Immune cell-mediated features of non-alcoholic steatohepatitis
Open accessAbstract
Non-alcoholic fatty liver disease (NAFLD) includes a range of hepatic manifestations, starting with liver steatosis and potentially evolving towards non-alcoholic steatohepatitis (NASH), cirrhosis or even hepatocellular carcinoma. NAFLD is a major health burden, and its incidence is increasing worldwide. Although it is primarily a disease of disturbed metabolism, NAFLD involves several immune cell-mediated inflammatory processes, particularly when reaching the stage of NASH, at which point inflammation becomes integral to the progression of the disease. The hepatic immune cell landscape is diverse at steady state and it further evolves during NASH with direct consequences for disease severity. In this Review, we discuss current concepts related to the role of immune cells in the onset and progression of NASH. A better understanding of the mechanisms by which immune cells contribute to NASH pathogenesis should aid the design of innovative drugs to target NASH, for which current therapeutic options are limited. Non-alcoholic steatohepatitis (NASH) is a serious chronic liver disorder of increasing prevalence worldwide. Metabolic by nature, the disease also mobilizes the immune system. Here, Huby and Gautier discuss current knowledge regarding how diverse immune cell subsets affect NASH onset and progression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Immune cells play a key role in both inflammation and fibrogenesis in MASLD/MASH.
“Immune cells are central to inflammation and fibrogenesis in MASLD/MASH4.”
Multiple innate-like T cell populations are enriched in NASH in human biopsies and murine models.
“Similarly, multiple innate-like T cell populations are enriched in NASH in human biopsies and murine models (5).”
From Hepatic Stellate Cell-Immune Interactions in NASH (2022) · cites this paper as [5]
Sustained inflammation is thought to drive the transition from simple steatosis to NASH.
“Sustained inflammation is thought to drive the transition from simple steatosis to NASH (4, 5).”
From Hepatic Stellate Cell-Immune Interactions in NASH (2022) · cites this paper as [5]
Interplay between HSCs and hepatic immune cells is an especially important determinant of NASH pathogenesis.
“Interplay between HSCs and hepatic immune cells, long recognized as a key feature of the hepatic injury response, has emerged as an especially important determinant of NASH pathogenesis (5, 7, 8).”
From Hepatic Stellate Cell-Immune Interactions in NASH (2022) · cites this paper as [5]
Human studies and rodent models have provided compelling insights into different immune cells and their presumed functions in NAFLD/NASH.
“Human studies and rodent models have provided compelling insights into the different immune cells and their presumed functions in NAFLD/NASH.24,49”
From An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH (2023) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Younossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L., & Wymer, M. (2016) · Hepatology · doi:10.1002/hep.28431 · Cited by 10,781 · see citing works
Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958 · see citing works
Eslam, M., Newsome, P. N., Sarin, S. K., Anstee, Q. M., Targher, G., Romero-Gomez, M., Zelber-Sagi, S., Wai-Sun Wong, V., Dufour, J.-F., Schattenberg, J. M., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.03.039 · Cited by 4,472 · see citing works
Mechanisms of NAFLD development and therapeutic strategies
Friedman, S. L., Neuschwander-Tetri, B. A., Rinella, M., & Sanyal, A. J. (2018) · Nature Medicine · doi:10.1038/s41591-018-0104-9 · Cited by 4,354 · see citing works
Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604 · see citing works
Neutrophil extracellular traps in immunity and disease
Papayannopoulos, V. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.105 · Cited by 3,428 · see citing works
MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease
Eslam, M., Sanyal, A. J., George, J., Sanyal, A., Neuschwander-Tetri, B., Tiribelli, C., Kleiner, D. E., Brunt, E., Bugianesi, E., Yki-Järvinen, H., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.312 · Cited by 3,286 · see citing works
Angulo, P., Kleiner, D. E., Dam-Larsen, S., Adams, L. A., Bjornsson, E. S., Charatcharoenwitthaya, P., Mills, P. R., Keach, J. C., Lafferty, H. D., Stahler, A., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.043 · Cited by 2,987 · see citing works
Ludwig, J., Viggiano, T. R., McGill, D. B., & Ott, B. J. (1980) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(24)00530-5 · Cited by 2,903 · see citing works
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · see citing works
Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309 · see citing works
Ekstedt, M., Hagström, H., Nasr, P., Fredrikson, M., Stål, P., Kechagias, S., & Hultcrantz, R. (2015) · Hepatology · doi:10.1002/hep.27368 · Cited by 2,287 · see citing works
NicheNet: Modeling intercellular communication by linking ligands to target genes
Browaeys, R., Saelens, W., & Saeys, Y. (2020) · Nature Methods · doi:10.1038/s41592-019-0667-5 · Cited by 2,192 · see citing works
Innate Lymphoid Cells: 10 Years On
Vivier, É., Artis, D., Colonna, M., Diefenbach, A., Santo, J. P. D., Eberl, G., Koyasu, S., Locksley, R. M., McKenzie, A. N. J., Mebius, R. E., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.017 · Cited by 2,136 · see citing works
A Placebo-controlled trial of subcutaneous semaglutide in nonalcoholic steatohepatitis
Newsome, P. N., Buchholtz, K., Cusi, K., Linder, M., Okanoue, T., Ratziu, V., Sanyal, A. J., Sejling, A.-S., & Harrison, S. A. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2028395 · Cited by 2,039 · see citing works
Estes, C., Anstee, Q. M., Arias, M., Bantel, H., Bellentani, S., Caballería, J., Colombo, M., Craxı̀, A., Crespo, J., Day, C. P., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.05.036 · Cited by 1,986 · see citing works
Resolving the fibrotic niche of human liver cirrhosis at single-cell level
Ramachandran, P., Dobie, R., Wilson-Kanamori, J. R., Dora, E. F., Henderson, B. E. P., Luu, N. T., Portman, J. R., Matchett, K. P., Brice, M., Marwick, J. A., et al. (2019) · Nature · doi:10.1038/s41586-019-1631-3 · Cited by 1,784 · see citing works
