Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes
Open accessAbstract
BACKGROUND: The Network for Pancreatic Organ Donors with Diabetes (nPOD) was established to recover and characterize pancreata and related organs from cadaveric organ donors with various risk levels for type 1 diabetes (T1D). These biospecimens are available to investigators for collaborative studies aimed at addressing questions related to T1D natural history and pathogenesis. RESEARCH DESIGN AND METHODS: Organ donors included T1D patients (new onset to long term), non-diabetic autoantibody-positive subjects, non-diabetic controls and individuals with disorders relevant to β-cell function. Pancreas recovery and transport met transplant-grade criteria. Additional samples recovered included serum, whole blood, spleen and pancreatic and non-pancreatic lymph nodes. Biospecimens were processed for cryopreserved cells, fixed paraffin and fresh frozen blocks and snap frozen samples. T1D autoantibodies, C-peptide levels and high-resolution HLA genotyping for risk alleles were also determined. RESULTS: Over 160 donors have been enrolled (ages of 1 day to >90 years). Standard operating procedures were established along with a quality management system. Donor demographics, laboratory assays and histopathological characterizations were shared through an open online informatics system. Biospecimens were distributed to more than 60 investigators. CONCLUSIONS: The nPOD programme provides access to high quality biospecimens without cost to investigators. Collaborations and open data sharing are emphasized to maximize research potential of each donor. On the basis of initial successes, the nPOD programme is expanding to recover additional organs relevant to T1D pathogenesis and complications from European countries (PanFin network).
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Efforts in Belgium, Finland, and the USA (Network for Pancreatic Organ Donors with Diabetes [nPOD]) collect tissues from cadaveric donors with serological evidence of anti-islet autoimmunity-a subset of whom would presumably have developed type 1 diabetes if they had survived.
“efforts are being made in Belgium, Finland, and the USA (Network for Pancreatic Organ Donors with Diabetes [nPOD]57) to collect tissues from cadaveric donors with serological evidence of anti-islet autoimmunity (ie, type 1 diabetes-associated autoantibodies)—a subset of whom would presumably have developed type 1 diabetes if they had survived.”
From Type 1 diabetes (2014) · cites this paper as [57]
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Care of Children and Adolescents With Type 1 Diabetes
Silverstein, J., Klingensmith, G., Copeland, K., Plotnick, L., Kaufman, F., Laffel, L., Deeb, L., Grey, M., Anderson, B., Holzmeister, L. A., et al. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.186 · Cited by 1,312 · see citing works
Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies
Van Belle, T. L., Coppieters, K. T., & Von Herrath, M. G. (2011) · Physiological Reviews · doi:10.1152/physrev.00003.2010 · Cited by 1,022 · see citing works
Incidence of diabetes in youth in the United States
SEARCH for Diabetes in Youth Study Group*, T. W. G. F. T. (2007) · JAMA · doi:10.1001/jama.297.24.2716 · Cited by 991 · cited 2× · see citing works
“Additional donors recovered included T1D Medalists [12], T2D [15], gestational diabetes [1], cystic fibrosis-related diabetes [2] and others ([6]; Turner Syndrome, acute hyperglycemia [2], acute eclampsia and unknown diabetes duration [2]).”
