Fatty liver disease caused by High-Alcohol-Producing Klebsiella pneumoniae
Open accessIntegrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
NAFLD pathogenesis has been linked to high-alcohol-producing K. pneumoniae.
“Interestingly, NAFLD pathogenesis has been linked to high-alcohol-producing K. pneumoniae.58”
From Novel therapeutic targets for cholestatic and fatty liver disease (2022) · cites this paper as [58]
Cited by
Sorted by citations
Phage therapy: From biological mechanisms to future directions
Strathdee, S. A., Hatfull, G. F., Mutalik, V. K., & Schooley, R. T. (2023) · Cell · doi:10.1016/j.cell.2022.11.017 · Cited by 817 · see citing works
What's in a name? Renaming ‘NAFLD’ to ‘MAFLD’
Fouad, Y. M., Waked, I. A., Bollipo, S. J., Gomaa, A., Ajlouni, Y., & Attia, D. I. (2020) · Liver International · doi:10.1111/liv.14478 · Cited by 297 · see citing works
Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease
Romeo, S., Sanyal, A. J., & Valenti, L. V. C. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.12.002 · Cited by 203 · see citing works
Novel therapeutic targets for cholestatic and fatty liver disease
Trauner, M., & Fuchs, C. D. (2022) · Gut · doi:10.1136/gutjnl-2021-324305 · Cited by 204 · see citing works
Sharpton, S. R., Schnabl, B., Knight, R., & Loomba, R. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.11.010 · Cited by 194 · see citing works
Mechanisms of Non-Alcoholic Fatty Liver Disease in the Metabolic Syndrome. A Narrative Review
Rinaldi, L., Pafundi, P. C., Galiero, R., Caturano, A., Morone, M. V., Silvestri, C., Giordano, M., Salvatore, T., & Sasso, F. C. (2021) · Antioxidants · doi:10.3390/antiox10020270 · Cited by 178 · see citing works
Gan, L., Feng, Y., Du, B., Fu, H., Tian, Z., Xue, G., Yan, C., Cui, X., Zhang, R., Cui, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39028-w · Cited by 162 · see citing works
“Speci fi c-pathogen-free (SPF) male C57BL/6J mice (6-7 weeks old, Charles River Corp., Beijing, China) were used for establishing murine models as previously described 7 .”
InfluentialSelf-citationEvolving Role for Pharmacotherapy in NAFLD/NASH
Attia, S. L., Softic, S., & Mouzaki, M. (2020) · Clinical and Translational Science · doi:10.1111/cts.12839 · Cited by 130 · see citing works
“This review summarizes emerging pharmacotherapies for the treatment of adult and pediatric NAFLD.”
BackgroundInfluentialLi, D., Sun, T., Tong, Y., Le, J., Yao, Q., Tao, J., Liu, H., Jiao, W.-E., Mei, Y., Chen, J., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.02.017 · Cited by 112 · see citing works
Ichikawa, M., Nakamoto, N., Kredo‐Russo, S., Weinstock, E., Weiner, I. N., Khabra, E., Ben-Ishay, N., Inbar, D., Kowalsman, N., Mordoch, R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39029-9 · Cited by 111 · see citing works
Acetate reprograms gut microbiota during alcohol consumption
Martino, C., Zaramela, L. S., Gao, B., Embree, M., Tarasova, J., Parker, S. J., Wang, Y., Chu, H., Chen, P., Lee, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31973-2 · Cited by 105 · see citing works
Why Do So Many Nonalcoholic Steatohepatitis Trials Fail?