Platelets and the immune continuum
Semple, J. W., Italiano, J. E., & Freedman, J. J. (2011) · Nature reviews. Immunology · doi:10.1038/nri2956 · Cited by 1,704 · see citing works
Transcriptional control of effector and memory CD8+ T cell differentiation
Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628 · see citing works
Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations
MacParland, S. A., Liu, J. C., Ma, X.-Z., Innes, B. T., Bartczak, A. M., Gage, B. K., Manuel, J., Khuu, N., Echeverri, J., Linares, I., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06318-7 · Cited by 1,552 · see citing works
Bataller, R. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524282c1 · Cited by 1,480 · see citing works
Liver Macrophages in Tissue Homeostasis and Disease
Krenkel, O., & Tacke, F. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.11 · Cited by 1,424 · see citing works
From NASH to HCC: current concepts and future challenges
Anstee, Q. M., Reeves, H. L., Kotsiliti, E., Govaere, O., & Heikenwalder, M. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0145-7 · Cited by 1,392 · see citing works
Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner
Jaitin, D. A., Adlung, L., Thaiss, C. A., Weiner, A., Li, B., Descamps, H., Lundgren, P., Bleriot, C., Liu, Z., Deczkowska, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.054 · Cited by 1,377 · see citing works
Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease
Chen, Z., Tian, R., She, Z., Cai, J., & Li, H. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.025 · Cited by 1,303 · see citing works
NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Pfister, D., Núñez, N. G., Pinyol, R., Govaere, O., Pinter, M., Szydlowska, M., Gupta, R., Qiu, M., Deczkowska, A., Weiner, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03362-0 · Cited by 1,294 · see citing works
The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe
Younossi, Z. M., Blissett, D. B., Blissett, R., Henry, L. L., Stepanova, M., Younossi, Y., Racila, A., Hunt, S., & Beckerman, R. (2016) · Hepatology · doi:10.1002/hep.28785 · Cited by 1,289 · see citing works
Younossi, Z. M., Ratziu, V., Loomba, R., Rinella, M., Anstee, Q. M., Goodman, Z., Bedossa, P., Geier, A., Beckebaum, S., Newsome, P. N., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)33041-7 · Cited by 1,277 · see citing works
An emerging role for neutrophil extracellular traps in noninfectious disease
Jorch, S. K., & Kubes, P. (2017) · Nature Medicine · doi:10.1038/nm.4294 · Cited by 1,244 · see citing works
Immunology in the liver — from homeostasis to disease
Heymann, F., & Tacke, F. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.200 · Cited by 1,180 · see citing works
Hoeffel, G., Chen, J., Lavin, Y., Low, D., Almeida, F. F., See, P., Beaudin, A. E., Lum, J., Low, I., Forsberg, E. C., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.011 · Cited by 1,135 · see citing works
Senolytic CAR T cells reverse senescence-associated pathologies
Amor, C., Feucht, J., Leibold, J., Ho, Y.-J., Zhu, C., Alonso-Curbelo, D., Mansilla-Soto, J., Boyer, J. A., Li, X., Giavridis, T., et al. (2020) · Nature · doi:10.1038/s41586-020-2403-9 · Cited by 1,098 · see citing works
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M., Burgart, L. J., Lindor, K. D., & Gores, G. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00907-7 · Cited by 1,085 · see citing works
Dynamics of B cells in germinal centres
De Silva, N. S., & Klein, U. (2015) · Nature Reviews Immunology · doi:10.1038/nri3804 · Cited by 1,084 · see citing works
An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway
Schiemann, B. J., Gommerman, J. L., Vora, K. A., Cachero, T. G., Shulga‐Morskaya, S., Dobles, M., Frew, E. M., & Scott, M. L. (2001) · Science · doi:10.1126/science.1061964 · Cited by 1,070 · see citing works
Type 2 immunity in tissue repair and fibrosis
Gieseck, R. L., Wilson, M. S., & Wynn, T. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.90 · Cited by 1,055 · see citing works
Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17–secreting T cells
Dusséaux, M., Martin, E., Serriari, N., Péguillet, I., Prémel, V., Louis, D., Milder, M., Bourhis, L. L., Soudais, C., Treiner, E., et al. (2010) · Blood · doi:10.1182/blood-2010-08-303339 · Cited by 1,031 · see citing works
Decoding cell death signals in liver inflammation
Brenner, C., Galluzzi, L., Kepp, O., & Kroemer, G. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.033 · Cited by 1,022 · see citing works
Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E
Huo, Y., Schober, A., Forlow, S. B., Smith, D. F., Hyman, M. C., Jung, S., Littman, D. R., Weber, C., & Ley, K. F. (2002) · Nature Medicine · doi:10.1038/nm810 · Cited by 1,008 · see citing works
The double life of a B-1 cell: self-reactivity selects for protective effector functions
Baumgarth, N. (2011) · Nature Reviews Immunology · doi:10.1038/nri2901 · Cited by 969 · see citing works
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
Scott, C. L., Zheng, F., De Baetselier, P., Martens, L., Saeys, Y., De Prijck, S., Lippens, S., Abels, C., Schoonooghe, S., Raes, G., et al. (2016) · Nature Communications · doi:10.1038/ncomms10321 · Cited by 860 · see citing works
Zhang, X., Coker, O. O., Chu, E. S., Fu, K., Lau, H. C. H., Wang, Y.-X., Chan, A. W. H., Wei, H., Yang, X., Sung, J. J. Y., et al. (2021) · Gut · doi:10.1136/gutjnl-2019-319664 · Cited by 841 · see citing works
Newsome, P. N., Sasso, M., Deeks, J. J., Paredes, A. H., Boursier, J., Chan, W., Yilmaz, Y. N., Czernichow, S., Zheng, M., Wong, V. W., et al. (2020) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(19)30383-8 · Cited by 823 · see citing works
Targeting cardiac fibrosis with engineered T cells
Aghajanian, H., Kimura, T., Rurik, J. G., Hancock, A. S., Leibowitz, M. S., Li, L., Scholler, J., Monslow, J., Lo, A., Han, W., et al. (2019) · Nature · doi:10.1038/s41586-019-1546-z · Cited by 801 · see citing works
Obesity and cancer—mechanisms underlying tumour progression and recurrence
Park, J., Morley, T. S., Kim, M. G., Clegg, D. J., & Scherer, P. E. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.94 · Cited by 792 · see citing works
Xiong, X., Kuang, H., Ansari, S., Liu, T., Gong, J., Wang, S., Zhao, X.-Y., Ji, Y., Li, C., Guo, L., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.07.028 · Cited by 784 · see citing works
NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis
Ma, C., Kesarwala, A. H., Eggert, T., Medina-Echeverz, J., Kleiner, D. E., Jin, P., Stroncek, D. F., Terabe, M., Kapoor, V., ElGindi, M., et al. (2016) · Nature · doi:10.1038/nature16969 · Cited by 766 · see citing works
Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells
Liu, Z., Gu, Y., Chakarov, S., Bleriot, C., Kwok, I., Chen, X., Shin, A., Huang, W., Dress, R. J., Dutertre, C.-A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.08.009 · Cited by 719 · see citing works
Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease
Softic, S., Cohen, D. E., & Kahn, C. R. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4054-0 · Cited by 709 · see citing works
Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance
Steinert, E. M., Schenkel, J. M., Fraser, K. A., Beura, L. K., Manlove, L. S., Igyártó, B. Z., Southern, P. J., & Masopust, D. (2015) · Cell · doi:10.1016/j.cell.2015.03.031 · Cited by 685 · see citing works
Intravascular Immune Surveillance by CXCR6+ NKT Cells Patrolling Liver Sinusoids
Geissmann, F., Cameron, T. O., Sidobre, S., Manlongat, N., Kronenberg, M., Briskin, M., Dustin, M. L., & Littman, D. R. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030113 · Cited by 681 · see citing works
Wolf, M. J., Adili, A., Piotrowitz, K., Abdullah, Z., Boege, Y., Stemmer, K., Ringelhan, M., Simonavicius, N., Egger, M., Wohlleber, D., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.003 · Cited by 678 · see citing works
Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis
Schwabe, R. F., Tabas, I., & Pajvani, U. B. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.311 · Cited by 671 · see citing works
Bonnardel, J., T’Jonck, W., Gaublomme, D., Browaeys, R., Scott, C. L., Martens, L., Vanneste, B., De Prijck, S., Nedospasov, S. A., Kremer, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.08.017 · Cited by 631 · see citing works
The Roles of CD8+ T Cell Subsets in Antitumor Immunity
Paul, M. S., & Ohashi, P. S. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.06.003 · Cited by 609 · see citing works
Neutrophils as protagonists and targets in chronic inflammation
Soehnlein, O., Steffens, S., Hidalgo, A., & Weber, C. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.10 · Cited by 606 · see citing works
Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis
Marı́, M., Caballero, F. G., Colell, A., Morales, A., Caballería, J., Fernandez, A., Enrich, C., Fernández-Checa, J. C., & García‐Ruiz, C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.006 · Cited by 605 · see citing works
Lee, Y. J., Holzapfel, K. L., Zhu, J., Jameson, S. C., & Hogquist, K. A. (2013) · Nature Immunology · doi:10.1038/ni.2731 · Cited by 604 · see citing works
Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma
Luedde, T., Beraza, N., Kotsikoris, V., Loo, G., Nenci, A., Vos, R. D., Roskams, T., Trautwein, C., & Pasparakis, M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.12.016 · Cited by 596 · see citing works
Remmerie, A., Martens, L., Thoné, T., Castoldi, A., Seurinck, R., Pavie, B., Roels, J., Vanneste, B., De Prijck, S., Vanhockerhout, M., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.08.004 · Cited by 592 · see citing works
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
Shalapour, S., Lin, X.-J., Bastian, I. N., Brain, J., Burt, A. D., Aksenov, A. A., Vrbanac, A. F., Li, W., Perkins, A., Matsutani, T., et al. (2017) · Nature · doi:10.1038/nature24302 · Cited by 589 · see citing works
Apoptosis and necroptosis in the liver: a matter of life and death
Schwabe, R. F., & Luedde, T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0065-y · Cited by 582 · see citing works
Regulation of hepatic blood flow: The hepatic arterial buffer response revisited
Eipel, C. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i48.6046 · Cited by 557 · see citing works
Daussy, C., Faure, F., Mayol, K., Viel, S., Gasteiger, G., Charrier, E., Bienvenu, J., Henry, T., Debien, E., Hasan, U. A., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131560 · Cited by 549 · see citing works
Liver-resident NK cells confer adaptive immunity in skin-contact inflammation
Peng, H. C., Jiang, X., Chen, Y., Sojka, D. K., Wei, H., Gao, X., Sun, R., Yokoyama, W. M., & Tian, Z. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66381 · Cited by 546 · see citing works
A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer
Asgharpour, A., Cazanave, S. C., Pacana, T., Seneshaw, M., Vincent, R., Banini, B. A., Kumar, D. P., Daita, K., Min, H.-K., Mirshahi, F., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.05.005 · Cited by 538 · see citing works
Control of Macrophage Activation and Function by PPARs
Chawla, A. (2010) · Circulation Research · doi:10.1161/circresaha.110.216523 · Cited by 531 · see citing works
Arroyave-Ospina, J. C., Wu, Z., Geng, Y., & Moshage, H. J. (2021) · Antioxidants · doi:10.3390/antiox10020174 · Cited by 531 · see citing works
ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development
Nakagawa, H., Umemura, A., Taniguchi, K., Font-Burgada, J., Dhar, D., Ogata, H., Zhong, Z., Valasek, M. A., Seki, E., Hidalgo, J., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.07.001 · Cited by 525 · see citing works
An improved mouse model that rapidly develops fibrosis in non‐alcoholic steatohepatitis
Matsumoto, M., Hada, N., Sakamaki, Y., Uno, A., Shiga, T., Tanaka, C., Ito, T., Katsume, A., & Sudoh, M. (2013) · International Journal of Experimental Pathology · doi:10.1111/iep.12008 · Cited by 523 · see citing works
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH
Dudek, M., Pfister, D., Donakonda, S., Filpe, P., Schneider, A., Laschinger, M., Hartmann, D., Hüser, N., Meiser, P., Bayerl, F., et al. (2021) · Nature · doi:10.1038/s41586-021-03233-8 · Cited by 512 · see citing works
Effector T cell plasticity: flexibility in the face of changing circumstances
Murphy, K. M., & Stockinger, B. (2010) · Nature Immunology · doi:10.1038/ni.1899 · Cited by 482 · see citing works
van der Windt, D. J., Sud, V., Zhang, H., Varley, P. R., Goswami, J., Yazdani, H. O., Tohme, S. T., Loughran, P., O'Doherty, R. M., Minervini, M. I., et al. (2018) · Hepatology · doi:10.1002/hep.29914 · Cited by 482 · see citing works
