Memory-aware curriculum federated learning for breast cancer classification
Open accessAbstract
Background and objective For early breast cancer detection, regular screening with mammography imaging is recommended. Routine examinations result in datasets with a predominant amount of negative samples. The limited representativeness of positive cases can be problematic for learning Computer-Aided Diagnosis (CAD) systems. Collecting data from multiple institutions is a potential solution to mitigate this problem. Recently, federated learning has emerged as an effective tool for collaborative learning. In this setting, local models perform computation on their private data to update the global model. The order and the frequency of local updates influence the final global model. In the context of federated adversarial learning to improve multi-site breast cancer classification, we investigate the role of the order in which samples are locally presented to the optimizers.Methods We define a novel memory-aware curriculum learning method for the federated setting. We aim to improve the consistency of the local models penalizing inconsistent predictions, i.e., forgotten samples. Our curriculum controls the order of the training samples prioritizing those that are forgotten after the deployment of the global model. Our approach is combined with unsupervised domain adaptation to deal with domain shift while preserving data privacy.Results Two classification metrics: area under the receiver operating characteristic curve (ROC-AUC) and area under the curve for the precision-recall curve (PR-AUC) are used to evaluate the performance of the proposed method. Our method is evaluated with three clinical datasets from different vendors. An ablation study showed the improvement of each component of our method. The AUC and PR-AUC are improved on average by 5% and 6%, respectively, compared to the conventional federated setting.Conclusions We demonstrated the benefits of curriculum learning for the first time in a federated setting. Our results verified the effectiveness of the memory-aware curriculum federated learning for the multi-site breast cancer classification. Our code is publicly available at: https://github.com/ameliajimenez/curriculum-federated-learning.
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TL;DR
The paper proposes a memory-aware curriculum federated learning method, combined with unsupervised domain adaptation, for multi-site breast cancer classification on mammograms. It reports that scheduling samples forgotten after global model deployment improves federated classification performance over conventional federated learning.
Key findings
- The proposed Fed-Align-CL achieved average AUC 0.79 and PR-AUC 0.82 across Hologic, Siemens, and GE, compared with Fed at AUC 0.75 and PR-AUC 0.77 in Table III.
- The abstract reports that AUC and PR-AUC improved on average by 5% and 6%, respectively, compared to the conventional federated setting.
- The best initialization strategy was pretrained weights from Wu et al. [51], with average AUC 0.75 in Table II, versus local model 0.53, scratch 0.63, and DDSM 0.65.
- Statistical testing reported significant improvements for Fed-Align-CL versus Fed (AUC p=1.46E-04; PR-AUC p=9.82E-06) and versus Fed-Align (AUC p=5.65E-02; PR-AUC p=1.42E-02) in Table V.
Methods
- The method builds on federated averaging with federated adversarial domain adaptation, differential privacy via Gaussian noise on shared weights/embeddings, and a memory-aware curriculum data scheduler. The scheduler scores samples higher when local prediction was correct but global prediction became incorrect after aggregation, using ρ=2.0 for forgotten samples and 1.0 otherwise.
- Experiments used three Full Field Digital Mammography datasets from different vendors: Hologic (1460 subjects; 730 benign/normal, 730 malignant), Siemens/INBreast (410 subjects; 287 benign/normal, 123 malignant), and GE (852 subjects; 421 benign/normal, 431 malignant). Each dataset was split approximately 70%:10%:20% for training, validation, and test.
- The feature extractor was a ResNet-22 pretrained with Wu et al. [51] weights; models were trained 5 times with different seeds, using Adam for 50 epochs, initial learning rate 1e-5, Q=120 optimization iterations, and Gaussian noise variance σ²=0.001. Evaluation metrics were ROC-AUC and PR-AUC.
Limitations
- The paper states there is still room for improvement when dealing with small datasets, such as Siemens, and that some sites trade a significant gain in generalization for a local performance drop.
- The paper states that the computational cost of analyzing high-resolution images imposes resource limitations, that Grad-CAM interpretation is subjective, and that patient reidentification or information leakage cannot be discarded unless anonymization destroys data fidelity.
- Evident from the text: the evaluation is limited to three mammography datasets from three vendors, with two private datasets and one public dataset, and the method relies on full mammograms and classification labels rather than region-wise ground truth.
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0 of 26 cited sources checked · 0 supported · 0 flagged
- Findingown data
The individual models (Single) achieve an average AUC of 0.83 for the three sites.