BackgroundKeenan, H. A., Sun, J. K., Levine, J., Doria, A., Aiello, L. P., Eisenbarth, G., Bonner-Weir, S., & King, G. L. (2010) · Diabetes · doi:10.2337/db10-0676 · Cited by 500 · see citing works
Self-citationNoble, J. A., Valdes, A. M., Cook, M., Klitz, W., Thomson, G., & Erlich, H. A. (1996) · PubMed Central · Cited by 481 · see citing works
Bonifacio, E., Yu, L., Williams, A. K., Eisenbarth, G. S., Bingley, P. J., Marcovina, S. M., Adler, K., Ziegler, A. G., Mueller, P. W., Schatz, D. A., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0293 · Cited by 291 · see citing works
Self-citationMallone, R., Mannering, S. I., Brooks‐Worrell, B., Durinovic‐Belló, I., Cilio, C., Wong, F. S., & Schloot, N. C. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04272.x · Cited by 261 · see citing works
Orban, T., Sosenko, J. M., Cuthbertson, D., Krischer, J. P., Skyler, J. S., Jackson, R., Yu, L., Palmer, J. P., Schatz, D., Eisenbarth, G., et al. (2009) · Diabetes Care · doi:10.2337/dc09-0934 · Cited by 260 · see citing works
Self-citationScreening for Insulitis in Adult Autoantibody-Positive Organ Donors
Veld, P. I. '., Lievens, D., Grijse, J. D., Ling, Z., der Auwera, B. J. R. V., Pipeleers-Marichal, M. A., Gorus, F., & PIPELEERS, D. G. (2007) · Diabetes · doi:10.2337/db07-0416 · Cited by 198 · see citing works
Dimorphic histopathology of long-standing childhood-onset diabetes
Gianani, R., Campbell-Thompson, M., Sarkar, S. A., Wasserfall, C., Pugliese, A., Solis, J. M., Kent, S. C., Hering, B. J., West, E., Steck, A., et al. (2010) · Diabetologia · doi:10.1007/s00125-009-1642-y · Cited by 158 · see citing works
Self-citationAutoimmune Markers in Diabetes
Winter, W. E., & Schatz, D. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.148205 · Cited by 142 · see citing works
Self-citationYip, L., Su, L., Sheng, D., Chang, P. P., Atkinson, M. A., Czesak, M., Albert, P. R., Collier, A.-R. Y., Turley, S. J., Fathman, C. G., et al. (2009) · Nature Immunology · doi:10.1038/ni.1773 · Cited by 140 · see citing works
Self-citationPrevention of Diabetes by FTY720-Mediated Stabilization of Peri-Islet Tertiary Lymphoid Organs
Peñaranda, C., Tang, Q., Ruddle, N. H., & Bluestone, J. A. (2010) · Diabetes · doi:10.2337/db09-1129 · Cited by 92 · see citing works
Development of Autoantibodies in the TrialNet Natural History Study
Vehik, K., Beam, C. A., Mahon, J. L., Schatz, D., Haller, M. J., Sosenko, J. M., Skyler, J. S., Krischer, J. P., & for the TrialNet Natural History Study Group (2011) · Diabetes Care · doi:10.2337/dc11-0560 · Cited by 75 · see citing works
Self-citationThe pancreas in human type 1 diabetes: providing new answers to age-old questions
Atkinson, M. A., & Gianani, R. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32832e06ba · Cited by 69 · see citing works
Self-citationThe pancreas in human type 1 diabetes
Rowe, P. A., Campbell‐Thompson, M., Schatz, D., & Atkinson, M. A. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0208-x · Cited by 61 · see citing works
Self-citationvon Herrath, M. (2009) · Nature · doi:10.1038/459518a · Cited by 59 · see citing works
Initial Results of Screening of Nondiabetic Organ Donors for Expression of Islet Autoantibodies
Gianani, R., Putnam, A. L., Still, T., Yu, L., Miao, D., Gill, R. G., Beilke, J. N., Supon, P., Valentine, A., Iveson, A., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1171 · Cited by 57 · see citing works
Self-citationLive pancreatic acinar imaging of exocytosis using syncollin-pHluorin
Fernandez, N. A., Liang, T., & Gaisano, H. Y. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00433.2010 · Cited by 30 · see citing works
On‐tissue identification of insulin: In situ reduction coupled with mass spectrometry imaging
Green-Mitchell, S. M., Cazares, L. H., Semmes, O. J., Nadler, J. L., & Nyalwidhe, J. O. (2011) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201000152 · Cited by 21 · see citing works
Campbell‐Thompson, M., Dixon, L. R., Wasserfall, C. H., Monroe, M., McGuigan, J., Schatz, D., Crawford, J. M., & Atkinson, M. A. (2008) · Diabetologia · doi:10.1007/s00125-008-1200-z · Cited by 21 · see citing works
Self-citationTauriainen, S., Salmela, K. T., Rantala, I. S., Knip, M., & Hyöty, H. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1129 · Cited by 16 · see citing works
Rapid Assays for Detection of Anti-islet Autoantibodies: Implications for Organ Donor Screening
Maniatis, A. K., Yu, L., Miao, D., Nelson, K., & Eisenbarth, G. S. (2001) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0457 · Cited by 15 · see citing works
Self-citationRetrospective Assessment of Islet Cell Autoantibodies in Pancreas Organ Donors