Ratziu, V., & Friedman, S. L. (2023) · Gastroenterology · doi:10.1053/j.gastro.2020.05.046 · Cited by 88 · see citing works
Characterization of the gut‐liver‐muscle axis in cirrhotic patients with sarcopenia
Ponziani, F. R., Picca, A., Marzetti, E., Calvani, R., Conta, G., CHIERICO, F. D., Capuani, G., Faccia, M., Fianchi, F., Funaro, B., et al. (2021) · Liver International · doi:10.1111/liv.14876 · Cited by 89 · see citing works
Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease
Shim, Y., & Jeong, W. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0438-5 · Cited by 81 · see citing works
Intestinal virome and therapeutic potential of bacteriophages in liver disease
Hsu, C. L., Duan, Y., Fouts, D. E., & Schnabl, B. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.08.003 · Cited by 77 · see citing works
An, H., Jang, Y., Choi, J.-I., Hur, J., Kim, S., & Kwon, Y. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.188 · Cited by 72 · see citing works
Comparison of Metagenomics and Metatranscriptomics Tools: A Guide to Making the Right Choice
Terron-Camero, L. C., Gordillo-González, F., Salas‐Espejo, E., & Andrés‐León, E. (2022) · Genes · doi:10.3390/genes13122280 · Cited by 71 · see citing works
Impact of drinking alcohol on gut microbiota: recent perspectives on ethanol and alcoholic beverage
Lee, E., & Lee, J. (2020) · Current Opinion in Food Science · doi:10.1016/j.cofs.2020.10.001 · Cited by 61 · see citing works
Luo, H., Li, M., Wang, F., Yang, Y., Wang, Q. L., Zhao, Y., Du, F., Chen, Y., Shen, J., Zhao, Q., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.72600 · Cited by 57 · see citing works
Self-citationThe Potential Gut Microbiota-Mediated Treatment Options for Liver Cancer
Zhang, C., Yang, M. J., & Ericsson, A. C. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.524205 · Cited by 50 · see citing works
“For instance, high-alcohol-producing bacterium Klebsiella pneumoniae is implicated in the pathogenesis of NAFLD in human patients, evidenced by oral gavage of a clinically isolated strain causing NAFLD in mice (29).”
BackgroundWu, J., Liu, M., Zhou, M., Wu, L., Yang, H., Huang, L., & Chen, C. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02193-3 · Cited by 50 · see citing works
Self-citationThe role of microbiota in nonalcoholic fatty liver disease
Ciaula, A. D., Bonfrate, L., & Portincasa, P. (2022) · European Journal of Clinical Investigation · doi:10.1111/eci.13768 · Cited by 43 · see citing works
A Role for Gut Microbiome Fermentative Pathways in Fatty Liver Disease Progression
Iruzubieta, P., Medina, J. M., Fernández-López, R., Crespo, J., & de la Cruz, F. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051369 · Cited by 44 · see citing works
“This was proven in a recent study, where the introduction of strains of Klebsiella pneumoniae with high alcohol production induced NAFLD in mice [56].”
ResultSi, J., Lee, G., You, H. J., Joo, S. K., Lee, D. H., Ku, B. J., Park, S., Kim, W. K., & Ko, G. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.10.032 · Cited by 41 · see citing works
Metabolic and alcohol-associated liver disease (MetALD): a representation of duality
Leal-Lassalle, H., Estévez‐Vázquez, O., Cubero, F. J., & Nevzorova, Y. A. (2025) · npj gut and liver. · doi:10.1038/s44355-024-00014-8 · Cited by 41 · see citing works
“Bacterial species belonging to the phylum Proteobacteria, lactic acid bacteria and Klebsiella pneumoniae 121 have been associated with fasting alcohol levels in MASLD.”
Wu, H., Chen, J., Guo, S., Deng, J., Zhou, Z., Zhang, X., Qi, T., Yu, F., & Yang, Q. L. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2500099 · Cited by 41 · see citing works
“75 Some researchers have identified other ethanol-producing microbiota in the gut, such as Limosilactobacillus fer-mentum, Enterocloster bolteae, Mediterraneibacter gnavus, Streptococcus mutans, Pichia kudriavzevii, Candida albicans and Candida glabrata Yeasts.”
