The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells
Open accessAbstract
Glutamine is an essential nutrient that regulates energy production, redox homeostasis, and signaling in cancer cells. Despite the importance of glutamine in mitochondrial metabolism, the mitochondrial glutamine transporter has long been unknown. Here, we show that the SLC1A5 variant plays a critical role in cancer metabolic reprogramming by transporting glutamine into mitochondria. The SLC1A5 variant has an N-terminal targeting signal for mitochondrial localization. Hypoxia-induced gene expression of the SLC1A5 variant is mediated by HIF-2α. Overexpression of the SLC1A5 variant mediates glutamine-induced ATP production and glutathione synthesis and confers gemcitabine resistance to pancreatic cancer cells. SLC1A5 variant knockdown and overexpression alter cancer cell and tumor growth, supporting an oncogenic role. This work demonstrates that the SLC1A5 variant is a mitochondrial glutamine transporter for cancer metabolic reprogramming.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For mitochondrial glutaminolysis, cytosolic glutamine must be transported through the inner mitochondrial membrane via the SLC1A5 variant, a mitochondrial glutamine transporter16.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“the mitochondrial glutamine transporter, encoded by a transcript variant of the SLC1A5 gene, which encodes a well-known plasma membrane glutamine transporter, was only recently discovered16.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“Although glutamate is the major downstream product of glutamine, glutamate supplementation during glutamine deprivation cannot rescue the impaired cell growth or mitochondrial respiration16,43–45, indicating that mitochondrial GLS-catalyzed cleavage of the gamma-nitrogen of glutamine is essential for glutaminolysis.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“Hypoxic conditions promote the uptake of glutamine by increasing the levels of glutamine transporters such as SLC1A5, the SLC1A5 variant, and SLC38A216,65”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“and the mitochondrial glutamine transporter is strongly associated with glutaminolysis-induced NADPH generation16.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“Furthermore, redox modulation augmented by increased glutathione synthesis from glutamine was reported to be the mechanism of resistance to gemcitabine in pancreatic cancer cells16.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“Impairing glutamine metabolism also induces sensitivity in gemcitabine-resistant pancreatic cancer cells16,84,85.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“Indeed, experiments using uniformly labeled 13C-glutamine showed that glutathione was enriched with five 13C atoms in glutathione, suggesting that glutamine is the major source of glutathione16,57,60.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“Recently, hypoxia-induced expression of the SLC1A5 variant was shown to be mediated by HIF-2α and to lead to metabolic reprogramming toward glutamine metabolism in pancreatic cancer cells16.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“Intriguingly, this study regarding elevated glutamine metabolism in cancer cells also showed that glutaminolysis could in turn reinforce metabolic reprogramming, thus implying that glutamine metabolism plays a crucial role in tumorigenesis and tumor progression16”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“Additionally, the level of the mitochondrial glutamine transporter controls the cellular ATP level stimulated by glutamine, suggesting that glutamine is an important energy source via mitochondrial glutaminolysis16.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“in addition, the expression of the SLC1A5 variant affected the levels of metabolites derived from glucose metabolism, including lactate and ribulose-5-phosphate, the intermediate metabolites in the PPP16.