Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth

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SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

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Oncogenic K‐Ras decouples glucose and glutamine metabolism to support cancer cell growth

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Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

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Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

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Targeting <scp>ASCT2</scp>‐mediated glutamine uptake blocks prostate cancer growth and tumour development

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Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19

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Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells

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Recent Molecular Advances in Mammalian Glutamine Transport

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ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

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The SLC38 family of sodium–amino acid co-transporters

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LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation

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A Tale of Two Glutaminases: Homologous Enzymes with Distinct Roles in Tumorigenesis

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Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport during Prostate Cancer Progression

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Targeting SLC1a5 ‐mediated glutamine dependence in non‐small cell lung cancer

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Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts

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Transporters in Drug Development and Clinical Pharmacology

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LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter

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A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus

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Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer

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Up-Regulation of LAT1 during Antiandrogen Therapy Contributes to Progression in Prostate Cancer Cells

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ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma

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Clinical Role of ASCT2 (SLC1A5) in KRAS-Mutated Colorectal Cancer

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Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism

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Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment

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Glutamine transport. From energy supply to sensing and beyond

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The MYC mRNA 3′‐UTR couples RNA polymerase II function to glutamine and ribonucleotide levels

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Proteoliposomes as Tool for Assaying Membrane Transporter Functions and Interactions with Xenobiotics

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Large scale production of the active human ASCT2 (SLC1A5) transporter in Pichia pastoris — functional and kinetic asymmetry revealed in proteoliposomes

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Prognostic significance of L-type amino acid transporter 1 (LAT1) expression in cutaneous melanoma

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A novel glutaminase isoform in mammalian tissues

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Pseudohypoxia induced by miR-126 deactivation promotes migration and therapeutic resistance in renal cell carcinoma

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LAT1 is a putative therapeutic target in endometrioid endometrial carcinoma

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Effects of targeting SLC1A5 on inhibiting gastric cancer growth and tumor development in vitro and in vivo

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Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts

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Purinergic receptors are a key bottleneck in tumor metabolic reprogramming: The prime suspect in cancer therapeutic resistance

Aria, H., Rezaei, M., Nazem, S., Daraei, A., Nikfar, G., Mansoori, B., Bahmanyar, M., Tavassoli, A., Vakil, M. K., & Mansoori, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.947885 · Cited by 26 · see citing works

The anti-proliferative effect of β-carotene against a triple-negative breast cancer cell line is cancer cell-specific and JNK-dependent

Antunes, A. P. D. O. L., Carmo, F., Pinto, S., Andrade, N., & Martel, F. (2022) · PharmaNutrition · doi:10.1016/j.phanu.2022.100320 · Cited by 27 · see citing works

Activation of TCA cycle restrains virus-metabolic hijacking and viral replication in mouse hepatitis virus-infected cells

Lee, S. R., ROH, J., Ryu, J., Shin, H., & Hong, E. (2022) · Cell & Bioscience · doi:10.1186/s13578-021-00740-z · Cited by 26 · see citing works

The Role of Metabolic Plasticity in Blood and Brain Stem Cell Pathophysiology

Libby, C. J., McConathy, J., Darley-Usmar, V. M., & Hjelmeland, A. B. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1169 · Cited by 25 · see citing works

Insights into the Transport Cycle of LAT1 and Interaction with the Inhibitor JPH203

Brunocilla, C., Console, L., Rovella, F., & Indiveri, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044042 · Cited by 24 · see citing works

Metabolic Changes in Polycystic Kidney Disease as a Potential Target for Systemic Treatment

Haumann, S., Müller, R., & Liebau, M. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176093 · Cited by 23 · see citing works

Tumor metabolism rewiring in epithelial ovarian cancer

Wang, M., Zhang, J., & Wu, Y. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-023-01196-0 · Cited by 23 · see citing works

Homology Modeling Informs Ligand Discovery for the Glutamine Transporter ASCT2

Garibsingh, R. A., Otte, N. J., Ndaru, E., Colas, C., Grewer, C. T., Holst, J., & Schlessinger, A. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00279 · Cited by 23 · see citing works

Metabolic reprogramming of glutamine involved in tumorigenesis, multidrug resistance and tumor immunity

Wang, X., Xiao-xia, Y., Peng-Fei, S., Zong-Xue, Z., & Xiu-li, G. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175323 · Cited by 23 · see citing works

Amino acid metabolic reprogramming in the tumor microenvironment and its implication for cancer therapy

Zhang, J., Chen, M., Yang, Y., Liu, Z., Guo, W., Xiang, P., Zeng, Z., Wang, D., & Xiong, W. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31349 · Cited by 23 · see citing works

Interaction of Cholesterol With the Human SLC1A5 (ASCT2): Insights Into Structure/Function Relationships

Scalise, M., Pochini, L., Cosco, J., Aloe, E., Mazza, T., Console, L., Esposito, A., & Indiveri, C. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00110 · Cited by 22 · see citing works

Alternative Energy: Breaking Down the Diverse Metabolic Features of Lung Cancers

Cargill, K. R., Hasken, W. L., Gay, C. M., & Byers, L. A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.757323 · Cited by 21 · see citing works

Mechanistic stoichiometric relationship between the rates of neurotransmission and neuronal glucose oxidation: Reevaluation of and alternatives to the pseudo‐malate‐aspartate shuttle model

Rothman, D. L., Behar, K. L., & Dienel, G. A. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15619 · Cited by 21 · see citing works

Enhancing the Efficacy of Tumor Vaccines Based on Immune Evasion Mechanisms

Chen, J., Zhang, H., Zhou, L., Hu, Y., Li, M., He, Y., & Li, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.584367 · Cited by 19 · see citing works