Human Gut Microbiome and Liver Diseases: From Correlation to Causation
Li, R., Mao, Z., Ye, X., & Zuo, T. (2021) · Microorganisms · doi:10.3390/microorganisms9051017 · Cited by 40 · see citing works
Kaufmann, B. K., Seyfried, N., Hartmann, D., & Hartmann, P. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00017.2023 · Cited by 39 · see citing works
The Janus of a disease: Diabetes and metabolic dysfunction-associated fatty liver disease
Francisco Barrera, M., Uribe, J., Olvares, N., Huerta, P., Cabrera, D., & Romero‐Gómez, M. (2024) · Annals of Hepatology · doi:10.1016/j.aohep.2024.101501 · Cited by 36 · see citing works
Mignini, I., Galasso, L., Piccirilli, G., Calvez, V., Termite, F., Esposto, G., Borriello, R., Miele, L., Ainora, M. E., Gasbarrini, A., et al. (2024) · Antioxidants · doi:10.3390/antiox13121532 · Cited by 33 · see citing works
“The rise in Bacteroidetes leads to increased methanol production, which can accumulate and cause oxidative damage in the gut and liver [82,83], a process that may be further worsened by alcohol-producing strains of K. pneumoniae [84,85].”
Ratti, C., Malaguti, M., D’Aniello, E., Bellasi, A., & Sanna, G. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.120495 · Cited by 38 · see citing works
Seven facts and five initiatives for gut microbiome research
Li, D., Gao, C., Zhang, F., Yang, R., Lan, C., Ma, Y., & Wang, J. (2020) · Protein & Cell · doi:10.1007/s13238-020-00697-8 · Cited by 34 · see citing works
Self-citationLanthier, N., & Delzenne, N. M. (2022) · Cells · doi:10.3390/cells11172718 · Cited by 34 · see citing works
Gut microbiota in MAFLD: therapeutic and diagnostic implications
Alghamdi, W., Mosli, M. H., & Alqahtani, S. A. (2024) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188241242937 · Cited by 31 · see citing works
“29,111,112 BAs and SCFAs.”
Yu, T., Luo, L., Xue, J., Tang, W., Wu, X., & Fan, Y. (2024) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2024.102458 · Cited by 34 · see citing works
Pathophysiological Mechanisms in Non-Alcoholic Fatty Liver Disease: From Drivers to Targets
Santos‐Laso, Á., Gutiérrez‐Larrañaga, M., Alonso‐Peña, M., Medina, J. M., Iruzubieta, P., Arias, M., López‐Hoyos, M., & Crespo, J. (2021) · Biomedicines · doi:10.3390/biomedicines10010046 · Cited by 32 · see citing works
Multi-Omics Reveals Inhibitory Effect of Baicalein on Non-Alcoholic Fatty Liver Disease in Mice
Li, P., Hu, J., Zhao, H., Feng, J., & Chai, B. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.925349 · Cited by 31 · see citing works
“Increasing evidence shows that disturbances in the gut microbiota may result in liver diseases including NAFLD (Tokuhara, 2021), since nutrients and microbiota-related components transfer from the intestines to the liver directly through the portal tract (Chen et al., 2019; Hong et al., 2019; Suk and Kim, 2019; Yuan e…”
BackgroundZhang, Y. L., Hu, J., Zhong, Y., Liu, S., Liu, L., Mu, X., Chen, C., Yang, S., Li, G., Zhang, D., et al. (2023) · Food & Function · doi:10.1039/d3fo04068b · Cited by 28 · see citing works
Self-citationHarnessing stepping-stone hosts to engineer, select, and reboot synthetic bacteriophages in one pot
Li, C., Deng, Z., Tao, H., Song, W., Xing, B., Liu, W., Kong, L., Yuan, S., Ma, Y., Wu, Y., et al. (2022) · Cell Reports Methods · doi:10.1016/j.crmeth.2022.100217 · Cited by 26 · see citing works
“In these cases, SHAPE might be an interesting option for building synthetic phages to treat chronic gut microbiome-related diseases (Dong et al., 2020; Duan et al., 2019; Kabwe et al., 2021; Yuan et al., 2019; Zheng et al., 2019).”