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“Recently, glutamine was shown to be a major fuel for mitochondrial oxygen consumption in pancreatic cancer cells”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“Thus, as the SLC1A5 variant is the only currently known glutamine transporter in the mitochondrial inner membrane16”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“Given the clinicopathological significance of SLC1A5201 and the observation that the level of the SLC1A5 variant is negatively correlated with prognosis in several cancer types16”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“Conversely, suppression of the SLC1A5 variant, a mitochondrial glutamine transporter, is sufficient to inhibit tumor growth by impairing glutamine metabolism in pancreatic cancer cells16.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [16]
In the citing paper
“HIF‐2α‐induced expression of the glutamine transporter solute carrier family 1, member 5 (SLC1A5) mediates glutamine‐induced ATP production and glutathione synthesis and renders pancreatic cancer resistant to gemcitabine.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [56]
Citations
Cites
Improved vectors and genome-wide libraries for CRISPR screening
Sanjana, N. E., Shalem, O., & Zhang, F. (2014) · Nature Methods · doi:10.1038/nmeth.3047 · Cited by 5,239
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088
Intracellular Functions of N-Linked Glycans
Helenius, A., & Aebi, A. M. (2001) · Science · doi:10.1126/science.291.5512.2364 · Cited by 2,405
From Krebs to clinic: glutamine metabolism to cancer therapy
Altman, B. J., Stine, Z. E., & Dang, C. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.71 · Cited by 2,119
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., Perera, R. M., Ferrone, C. R., Mullarky, E., Shyh-Chang, N., et al. (2013) · Nature · doi:10.1038/nature12040 · Cited by 1,990
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., Yang, H., Hild, M., Kung, C., Wilson, C., et al. (2009) · Cell · doi:10.1016/j.cell.2008.11.044 · Cited by 1,798
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell, C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. (2012) · Nature · doi:10.1038/nature10602 · Cited by 1,791
Glutamine addiction: a new therapeutic target in cancer
Wise, D. R., & Thompson, C. B. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.003 · Cited by 1,770
Semenza, G. L., Jiang, B.-H., Leung, S. W., Passantino, R., Concordet, J.-P., Maire, P., & Giallongo, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32529 · Cited by 1,752
Importing Mitochondrial Proteins: Machineries and Mechanisms
Chacińska, A., Koehler, C. M., Milenkovic, D., Lithgow, T. J., & Pfanner, N. (2009) · Cell · doi:10.1016/j.cell.2009.08.005 · Cited by 1,528
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 447
A prismatic view of the epigenetic-metabolic regulatory axis in breast cancer therapy resistance
Das, C., Bhattacharya, A., Adhikari, S., Mondal, A., Mondal, P., Adhikary, S., Roy, S., Ramos, K. S., Yadav, K. K., Tainer, J. A., et al. (2024) · Oncogene · doi:10.1038/s41388-024-03054-9 · Cited by 39
Glutaminase inhibition as potential cancer therapeutics: current status and future applications
Cyriac, R., & Lee, K. (2023) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2023.2290911 · Cited by 38
Amino Acid Transporters on the Guard of Cell Genome and Epigenome
Kahya, U., Köseer, A. S., & Dubrovska, A. (2021) · Cancers · doi:10.3390/cancers13010125 · Cited by 37
ASCT1 and ASCT2: Brother and Sister?
Scalise, M., Console, L., Cosco, J., Pochini, L., Galluccio, M., & Indiveri, C. (2021) · SLAS DISCOVERY · doi:10.1177/24725552211030288 · Cited by 40
Pan, Y., Han, M., Zhang, X., He, Y., Yuan, C., Xiong, Y., Li, X., Zeng, C., Lu, K., Zhu, H., et al. (2022) · Cellular Oncology · doi:10.1007/s13402-022-00659-8 · Cited by 37
The interplay of miRNAs and ferroptosis in diseases related to iron overload
Jin, S., Liu, P.-S., Zheng, D., & Xie, X. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01890-w · Cited by 37
Regulation of tumor metabolism by post translational modifications on metabolic enzymes
