The DOI matches its Crossref record; 183 of the 183 references it cites were found in a registry or an index.
Tryptophan metabolism in health and disease
Open accessAbstract
Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, immune responses, and neurological function. Emerging evidence supports an intimate relationship between Trp metabolism disorder and diseases. The levels or ratios of Trp metabolites are significantly associated with many clinical features. Additionally, studies have shown that disease progression can be controlled by modulating Trp metabolism. Indoleamine-2,3-dioxygenase, Trp-2,3-dioxygenase, kynurenine-3-monooxygenase, and Trp hydroxylase are the rate-limiting enzymes that are critical for Trp metabolism. These key regulatory enzymes can be targeted for treating several diseases, including tumors. These findings provide novel insights into the treatment of diseases. In this review, we have summarized the recent research progress on the role of Trp metabolites in health and disease along with their clinical applications.
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Cites
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From Microbial Switches to Metabolic Sensors: Rewiring the Gut–Brain Kynurenine Circuit
Tanaka, M., & Vécsei, L. (2025) · doi:10.20944/preprints202506.0880.v1 · Cited by 24
Aberrant Tryptophan Metabolism Manipulates Osteochondral Homeostasis
Xiang, T., Yang, C., Xie, L., Xiao, S., Tang, Y., Huang, G., Sun, D., Chen, Y., & Luo, F. (2025) · Research · doi:10.34133/research.0728 · Cited by 17
Wang, N., Zhu, S., Chen, S., Zou, J., Zeng, P., & Tan, S. (2025) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0147 · Cited by 12
Chehadi, A. C., Pereira de Lima, E., Detregiachi, C. R. P., Santos de Argollo Haber, R., Catharin, V. M. C. S., Fornari Laurindo, L., Engracia Valenti, V., Machado Galhardi, C., Tanaka, M., & Maria Barbalho, S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27010465 · Cited by 8
Metadata
- Authors
- Xue, C., Li, G., Zheng, Q., Gu, X., Shi, Q., Su, Y., Chu, Q., Yuan, X., Bao, Z., Lu, J., & Li, L.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2023-08
- Volume
- 35
- Issue
- 8
- Pages
- 1304-1326
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W4381620517
- Cited by
- 961
- References
- 183
- FWCI
- 60.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Xue, C., Li, G., Zheng, Q., Gu, X., Shi, Q., Su, Y., Chu, Q., Yuan, X., Bao, Z., Lu, J., & Li, L. (2023). Tryptophan metabolism in health and disease. Cell Metabolism. https://doi.org/10.1016/j.cmet.2023.06.004
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