Balmer, M. L., Slack, E., de Gottardi, A., Lawson, M. A. E., Hapfelmeier, S., Miele, L., Grieco, A., Van Vlierberghe, H., Fahrner, R., Patuto, N., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008618 · Cited by 470 · see citing works
Obesity as a multisystem disease: Trends in obesity rates and obesity‐related complications
Sarma, S., Sockalingam, S., & Dash, S. (2021) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14290 · Cited by 461 · see citing works
The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease
Gadd, V. L., Skoien, R., Powell, E. E., Fagan, K. J., Winterford, C., Horsfall, L., Irvine, K., & Clouston, A. D. (2014) · Hepatology · doi:10.1002/hep.26937 · Cited by 452 · see citing works
Srivastava, A., Gailer, R., Tanwar, S., Trembling, P. M., Parkes, J., Rodger, A. J., Suri, D., Thorburn, D., Sennett, K., Morgan, S., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.03.033 · Cited by 449 · see citing works
Seidman, J. S., Troutman, T. D., Sakai, M., Gola, A., Spann, N. J., Bennett, H., Bruni, C. M., Ouyang, Z., Li, R. Z., Sun, X., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.001 · Cited by 443 · see citing works
The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer
Sun, L., Cai, J., & Gonzalez, F. J. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00404-2 · Cited by 443 · see citing works
Koenen, R. R., von Hundelshausen, P., Nesmelova, I. V., Zernecke, A., Liehn, E. A., Sarabi, A., Kramp, B. K., Piccinini, A. M., Paludan, S. R., Kowalska, M. A., et al. (2009) · Nature Medicine · doi:10.1038/nm.1898 · Cited by 440 · see citing works
Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection
Fernandez-Ruiz, D., Ng, W. Y., Holz, L. E., Ma, J. Z., Zaid, A., Wong, Y. C., Lau, L. S., Mollard, V., Cozijnsen, A., Collins, N., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.011 · Cited by 438 · see citing works
NAFLD and liver transplantation: Current burden and expected challenges
Pais, R., Barritt, A. S., Calmus, Y., Scatton, O., Runge, T. M., Lebray, P., Poynard, T., Ratziu, V., & Conti, F. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.07.033 · Cited by 429 · see citing works
From NAFLD to MAFLD: Implications of a Premature Change in Terminology
Younossi, Z. M., Rinella, M. E., Sanyal, A. J., Harrison, S. A., Brunt, E. M., Goodman, Z. D., Cohen, D. E., & Loomba, R. S. (2020) · Hepatology · doi:10.1002/hep.31420 · Cited by 419 · see citing works
Sakai, M., Troutman, T. D., Seidman, J. S., Ouyang, Z., Spann, N. J., Abe, Y., Ego, K. M., Bruni, C. M., Deng, Z., Schlachetzki, J. C. M., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.002 · Cited by 418 · see citing works
Gomes, A. L., Teijeiro, A., Burén, S., Tummala, K. S., Yilmaz, M., Waisman, A., Theurillat, J.-P., Perna, C., & Djouder, N. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.020 · Cited by 401 · see citing works
Tran, S., Baba, I., Poupel, L., Dussaud, S., Moreau, M., Gélineau, A., Marcelin, G., Magréau-Davy, E., Ouhachi, M., Lesnik, P., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.003 · Cited by 400 · see citing works
Self-citationMalehmir, M., Pfister, D., Gallage, S., Szydlowska, M., Inverso, D., Kotsiliti, E., Leone, V., Peiseler, M., Surewaard, B. G. J., Rath, D., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0379-5 · Cited by 398 · see citing works
Rahimpour, A., Koay, H., Enders, A., Clanchy, R., Eckle, S. B. G., Meehan, B. S., Chen, Z., Whittle, B., Liu, L., Fairlie, D. P., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20142110 · Cited by 384 · see citing works
Machado, M. V., Michelotti, G. A., Xie, G., Pereira, T. A., Boursier, J., Bohnic, B., Guy, C. D., & Diehl, A. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127991 · Cited by 381 · see citing works
Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
Grohmann, M., Wiede, F., Dodd, G. T., Gurzov, E. N., Ooi, G. J., Butt, T., Rasmiena, A. A., Kaur, S., Gulati, T., Goh, P. K., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.053 · Cited by 373 · see citing works
Wong, C. H. Y., Jenne, C., Petri, B., Chrobok, N. L., & Kubes, P. (2013) · Nature Immunology · doi:10.1038/ni.2631 · Cited by 367 · see citing works
Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease
Hammoutene, A., & Rautou, P.-E. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.02.012 · Cited by 364 · see citing works
IL-7 Licenses Activation of Human Liver Intrasinusoidal Mucosal-Associated Invariant T Cells
Tang, X.-Z. E., Jo, J., Tan, A. T., Sandalova, E., Chia, A., Tan, K. C., Lee, K. H., Gehring, A. J., Libero, G. D., & Bertoletti, A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203218 · Cited by 356 · see citing works
Thomas, J. A., Pope, C., Wojtacha, D., Robson, A. J., Gordon-Walker, T. T., Hartland, S., Ramachandran, P., Van Deemter, M., Hume, D. A., Iredale, J. P., et al. (2011) · Hepatology · doi:10.1002/hep.24315 · Cited by 346 · see citing works
Imajo, K., Fujita, K., Yoneda, M., Nozaki, Y., Ogawa, Y., Shinohara, Y., Kato, S., Mawatari, H., Shibata, W., Kitani, H., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.05.012 · Cited by 341 · see citing works
ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P
Kim, J. Y., Garcia-Carbonell, R., Yamachika, S., Zhao, P., Dhar, D., Loomba, R., Kaufman, R. J., Saltiel, A. R., & Karin, M. (2018) · Cell · doi:10.1016/j.cell.2018.08.020 · Cited by 333 · see citing works
Fructose stimulated de novo lipogenesis is promoted by inflammation
Todoric, J., Di Caro, G., Reibe, S., Henstridge, D. C., Green, C. R., Vrbanac, A., Ceteci, F., Conche, C., McNulty, R., Shalapour, S., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0261-2 · Cited by 328 · see citing works
Lefebvre, E., Moyle, G., Reshef, R., Richman, L. P., Thompson, M., Hong, F., Chou, H.-L., Hashiguchi, T., Plato, C., Poulin, D., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0158156 · Cited by 323 · see citing works
Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge
Pellicci, D. G., Koay, H., & Berzins, S. P. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0345-y · Cited by 322 · see citing works
The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells
Omenetti, S., Bussi, C., Metidji, A., Iseppon, A., Lee, S., Tolaini, M., Li, Y., Kelly, G., Chakravarty, P., Shoaie, S., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.05.004 · Cited by 317 · see citing works
