Cited by 40Antifungal resistance and susceptibilityFungal Infections and StudiesOcular Infections and Treatments

Antifungal susceptibility testing in Candida, Aspergillus and Cryptococcus infections: are the MICs useful for clinicians?

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Bassetti, M., Vena, A., Bouza, E., Peghin, M., Muñoz, P., Righi, E., Pea, F., Lackner, M. +1 more·2020·Clinical Microbiology and Infection

Abstract

Background Invasive fungal infections (IFIs) represent a global issue and affect various patient populations. In recent years, resistant fungal isolates showing increased azole or echinocandin MICs have been reported, and their potential clinical impact has been investigated.Aims To provide an update on the epidemiology of resistance among fungi (e.g., Candida spp., Aspergillus spp., and Cryptococcus spp.) and to offer a critical appraisal of the relevant literature regarding the impact of MICs on clinical outcome in patients with IFI.Sources PubMed search with relevant keywords along with a personal collection of relevant publications.Content Although antifungal resistance has been associated with a poorer response to antifungal therapy in various studies, other factors such as comorbidities, septic shock and source of infection appear to be key determinants affecting the clinical outcome of patients with IFI.Implications Future international collaborative studies are required to tease out the relative contribution of in vitro antifungal resistance on patient outcomes, thus enabling the optimization of IFI management.

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Crossref · 10.1016/j.cmi.2020.02.017

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Authors
Bassetti, M., Vena, A., Bouza, E., Peghin, M., Muñoz, P., Righi, E., Pea, F., Lackner, M., & Lass-Flörl, C.
Affiliations
  • University of Udine (IT)
  • Universidad Complutense de Madrid (ES)
  • University of Verona (IT)
  • Innsbruck Medical University (AT)
Corresponding author
Bassetti, M.
Venue
Clinical Microbiology and Infection
Publisher
Elsevier BV
Published
2020-08
Volume
26
Issue
8
Pages
1024-1033
ISSN
1198-743X (ISSN-L)
OpenAlex
W3006735110
Cited by
40
References
68
Citations by year
2026: 6 · 2025: 6 · 2024: 4 · 2023: 9 · 2022: 4 · 2021: 6 · 2020: 5
FWCI
0.28
Type
journal article
Language
en
Open access
Locations
  • Clinical Microbiology and Infection (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System (University of Udine) (submittedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • IrInSubria (University of Insubria) (submittedVersion)
  • CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Keywords
invasive fungal infections, antifungal susceptibility, minimum inhibitory concentration, antifungal resistance, Candida, Aspergillus, Cryptococcus, azole resistance, echinocandin resistance, clinical outcomes, comorbidities, septic shock, infection source
MeSH terms
Invasive Fungal Infections, Antifungal Agents, Aspergillus, Candida, Cryptococcus, Fungi, Humans, Microbial Sensitivity Tests, Risk Factors, Comorbidity, Drug Resistance, Fungal

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