Diamantopoulos, S., Allende, G., Ferreira, J. M., Ciancio, G., Burke, G. W., & Pugliese, A. (2008) · Diabetes Care · doi:10.2337/dc08-0652 · Cited by 9 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60591-7 · Cited by 2,713 · see citing works
Self-citationThe human body at cellular resolution: the NIH Human Biomolecular Atlas Program
HuBMAP Consortium, Writing Group, Snyder, M. P., Lin, S., Posgai, A., Atkinson, M., Regev, A., Rood, J., Rozenblatt-Rosen, O., Gaffney, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1629-x · Cited by 595 · see citing works
Self-citationButler, A. E., Campbell-Thompson, M., Gurlo, T., Dawson, D. W., Atkinson, M., & Butler, P. C. (2013) · Diabetes · doi:10.2337/db12-1686 · Cited by 457 · see citing works
Self-citationInsulitis and β-Cell Mass in the Natural History of Type 1 Diabetes
Campbell‐Thompson, M., Fu, A. D., Kaddis, J. S., Wasserfall, C. H., Schatz, D., Pugliese, A., & Atkinson, M. A. (2015) · Diabetes · doi:10.2337/db15-0779 · Cited by 359 · see citing works
Self-citationIslet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes
Richardson, S. J., Rodriguez-Calvo, T., Gerling, I. C., Mathews, C. E., Kaddis, J. S., Russell, M. A., Zeissler, M., Leete, P., Krogvold, L., Dahl-Jørgensen, K., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-4067-4 · Cited by 298 · see citing works
Self-citationA Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry
Damond, N., Engler, S., Zanotelli, V., Schapiro, D., Wasserfall, C., Kusmartseva, I., Nick, H., Thorel, F., Herrera, P., Atkinson, M., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.11.014 · Cited by 288 · see citing works
Self-citation100 years of insulin: celebrating the past, present and future of diabetes therapy
Sims, E. K., Carr, A. L. J., Oram, R. A., DiMeglio, L. A., & Evans-Molina, C. (2021) · Nature Medicine · doi:10.1038/s41591-021-01418-2 · Cited by 270 · see citing works
Type 1 diabetes: translating mechanistic observations into effective clinical outcomes
Herold, K. C., Vignali, D. A. A., Cooke, A., & Bluestone, J. A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3422 · Cited by 237 · see citing works
Wang, Y. J., Traum, D., Schug, J., Gao, L., Liu, C., Atkinson, M. A., Powers, A. C., Feldman, M. D., Naji, A., Chang, K.-M., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.003 · Cited by 228 · see citing works
Self-citationFasolino, M., Schwartz, G. W., Patil, A. R., Mongia, A., Golson, M. L., Wang, Y. J., Morgan, A. R., Liu, C., Schug, J., Liu, J., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00531-x · Cited by 223 · see citing works
The immunology of type 1 diabetes
Herold, K. C., Delong, T., Perdigoto, A. L., Biru, N., Brusko, T. M., & Walker, L. S. K. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-023-00985-4 · Cited by 222 · see citing works
Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes
Michels, A. W., Landry, L. G., McDaniel, K. A., Yu, L., Campbell‐Thompson, M., Kwok, W. W., Jones, K. L., Gottlieb, P. A., Kappler, J. W., Tang, Q., et al. (2016) · Diabetes · doi:10.2337/db16-1025 · Cited by 192 · see citing works
Self-citationThe diagnosis of insulitis in human type 1 diabetes
Campbell‐Thompson, M., Atkinson, M. A., Butler, A. E., Chapman, N. M., Frisk, G., Gianani, R., Giepmans, B. N. G., von Herrath, M. G., Hyöty, H., Kay, T. W. H., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-3043-5 · Cited by 187 · see citing works
Self-citationMass Cytometry Imaging for the Study of Human Diseases—Applications and Data Analysis Strategies
Baharlou, H., Canete, N. P., Cunningham, A. L., Harman, A. N., & Patrick, E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02657 · Cited by 176 · see citing works
Heterogeneity and endotypes in type 1 diabetes mellitus
REDONDO, M. J., & Morgan, N. G. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00853-0 · Cited by 172 · see citing works
Kusmartseva, I., Wu, W., Syed, F., van der Heide, V., Jorgensen, M., Joseph, P., Tang, X., Candelario‐Jalil, E., Yang, C., Nick, H. S., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.11.005 · Cited by 166 · see citing works
Self-citationWigger, L., Barovic, M., Brunner, A., Marzetta, F., Schöniger, E., Mehl, F., Kipke, N., Friedland, D., Burdet, F., Kessler, C., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00420-9 · Cited by 158 · see citing works
Campbell‐Thompson, M., Wasserfall, C. H., Montgomery, E. L., Atkinson, M. A., & Kaddis, J. S. (2012) · JAMA · doi:10.1001/jama.2012.15008 · Cited by 147 · see citing works
Self-citationCandidate genes for type 1 diabetes modulate pancreatic islet inflammation and β ‐cell apoptosis
Santín, I., & Eizirik, D. L. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12162 · Cited by 140 · see citing works
Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes.