Lefere, S., Puengel, T., Hundertmark, J., Penners, C., Frank, A. K., Guillot, A., de Muynck, K., Heymann, F., Adarbes, V., Defrêne, E., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.04.025 · Cited by 310 · see citing works
How B cells capture, process and present antigens: a crucial role for cell polarity
Yuseff, M.-I., Pierobon, P., Reversat, A., & Lennon‐Duménil, A. (2013) · Nature reviews. Immunology · doi:10.1038/nri3469 · Cited by 308 · see citing works
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis
Zhao, P., Sun, X., Chaggan, C., Liao, Z., Wong, K. I., He, F., Singh, S., Loomba, R. S., Karin, M., Witztum, J. L., et al. (2020) · Science · doi:10.1126/science.aay0542 · Cited by 308 · see citing works
Rau, M., Schilling, A.-K., Meertens, J., Hering, I., Weiss, J., Jurowich, C., Kudlich, T., Hermanns, H. M., Bantel, H., Beyersdorf, N., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501175 · Cited by 302 · see citing works
Savard, C. E., Tartaglione, E. V., Kuver, R., Haigh, G. W., Farrell, G. C., Subramanian, S., Chait, A., Yeh, M. M., Quinn, L. S., & Ioannou, G. N. (2012) · Hepatology · doi:10.1002/hep.25789 · Cited by 297 · see citing works
Barreyro, F. J., Holod, S., Finocchietto, P. V., Camino, A. M., Aquino, J. B., Avagnina, A., Carreras, M. C., Poderoso, J. J., & Gores, G. J. (2014) · Liver International · doi:10.1111/liv.12570 · Cited by 295 · see citing works
Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease
Tang, Y., Bian, Z., Zhao, L., Liu, Y., Liang, S., Wang, Q., Han, X., Peng, Y., Chen, X., Shen, L., et al. (2011) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2011.04471.x · Cited by 294 · see citing works
Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis
Rensen, S. S., Slaats, Y., Nijhuis, J., Jans, A., Bieghs, V., Driessen, A., Malle, E., Greve, J. W., & Buurman, W. A. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080999 · Cited by 290 · see citing works
Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease
Syn, W.-K., Oo, Y. H., Pereira, T. A., Karaca, G. F., Jung, Y., Omenetti, A., Witek, R. P., Choi, S. S., Guy, C. D., Fearing, C. M., et al. (2010) · Hepatology · doi:10.1002/hep.23599 · Cited by 283 · see citing works
Kakazu, E., Mauer, A. S., Yin, M., & Malhi, H. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m063412 · Cited by 280 · see citing works
Therapeutic pipeline in nonalcoholic steatohepatitis
Vuppalanchi, R., Noureddin, M., Alkhouri, N., & Sanyal, A. J. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00408-y · Cited by 278 · see citing works
Syn, W.-K., Choi, S. S., Liaskou, E., Karaca, G. F., Agboola, K. M., Oo, Y. H., Mi, Z., Pereira, T. A., Zdanowicz, M., Malladi, P., et al. (2011) · Hepatology · doi:10.1002/hep.23998 · Cited by 275 · see citing works
Mouse models of nonalcoholic steatohepatitis in preclinical drug development
Hansen, H. H., Feigh, M., Veidal, S. S., Rigbolt, K. T. G., Vrang, N., & Fosgerau, K. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.06.007 · Cited by 274 · see citing works
Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning
Drucker, D. J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.01.016 · Cited by 272 · see citing works
NKT-Associated Hedgehog and Osteopontin Drive Fibrogenesis in Non-Alcoholic Fatty Liver Disease
Syn, W.-K., Agboola, K. M., Swiderska, M., Michelotti, G. A., Liaskou, E., Pang, H., Xie, G., Philips, G., Chan, I. S., Karaca, G. F., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-301857 · Cited by 266 · see citing works
A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis
Harrison, S. A., Goodman, Z., Jabbar, A., Vemulapalli, R., Younes, Z. H., Freilich, B., Sheikh, M. Y., Schattenberg, J. M., Kayali, Z., Zivony, A., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2019.11.024 · Cited by 260 · see citing works
Harrison, S. A., Ratziu, V., Boursier, J., Francque, S., Bédossa, P., Majd, Z., Cordonnier, G., Sudrik, F. B., Darteil, R., Liebe, R., et al. (2020) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(20)30252-1 · Cited by 258 · see citing works
Sierro, F., Evrard, M., Rizzetto, S., Melino, M., Mitchell, A. J., Flórido, M., Beattie, L., Walters, S. B., Tay, S. S., Lü, B., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.018 · Cited by 256 · see citing works
Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis #
Witek, R. P., Stone, C. W., Karaca, G., Syn, W., Pereira, T. A., Agboola, K. M., Omenetti, A., Jung, Y., Teaberry, V. S., Choi, S. S., et al. (2009) · Hepatology · doi:10.1002/hep.23167 · Cited by 252 · see citing works
Commensal-driven Immune Zonation of the Liver Promotes Host Defense
Gola, A., Dorrington, M. G., Speranza, E., Sala, C., Shih, R. M., Radtke, A. J., Wong, H. S., Baptista, A., Hernandez, J. M., Castellani, G., et al. (2020) · Nature · doi:10.1038/s41586-020-2977-2 · Cited by 241 · see citing works
CD1d-Restricted NKT Cells: An Interstrain Comparison
Hammond, K. J. L., Pellicci, D. G., Poulton, L. D., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1164 · Cited by 238 · see citing works
Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver
Hegde, P., Weiss, E., Paradis, V., Wan, J., Mabire, M., Sukriti, S., Rautou, P.-E., Albuquerque, M., Picq, O., Gupta, A. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04450-y · Cited by 232 · see citing works
Meakin, P. J., Chowdhry, S., Sharma, R. S., Ashford, F. B., Walsh, S. V., McCrimmon, R. J., Dinkova‐Kostova, A. T., Dillon, J. F., Hayes, J. D., & Ashford, M. L. J. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00677-14 · Cited by 229 · see citing works
Liang, Q., Teoh, N., Xu, L., Pok, S., Li, X., Chu, E. S., Chiu, J., Dong, L., Arfianti, A., Haigh, W. G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06931-6 · Cited by 223 · see citing works
Krenkel, O., Hundertmark, J., Abdallah, A. T., Kohlhepp, M., Puengel, T., Roth, T., Branco, D. P. P., Mossanen, J. C., Luedde, T., Trautwein, C., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-318382 · Cited by 220 · see citing works
Zhang, X., Shen, J., Man, K., Chu, E. S., Yau, T. O., Sung, J. C. Y., Go, M. Y. Y., Deng, J., Lu, L., Wong, V. W., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.07.006 · Cited by 219 · see citing works