Inhibition of Metabolic Shift can Decrease Therapy Resistance in Human High-Grade Glioma Cells

Petővári, G., Dankó, T., Krencz, I., Hujber, Z., Rajnai, H., Vetlényi, E., Raffay, R. E., Pápay, J., Jeney, A., & Sebestyén, A. R. (2019) · Pathology & Oncology Research · doi:10.1007/s12253-019-00677-2 · Cited by 19 · see citing works

A structural view onto disease-linked mutations in the human neutral amino acid exchanger ASCT1

Stehantsev, P., Stetsenko, A., Nemchinova, M., Aduri, N. G., Marrink, S., Gati, C., & Guskov, A. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.09.015 · Cited by 18 · see citing works

Role of Mitochondrial Transporters on Metabolic Rewiring of Pancreatic Adenocarcinoma: A Comprehensive Review

Lauria, G., Curcio, R., Lunetti, P., Tiziani, S., Coppola, V., Dolce, V., Fiermonte, G., & Ahmed, A. (2023) · Cancers · doi:10.3390/cancers15020411 · Cited by 18 · see citing works

Glutamine metabolism controls amphiregulin-facilitated chemoresistance to cisplatin in human chondrosarcoma

Wu, Y., Law, Y., Huang, Y.-W., Tran, N. B., Lin, C., Lai, C.-Y., Huang, Y., Tsai, C., Ko, C.-Y., Chou, M., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.86116 · Cited by 18 · see citing works

Programmable Nanomodulators for Precision Therapy, Engineering Tumor Metabolism to Enhance Therapeutic Efficacy

Liu, S., Liu, Z., Lei, H., Miao, Y., & Chen, J. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202403019 · Cited by 17 · see citing works

Kruppel-like factor 2 disturb non-small cell lung cancer energy metabolism by inhibited glutamine consumption

Song, X., Jin-xiang, Y., Long, T., Lu, X., Hong, G., Jie‐Cheng, Y., & Fei, Z. (2020) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13252 · Cited by 15 · see citing works

A multifaceted review of monosodium glutamate effects on human health and its natural remedies

Yang, L., Gao, Y., Gong, J., Peng, L., El-Seedi, H. R., Farag, M. A., Zhao, Y., & Xiao, J. (2023) · Food Materials Research · doi:10.48130/fmr-2023-0016 · Cited by 15 · see citing works

Genotoxicity of Monosodium Glutamate: A Review on its Causes, Consequences and Prevention

Rabbani, S. I. (2019) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.53.4s.145 · Cited by 15 · see citing works

Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling

Gaglio, D., Bonanomi, M., Valtorta, S., Bharat, R., Ripamonti, M., Conte, F., Fiscon, G., Righi, N., Napodano, E., Papa, F., et al. (2020) · Cancer & Metabolism · doi:10.1186/s40170-020-00227-4 · Cited by 15 · see citing works

The involvement of sodium in the function of the human amino acid transporter ASCT2

Mazza, T., Scalise, M., Pappacoda, G., Pochini, L., & Indiveri, C. (2021) · FEBS Letters · doi:10.1002/1873-3468.14224 · Cited by 15 · see citing works

SLC38A6, regulated by EP300-mediated modifications of H3K27ac, promotes cell proliferation, glutamine metabolism and mitochondrial respiration in hepatocellular carcinoma

Huang, L., Li, L., Cheng, B., & Xing, T. (2022) · Carcinogenesis · doi:10.1093/carcin/bgac061 · Cited by 15 · see citing works

PRC2 mediated KLF2 down regulation: a therapeutic and diagnostic axis during tumor progression

Taghehchian, N., Maharati, A., Akhlaghipour, I., Zangouei, A. S., & Moghbeli, M. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03086-3 · Cited by 15 · see citing works

Exploiting Cysteine Residues of SLC Membrane Transporters as Targets for Drugs

Scalise, M., Console, L., Galluccio, M., Pochini, L., Tonazzi, A., Giangregorio, N., & Indiveri, C. (2019) · SLAS DISCOVERY · doi:10.1177/2472555219856601 · Cited by 15 · see citing works

Mitochondrial uncoupling and the disruption of the metabolic network in hepatocellular carcinoma

Turcios, L. M., Martí, F., Watt, D. S., Kril, L. M., Khurana, A., Chapelin, F., Liu, C., Zwischenberger, J. B., Evers, B. M., & Gedaly, R. (2020) · Oncotarget · doi:10.18632/oncotarget.27680 · Cited by 15 · see citing works

Glutamine Transport and Metabolism in Cancer

Bode, B. P. (2017) · CRC Press eBooks · doi:10.1201/9781315373164-19 · Cited by 1 · see citing works

Q-ing tumor glutaminase therapy

Stine, Z. E., & Dang, C. V. (2015) · Oncotarget · doi:10.18632/oncotarget.6301 · Cited by 4 · see citing works

Abstract 5161: Role of glutamine in cancer growth, invasion and progression: Therapeutic modulation of glutamine pathway

Yang, L., & Nagrath, D. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-5161

Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis

Sharma, S., Agnihotri, N., & Kumar, S. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114943 · Cited by 42 · see citing works

Abstract 1166: ASCT2: A novel metabolic target for cancer therapy

Pore, N., King, W., Lekstrom, K. J., Wilson, S. A., Hollingsworth, R. E., Tice, D. A., & Michelotti, E. F. (2015) · Cancer Research · doi:10.1158/1538-7445.am2015-1166