Seay, H. R., Yusko, E., Rothweiler, S., Zhang, L., Posgai, A., Campbell-Thompson, M., Vignali, M., Emerson, R., Kaddis, J. S., Ko, D., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.88242 · Cited by 137 · see citing works
Self-citationRichardson, S. J., Leete, P., Bone, A. J., Foulis, A. K., & Morgan, N. G. (2012) · Diabetologia · doi:10.1007/s00125-012-2745-4 · Cited by 137 · see citing works
Immune mechanisms in type 1 diabetes
Wållberg, M., & Cooke, A. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.08.005 · Cited by 155 · see citing works
Pugliese, A., Yang, M., Kusmartseva, I., Heiple, T., Vendrame, F., Wasserfall, C. H., Rowe, P. A., Moraski, J., Ball, S., Jebson, L., et al. (2013) · Pediatric Diabetes · doi:10.1111/pedi.12097 · Cited by 136 · see citing works
Self-citationInsulitis in human type 1 diabetes: a comparison between patients and animal models
Veld, P. I. '. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0438-4 · Cited by 131 · see citing works
The influence of type 1 diabetes on pancreatic weight
Campbell‐Thompson, M., Kaddis, J. S., Wasserfall, C. H., Haller, M. J., Pugliese, A., Schatz, D., Shuster, J. J., & Atkinson, M. A. (2015) · Diabetologia · doi:10.1007/s00125-015-3752-z · Cited by 122 · see citing works
Self-citationType 1 diabetes: A predictable disease
Simmons, K. M. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i3.380 · Cited by 119 · see citing works
Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell
Menegaz, D., Hagan, D., Almaça, J., Cianciaruso, C., Rodriguez-Diaz, R., Molina, J., Dolan, R. M., Becker, M., Schwalie, P. C., Nano, R., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0135-7 · Cited by 99 · see citing works
Wasserfall, C. H., Nick, H. S., Campbell‐Thompson, M., Beachy, D. E., Haataja, L., Kusmartseva, I., Posgai, A. L., Beery, M. L., Rhodes, C. J., Bonifacio, E. E., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.013 · Cited by 106 · see citing works
Self-citationEsposito, I., Hruban, R. H., Verbeke, C. S., Terris, B., Zamboni, G., Scarpa, A., Morohoshi, T., Suda, K., Luchini, C., Klimstra, D. S., et al. (2020) · Pancreatology · doi:10.1016/j.pan.2020.04.009 · Cited by 88 · see citing works
Abnormal islet sphingolipid metabolism in type 1 diabetes
Holm, L. J., Krogvold, L., Hasselby, J. P., Kaur, S., Claessens, L. A., Russell, M. A., Mathews, C. E., Hanssen, K. F., Morgan, N. G., Koeleman, B. P. C., et al. (2018) · Diabetologia · doi:10.1007/s00125-018-4614-2 · Cited by 87 · see citing works
Montemurro, C., Nomoto, H., Pei, L., Parekh, V. S., Vongbunyong, K. E., Vadrevu, S., Gurlo, T., Butler, A. E., Subramaniam, R., Ritou, E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10444-1 · Cited by 85 · see citing works
Marchand, L., Jalabert, A., Meugnier, E., Hende, K. V. D., Fabien, N., Nicolino, M. P., Madec, A., Thivolet, C. H., & Rome, S. (2016) · Journal of Diabetes Research · doi:10.1155/2016/1869082 · Cited by 83 · see citing works
Leete, P., Mallone, R., Richardson, S. J., Sosenko, J. M., REDONDO, M. J., & Evans‐Molina, C. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1083-4 · Cited by 80 · see citing works
Large-scale electron microscopy database for human type 1 diabetes
de Boer, P., Pirozzi, N. M., Wolters, A. H. G., Kuipers, J., Kusmartseva, I., Atkinson, M. A., Campbell‐Thompson, M., & Giepmans, B. N. G. (2020) · Nature Communications · doi:10.1038/s41467-020-16287-5 · Cited by 81 · see citing works
Self-citationPancreatic Pathology in Type 1 Diabetes Mellitus
Richardson, S. J., Morgan, N. G., & Foulis, A. K. (2014) · Endocrine Pathology · doi:10.1007/s12022-014-9297-8 · Cited by 80 · see citing works
Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis.