A Role for Perforin in Downregulating T-Cell Responses during Chronic Viral Infection
Matloubian, M., Suresh, M., Glass, A. A., Galvan, M., Chow, K., Whitmire, J. K., Walsh, C. M., Clark, W. R., & Ahmed, R. (1999) · Journal of Virology · doi:10.1128/jvi.73.3.2527-2536.1999 · Cited by 218 · see citing works
Barrow, F., Khan, S., Fredrickson, G., Wang, H., Dietsche, K., Parthiban, P., Robert, S., Kaiser, T., Winer, S., Herman, A., et al. (2021) · Hepatology · doi:10.1002/hep.31755 · Cited by 210 · see citing works
David, B. A., Rezende, R. M., Antunes, M. M., Santos, M. M., Lopes, M. A. F., Diniz, A. B., Pereira, R. V. S., Marchesi, S. C., Alvarenga, D. M., Nakagaki, B. N., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.08.024 · Cited by 205 · see citing works
Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis
Sun, X., Seidman, J. S., Zhao, P., Troutman, T. D., Spann, N. J., Que, X., Zhou, F., Liao, Z., Pasillas, M. P., Yang, X., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.10.014 · Cited by 205 · see citing works
Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis
Wang, X., Cai, B., Yang, X., Sonubi, O. O., Zheng, Z., Ramakrishnan, R., Shi, H., Valenti, L., Pajvani, U. B., Sandhu, J., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.03.010 · Cited by 204 · see citing works
Safety profile of autologous macrophage therapy for liver cirrhosis
Moroni, F., Dwyer, B. J., Graham, C., Pass, C., Bailey, L., Ritchie, L., Mitchell, D., Glover, A., Laurie, A., Doig, S., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0599-8 · Cited by 202 · see citing works
XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis
Deczkowska, A., David, E., Ramadori, P., Pfister, D., Safran, M., Li, B., Giladi, A., Jaitin, D. A., Barboy, O., Cohen, M., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01344-3 · Cited by 197 · see citing works
Im, Y. R., Hunter, H., de Gracia Hahn, D., Duret, A., Cheah, Q., Dong, J., Fairey, M., Hjalmarsson, C., Li, A., Lim, H. K., et al. (2021) · Hepatology · doi:10.1002/hep.31897 · Cited by 195 · see citing works
Li, F., Hao, X., Chen, Y., Bai, L., Gao, X., Lian, Z., Wei, H., Sun, R., & Tian, Z. (2017) · Nature Communications · doi:10.1038/ncomms13839 · Cited by 191 · see citing works
Dasgupta, D., Nakao, Y., Mauer, A. S., Thompson, J., Sehrawat, T. S., Liao, C., Krishnan, A., Lucien, F., Guo, Q., Liu, M., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.06.031 · Cited by 188 · see citing works
Foxp3+ T Cells Induce Perforin-Dependent Dendritic Cell Death in Tumor-Draining Lymph Nodes
Boissonnas, A., Scholer‐Dahirel, A., Simon-Blancal, V., Pace, L., Valet, F., Kissenpfennig, A., Sparwasser, T. D., MALISSEN, B., Fetler, L., & Amigorena, S. (2010) · Immunity · doi:10.1016/j.immuni.2009.11.015 · Cited by 184 · see citing works
Toubal, A., Kiaf, B., Beaudoin, L., Cagninacci, L., Rhimi, M., Fruchet, B., da Silva, J., Corbett, A. J., Simoni, Y., Lantz, O., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17307-0 · Cited by 165 · see citing works
Rolla, S., Alchera, E., Imarisio, C., Bardina, V., Valente, G., Cappello, P., Mombello, C., Follenzi, A., Novelli, F., & Carini, R. (2016) · Clinical Science · doi:10.1042/cs20150405 · Cited by 158 · see citing works
Moreno‐Fernandez, M. E., Giles, D. A., Oates, J. R., Chan, C. C., Damen, M. S. M. A., Doll, J., Stankiewicz, T. E., Chen, X., Chetal, K., Karns, R. A., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.04.018 · Cited by 158 · see citing works
Zhang, X., Han, J., Man, K., Li, X., Du, J., Chu, E. S., Go, M. Y. Y., Sung, J. J. �., & Yu, J. Q. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.09.005 · Cited by 156 · see citing works
Haas, J. T., Vonghia, L., Mogilenko, D. A., Verrijken, A., Molendi-Coste, O., Fleury, S., Deprince, A., Nikitin, A., Woitrain, E., Ducrocq-Geoffroy, L., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0076-1 · Cited by 155 · see citing works
TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice
Wandrer, F., Liebig, S., Marhenke, S., Vogel, A., John, K., Manns, M. P., Teufel, A., Itzel, T., Longerich, T., Maier, O., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2411-6 · Cited by 153 · see citing works
Perforin is a critical physiologic regulator of T-cell activation
Lykens, J. E., Terrell, C. E., Zoller, E. E., Risma, K., & Jordan, M. B. (2011) · Blood · doi:10.1182/blood-2010-12-324533 · Cited by 150 · see citing works
McDonald, B., Zucoloto, A. Z., Yu, I.-L., Burkhard, R., Brown, K., Geuking, M. B., & McCoy, K. D. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.07.014 · Cited by 148 · see citing works
Schattenberg, J. M., Lazarus, J. V., Newsome, P. N., Serfaty, L., Aghemo, A., Augustín, S., Tsochatzis, E. A., de Lédinghen, V., Bugianesi, E., Romero‐Gómez, M., et al. (2021) · Liver International · doi:10.1111/liv.14825 · Cited by 144 · see citing works
Bruzzì, S., Sutti, S., Giudici, G., Burlone, M. E., Ramavath, N. N., Toscani, A., Bozzola, C., Schneider, P., Morello, E., Parola, M., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.06.015 · Cited by 139 · see citing works
Terrell, C. E., & Jordan, M. B. (2013) · Blood · doi:10.1182/blood-2013-04-495309 · Cited by 138 · see citing works
Impact of obeticholic acid on the lipoprotein profile in patients with non-alcoholic steatohepatitis
Siddiqui, M. S., Natta, M. L. V., Connelly, M. A., Vuppalanchi, R., Neuschwander‐Tetri, B. A., Tonascia, J., Guy, C. D., Loomba, R. S., Dasarathy, S., Wattacheril, J. J., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.10.006 · Cited by 136 · see citing works
Ganz, M., Bukong, T., Csák, T., Saha, B., Park, J.-K., Ambade, A. V., Kodys, K., & Szabo, G. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0552-7 · Cited by 135 · see citing works
Cost of non-alcoholic steatohepatitis in Europe and the USA: The GAIN study
O’Hara, J., Finnegan, A. P., Dhillon, H. S., Ruiz‐Casas, L., Pedra, G., Franks, B., Morgan, G., Hebditch, V., Jönsson, B., Mabhala, M. A., et al. (2020) · JHEP Reports · doi:10.1016/j.jhepr.2020.100142 · Cited by 129 · see citing works
Serum Immunoglobulin Levels Predict Fibrosis in Patients With Non-Alcoholic Fatty Liver Disease
McPherson, S., Henderson, E., Burt, A. D., Day, C. P., & Anstee, Q. M. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.01.010 · Cited by 124 · see citing works