“Second, the individual models (Single) achieve an average AUC of 0.83 for the three sites.”
Quote in the paperNot a substantial claim - Findingown data
An ablation study showed the improvement of each component of our method.
“An ablation study showed the improvement of each component of our method.”
Quote in the paperSubstantial claim - Findingnone given
The performance for the different domains of Fed and Fed-CL can be uneven.
“However, the performance for the different domains of these two methods can be uneven.”
Quote in the paperSubstantial claim - Findingnone given
Classification results were better when all local models were initialized either randomly or pretrained on a single dataset (DDSM) than when each of them was pretrained on a small private dataset.
“Interestingly as well, classification results were better when all local models were initialized either randomly or pretrained on a single dataset (DDSM) than when each of them was pretrained on a small private dataset.”
Quote in the paperNot a substantial claim - Findingown data
Some qualitative results using Gradient-weighted Class Activation Mappings (Grad-CAMs) show the generalisation effect of the federated approaches.
“Some qualitative results using Gradient-weighted Class Activation Mappings (Grad-CAMs) [58] show the generalisation effect of the federated approaches in Fig. 7 (Suppl.Material).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [58] Tse, 2007, Calcification in breast lesions: pathologists’ perspective, Journal of Clinical Pathology source
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- Findingreasoning
The best approach was using the pretrained weights from Wu et al.
“We found that the best approach was using the pretrained weights from Wu et al. [51].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [51] Selvaraju, 2017, Grad-CAM: visual explanations from deep networks via gradient-based localization
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- Findingown data
Our results verified the effectiveness of the memory-aware curriculum federated learning for the multi-site breast cancer classification.
“Our results verified the effectiveness of the memory-aware curriculum federated learning for the multi-site breast cancer classification.”
Quote in the paperSubstantial claim - Findingcitation
The classification metrics were better with the pretrained weights from Wu et al.
“However, the classification metrics were better with the pretrained weights [51], as discussed in the previous experiment.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [51] Selvaraju, 2017, Grad-CAM: visual explanations from deep networks via gradient-based localization
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- Findingown data
Our analysis shows that the classification improvement of our method is statistically significant.
“Our analysis shows that the classification improvement of our method is statistically significant.”
Quote in the paperSubstantial claim - Findingown data
Cross models do not generalize well across manufacturers.
“First, as expected, we find that the Cross models do not generalize well across manufacturers.”
Quote in the paperSubstantial claim - Findingown data
We also find a consistent improvement with our proposed method when the models are trained from scratch.
“We also find a consistent improvement with our proposed method when the models are trained from scratch.”
Quote in the paperNot a substantial claim - Findingnone given
There is a direct correlation between the amount of noise introduced in the system and the model performance.
“There is a direct correlation between the amount of noise introduced in the system and the model performance”
Quote in the paperNot a substantial claim - Findingown data
Different system vendors produce images following significantly different intensity profiles for the same imaging modality.
“For the same imaging modality, different system vendors produce images following significantly different intensity profiles.”
- Also stated in: § A. Datasets · plain
“Intensity profiles [50] among the datasets varied significantly, as can be observed in Fig. 1.”
Quote in the paperSubstantial claim - Also stated in: § A. Datasets · plain
- Findingnone given
Our CL strategy is shown effective for the multi-site breast cancer classification on high-resolution mammograms of clinical datasets from different vendors.
“Our CL strategy is shown effective for the multi-site breast cancer classification on high-resolution mammograms of clinical datasets from different vendors.”
Quote in the paperSubstantial claim - Findingown data
Fed-CL method improves on average the PR-AUC with respect to Fed.
“First, we find that the Fed-CL method improves on average the PR-AUC with respect to Fed.”
Quote in the paperSubstantial claim - Findingown data
Fed-Align-CL outperforms the compared approaches in uncertain and difficult cases.
“We noted that the proposed method (Fed-Align-CL) outperforms the compared approaches in uncertain and difficult cases.”
Quote in the paperSubstantial claim - Findingown data
The combination of FL with CL results in samples more spread along the manifold, although still dependent on the domain.
“Second, the combination of FL with CL results in samples more spread along the manifold, although still dependent on the domain.”
Quote in the paperNot a substantial claim - Findingreasoning
On the GE site, the domain adaptation component has a higher effect than the curriculum.
“Regarding the federated models on the GE site, the domain adaptation component has a higher effect than the curriculum.”