Panzer, J., Hiller, H., Cohrs, C., Almaça, J., Enos, S. J., Beery, M. L., Cechin, S., Drotar, D. M., Weitz, J., Santini, J., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.134525 · Cited by 74 · see citing works
Self-citation3D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk
Su, C., Gao, L., May, C. L., Pippin, J. A., Boehm, K. D., Lee, M., Liu, C., Pahl, M. C., Golson, M. L., Naji, A., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.08.014 · Cited by 78 · see citing works
Lernmark, Å., & Alshiekh, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.15001-5 · Cited by 79 · see citing works
Islet inflammation in human type 1 diabetes mellitus
Morgan, N. G., Leete, P., Foulis, A. K., & Richardson, S. J. (2014) · IUBMB Life · doi:10.1002/iub.1330 · Cited by 75 · see citing works
The Streetlight Effect in Type 1 Diabetes
Battaglia, M., & Atkinson, M. A. (2015) · Diabetes · doi:10.2337/db14-1208 · Cited by 75 · see citing works
Self-citationProgress in immune-based therapies for type 1 diabetes
von Herrath, M., Peakman, M., & Roep, B. O. (2013) · Clinical & Experimental Immunology · doi:10.1111/cei.12085 · Cited by 74 · see citing works
Morgan, N., & Richardson, S. (2018) · Diabetologia · doi:10.1007/s00125-018-4731-y · Cited by 64 · see citing works
The multiple origins of Type 1 diabetes
Pugliese, A. (2012) · Diabetic Medicine · doi:10.1111/dme.12081 · Cited by 66 · see citing works
Self-citationWu, M., Lee, M. Y. Y., Bahl, V., Traum, D., Schug, J., Kusmartseva, I., Atkinson, M. A., Fan, G., & Kaestner, K. H. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109919 · Cited by 66 · see citing works
Self-citationWakeling, M. N., Owens, N. D. L., Hopkinson, J. R., Johnson, M. B., Houghton, J., Dastamani, A., Flaxman, C. S., Wyatt, R. C., Hewat, T. I., Hopkins, J. J., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01204-x · Cited by 66 · see citing works
Abnormalities in proinsulin processing in islets from individuals with longstanding T1D
Sims, E. K., Syed, F., Nyalwidhe, J. O., Bahnson, H. T., Haataja, L., Speake, C., Morris, M. A., Balamurugan, A. N., Mirmira, R. G., Nadler, J. L., et al. (2019) · Translational research · doi:10.1016/j.trsl.2019.08.001 · Cited by 58 · see citing works
Park, J., Lucas, A., Zhang, X., Chaudhary, K., Cho, J. H., Nadkarni, G. N., Dobbyn, A. L., Chittoor, G., Josyula, N. S., Katz, N., et al. (2021) · Nature Medicine · doi:10.1038/s41591-020-1133-8 · Cited by 57 · see citing works
Phelps, E. A., Cianciaruso, C., Domingo, J. S., Pasquier, M. C., Galliverti, G., Piemonti, L., Berishvili, E., Burri, O., Wiederkehr, A., Hubbell, J. A., et al. (2017) · Scientific Reports · doi:10.1038/srep45961 · Cited by 52 · see citing works
Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment
Newby, B. N., & Mathews, C. E. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00232 · Cited by 57 · see citing works
Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes
Korpos, É., Kadri, N., Loismann, S., Findeisen, C. R., Arfuso, F., Burke, G. W., Richardson, S. J., Morgan, N. G., Bogdani, M., Pugliese, A., et al. (2021) · Diabetologia · doi:10.1007/s00125-021-05453-z · Cited by 56 · see citing works
Self-citationNeoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets
Calvo, T. R., Johnson, J. D., Overbergh, L., & Dunne, J. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.667989 · Cited by 55 · see citing works
Neuropeptide Y expression marks partially differentiated β cells in mice and humans
Rodnoi, P., Rajkumar, M. S., Moin, A. S. M., Georgia, S. K., Butler, A. E., & Dhawan, S. (2017) · JCI Insight · doi:10.1172/jci.insight.94005 · Cited by 55 · see citing works
Vinckier, N. K., Patel, N. A., Geusz, R. J., Wang, A., Wang, J., Matta, I., Harrington, A. R., Wortham, M., Wetton, N., Wang, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16017-x · Cited by 51 · see citing works
Reanalysis of study of pancreatic effects of incretin therapy: methodological deficiencies
