Cited by 573Liver Disease Diagnosis and TreatmentLiver physiology and pathologyLiver Diseases and Immunity

Immune cell-mediated features of non-alcoholic steatohepatitis

Open access
Huby, Thierry, Gautier, Emmanuel L.·2022·Nature Reviews Immunology

Abstract

Non-alcoholic fatty liver disease (NAFLD) includes a range of hepatic manifestations, starting with liver steatosis and potentially evolving towards non-alcoholic steatohepatitis (NASH), cirrhosis or even hepatocellular carcinoma. NAFLD is a major health burden, and its incidence is increasing worldwide. Although it is primarily a disease of disturbed metabolism, NAFLD involves several immune cell-mediated inflammatory processes, particularly when reaching the stage of NASH, at which point inflammation becomes integral to the progression of the disease. The hepatic immune cell landscape is diverse at steady state and it further evolves during NASH with direct consequences for disease severity. In this Review, we discuss current concepts related to the role of immune cells in the onset and progression of NASH. A better understanding of the mechanisms by which immune cells contribute to NASH pathogenesis should aid the design of innovative drugs to target NASH, for which current therapeutic options are limited. Non-alcoholic steatohepatitis (NASH) is a serious chronic liver disorder of increasing prevalence worldwide. Metabolic by nature, the disease also mobilizes the immune system. Here, Huby and Gautier discuss current knowledge regarding how diverse immune cell subsets affect NASH onset and progression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s41577-021-00639-3

Cites

181 of 181 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Huby, T., & Gautier, E. L.
Affiliations
Inserm (FR)
Corresponding author
Gautier, Emmanuel L.
Venue
Nature Reviews Immunology
Published
2021-11-05
Volume
22
Issue
7
Pages
429-443
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W3208498374
Cited by
573
References
181
Citations by year
2026: 77 · 2025: 163 · 2024: 168 · 2023: 116 · 2022: 48 · 2021: 1
FWCI
13.18
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • HAL (submittedVersion)
Funders
  • Agence Nationale de la Recherche (ANR-17-CE14-0009, ANR-15-CE14, ANR-17-CE14-0023, ANR-20-CE15-0018, ANR-17, ANR-17-CE14-0044, ANR-15-CE14-0015)
  • Institut National de la Santé et de la Recherche Médicale
  • Fondation de France (00056835, 00096295)
  • Sorbonne Université
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Keywords
nonalcoholic steatohepatitis, non-alcoholic fatty liver disease, liver inflammation, immune cells, NASH pathogenesis, disease progression
MeSH terms
Humans, Inflammation, Liver Cirrhosis, Severity of Illness Index, Non-alcoholic Fatty Liver Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review