Quote in the paperNot a substantial claim - Findingown data
Some barely visible masses are correctly captured as malignant by Fed-Align-CL.
“Moreover, some of the barely visible masses are correctly captured as malignant by our method.”
Quote in the paperNot a substantial claim - Findingown data
Models trained on single-vendor images do not generalize adequately to other sites.
“Models trained on single-vendor images do not generalize adequately to other sites.”
Quote in the paperSubstantial claim - Findingown data
Fed-Align-CL correctly classifies a larger percentage of images from the Malignant class than other methods.
“We found that our proposed method correctly classifies a larger percentage of images from the Malignant class than other methods.”
Quote in the paperSubstantial claim - Findingown data
Models that perform domain adaptation have input images better clusterized according to the label instead of the domain.
“In the plots that correspond to the models that perform DA, we can see that the input images are better clusterized according to the label instead of the domain.”
Quote in the paperNot a substantial claim - Findingown data
The negative effect of domain shift for malignancy classification with multi-site mammograms is confirmed.
“In this work, we have investigated and confirmed the negative effect of domain shift for malignancy classification with multi-site mammograms.”
Quote in the paperSubstantial claim - Findingown data
Domain alignment is particularly helpful for Siemens.
“We find that the domain alignment is particularly helpful for Siemens.”
Quote in the paperNot a substantial claim - Findingnone given
There is still room for improvement when dealing with small datasets, such as Siemens.
“However, there is still some room for improvement when dealing with small datasets, such as Siemens.”
Quote in the paperNot a substantial claim - Findingown data
The features learned by Fed are better clusterized according to the input domain, i.e., Fed learns domain-variant features.
“First, we can see that the features learned by Fed are better clusterized according to the input domain, i.e., Fed learns domain-variant features.”
Quote in the paperNot a substantial claim - Findingown data
Fed-Align-CL avoids the misclassification of benign samples containing benign calcifications and benign distortions (e.g. surgery remainings).
“That is, our method allows to avoid the misclassification of benign samples containing benign calcifications and benign distortions (e.g.surgery remainings).”
Quote in the paperSubstantial claim - Premisecitation
There is only one prior FL work in the context of breast imaging, dealing with the problem of density classification.
“To the best of our knowledge there is only one prior FL work in the context of breast imaging [29] dealing with the problem of density classification.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [29] X. Li, M. Jiang, X. Zhang, M. Kamp, Q. Dou, FedBN: federated learning on non-IID features via local batch normalization, arXiv preprint arXiv:2102.07623(2021).
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- Interpretationnone given
The Fed-Align approach helps to learn domain-invariant features that are beneficial for the classification task.
“The Fed-Align approach helps to learn domain-invariant features that are beneficial for the classification task.”
Quote in the paperSubstantial claim - Premisecitation
It is often the case that important cues for diagnosis are subtle findings in the image, which could be as small as 10 pixels in length.
“It is often the case that important cues for diagnosis are subtle findings in the image, which could be as small as 10 pixels in length [3].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [3] Bengio, 2009, Curriculum learning
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- Premisecitation
The above UDA approaches need access to both source and target data despite less annotation requirements.
“Despite less annotation requirements, the above UDA approaches need access to both source and target data [33], [34].”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [33] Lu, 2022, Federated learning for computational pathology on gigapixel whole slide images, Medical Image Analysis source
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- cites [34] Luo, 2022, FedSLD: federated learning with shared label distribution for medical image classification
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- Interpretationown data
We demonstrated the benefits of curriculum learning for the first time in a federated setting.
“We demonstrated the benefits of curriculum learning for the first time in a federated setting.”
Quote in the paperSubstantial claim - Interpretationnone given
The variability in intensity profiles among the datasets is mainly due to the different mammography systems and acquisition protocols used to generate digital mammograms.
“This variability is mainly due to the different mammography systems and acquisition protocols used to generate digital mammograms.”
Quote in the paperSubstantial claim - Interpretationcitation
The proposed method can be effective to deal with performance inconsistency across data sets and models.
“Furthermore, our proposed method can be effective to deal with performance inconsistency across data sets and models [56].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [56] Sung, 2021, Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA: A Cancer Journal for Clinicians
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- Interpretationnone given
By monitoring the local and global classification predictions, we can schedule the training samples to boost the alignment between domain pairs and improve the classification performance.