Fatty liver is an independent predictor of early carotid atherosclerosis
Pais, R., Giral, P., Khan, J.-F., Rosenbaum, D. H., Housset, C., Poynard, T., & Ratziu, V. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.023 · Cited by 123 · see citing works
Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease
Fujita, K., Nozaki, Y., Wada, K., Yoneda, M., Endo, H., Takahashi, H., Iwasaki, T., Inamori, M., Abe, Y., Kobayashi, N., et al. (2008) · Gut · doi:10.1136/gut.2007.144550 · Cited by 121 · see citing works
Luo, X.-Y., Takahara, T., Kawai, K., Fujino, M., Sugiyama, T., Tsuneyama, K., Tsukada, K., Nakae, S., Zhong, L., & Li, X.-K. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00193.2013 · Cited by 120 · see citing works
Giles, D. A., Moreno-Fernandez, M. E., Stankiewicz, T. E., Cappelletti, M., Huppert, S. S., Iwakura, Y., Dong, C., Shanmukhappa, S. K., & Divanovic, S. (2016) · PLOS ONE · doi:10.1371/journal.pone.0149783 · Cited by 116 · see citing works
Zhao, X., Yang, L., Chang, N., Hou, L., Zhou, X., Yang, L., & Li, L. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2582-1 · Cited by 115 · see citing works
Crosstalk Between Liver Macrophages and Surrounding Cells in Nonalcoholic Steatohepatitis
Li, H., Zhou, Y., Wang, H., Zhang, M., Qiu, P., Zhang, M., Zhang, R., Zhao, Q., & Liu, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01169 · Cited by 114 · see citing works
Segovia-Miranda, F., Morales-Navarrete, H., Kücken, M., Moser, V., Seifert, S., Repnik, U., Rost, F., Brosch, M., Hendricks, A., Hinz, S., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0660-7 · Cited by 109 · see citing works
Li, Y., Huang, B., Jiang, X., Chen, W., Zhang, J., Wei, Y., Chen, Y., Lian, M., Bian, Z., Miao, Q., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01994 · Cited by 107 · see citing works
Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop
Bai, L., Vienne, M., Tang, L., Kerdiles, Y. M., Etiennot, M., Escalière, B., Galluso, J., Wei, H., Sun, R., Vivier, É., et al. (2021) · Science · doi:10.1126/science.aba4177 · Cited by 105 · see citing works
Munteanu, M., TINIAKOS, D. G., Anstee, Q. M., Charlotte, F., Marchesini, G., Bugianesi, E., Trauner, M. A., Romero‐Gómez, M., de Oliveira, C. P. M. S., Day, C. P., et al. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13770 · Cited by 95 · see citing works
Murine CD103+ dendritic cells protect against steatosis progression towards steatohepatitis
Heier, E.-C., Meier, A., Julich-Haertel, H., Djudjaj, S., Rau, M., Tschernig, T., Geier, A., Boor, P., Lammert, F., & Lukacs-Kornek, V. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.01.008 · Cited by 94 · see citing works
Maricic, I., Marrero, I., Eguchi, A., Nakamura, R., Johnson, C. D., Dasgupta, S., Hernandez, C. D., Nguyen, P. S., Swafford, A. D., Knight, R., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800614 · Cited by 92 · see citing works
Shimamura, T., Fujisawa, T., Husain, S. R., Kioi, M., Nakajima, A., & Puri, R. K. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4656 · Cited by 91 · see citing works
Her, Z., Tan, J. H. L., Lim, Y.-S., Tan, S. Y., Chan, X., Tan, W., Liu, M., Yong, K. S. M., Lai, F., Ceccarello, E., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.580968 · Cited by 90 · see citing works
Moro-Sibilot, L., Blanc, P., Taillardet, M., Bardel, É., Couillault, C., Boschetti, G., Traverse‐Glehen, A., Defrance, T., Kaiserlian, D., & Dubois, B. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.04.014 · Cited by 89 · see citing works
Ichimura‐Shimizu, M., Kawase, M., Masuzumi, M., Sakaki, M., Nagata, Y., Tanaka, K., Suruga, K., Tamaru, S., Kato, S., Tsuneyama, K., et al. (2014) · Hepatology Research · doi:10.1111/hepr.12358 · Cited by 88 · see citing works
Zang, S., Wang, L., Ma, X., Zhu, G., Zhuang, Z., Xun, Y., Zhao, F., Yang, W., Liu, J., Luo, Y., et al. (2015) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-015-0682-9 · Cited by 80 · see citing works
Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis
Kjærgaard, K., Frisch, K., Sørensen, M., Munk, O. L., Hofmann, A. F., Horsager, J., Schacht, A. C., Erickson, M., Shapiro, D., & Keiding, S. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.07.028 · Cited by 80 · see citing works
IL-33 treatment attenuated diet-induced hepatic steatosis but aggravated hepatic fibrosis
Gao, Y., Liu, Y., Yang, M., Guo, X., Zhang, M., Li, H., Li, J., & Zhao, J. (2016) · Oncotarget · doi:10.18632/oncotarget.9259 · Cited by 79 · see citing works
Forkel, M., Berglin, L., Kekäläinen, E., Carlsson, A., Svedin, E., Michaëlsson, J., Nagasawa, M., Erjefalt, J. S., Mori, M., Flodström‐Tullberg, M., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201646890 · Cited by 79 · see citing works
Immune surveillance of the liver by T cells
Ficht, X., & Iannacone, M. (2020) · Science immunology · doi:10.1126/sciimmunol.aba2351 · Cited by 74 · see citing works
Kruger, A. J., Fuchs, B. C., Masia, R., Holmes, J. A., Salloum, S., Sojoodi, M., Ferreira, D. S., Rutledge, S. M., Caravan, P. D., Alatrakchi, N., et al. (2018) · Hepatology Communications · doi:10.1002/hep4.1160 · Cited by 67 · see citing works
Pais, R., Redheuil, A. B., Cluzel, P., Ratziu, V., & Giral, P. (2018) · Hepatology · doi:10.1002/hep.30223 · Cited by 67 · see citing works
Miyake, T., Abe, M., Tokumoto, Y., Hirooka, M., Furukawa, S., Kumagi, T., Hamada, M., Kawasaki, K., Tada, F., Ueda, T., et al. (2013) · Hepatology International · doi:10.1007/s12072-012-9345-8 · Cited by 59 · see citing works
B cells and their cytokine activities implications in human diseases
Fillatreau, S. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.07.020 · Cited by 59 · see citing works
Wang, T., Sun, G.-Y., Wang, Y., Li, S.-X., Zhao, X.-Y., Zhang, C.-P., Jin, H., Tian, D., Liu, K., Shi, W., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802534rr · Cited by 40 · see citing works
Adreno-cortical function tests in lepra reaction.
Balakrishnan, S., Ramanujam, K., & Ramu, G. (1974) · PubMed · Cited by 4 · see citing works
Jaundice, Hepatomegaly, and Abnormal Liver Function
Rutka, J. T., Ryning, F. W., & Meter, S. W. V. (1988) · Hospital Practice · doi:10.1080/21548331.1988.11703587 · Cited by 1 · see citing works
[Forum of male and female romand nurses. We now have to put into practice....].