Dessai, A. S., Kalhotra, P., Novickis, A. T., & Dasgupta, S. (2022) · Cancer Gene Therapy · doi:10.1038/s41417-022-00521-x · Cited by 38
Bouthelier, A., & Aragonés, J. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118733 · Cited by 37
Beyond mitochondria: Alternative energy-producing pathways from all strata of life
Auger, C., Vinaik, R., Appanna, V. D., & Jeschke, M. G. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154733 · Cited by 36
Chang, Z., Fu, Y., Jia, Y., Gao, M., Song, L., Zhang, W., Zhao, R., & Qin, Y. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02156-8 · Cited by 36
Lv, Z., Wang, J., Wang, X., Mo, M., Tang, G., Xu, H., Wang, J., Li, Y., & Liu, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.666025 · Cited by 35
Metabolic stress induces GD2+ cancer stem cell-like phenotype in triple-negative breast cancer
Jaggupilli, A., Ly, S., Nguyen, K., Anand, V., Yuan, B., El-Dana, F., Yan, Y., Arvanitis, Z., Piyarathna, D. W. B., Putluri, N., et al. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01636-y · Cited by 35
Metabolomic biomarkers in liquid biopsy: accurate cancer diagnosis and prognosis monitoring
Wang, W., Zhen, S., Yu, P., Wang, L., & Zhang, Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1331215 · Cited by 35
Zhang, T., Lv, Q., & Jin, W. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189137 · Cited by 36
Active mitochondrial respiration in cancer: a target for the drug
Bedi, M., Ray, M., & Ghosh, A. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04281-4 · Cited by 34
Comprehensive review of amino acid transporters as therapeutic targets
Xia, R., Peng, H.-F., Zhang, X., & Zhang, H. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129646 · Cited by 34
The regulation of cell metabolism by hypoxia and hypercapnia
Reddan, B., & Cummins, E. P. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108252 · Cited by 34
Targeting Pulmonary Fibrosis by SLC1A5-Dependent Glutamine Transport Blockade
Choudhury, M., Schaefbauer, K. J., Kottom, T. J., Yi, E. S., Tschumperlin, D. J., & LIMPER, A. H. (2023) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2022-0339oc · Cited by 33
Hallmarks of aging: A user’s guide for comparative biologists
Biga, P. R., Duan, J. E., Young, T. E., Marks, J. R., Bronikowski, A. M., Decena-Segarra, L. P., Randolph, E. C., Pavuluri, A., Li, G., Fang, Y., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102616 · Cited by 33
Bush, S. J., McCulloch, M. E. B., Lisowski, Z. M., Muriuki, C., Clark, E. L., Young, R. A., Pridans, C., Prendergast, J. G. D., SUMMERS, K. M., & Hume, D. A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00661 · Cited by 34
Chisari, A. N., Golán, I., Campisano, S., Gélabert, C., Moustakas, A., Sancho, P., & Caja, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.723798 · Cited by 33
Liu, Y., Cao, L., Song, Y., Kang, Z., Liu, T., Ding, J., Hu, G., & Lu, M. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05399-z · Cited by 32
Smorodina, E., Diankin, I. D., Tao, F., Qing, R., Yang, S., & Zhang, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-23764-y · Cited by 32
The therapeutic effects of berberine for gastrointestinal cancers
Davoodvandi, A., Sadeghi, S., Alavi, S. M. A., Alavi, S. S., Jafari, A., Khan, H. Z., Aschner, M., Mirzaei, H., Sharifi, M., & Asemi, Z. (2023) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.13941 · Cited by 33
Park, Y., & Jeong, E. M. (2024) · International Journal of Stem Cells · doi:10.15283/ijsc24060 · Cited by 31
Ferroptosis: iron release mechanisms in the bioenergetic process
Lee, J., & Roh, J. (2025) · Cancer and Metastasis Reviews · doi:10.1007/s10555-025-10252-8 · Cited by 34
Self-citationAn, L., & Li, Z. (2025) · Biomarker Research · doi:10.1186/s40364-025-00844-5 · Cited by 32
The Ubiquitin–Proteasome System in Tumor Metabolism
Wang, J., Xiang, Y., Fan, M., Fang, S., & Hua, Q. (2023) · Cancers · doi:10.3390/cancers15082385 · Cited by 32
Senolytics: charting a new course or enhancing existing anti-tumor therapies?