“We have shown that, by monitoring the local and global classification predictions, we can schedule the training samples to boost the alignment between domain pairs and improve the classification performance.”
Quote in the paperSubstantial claim
- May combine two claims. 19
- Classified as probably not a substantial claim. 18
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Findingown dataThe AUC and PR-AUC are improved on average by 5% and 6%, respectively, compared to the conventional federated setting.
“The AUC and PR-AUC are improved on average by 5% and 6%, respectively, compared to the conventional federated setting.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataOur proposed Fed-Align-CL achieves on average the highest AUC and PR-AUC.
“Finally, we can see that our proposed Fed-Align-CL achieves on average the highest AUC and PR-AUC.”
Quote in the paperSubstantial claimMay combine two claims.
Findingnone givenWe combine our data scheduler with federated adversarial learning and show that the association is beneficial for the classification and the alignment between domain pairs.
“We combine our data scheduler with federated adversarial learning and show that the association is beneficial for the classification and the alignment between domain pairs.”
Quote in the paperSubstantial claimMay combine two claims.
FindingreasoningThe best performing model is Mix, which is trained with mammography images and their corresponding annotations from all sites, thus, not preserving privacy.
“As expected, the best performing model is Mix, which is trained with mammography images and their corresponding annotations from all sites, thus, not preserving privacy.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataWhen comparing our performance to other works on the publicly available INBreast dataset (Siemens), we achieve an AUC comparable to Wu et al., but lower than two other works with an AUC of 0.95.
“When comparing our performance to other works on the publicly available INBreast dataset (Siemens), we achieve an AUC comparable to [51], but lower than [50], [57] with an AUC of 0.95.”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [51] Selvaraju, 2017, Grad-CAM: visual explanations from deep networks via gradient-based localization
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- cites [50] Samuli, 2017, Temporal ensembling for semi-supervised learning
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- cites [57] Tang, 2018, Attention-guided curriculum learning for weakly supervised classification and localization of thoracic diseases on chest radiographs
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Probably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataFig. 6 in Supplementary Material shows a similar behaviour for the penultimate classification layer.
“Fig. 6 in Supplementary Material shows a similar behaviour for the penultimate classification layer.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataSome sites preserve the performance on the local test set after collaborative training, while others trade a significant gain in generalization for a local performance drop.
“While some sites preserve the performance on the local test set after collaborative training, others trade a significant gain in generalization for a local performance drop.”
Quote in the paperSubstantial claimMay combine two claims.
Findingnone givenWith the same collaborative training, there is no onsite performance drop for the GE and Hologic sites, which benefit from a significant generalization improvement at no cost.
“With the same collaborative training, there is no onsite performance drop for the GE and Hologic sites, which benefit from a significant generalization improvement at no cost.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
Findingnone givenThe computational cost of analyzing high-resolution images imposes some resource limitations on the federated scenario.
“The computational cost of analyzing high-resolution images imposes some resource limitations on our federated scenario.”
Quote in the paperSubstantial claim- Rests on an assumption: The small size of the lesion requires high-resolution images showing tissue details to provide a precise diagnosis.
May combine two claims.
Findingown dataFed-Align-CL reduces activations on the boundary or outside the breast and better focuses on lesions.
“Our method (Fed-Align-CL) reduces activations on the boundary or outside the breast and better focuses on lesions.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductown dataWe applied one-way ANOVA followed by Bonferroni's post-hoc t-test comparisons tests to evaluate for differences in the performance of the federated approaches and reported the p-values in Table 5.
“We applied one-way ANOVA followed by Bonferroni's post-hoc t-test comparisons tests to evaluate for differences in the performance of the federated approaches and reported the p-values in Table 5 (Suppl.Material).”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenWe train our models 5 times with different seed initialization for the classifier Cls and domain discriminator D.
“We train our models 5 times with different seed initialization for the classifier Cls and domain discriminator D.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim. May combine two claims.
PremisecitationWe employ as feature extractor F the architecture proposed by Wu et al., a ResNet-22 that is adapted to take high-resolution images (∼ 4 megapixels) as input, and achieved state-of-the-art classification performance for breast cancer screening.
“We employ as feature extractor F the architecture proposed by Wu et al. [51], a ResNet-22 [52] that is adapted to take high-resolution images (∼ 4 megapixels) as input, and achieved state-of-the-art classification performance for breast cancer screening.”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [51] Selvaraju, 2017, Grad-CAM: visual explanations from deep networks via gradient-based localization
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- cites [52] Sheller, 2018, Multi-institutional deep learning modeling without sharing patient data: a feasibility study on brain tumor segmentation
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Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationUDA methods force the model to learn domain-agnostic features through adversarial learning or a specific type of batch normalization.