BackgroundYao, N., Yang, Y., Li, X., Wang, Y., Guo, R., Wang, X., Li, J., Xie, Z., Li, B., & Cui, W. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.906511 · Cited by 28 · see citing works
“Clostridium (87–89)] can also accelerate the development of MAFLD (88).”
BackgroundSelf-citationByndloss, M. X., Devkota, S., Duca, F. A., Niess, J. H., Nieuwdorp, M., Orho‐Melander, M., Sanz, Y., Tremaroli, V., & Zhao, L. (2024) · Diabetes Care · doi:10.2337/dci24-0052 · Cited by 31 · see citing works
New perspective on fecal microbiota transplantation in liver diseases
Suk, K. T., & Koh, H. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15729 · Cited by 28 · see citing works
Two years on, a perspective on MAFLD
Eslam, M., & George, J. (2023) · eGastroenterology · doi:10.1136/egastro-2023-100019 · Cited by 24 · see citing works
Immunological dynamics in MASH: from landscape analysis to therapeutic intervention
Rabiu, L., Zhang, P., Afolabi, L. O., Saliu, M., Dabai, S. M., Suleiman, R. B., Gidado, K. I., Ige, M. A., Ibrahim, A., Zhang, G.-Z., et al. (2024) · Journal of gastroenterology · doi:10.1007/s00535-024-02157-0 · Cited by 23 · see citing works
“For instance, Kleb‑ siella pneumoniae , an alcohol-producing bacterium, and Porphyromonas gingivalis are associated with increased fibrosis, with the latter directly promoting HSC activation, linking specific microbial strains to immune-mediated fibrogenesis [117–119].”
Gupta, M., Krishan, P., Kaur, A., Arora, S., Trehanpati, N., Singh, T. G., & Bedi, O. (2021) · Inflammation Research · doi:10.1007/s00011-021-01480-z · Cited by 21 · see citing works
Guo, K., Xu, S., & Zeng, Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1050709 · Cited by 20 · see citing works
The paradigm shift from NAFLD to MAFLD : A global primary care viewpoint
Farahat, T. M., Ungan, M., Vilaseca, J., Ponzo, J., Gupta, P. P., Schreiner, A. D., Sharief, W., Casler, K., Abdelkader, T., Abenavoli, L., et al. (2022) · Liver International · doi:10.1111/liv.15188 · Cited by 21 · see citing works
Gut mycobiome in metabolic diseases: Mechanisms and clinical implication
Zhou, X., Zhang, X., & Yu, J. Q. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.100625 · Cited by 22 · see citing works
“Bacteria such as Klebsiella pneumoniae [51], Escherichia [52] and Citrobacter [53] were reported to produced endogenous ethanol in NASH.”
BackgroundBetaine regulates the gut-liver axis: a therapeutic approach for chronic liver diseases
Perumal, S. K., Arumugam, M. K., Osna, N. A., Rasineni, K., & Kharbanda, K. K. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1478542 · Cited by 20 · see citing works
“…through various mechanisms, including disruption of liver choline metabolism (necessary for VLDL synthesis and liver lipid export) (150), alterations in bile acid synthesis (151, 152), ethanol production (153), and increased lipopolysaccharides (LPS), which results in liver inflammation (154–156).”
Pekkala, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054855 · Cited by 19 · see citing works
“Previously, it has been shown, for instance, that high-alcohol-producing strains of Klebsiella pneumoniae exist in humans with NAFLD [40].”
BackgroundJiang, X., Yan, C., Zhang, H., Chen, L., Jiang, R. J., Zheng, K., Jin, W., Ma, H., Liu, X., & Dong, M. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.04294-22 · Cited by 18 · see citing works
“Endogenous ethanol produced by intestinal bacteria impaired mitochondrial function in NAFLD (51).”