Czajkowski, K., Herbet, M., Murias, M., & Piątkowska‐Chmiel, I. (2024) · Cellular Oncology · doi:10.1007/s13402-024-01018-5 · Cited by 35
Total Cellular ATP Production Changes With Primary Substrate in MCF7 Breast Cancer Cells
Louie, M. C., Ton, J., Brady, M. L., Le, D. T., Mar, J. N., Lerner, C. A., Gerencser, A. A., & Mookerjee, S. A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01703 · Cited by 30
Zhang, Z., Bao, C., Jiang, L., Wang, S., Wang, K., Lu, C., & Fang, H. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1054233 · Cited by 30
Tian, Y., Gao, Q., Han, Y., Liu, D., Dong, S., Zhou, Y., Yang, W., Xue, N., Bao, H., & Yu, Y. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.124 · Cited by 29
Zhao, J., Yang, Z., Tu, M., Meng, W., Gao, H., Li, M. D., & Li, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.608641 · Cited by 29
Marsico, M., Santarsiero, A., Pappalardo, I., Convertini, P., Chiummiento, L., Sardone, A., Noia, M. A. D., Infantino, V., & Todisco, S. (2021) · Biomedicines · doi:10.3390/biomedicines9111664 · Cited by 30
Yang, S., Tan, H.-X., Lai, Z., Peng, H., Yang, H., Fu, Q., Wang, H., Li, D., & Li, M. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04639-x · Cited by 33
Hayasaka, R., Tabata, S., Hasebe, M., Ikeda, S., Ohnuma, S., Mori, M., Soga, T., Tomita, M., & Hirayama, A. (2021) · Metabolites · doi:10.3390/metabo11040215 · Cited by 28
Cui, S., Chen, T., Wang, M., Chen, Y., Zheng, Q., Feng, X., Li, S., & Wang, J. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.153958 · Cited by 28
Chen, F., Ni, C., Wang, X.-X., Cheng, R., Pan, C., Wang, Y., Liang, J., Zhang, J., Cheng, J., Chin, Y. E., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202114904 · Cited by 28
Peng, S., Wang, R., Zhou, Y., Wei, W., Zhong, G., Huang, X.-T., Yang, S., Liu, Q., & Liu, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.872910 · Cited by 27
Shi, X., Zhang, Y., Wang, Y., Wang, J., Gao, Y., Wang, R., Wang, L., Xiong, M., Cao, Y., Ou, N., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01323-4 · Cited by 27
Loss of SDHB Induces a Metabolic Switch in the hPheo1 Cell Line toward Enhanced OXPHOS
Tabebi, M., Dutta, R. K., Skoglund, C., Söderkvist, P., & Gimm, O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010560 · Cited by 27
Dysregulation of Astrocytic Glutamine Transport in Acute Hyperammonemic Brain Edema
Zielińska, M., Albrecht, J., & Popek, M. P. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.874750 · Cited by 26
TRIM6 Reduces Ferroptosis and Chemosensitivity by Targeting SLC1A5 in Lung Cancer
Zhang, Y., Dong, P., Liu, N., Yang, J., Wang, H., & Geng, Q. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/9808100 · Cited by 26
Tumor-intrinsic metabolic reprogramming and how it drives resistance to anti-PD-1/PD-L1 treatment
Laubach, K., Turan, T., Mathew, R. S., Wilsbacher, J. L., Engelhardt, J., & Samayoa, J. A. (2023) · Cancer Drug Resistance · doi:10.20517/cdr.2023.60 · Cited by 27
Current advances in modulating tumor hypoxia for enhanced therapeutic efficacy
Liu, Z., Liu, X., Zhang, W., Gao, R., Wei, H., & Yu, C. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.01.010 · Cited by 26
Yue, B., Gao, Y., Hu, Y., Zhan, M., Wu, Y., & Lu, L. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1731 · Cited by 26
Metabolomics and cellular altered pathways in cancer biology: A review
Bhardwaj, J. K., Siwach, A., & Sachdeva, S. N. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23807 · Cited by 27
Metabolic reprogramming in cancer and senescence
Zhang, Y., Tang, J., Jiang, C., Yi, H., Shu, G., Yin, G., & Wang, M. (2025) · MedComm · doi:10.1002/mco2.70055 · Cited by 25
Comprehensive metabolomic profiling of osteosarcoma based on UHPLC-HRMS
Lv, D., Zou, Y., Zeng, Z., Yao, H., Ding, S., Bian, Y., Wen, L., & Xie, X. (2020) · Metabolomics · doi:10.1007/s11306-020-01745-4 · Cited by 25
