., et al. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12688 · Cited by 40
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Cullen, T., Thomas, G., & Wadley, A. J. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002207 · Cited by 41
Rajendran, S. H., Anquetil, F., Quesada‐Masachs, E., Graef, M., Gonzalez, N., McArdle, S., Chu, T., Krogvold, L., Dahl‐Jørgensen, K., & von Herrath, M. (2019) · Clinical Immunology · doi:10.1016/j.clim.2019.108320 · Cited by 41
Yang, D.-F., Shen, Y.-L., Wu, C. W., Huang, Y.-S., Lee, P.-Y., Ng, X. E., Huang, W.-C., & Tung, Y. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116835 · Cited by 41
Abe, T., Song, J. S., Bell, Z. W., Wong, V. H. Y., Spitz, R. W., Yamada, Y., & Loenneke, J. P. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00942-1 · Cited by 36
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Esteves, J. V. D. C., & Stanford, K. I. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00144.2024 · Cited by 39
Garritson, J. D., & Boudina, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.772894 · Cited by 36
Lei, L., Li, J., Wang, W., Yu, Y., Pu, B., Peng, Y., Zhang, L., & Zhao, Z. (2024) · Obesity · doi:10.1002/oby.23986 · Cited by 34
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Chalise, J. P., Hashimoto, S., Parajuli, G., Kang, S., Singh, S. K., Gemechu, Y., Metwally, H., Nyati, K. K., Dubey, P. K., Zaman, M. M.-U., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906712116 · Cited by 32
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Bogdanet, D., Reddin, C., Murphy, D., Doheny, H. C., Halperin, J. A., Dunne, F., & O’Shea, P. M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10071533 · Cited by 33
Jiang, M.-H., Li, D.-C., Piao, J.-M., Li, J.-Y., Sun, H., Chen, L.-P., Chen, S., Pi, J., Zhang, R., Chen, R., et al. (2020) · Science of the Total Environment · doi:10.1016/j.scitotenv.2020.138652 · Cited by 30
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Cao, M., Tang, Y., & Zou, Y. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11185436 · Cited by 30
Metadata
- Authors
- Wedell-Neergaard, A.-S., Lang Lehrskov, L., Christensen, R. H., Legaard, G. E., Dorph, E., Larsen, M. K., Launbo, N., Fagerlind, S. R., Seide, S. K., Nymand, S., Ball, M., Vinum, N., Dahl, C. N., Henneberg, M., Ried-Larsen, M., Nybing, J. D., Christensen, R., Rosenmeier, J. B., Karstoft, K., Pedersen, B. K., Ellingsgaard, H., & Krogh-Madsen, R.
- Affiliations
- University of Copenhagen (DK)
- Bispebjerg Hospital (DK)
- Corresponding author
- Ellingsgaard, Helga
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 29
- Issue
- 4
- Pages
- 844-855.e3
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2906928401
- Cited by
- 403
- References
- 54
- Citations by year
- 2026: 38 · 2025: 54 · 2024: 56 · 2023: 56 · 2022: 64 · 2021: 59 · 2020: 42 · 2019: 33
- FWCI
- 26.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- SSRN Electronic Journal (acceptedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Danish Diabetes Academy
- TrygFonden
- Novo Nordisk Fonden
- Oak Foundation (OCAY-13-309)
- Hjerteforeningen (16-R107-A6704-22970)
- Strategiske Forskningsråd (09-067009, 09-075724)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- visceral adipose tissue, interleukin-6, exercise training, tocilizumab, IL-6 receptor inhibition, abdominal obesity, lipolysis, skeletal muscle, cholesterol, body weight, lean body mass, adipose tissue mass
- MeSH terms
- Adult, Double-Blind Method, Female, Humans, Male, Middle Aged, Organ Size, Signal Transduction, Exercise, Interleukin-6, Intra-Abdominal Fat
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