BackgroundSelf-citationThe role of the gut microbiome in graft fibrosis after pediatric liver transplantation
Qin, T., Fu, J., & Verkade, H. J. (2020) · Human Genetics · doi:10.1007/s00439-020-02221-8 · Cited by 18 · see citing works
Cheng, W., Wang, Z., Xiong, Y., Wu, Z., Tan, X., Yang, Y., Zhang, H., Zhu, X., Wei, H., & Tao, S. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.146347 · Cited by 16 · see citing works
Self-citationGruzdev, S., Podoprigora, I. V., & Gizinger, O. A. (2024) · Archives of Microbiology · doi:10.1007/s00203-023-03752-0 · Cited by 16 · see citing works
“One of the articles has demonstrated that Klebsiella pneumoniae A7 produces large amounts of endogenous alcohol that was linked to NAFLD progression in humans (Yuan et al. 2019).”
Inflammatory liver diseases and susceptibility to sepsis
Lü, H. (2024) · Clinical Science · doi:10.1042/cs20230522 · Cited by 17 · see citing works
Jiang, L., Chen, S., Ai, C., Wen, C., & Song, S. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1400063 · Cited by 16 · see citing works
Fan, Z., Fu, T., Li, Z., Du, B., Cui, X., Zhang, R., Feng, Y., Zhao, H., Xue, G., Cui, J., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.01170-23 · Cited by 15 · see citing works
“Our previous study found that HiAlc Kpn is associated with nearly 60% of individu als with NAFLD in a Chinese cohort (2).”
BackgroundInfluentialSelf-citationUtilization of Food-Derived β-Glucans to Prevent and Treat Non-Alcoholic Fatty Liver Disease (NAFLD)
Kei, N., Wong, V. W., Lauw, S., You, L., & Cheung, P. C. K. (2023) · Foods · doi:10.3390/foods12173279 · Cited by 14 · see citing works
Martins, A. S. D. P., Campos, S. B. G., Goulart, M. O. F., Fabiana, & Moura, F. A. (2021) · Biocell · doi:10.32604/biocell.2021.014332 · Cited by 13 · see citing works
Zhang, R., Xu, Z., Xue, G., Feng, J., Du, B., Gan, L., Fan, Z., Fu, T., Feng, Y., Zhao, H., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.05323-22 · Cited by 12 · see citing works
“induced liver injury, which is consistent with the findings in a previous study (5).”
BackgroundMethodResultInfluentialSelf-citationInterventions for non-alcoholic liver disease: a gut microbial metabolites perspective
Guo, J., Shi, C., Zhang, Q., Deng, W., Zhang, L., Chen, Q., Zhang, D., & Gong, Z. (2022) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848221138676 · Cited by 12 · see citing works
Self-citationNonalcoholic Fatty Liver Disease and the Intestinal Microbiome: An Inseparable Link
Effenberger, M., Grander, C., Grabherr, F., & Tilg, H. (2023) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2023.00069 · Cited by 12 · see citing works
Novel approaches to liver disease diagnosis and modeling
de Oliveira, A. G., & Fiorotto, R. (2020) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh-20-109 · Cited by 10 · see citing works
Mouzaki, M., & Loomba, R. S. (2020) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-020-00290-2 · Cited by 9 · see citing works
Acharya, S., & Thirunavukkarasu, C. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2902067 · Cited by 10 · see citing works
Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1
Li, X., Cui, J., Ding, Z., Tian, Z., Kong, Y., Li, L., Liu, Y., Zhao, W., Chen, X., Guo, H., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-024-02002-0 · Cited by 11 · see citing works
“K.pn strain with high alcohol-producing activity was confirmed to contribute to nonalcoholic fatty liver disease [10].”