Roh, J., Im, M., Chae, Y., Kang, J., & Kim, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314808 · Cited by 25
Self-citationHwang, Y., Yun, H. J., Jeong, J. W., Kim, M., Joo, S., Lee, H., Chang, H., Kim, S., & Fang, S. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06041-2 · Cited by 25
Self-citationYan, R., Cai, H., Zhou, X., Bao, G., Bai, Z., & Ge, R. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1344971 · Cited by 28
Ahmed, A., Iaconisi, G. N., Molfetta, D. D., Coppola, V., Caponio, A., Singh, A., Bibi, A., Capobianco, L., Palmieri, L., Dolce, V., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010092 · Cited by 24
Metabolic plasticity in pancreatic cancer: The mitochondrial connection
Noemi, G., Abbo, D., Anastasia, B., Costamagna, A., Porporato, P. E., & Martini, M. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102089 · Cited by 24
A Systematic Role of Metabolomics, Metabolic Pathways, and Chemical Metabolism in Lung Cancer
Kannampuzha, S., Mukherjee, A. G., Wanjari, U. R., Gopalakrishnan, A. V., Murali, R., Namachivayam, A., Renu, K., Dey, A., Vellingiri, B., Madhyastha, H., et al. (2023) · Vaccines · doi:10.3390/vaccines11020381 · Cited by 24
Insights on Metabolic Reprogramming and Its Therapeutic Potential in Acute Leukemia
Martino, L. D., Tosello, V., Peroni, E., & Piovan, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168738 · Cited by 25
Islam, M. M., Goertzen, A., Singh, P. K., & Saha, R. (2022) · iScience · doi:10.1016/j.isci.2022.104483 · Cited by 24
Beier, A.-M. K., Ebersbach, C., Siciliano, T., Scholze, J., Hofmann, J., Hönscheid, P., Baretton, G. B., Woods, K., Guezguez, B., Dubrovska, A., et al. (2024) · Oncogene · doi:10.1038/s41388-024-03059-4 · Cited by 23
Glutamine Metabolism and Prostate Cancer
Erb, H. H. H., Polishchuk, N., Stasyk, O. V., Kahya, U., Weigel, M. M., & Dubrovska, A. (2024) · Cancers · doi:10.3390/cancers16162871 · Cited by 23
Ye, X., Wei, X., Liao, J., Chen, P., Li, X., Chen, Y., Yang, Y., Zhao, Q., Sun, H., Pan, L., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.617190 · Cited by 24
Lactate metabolism and lactylation in cancer: from pathogenesis to therapeutic advances
Fang, C., Zhou, S., Yu, K., Zhang, L., Lian, W., Tie, X., Chen, S., Dai, J., Li, Q. H., & Wang, X. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02672-x · Cited by 28
Polat, I. H., Tarrado‐Castellarnau, M., Benito, A., Hernández-Carro, C., Centelles, J. J., Marín, S., & Cascante, M. (2021) · Antioxidants · doi:10.3390/antiox10091349 · Cited by 26
Tumor-suppressive function of EZH2 is through inhibiting glutaminase
Liu, Y., Tu, C., Guo, X., Wu, C., Gu, C.-C., Lai, Q., Fang, Y., Huang, J., Wang, Z., Li, A., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04212-7 · Cited by 22
Wang, X., Xiao-xia, Y., Peng-Fei, S., Zong-Xue, Z., & Xiu-li, G. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175323 · Cited by 23
Cimmino, T. P., Pagano, E., Stornaiuolo, M., Esposito, G., Ammendola, R., & Cattaneo, F. (2022) · Antioxidants · doi:10.3390/antiox11091692 · Cited by 23
Rothman, D. L., Behar, K. L., & Dienel, G. A. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15619 · Cited by 21
Metabolic Rewiring and Stemness: A Critical Attribute of Pancreatic Cancer Progression
Ogunleye, A. O., Nimmakayala, R. K., Batra, S. K., & Ponnusamy, M. P. (2023) · Stem Cells · doi:10.1093/stmcls/sxad017 · Cited by 21
lncRNA SYTL5-OT4 promotes vessel co-option by inhibiting the autophagic degradation of ASCT2
Wen, Q., Huang, M., Xie, J., Liu, R., Miao, Q., Huang, J., Zhang, J., Lyu, W.-Y., Qi, M., Wu, C., et al. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.100975 · Cited by 21
Lee, S.-A., Cho, G.-J., Kim, D., & Kim, D. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1335636 · Cited by 23