Bonner‐Weir, S., In't Veld, P. A., & Weir, G. C. (2014) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12257 · Cited by 54 · see citing works
Fasolino, M., Goldman, N., Wang, W., Cattau, B., Zhou, Y., Petrovic, J., Link, V. M., Coté, A., Chandra, A., Silverman, M. A., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.01.003 · Cited by 51 · see citing works
Increased Hormone-Negative Endocrine Cells in the Pancreas in Type 1 Diabetes
Moin, A. S. M., Dhawan, S., Shieh, C., Butler, P. C., Cory, M., & Butler, A. E. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1350 · Cited by 53 · see citing works
Increased Complement Activation in Human Type 1 Diabetes Pancreata
Rowe, P. A., Wasserfall, C. H., Croker, B. P., Campbell‐Thompson, M., Pugliese, A., Atkinson, M. A., & Schatz, D. (2013) · Diabetes Care · doi:10.2337/dc13-0203 · Cited by 52 · see citing works
Self-citationUsing the T Cell Receptor as a Biomarker in Type 1 Diabetes
Nakayama, M., & Michels, A. W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.777788 · Cited by 48 · see citing works
Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes
Campbell-Thompson, M., Butterworth, E., Boatwright, J., Nair, M. A., Nasif, L., Nasif, K., Revell, A., Riva, A., Mathews, C., Gerling, I., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-85659-8 · Cited by 41 · see citing works
Self-citationThe case for an autoimmune aetiology of type 1 diabetes
Mannering, S. I., Pathiraja, V., & Kay, T. W. H. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12699 · Cited by 49 · see citing works
Wasserfall, C. H., Montgomery, E., Yu, L., Michels, A. W., Gianani, R., Pugliese, A., Nierras, C. R., Kaddis, J. S., Schatz, D., Bonifacio, E. E., et al. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12797 · Cited by 48 · see citing works
Self-citationCampbell-Thompson, M. (2015) · Pediatric Diabetes · doi:10.1111/pedi.12286 · Cited by 46 · see citing works
Self-citationKaddis, J. S., Pugliese, A., & Atkinson, M. A. (2015) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000171 · Cited by 46 · see citing works
Self-citationAdvanced Glycation End Products and Inflammation in Type 1 Diabetes Development
Du, C., Whiddett, R. O., Buckle, I., Chen, C., Forbes, J. M., & Fotheringham, A. K. (2022) · Cells · doi:10.3390/cells11213503 · Cited by 47 · see citing works
New Insight on Human Type 1 Diabetes Biology: nPOD and nPOD-Transplantation
Pugliese, A., Vendrame, F., Reijonen, H., Atkinson, M. A., Campbell‐Thompson, M., & Burke, G. W. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0530-0 · Cited by 45 · see citing works
Self-citationGraves, C. L., Harden, S. W., LaPato, M., Nelson, M., Amador, B., Sorenson, H. L., Frazier, C. J., & Wallet, S. M. (2014) · Journal of Immunological Methods · doi:10.1016/j.jim.2014.08.002 · Cited by 45 · see citing works
Islet Microvasculature Alterations With Loss of Beta-cells in Patients With Type 1 Diabetes
Canzano, J. S., Nasif, L., Butterworth, E., Fu, D.-T. A., Atkinson, M., & Campbell-Thompson, M. (2018) · Journal of Histochemistry and Cytochemistry · doi:10.1369/0022155418778546 · Cited by 35 · see citing works
Self-citationThomaidou, S., Kracht, M. J. L., van der Slik, A. R., Laban, S., de Koning, E. J. P., Carlotti, F., Hoeben, R. C., Roep, B. O., & Zaldumbide, A. (2020) · Diabetes · doi:10.2337/db19-0984 · Cited by 43 · see citing works
Driver, J. P., Chen, Y., & Mathews, C. E. (2012) · The Review of Diabetic Studies · doi:10.1900/rds.2012.9.169 · Cited by 43 · see citing works
Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis
Hackeng, W. M., Brosens, L. A. A., Poruk, K. E., Noë, M., Hosoda, W., Poling, J., Rizzo, A. J., Campbell‐Thompson, M., Atkinson, M. A., Konukiewitz, B., et al. (2016) · Human Pathology · doi:10.1016/j.humpath.2016.06.006 · Cited by 42 · see citing works
Self-citationBonnet-Serrano, F., Diedisheim, M., Mallone, R., & Larger, É. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191528 · Cited by 41 · see citing works