InfluentialSelf-citationZhang, Z., Li, M., Cui, B., & Chen, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.829686 · Cited by 9 · see citing works
Self-citationHabermaass, V., Olivero, D., Gori, E., Mariti, C., Longhi, E., & Marchetti, V. (2023) · Animals · doi:10.3390/ani13203174 · Cited by 9 · see citing works
Gut microbiome influences exercise response
Greenhill, C. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0309-0 · Cited by 8 · see citing works
Casañas, M., Barbero-Herranz, R., González, D. A., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.12.005 · Cited by 7 · see citing works
Hepatocellular Cancer and Gut Microbiome: Time to Untie Gordian’s Knot
Aygün, C., & Tozun, N. A. (2021) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-021-00736-5 · Cited by 7 · see citing works
“HCC Increased: Bacteroides, Bacteroidales, Ruminococcaceae, Enterococcus and Enterococceaea, Phascolarctobacterium, Oscillospira, Escherichia coli, Helicobacter pylori Decreased: Bifidobacterium, Bifidobacteriaceae, Bifidobacteriales, Bifidobacterium adolescentis, Blautia [4, 29]”
ResultSong, W., Hu, J., Zhu, L., Chen, B., Li, L., Cui, X., Zhang, T., Miao, Y., Su, K., Liu, C., et al. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250040 · Cited by 6 · see citing works
Gao, Y., Zhang, J., Xiao, X., Ren, Y., Yan, X., Yue, J., Wang, T., Wu, Z., Lv, Y., & Wu, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.640448 · Cited by 6 · see citing works
You, Q., Wang, K., Zhao, Z., Zhou, H., Lan, Z., Liang, H., Deng, R., Li, W., Shen, S., Wang, R., et al. (2025) · Journal of Medical Virology · doi:10.1002/jmv.70395 · Cited by 5 · see citing works
Self-citationCordell, B., Kanodia, A. K., & Miller, G. K. (2021) · F1000Research · doi:10.12688/f1000research.52743.1 · Cited by 5 · see citing works
Hu, Y., Huang, Y., Wang, M., et al. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.153514 · Cited by 4 · see citing works
Self-citationCurtis-Joseph, N., Peterson, R., Brown, C. E., Beekman, C. N., & Belenky, P. A. (2024) · Frontiers in Microbiomes · doi:10.3389/frmbi.2024.1432202 · Cited by 4 · see citing works
“Understanding why these species bloom is important, as each species has multiple associated morbidities ranging from infection to auto-brewery syndrome (Yuan et al., 2019).”
Mouratidis, I., Chantzi, N., Khan, U., Konnaris, M. A., Chan, C. S. Y., Mareboina, M., Moeckel, C., & Georgakopoulos-Soares, I. (2023) · BMC Genomics · doi:10.1186/s12864-023-09861-w · Cited by 3 · see citing works
“…show that the majority of high importance fre-quentmers originate from microorganisms known to be associated with liver cirrhosis, such as Prevotella copri , Faecalibacterium prausnitzii and Klebsiella pneumoniae , multiple of which have been previously associated with liver cirrhosis [24, 27, 28].”
BackgroundReciprocal oscillation and host-microbial communication in liver metabolic control
Sun, J., & DeBosch, B. J. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2545413 · Cited by 3 · see citing works
Gold digging: Searching for gut microbiota that enhances antitumor immunity
Hou, F., Pan, Z., Yang, R., Zhi, F., & Bi, Y. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30272 · Cited by 3 · see citing works
Self-citationStarling, S. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0159-9 · Cited by 3 · see citing works
AR-CDT NET: a deep deformable convolutional network for gut microbiome-based disease classification
Li, J., Sun, Z., Chai, S., Li, H.-J., Wang, Y., & Tian, J. (2025) · BMC Bioinformatics · doi:10.1186/s12859-025-06357-0 · Cited by 2 · see citing works
“This aligns with reports of endogenous alcohol production by gut bacteria, which can directly damage the liver and drive NAFLD progression [32].”
Self-citationIn vitro models of the gut-liver axis: what we’ve learned and what remains to be built
Sung, J. H., & Kim, R. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1858289 · Cited by 2 · see citing works
“However, speci fi c microbial species, not their metabolites, can causally contribute to liver disease, as demonstrated by endotoxin-producing Enterobacter cloacae or high-alcohol-producing Klebsiella pneumoniae (67, 68).”