A Review of Advances in Mitochondrial Research in Cancer
Li, Z., Zhang, W., Guo, S., Qi, G., Huang, J., Gao, J., Zhao, J., Kang, L., & Li, Q. (2024) · Cancer Control · doi:10.1177/10732748241299072 · Cited by 22
Enhanced protein quality and antioxidant activity of fermented Brown rice with Gryllus bimaculatus
Seong, H.-Y., & Kim, M. (2021) · LWT · doi:10.1016/j.lwt.2021.111948 · Cited by 21
Metabolic regulation of mRNA splicing
Cui, H., Shi, Q., Macarios, C. M., & SCHIMMEL, P. R. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.02.002 · Cited by 22
GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels
Soro-Arnáiz, I., Fitzgerald, G., Cherkaoui, S., Zhang, J., Gilardoni, P. A., Ghosh, A., Bar‐Nur, O., Masschelein, E., Maechler, P., Zamboni, N., et al. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.07.015 · Cited by 20
Targeting mitochondrial dysfunctions in pancreatic cancer evokes new therapeutic opportunities
Sarwar, A., Zhu, M., Su, Q., Zhu, Z., Yang, T., Chen, Y., Peng, X., & Zhang, Y. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103858 · Cited by 20
Du, D., Qin, M., Shi, L., Liu, C., Jiang, J., Liao, Z., Wang, H., Zhang, Z., Sun, L., Fan, H., et al. (2023) · Oncogene · doi:10.1038/s41388-023-02795-3 · Cited by 20
Glutamine metabolism in tumor metastasis: Genes, mechanisms and the therapeutic targets
Zhong, X., He, Z., Li, Y., Fan, Y., Yu, T., Kang, Y., & Bi, Q. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20656 · Cited by 20
Unravelling the Triad of Lung Cancer, Drug Resistance, and Metabolic Pathways
Mohanty, P., Pande, B., Acharya, R. K., Bhaskar, L. V., & Verma, H. K. (2024) · Diseases · doi:10.3390/diseases12050093 · Cited by 20
Targeting glutamine metabolism crosstalk with tumor immune response
Dong, C., Zhao, Y., Han, Y., Li, M., & Wang, G. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189257 · Cited by 21
Cellular senescence: from homeostasis to pathological implications and therapeutic strategies
Li, C., Yuan, Y., Jia, Y., Zhou, Q., Wang, Q., & Jiang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1534263 · Cited by 21
The solute carrier superfamily interactome
Frommelt, F., Ladurner, R., Goldmann, U., Wolf, G., Inglés‐Prieto, Á., Liñeiro, E., Gelová, Z., Hopp, A.-K., Christodoulaki, E., Teoh, S. T., et al. (2025) · Molecular Systems Biology · doi:10.1038/s44320-025-00109-1 · Cited by 22
Research Progress of Sirtuin4 in Cancer
Bai, Y., Yang, J., Cui, Y., Yao, Y., Wu, F., Liu, C., Fan, X., & Zhang, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.562950 · Cited by 20
Glutamine Skipping the Q into Mitochondria
Stine, Z. E., & Dang, C. V. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.11.004 · Cited by 19
Lactylation in cancer: molecular mechanisms and advances in clinical study
Li, J., Miao, C., Guo, H., Lin, M., Chen, R., Peng, J., Wang, J., Tang, C., & Chen, Z. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02573-1 · Cited by 21
Identification of Metabolic-Associated Genes for the Prediction of Colon and Rectal Adenocarcinoma
Cui, Y., Han, B., Zhang, H., Liu, H., Zhang, F., & Niu, R. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s297134 · Cited by 19
Unlocking the potential of the tumor microenvironment for cancer therapy
Tufail, M. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154846 · Cited by 20
Speck, S. L., Bhatt, D. P., Zhang, Q., Adak, S., Li, Y., Dong, G., Chu, F., Zhang, W., Major, M. B., Wei, X., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113389 · Cited by 20
Yang, Y., Zhang, B., Xu, Y., Zhu, W., Zhu, Z., Zhang, X., Wu, W., Chen, J., & Yu, Z. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.08.028 · Cited by 18
Amino acids metabolism: a potential target for cancer treatment