Modeling human T1D-associated autoimmune processes
Maharlooei, M. K., Madley, R., Borsotti, C., Ferreira, L. M. R., Sharp, R. C., Brehm, M. A., Greiner, D. L., Parent, A. V., Anderson, M. S., Sykes, M., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101417 · Cited by 42 · see citing works
Lin, H., Wang, C., Tsai, F., Hwang, K., Chen, W. W., Lin, C., & Li, T. (2014) · Diabetologia · doi:10.1007/s00125-014-3400-z · Cited by 42 · see citing works
Carr, A. L. J., Inshaw, J. R. J., Flaxman, C. S., Leete, P., Wyatt, R. C., Russell, L. A., Palmer, M., Prasolov, D., Worthington, T., Hull, B., et al. (2022) · Diabetes · doi:10.2337/db22-0097 · Cited by 40 · see citing works
Islet–immune interactions in type 1 diabetes: the nexus of beta cell destruction
Peters, L. D., Posgai, A., & Brusko, T. (2019) · Clinical and Experimental Immunology · doi:10.1111/cei.13349 · Cited by 39 · see citing works
Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System
Mann, S. E., Zhou, Z., Landry, L. G., Anderson, A. M., Alkanani, A. K., Fischer, J., Peakman, M., Mallone, R., Campbell, K. R., Michels, A. W., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00633 · Cited by 40 · see citing works
Expression Pattern of 12-Lipoxygenase in Human Islets With Type 1 Diabetes and Type 2 Diabetes
Grzesik, W. J., Nadler, J., Machida, Y., Nadler, J. L., Imai, Y., & Morris, M. A. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3630 · Cited by 38 · see citing works
Nyalwidhe, J. O., Grzesik, W. J., Burch, T. C., Semeraro, M. L., Waseem, T. C., Gerling, I., Mirmira, R. G., Morris, M. A., & Nadler, J. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183908 · Cited by 37 · see citing works
Phelps, E. A., Cianciaruso, C., Michael, I. P., Pasquier, M. C., Kanaani, J., Nano, R., Lavallard, V., Billestrup, N., Hubbell, J. A., & Bækkeskov, S. (2016) · Diabetes · doi:10.2337/db16-0180 · Cited by 36 · see citing works
Apaolaza, P. S., Πετροπούλου, Π.-Ι., & Calvo, T. R. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.689799 · Cited by 35 · see citing works
Pancreatic biopsies in type 1 diabetes: revisiting the myth of Pandora’s box
Atkinson, M. A. (2014) · Diabetologia · doi:10.1007/s00125-013-3159-7 · Cited by 34 · see citing works
Self-citationTang, X., Kusmartseva, I., Kulkarni, S., Posgai, A. L., Speier, S., Schatz, D. A., Haller, M. J., Campbell‐Thompson, M., Wasserfall, C. H., Roep, B. O., et al. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.11.010 · Cited by 33 · see citing works
Self-citationDiedisheim, M., Mallone, R., Boîtard, C., & Larger, É. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3756 · Cited by 32 · see citing works
An Analysis of Characteristics of Subjects Examined for Incretin Effects on Pancreatic Pathology
Harja, E., Lord, J., & Skyler, J. S. (2013) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2013.0177 · Cited by 31 · see citing works
Innate Immunity in Type 1 DiabetesPreprint
Bertrand, L., Chervonsky, A. V., & Lehuen, A. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041595 · Cited by 30 · see citing works
The role of the interferon/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes
Russell, M. A., Richardson, S. J., & Morgan, N. G. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1270325 · Cited by 28 · see citing works
Burch, T. C., Morris, M. A., Campbell‐Thompson, M., Pugliese, A., Nadler, J. L., & Nyalwidhe, J. O. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135663 · Cited by 28 · see citing works
Self-citationIslet amyloidosis in a child with type 1 diabetes
Beery, M. L., Jacobsen, L. M., Atkinson, M. A., Butler, A. E., & Campbell‐Thompson, M. (2019) · Islets · doi:10.1080/19382014.2019.1599707 · Cited by 28 · see citing works
Self-citationEstorninho, M., Gibson, V. B., Kronenberg‐Versteeg, D., Liu, Y., Ni, C., Cerosaletti, K. M., & Peakman, M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300622 · Cited by 26 · see citing works