“UDA methods force the model to learn domain-agnostic features through adversarial learning [6] or a specific type of batch normalization [7].”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [6] Carlucci, 2017, Just dial: domain alignment layers for unsupervised domain adaptation
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- cites [7] Darzidehkalani, 2022, Federated learning in medical imaging: Part II: methods, challenges, and considerations, Journal of the American College of Radiology source
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PremisecitationFedAvg is a generalization of FedSGD, which allows local nodes to perform more than one batch update on local data and exchanges the updated weights rather than the gradients.
“Federated averaging FedAvg is a generalization of FedSGD [46], which allows local nodes to perform more than one batch update on local data and exchanges the updated weights rather than the gradients.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [46] Ribli, 2018, Detecting and classifying lesions in mammograms with deep learning, Scientific Reports source
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Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
InterpretationreasoningThis behaviour is expected because their model was trained with a very-large private dataset.
“This behaviour is expected because their model was trained with a very-large private dataset.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationOur scoring function is related to temporal ensembling and consistency training, which are used in semi-supervised setups.
“Our scoring function is related to temporal ensembling [44] and consistency training [45], which are used in semi-supervised setups.”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [44] D. Peterson, P. Kanani, V.J. Marathe, Private federated learning with domain adaptation, arXiv preprint arXiv:1912.06733(2019).
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- cites [45] Redmon, 2016, You only look once: unified, real-time object detection
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Classified as probably not a substantial claim. May combine two claims.
Study design and conductnone givenWe do not use any site-specific image filtering to compensate the domain shift, and we apply the same preprocessing to the images from the three sites.
“We do not use any site-specific image filtering to compensate the domain shift, and we apply the same preprocessing to the images from the three sites.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationThe later two works rely on regionwise ground truth: the first leveraging ROI localization and the second one using patch pretraining.
“However, the later two works rely on regionwise ground truth: the first leveraging ROI localization and the second one using patch pretraining.”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [50] Samuli, 2017, Temporal ensembling for semi-supervised learning
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- cites [57] Tang, 2018, Attention-guided curriculum learning for weakly supervised classification and localization of thoracic diseases on chest radiographs
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Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationDifferential privacy perturbs the parameters of each local model by purposely adding noise before uploading them to the server for aggregation.
“Differential privacy perturbs the parameters of each local model by purposely adding noise before uploading them arXiv:2107.02504v2[cs.CV] 6 Jan 2023 to the server for aggregation.”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [9] Dong, 2021, Federated contrastive learning for decentralized unlabeled medical images
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- cites [10] A. Dosovitskiy, L. Beyer, A. Kolesnikov, D. Weissenborn, X. Zhai, T. Unterthiner, M. Dehghani, M. Minderer, G. Heigold, S. Gelly, et al., An image is worth 16x16 words: transformers for image recognition at scale, International Conference on Learning Representations (2021).
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Premisenone givenIn the federated setting, data is stored locally and cannot be shared.
“However, in the federated setting, data is stored locally and cannot be shared.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenInstitutional board approvals were obtained for each of the datasets.
“Institutional board approvals were obtained for each of the datasets.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationCL has already demonstrated an improved performance in medical image classification tasks, such as thoracic disease, skin disease, proximal femur fractures and breast screening classification.
“CL has already demonstrated an improved performance in medical image classification tasks, such as thoracic disease [36], skin disease [37], proximal femur fractures [12], [38] and breast screening classification [39].”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [36] Maicas, 2018, Training medical image analysis systems like radiologists
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- cites [37] M. Mancini, Z. Akata, E. Ricci, B. Caputo, Towards recognizing unseen categories in unseen domains, European Conference on Computer Vision. Springer, Cham, 2020. source
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- cites [12] Dwork, 2014, The algorithmic foundations of differential privacy, Foundations and Trends in Theoretical Computer Science
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Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationSuch inconsistent performance is a known problem of deep learning methods for mammography classification.
“Such inconsistent performance is a known problem of deep learning methods for mammography classification [56].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [56] Sung, 2021, Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA: A Cancer Journal for Clinicians
Not checked in the free run.
Probably not a substantial claim: may not pass S4 (based). May combine two claims.