Wu, C., & Tseng, C. (2023) · Springer eBooks · doi:10.1007/978-981-19-4492-5_5 · Cited by 2 · see citing works
Feng, J., Wang, J., Hu, J.-R., Li, P., Lv, P., He, H., Cheng, X.-W., Cao, Z., Han, J.-J., Wang, Q., et al. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i15.104996 · Cited by 1 · see citing works
Self-citationEun, J. W., Cheong, J. Y., & Kim, S. S. (2026) · Journal of Korean Medical Association · doi:10.5124/jkma.26.0074 · Cited by 1 · see citing works
Non-alcoholic Fatty Liver Disease - New Insight and Glance Into Disease Pathogenesis
Kang, S. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.100998 · Cited by 1 · see citing works
Revised Nomenclature for Fatty Liver Disease: Cutting through the Confusion
Alswat, K., Hashim, A. H., Alboraie, M. A. A., & Fouad, Y. M. (2020) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2020.00049 · Cited by 1 · see citing works
Glutathione Ameliorates Mouse Steatohepatitis
Cai, Q. (2020) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2020.29.004851
Molecular Phenomics of Gut Ecosystem in COVID-19 PatientsPreprint
Yan, Z., He, F., He, H., Li, D., Pang, P., Fang, Z., Jiang, G., Huang, S., Li, K., Gu, Z., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-208797/v1
Self-citationMetagenomics from bench to bedside and from bedside to bench
Jia, H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91369-0.00006-6 · Cited by 1 · see citing works
Klebsiella pneumoniae aggravates lung injury through ethanol productionPreprint
Cui, J., Xu, Z., Yu, Z., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2082937/v1
Self-citationJin, X., Wu, J., Wang, C., Tang, B., Yang, H., & Liu, Y. (2023) · doi:10.22541/au.167587024.47659435/v1
Self-citationGruzdev, S., Viktorovna, P. I., & Anatolievna, G. O. (2023) · doi:10.22541/au.169332662.25916191/v1
Wu, J., Liu, M., Zhou, M., Wu, L., Yang, H., Huang, L., & Chen, C. (2021) · Figshare · doi:10.6084/m9.figshare.14471681
Self-citationBeier, J. I., Medici, V., Spencer, S. P., Fan, W., & Torok, N. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99649-5.00006-6
Zhu, B., Yu, H., Du, B.-X., Yu, H., & Shi, J. (2025) · Big Data Mining and Analytics · doi:10.26599/bdma.2024.9020094
Di, T., Zhang, H., Zhang, C., Tian, L., Chang, M., Han, W., Qiao, R., Li, M., Zhang, S., & Yang, G. (2025) · Microorganisms · doi:10.3390/microorganisms13071666
Shevlyukova, T. P., Bulatova, I. A., Vladimirskiy, V. E., Смирнова, E. N., Trofimova, E. S., & Yusupova, A. A. (2025) · Perm Medical Journal · doi:10.17816/pmj42420-40
- Authors
- Yuan, J., Chen, C., Cui, J., Lu, J., Yan, C., Wei, X., Zhao, X., Li, N., Li, S., Xue, G., Cheng, W., Li, B., Li, H., Lin, W., Tian, C., Zhao, J., Han, J., An, D., Zhang, Q., Wei, H., Zheng, M., Ma, X., Li, W., Chen, X., Zhang, Z., Zeng, H., Ying, S., Wu, J., Yang, R., & Liu, D.
- Corresponding author
- Yuan, Jing
- Yang, Ruifu
- Liu, Di
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 30
- Issue
- 6
- Pages
- 1172
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W4238732480
- Cited by
- 118
- References
- 0
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 16 · 2023: 19 · 2022: 15 · 2021: 31 · 2020: 17 · 2019: 2
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- non-alcoholic fatty liver disease, Klebsiella pneumoniae, gut microbiota, blood alcohol concentration
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
