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Cited by 139Liver Disease Diagnosis and TreatmentLiver physiology and pathologyLiver Diseases and Immunity

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The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease

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Sawada, Keisuke, Chung, Hak, Softic, Samir, Moreno-Fernandez, Maria E., Divanovic, Senad·2023·Cell Metabolism
DOI 10.1016/j.cmet.2023.10.009PMC PMC10680147
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Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an unabated risk factor for end-stage liver diseases with no available therapies. Dysregulated immune responses are critical culprits of MASLD pathogenesis. Independent contributions from either the innate or adaptive arms of the immune system or their unidirectional interplay are commonly studied in MASLD. However, the bidirectional communication between innate and adaptive immune systems and its impact on MASLD remain insufficiently understood. Given that both innate and adaptive immune cells are indispensable for the development and progression of inflammation in MASLD, elucidating pathogenic contributions stemming from the bidirectional interplay between these two arms holds potential for development of novel therapeutics for MASLD. Here, we review the immune cell types and bidirectional pathways that influence the pathogenesis of MASLD and highlight potential pharmacologic approaches to combat MASLD based on current knowledge of this bidirectional crosstalk.

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Metadata

Authors
Sawada, K., Chung, H., Softic, S., Moreno-Fernandez, M. E., & Divanovic, S.
Affiliations
  • Cincinnati Children's Hospital Medical Center (US)
  • University of Kentucky (US)
Corresponding author
Divanovic, Senad
ORCID
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2023-11
Volume
35
Issue
11
Pages
1852-1871
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2023.10.009
PMC
PMC10680147
OpenAlex
W4388452323
Cited by
139
References
316
Citations by year
2026: 56 · 2025: 51 · 2024: 32
FWCI
5.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Metabolism (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • American Heart Association (17POST33650045)
  • CCHMC
  • Cincinnati Children’s Research Foundation
  • National Institutes of Health (R01DK099222)
  • U.S. Department of Defense (W81XWH2010392)
  • American Diabetes Association (1-18-IBS-100)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Keywords
non-alcoholic fatty liver disease, innate immunity, adaptive immunity, liver inflammation, immune cell types, therapeutic target
MeSH terms
Fatty Liver, Humans, Inflammation, Metabolic Diseases, Pancreas, Risk Factors

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