Apaolaza, P. S., Balcacean, D., Zapardiel‐Gonzalo, J., & Calvo, T. R. (2023) · Diabetologia · doi:10.1007/s00125-023-05888-6 · Cited by 26 · see citing works
Nigi, L., Maccora, C., Dotta, F., & Sebastiani, G. (2019) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3264 · Cited by 24 · see citing works
The β-Cell Genomic Landscape in T1D: Implications for Disease Pathogenesis
Ramos-Rodríguez, M., Pérez-González, B., & Pasquali, L. (2021) · Current Diabetes Reports · doi:10.1007/s11892-020-01370-4 · Cited by 25 · see citing works
Sanyoura, M., Jacobsen, L. M., Carmody, D., del Gaudio, D., Alkorta‐Aranburu, G., Arndt, K., Hu, Y., Kobiernicki, F., Kusmartseva, I., Atkinson, M. A., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01159 · Cited by 25 · see citing works
Self-citationPedersen, K., Haupt‐Jorgensen, M., Krogvold, L., Kaur, S., Gerling, I., Pociot, F., Dahl‐Jørgensen, K., & Buschard, K. (2021) · Diabetologia · doi:10.1007/s00125-021-05469-5 · Cited by 24 · see citing works
Carr, A. L. J., Perry, D. J., Lynam, A. L., Chamala, S., Flaxman, C. S., Sharp, S. A., Ferrat, L. A., Jones, A. G., Beery, M. L., Jacobsen, L. M., et al. (2020) · Diabetic Medicine · doi:10.1111/dme.14361 · Cited by 23 · see citing works
Self-citationKrogvold, L., Leete, P., Mynarek, I. M., Russell, M. A., Gerling, I., Lenchik, N. I., Mathews, C. E., Richardson, S. J., Morgan, N. G., & Dahl‐Jørgensen, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.881997 · Cited by 23 · see citing works
Parveen, N., Wang, J. K., Bhattacharya, S., Cuala, J., Rajkumar, M. S., Butler, A. E., Wu, X., Shih, H.-P., Georgia, S. K., & Dhawan, S. (2023) · Diabetes · doi:10.2337/db22-0506 · Cited by 23 · see citing works
Insulitis in human type 1 diabetes: lessons from an enigmatic lesion
Morgan, N. G. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae002 · Cited by 23 · see citing works
Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes
Sona, C., Yeh, Y., Patsalos, A., Halász, L., Yan, X., Kononenko, N. L., Nagy, L., & Poy, M. N. (2022) · JCI Insight · doi:10.1172/jci.insight.153136 · Cited by 22 · see citing works
Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation
Ortega, H. I., Udler, M. S., Gloyn, A. L., & Sharp, S. A. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01132-w · Cited by 23 · see citing works
- Authors
- Campbell‐Thompson, M., Wasserfall, C., Kaddis, J., Albanese‐O'Neill, A., Staeva, T., Nierras, C., Moraski, J., Rowe, P., Gianani, R., Eisenbarth, G., Crawford, J., Schatz, D., Pugliese, A., & Atkinson, M.
- Affiliations
- University of Florida Health (US)
- City Of Hope National Medical Center (US)
- Department of Pathology, Immunology and Laboratory Medicine, College of Medicine University of Florida Gainesville FL USA
- Breakthrough T1D (US)
- University of Colorado Denver (US)
- Northwell Health (US)
- University of Miami (US)
- Corresponding author
- Campbell‐Thompson, Martha
- ORCID
- Venue
- Diabetes/Metabolism Research and Reviews
- Publisher
- Wiley
- Published
- 2012-10
- Volume
- 28
- Issue
- 7
- Pages
- 608-617
- ISSN
- 1520-7552 (ISSN-L)
- 1520-7560
- PMC
- PMC3456997
- OpenAlex
- W1504366326
- Cited by
- 236
- References
- 24
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 30 · 2023: 9 · 2022: 20 · 2021: 24 · 2020: 18 · 2019: 14 · 2018: 6 · 2017: 12 · 2016: 20 · 2015: 13 · 2014: 18 · 2013: 18 · 2012: 5
- FWCI
- 10.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Diabetes/Metabolism Research and Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000064)
- National Institute of Allergy and Infectious Diseases (P01 AI42288, P01AI042288)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 1 diabetes, deceased donor, biospecimen access, autoantibodies, C-peptide, HLA risk alleles, beta-cell function, lymph nodes, open data sharing
- MeSH terms
- Cadaver, Diabetes Mellitus, Type 1, Florida, Humans, Pancreas, Tissue Banks, Biomedical Research, Insulin-Secreting Cells
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