Kocher, B. (1987) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment
Llovet, J. M., Willoughby, C. E., Singal, A. G., Greten, T. F., Heikenwälder, M., El-Serag, H. B., Finn, R. S., & Friedman, S. L. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00754-7 · Cited by 354 · see citing works
An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH
Tacke, F., Puengel, T., Loomba, R., & Friedman, S. L. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.03.038 · Cited by 321 · see citing works
Natural history and progression of metabolic dysfunction-associated steatotic liver disease
Hagström, H., Shang, Y., Hegmar, H., & Nasr, P. (2024) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(24)00193-6 · Cited by 310 · see citing works
Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
Bu, T., Sun, Z., Pan, Y., Deng, X., & Yuan, G. (2024) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2023.0277 · Cited by 131 · see citing works
Kupffer cell–like syncytia replenish resident macrophage function in the fibrotic liver
Peiseler, M., Araujo David, B., Zindel, J., Surewaard, B. G. J., Lee, W.-Y., Heymann, F., Nusse, Y., Castanheira, F. V. S., Shim, R., Guillot, A., et al. (2023) · Science · doi:10.1126/science.abq5202 · Cited by 123 · see citing works
Nuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease
Puengel, T., Liu, H., Guillot, A., Heymann, F., Tacke, F., & Peiseler, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052668 · Cited by 95 · see citing works
Hepatic Stellate Cell-Immune Interactions in NASH
Carter, J. K., & Friedman, S. L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.867940 · Cited by 79 · see citing works
Immunopathogenic mechanisms and immunoregulatory therapies in MASLD
He, Y., Chen, Y., Qian, S., van Der Merwe, S., Dhar, D., Brenner, D. A., & Tacke, F. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01307-5 · Cited by 81 · see citing works
“…stress, mitochondrial dysfunction, and oxidative stress culminate in hepatocyte injury, leading to apoptosis, necrosis, and necroptosis and the release of damage-associated molecular patterns (DAMPs) and proin fl ammatory mediators that drive immune cell in fi ltration and liver in fl ammation [138].”
Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis
Xiao, Y., Batmanov, K., Hu, W., Zhu, K., Tom, A. Y., Guan, D., Jiang, C., Cheng, L., McCright, S. J., Yang, E. C., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adc9653 · Cited by 69 · see citing works
Wang, Y.-F., Zhang, W.-L., Li, Z.-X., Liu, Y., Tan, J., Yin, H.-Z., Zhang, Z.-C., Piao, X.-J., Ruan, M.-H., Dai, Z.-H., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01797-1 · Cited by 69 · see citing works
The interplay between nonalcoholic fatty liver disease and atherosclerotic cardiovascular disease
Finney, A. C., Das, S., Kumar, D., McKinney, M. P., Cai, B., Yurdagul, A., & Rom, O. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1116861 · Cited by 40 · see citing works
Martin, O. P., Wallace, M. S., Oetheimer, C., Patel, H. B., Butler, E. C., Wong, L. P., Huang, P., Elbaz, J., Costentin, C., Salloum, S., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02255-y · Cited by 45 · see citing works
Recent insights into the pathogenesis and therapeutic targets of chronic liver diseases
Wen, Y., Ma, L., & Ju, C. (2023) · eGastroenterology · doi:10.1136/egastro-2023-100020 · Cited by 31 · see citing works
Ag-driven CD8+ T cell clonal expansion is a prominent feature of MASH in humans and mice
Burtis, A. E. C., DeNicola, D. M. C., Ferguson, M. E., Santos, R. G., Pinilla, C., Kriss, M. S., Orlicky, D. J., Tamburini, B. A. J., Gillen, A. E., & Burchill, M. A. (2025) · Hepatology · doi:10.1097/hep.0000000000000971 · Cited by 30 · see citing works
Iwata, A., Maruyama, J., Natsuki, S., Nishiyama, A., Tamura, T., Tanaka, M., Shichino, S., Seki, T., Komai, T., Okamura, T., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06357-5 · Cited by 25 · see citing works
The Nr4a family regulates intrahepatic Treg proliferation and liver fibrosis in MASLD models
Aki, D., Hayakawa, T., Srirat, T., Shichino, S., Ito, M., Saitoh, S.-I., Mise-Omata, S., & Yoshimura, A. (2024) · Journal of Clinical Investigation · doi:10.1172/jci175305 · Cited by 22 · see citing works
Advancements in MAFLD Modeling with Human Cell and Organoid Models
Wang, S.-X., Yan, J.-S., & Chan, Y.-S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911850 · Cited by 22 · see citing works
A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis
Park, J.-S., Lee, J., Wang, F., Ma, H., Zhou, Z., Lee, Y.-S., Oh, K., Lee, H., Sui, G., Lee, S., et al. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01408-1 · Cited by 15 · see citing works
Novel regulators of hepatic macrophages in liver fibrosis
Tang, X., Bai, M., Du, X., Wang, H., Liu, M., Fu, X., Zhang, H., Liang, S., & Wang, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1705503 · Cited by 12 · see citing works
Yanagisawa, H., Maeda, H., Noguchi, I., Tanaka, M., Wada, N., Nagasaki, T., Kobayashi, K., Kanazawa, G., Taguchi, K., Chuang, V. T. G., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103314 · Cited by 10 · see citing works
Jin, H., Zhong, X., Zhang, C., Wu, Y., Sun, J., Wang, X., Wang, Z., Zhu, J., Jiang, Y., Du, X., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102131 · Cited by 2 · see citing works
Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis
Hanna, B. S., Langston, P. K., Marin-Rodero, M., Ramirez, R. N., Wan, M., Benoist, C., & Mathis, D. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536314123 · Cited by 1 · see citing works
“It is by now well accepted that inflammation is an important element of MASH (12).”
- Authors
- Huby, T., & Gautier, E. L.
- Affiliations
- Inserm (FR)
- Corresponding author
- Gautier, Emmanuel L.
- Venue
- Nature Reviews Immunology
- Published
- 2021-11-05
- Volume
- 22
- Issue
- 7
- Pages
- 429-443
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC8570243
- OpenAlex
- W3208498374
- Cited by
- 573
- References
- 181
- Citations by year
- 2026: 77 · 2025: 163 · 2024: 168 · 2023: 116 · 2022: 48 · 2021: 1
- FWCI
- 13.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-17-CE14-0009, ANR-15-CE14, ANR-17-CE14-0023, ANR-20-CE15-0018, ANR-17, ANR-17-CE14-0044, ANR-15-CE14-0015)
- Institut National de la Santé et de la Recherche Médicale
- Fondation de France (00056835, 00096295)
- Sorbonne Université
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- nonalcoholic steatohepatitis, non-alcoholic fatty liver disease, liver inflammation, immune cells, NASH pathogenesis, disease progression
- MeSH terms
- Humans, Inflammation, Liver Cirrhosis, Severity of Illness Index, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review