Antifungal susceptibility testing in Candida, Aspergillus and Cryptococcus infections: are the MICs useful for clinicians?
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Background Invasive fungal infections (IFIs) represent a global issue and affect various patient populations. In recent years, resistant fungal isolates showing increased azole or echinocandin MICs have been reported, and their potential clinical impact has been investigated.Aims To provide an update on the epidemiology of resistance among fungi (e.g., Candida spp., Aspergillus spp., and Cryptococcus spp.) and to offer a critical appraisal of the relevant literature regarding the impact of MICs on clinical outcome in patients with IFI.Sources PubMed search with relevant keywords along with a personal collection of relevant publications.Content Although antifungal resistance has been associated with a poorer response to antifungal therapy in various studies, other factors such as comorbidities, septic shock and source of infection appear to be key determinants affecting the clinical outcome of patients with IFI.Implications Future international collaborative studies are required to tease out the relative contribution of in vitro antifungal resistance on patient outcomes, thus enabling the optimization of IFI management.
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The resistance rate of Candida tropicalis for fluconazole in the present study (10.1-30.5%) was higher than previously reported for other regions.
“In the present study, the resistance rate of C. tropicalis for FLCZ (10.1–30.5%) was higher than that previously reported for other regions.”
The fluconazole resistance rates around the world were 0.6-1.7% in C. albicans, 8.0-16.2% in C. glabrata, 1.3-15.0% in C. parapsilosis, and 1.1-5.1% in C. tropicalis.
“the resistance rate of fluconazole (FLCZ) was found to be 0.6–1.7% in C. albicans, 8.0–16.2% in C. glabrata, 1.3–15.0% in C. parapsilosis, and 1.1–5.1% in C. tropicalis around the world.9”
Bassetti et al. reported the resistance rate of Candida tropicalis for fluconazole to be 1.1% and 5.1% in Latin America and North America, respectively.
“Bassetti, et al. reported the resistance rate of C. tropicalis for FLCZ to be 1.1% and 5.1% in Latin America and North America, respectively.9”
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- Authors
- Bassetti, M., Vena, A., Bouza, E., Peghin, M., Muñoz, P., Righi, E., Pea, F., Lackner, M., & Lass-Flörl, C.
- Affiliations
- University of Udine (IT)
- Universidad Complutense de Madrid (ES)
- University of Verona (IT)
- Innsbruck Medical University (AT)
- Corresponding author
- Bassetti, M.
- Venue
- Clinical Microbiology and Infection
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 26
- Issue
- 8
- Pages
- 1024-1033
- ISSN
- 1198-743X (ISSN-L)
- OpenAlex
- W3006735110
- Cited by
- 40
- References
- 68
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 4 · 2023: 9 · 2022: 4 · 2021: 6 · 2020: 5
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Clinical Microbiology and Infection (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (University of Udine) (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- IrInSubria (University of Insubria) (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Keywords
- invasive fungal infections, antifungal susceptibility, minimum inhibitory concentration, antifungal resistance, Candida, Aspergillus, Cryptococcus, azole resistance, echinocandin resistance, clinical outcomes, comorbidities, septic shock, infection source
- MeSH terms
- Invasive Fungal Infections, Antifungal Agents, Aspergillus, Candida, Cryptococcus, Fungi, Humans, Microbial Sensitivity Tests, Risk Factors, Comorbidity, Drug Resistance, Fungal
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