Ren, S., Zhou, X., Wang, Z., & Yuan, K. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02523-3 · Cited by 19
Lauria, G., Curcio, R., Lunetti, P., Tiziani, S., Coppola, V., Dolce, V., Fiermonte, G., & Ahmed, A. (2023) · Cancers · doi:10.3390/cancers15020411 · Cited by 18
Ma, Z., Ye, W., Wang, J., Huang, X., Huang, J., Li, X., Hu, C., Li, C., Zhou, Y., Lin, X., et al. (2023) · British Journal of Haematology · doi:10.1111/bjh.18884 · Cited by 18
The Roles of White Adipose Tissue and Liver NADPH in Dietary Restriction-Induced Longevity
Jamerson, L. E., & Bradshaw, P. C. (2024) · Antioxidants · doi:10.3390/antiox13070820 · Cited by 22
A Metabolic Gene Signature to Predict Overall Survival in Head and Neck Squamous Cell Carcinoma
Wu, Z., Tang, Y., & Zhou, Y. (2020) · Mediators of Inflammation · doi:10.1155/2020/6716908 · Cited by 18
Comprehensive molecular and clinical characterization of SLC1A5 in human cancers
Zhang, H., Cui, K., Yao, S., Yin, Y., Liu, D., & Huang, Z. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153525 · Cited by 18
Afonso, J., Barbosa-Matos, C., Silvestre, R., Pereira-Vieira, J., Gonçalves, S. M., Mendes-Alves, C., Parpot, P., Pinto, J., Carapito, Â., de Pinho, P. G., et al. (2024) · Cancers · doi:10.3390/cancers16071418 · Cited by 17
Sung, Y., Kim, D. K., Kim, J. S., Kim, S.-J., Kim, J. H., & Han, J. M. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01697-0 · Cited by 18
Self-citationLi, J., Duan, W., Wang, L., Lu, Y., Shi, Z., & Lu, T. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.0c00247 · Cited by 17
Yuan, M., Zhang, J., He, Y., Yi, G., Rong, L., Zheng, L., Zhan, T., & Zhou, C. (2022) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-022-06481-9 · Cited by 17
The role of amino acid metabolism alterations in pancreatic cancer: From mechanism to application
Fu, S., Xu, S., & Zhang, S. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188893 · Cited by 18
Glutamine addiction and therapeutic strategies in pancreatic cancer
Ren, L., Mao, T., Meng, P., Zhang, L., Wei, H., & Tian, Z. (2023) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v15.i11.1852 · Cited by 16
Wei, Y., Geng, S., Si, Y., Yang, Y., Chen, Q., Huang, S., Chen, X., Xu, W., Liu, Y., & Jiang, J. (2023) · Advanced Science · doi:10.1002/advs.202306715 · Cited by 16
Metadata
- Authors
- Yoo, H. C., Park, S. J., Nam, M., Kang, J., Kim, K., Yeo, J. H., Kim, J.-K., Heo, Y., Lee, H. S., Lee, M. Y., Lee, C. W., Kang, J. S., Kim, Y.-H., Lee, J., Choi, J., Hwang, G.-S., Bang, S., & Han, J. M.
- Affiliations
- Yonsei University (KR)
- Korea Basic Science Institute (KR)
- National Cancer Center (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Corresponding author
- Han, Jung Min
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 31
- Issue
- 2
- Pages
- 267-283.e12
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2995576736
- Cited by
- 449
- References
- 54
- Citations by year
- 2026: 65 · 2025: 78 · 2024: 87 · 2023: 67 · 2022: 67 · 2021: 55 · 2020: 29
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- KRIBB Repository (submittedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Research Foundation of Korea
- Korea Basic Science Institute
- Ministry of Education (2018R1A6A1A03023718)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- glutamine transport, tumor metabolic reprogramming, mitochondrial targeting signal, HIF-2α, hypoxia, glutathione synthesis, ATP production, gemcitabine resistance, pancreatic cancer, tumor growth
- MeSH terms
- Tumor Hypoxia, Endothelial PAS Domain-Containing Protein 1, Animals, Female, Glutamine, Humans, Mice, Inbred BALB C, Mitochondria, Neoplasms, Minor Histocompatibility Antigens, Amino Acid Transport System ASC, Cell Line, Tumor, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Cellular Reprogramming
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
