Azole Antifungal Resistance Today: Focus on Aspergillus

Bowyer, Paul; Moore, Caroline B.; Rautemaa, Riina; Denning, David W.; Richardson, Malcolm D.

doi:10.1007/s11908-011-0218-4

Cited by 44Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Plant Pathogen Control

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Azole Antifungal Resistance Today: Focus on Aspergillus

Bowyer, Paul, Moore, Caroline B., Rautemaa, Riina, Denning, David W., Richardson, Malcolm D.·2011·Current Infectious Disease Reports

DOI 10.1007/s11908-011-0218-4

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Abstract

Oral triazole therapy is well established for the treatment of invasive aspergillosis (IPA), allergic aspergillosis (ABPA), and chronic pulmonary aspergillosis (CPA), and is often long-term. Resistance to triazole azole antifungal drugs in Aspergillus fumigatus is now a major clinical problem in a number of European locations, in China, Canada and the USA with particularly high frequencies from the north-west of the UK, and The Netherlands. A number of centers are reporting the continuing increasing frequency and evolution of resistance mechanisms in A. fumigatus, in both azole-naïve and patients treated with azoles. The increasing rate of resistance is of concern. A number of resistance mechanisms have been found. The biofilm modality of Aspergillus growth may have a number of therapeutic implications for aspergillosis, including antifungal resistance. Microbiological diagnosis of aspergillosis is limited by poor culture yield, leading to uncertainty about the frequency of triazole resistance. Direct resistance testing in culture-negative clinical samples may add additional insights into the prevalence of azole resistance in A. fumigatus.

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Members from Acremonium, Aspergillus, Cladosporium, Fusarium, and Pneumocystis, in addition to Candida, are among the biofilm formers tested for drug susceptibility in vitro.
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From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [20]
Cells in biofilms have been found to be more resistant to drugs compared with cells grown in suspension culture.
“For example, a number of these biofilm formers (Table 3) have been tested for drug susceptibility in vitro, and cells in biofilms have been found to be more resistant to drugs compared with cells grown in suspension culture.”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [20]

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Azole resistance in Aspergillus fumigatus
Verweij, P. E., Snelders, E., & Melchers, W. J. G. (2008) · Wageningen Academic Publishers eBooks · doi:10.3920/9789086866359_014 · Cited by 1

Authors: Bowyer, P., Moore, C. B., Rautemaa, R., Denning, D. W., & Richardson, M. D.
Affiliations: Manchester Academic Health Science Centre (GB)
Corresponding author: Richardson, Malcolm D.
ORCID: Bowyer, Paul
Moore, Caroline B.
Denning, David W.
Richardson, Malcolm D.
Venue: Current Infectious Disease Reports
Publisher: Springer Science and Business Media LLC
Published: 2011-09-20
Volume: 13
Issue: 6
Pages: 485-491
ISSN: 1523-3847 (ISSN-L)
1534-3146
DOI: 10.1007/s11908-011-0218-4
OpenAlex: W2070897511
Cited by: 44
References: 32
Citations by year: 2024: 2 · 2022: 2 · 2020: 6 · 2019: 3 · 2017: 4 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 7 · 2012: 5
FWCI: 3.45
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Infectious Disease Reports (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
Keywords: azole resistance, triazole resistance, Aspergillus fumigatus, invasive aspergillosis, allergic bronchopulmonary aspergillosis, chronic pulmonary aspergillosis, antifungal resistance mechanisms, biofilm formation, resistance testing

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Azole Antifungal Resistance Today: Focus on Aspergillus

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