Premisenone givenThe new order of training samples has an impact on the local minimum achieved by the optimizer, leading to an improvement in the classification accuracy.
“This new order has an impact on the local minimum achieved by the optimizer, leading to an improvement in the classification accuracy.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataOne-way ANOVA followed by Bonferroni's post-hoc t-test comparisons tests were applied to evaluate for differences in the performance of the federated approaches and p-values were reported.
“In Table V, we applied one-way ANOVA followed by Bonferroni's post-hoc t-test comparisons tests to evaluate for differences in the performance of the federated approaches and reported the p-values.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S4 (based).
Premisenone givenMedical images collected from different healthcare providers may originate from diverse devices or imaging protocols, leading to a domain shift problem when deploying algorithms trained on a single domain.
“Medical images collected from different healthcare providers may originate from diverse devices or imaging protocols, leading to a domain shift problem when deploying algorithms trained on a single domain.”
Quote in the paperNot a substantial claimMay combine two claims.
InterpretationreasoningDomain alignment keeps the performance from dropping, but there are fewer corrections for the curriculum to account for after the update.
“In this sense, domain alignment keeps the performance from dropping, but there are fewer corrections for the curriculum to account for after the update.”
Quote in the paperNot a substantial claim
The paper relies on this without support.
The limited representativeness of positive cases can be problematic for learning-based CAD systems.
“The limited representativeness of positive cases can be problematic for learning-based Computer-Aided Diagnosis (CAD) systems.”
The paper relies on this without support.
A potential solution to mitigate the limited representativeness of positive cases and to increase the size of the annotated dataset is to employ data coming from multiple institutions.
“A potential solution to mitigate this problem and to increase the size of the annotated dataset is to employ data coming from multiple institutions.”
The paper relies on this without support.
Sharing medical information across institutions is challenging in terms of privacy, technical and legal issues.
“However, sharing medical information across (international) institutions is challenging in terms of privacy, technical and legal issues.”
The authors state this as an assumption.
Each site has local data storage, a computing server, and a memory-aware CL module.
“We assume that each site has local data storage, a computing server, and a memory-aware CL module.”
The paper relies on this without support.
Both global and local models share the same architecture.
“In this type of FL setting, both global and local models share the same architecture, and it is common to share the model weights and aggregate them at the central server.”
The authors state this as an assumption.
Each site has mammography systems of different vendors.
“In this work, we assume the most challenging scenario, in which we consider that each site has mammography systems of different vendors (see Fig. 1).”
The authors state this as an assumption.
Data owners collaboratively train a global model without sharing their image data.
“We assume that data owners collaboratively train a global model without sharing their image data.”
The paper relies on this without support.
FL allows for collaboratively training a model without sharing private data from different sites.
“FL allows for collaboratively training a model without sharing private data from different sites.”
The paper relies on this without support.
The small size of the lesion requires high-resolution images showing tissue details to provide a precise diagnosis.
“Indeed, the small size of the lesion requires high-resolution images showing tissue details to provide a precise diagnosis.”
The paper relies on this without support.
Standard clinical protocols do not include the lesion delineation.
“However, the level of annotation required would be much higher as standard clinical protocols do not include the lesion delineation.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Early cancer diagnosis accuracy has been shown to significantly improve with federated learning.
“Early cancer diagnosis accuracy has been shown to significantly improve with FL.”
From Federated Learning in Smart Healthcare: A Comprehensive Review on Privacy, Security, and Predictive Analytics with IoT Integration (2024) · cites this paper as [4]
The Abstract reports improved breast-cancer classification metrics for the proposed method, and the results section (‘a)’, page not provided) says its improvement over other federated approaches was statistically significant. The source does not establish that federated learning generally improves early cancer diagnosis accuracy: it tests a specific breast-cancer classification method, primarily against other federated methods. (LLM, conf=0.88)
Experimental — accuracy not yet measuredUsing differential privacy, a memory-aware curriculum federated learning strategy increased the precision of local models in breast tumor prediction by up to 20% while protecting patient information confidentiality.
“For example, using sophisticated privacy-preserving techniques like differential privacy, a memory-aware curriculum FL strategy increased the precision of local models in breast tumor prediction by up to 20% while protecting patient information confidentiality [4].”
From Federated Learning in Smart Healthcare: A Comprehensive Review on Privacy, Security, and Predictive Analytics with IoT Integration (2024) · cites this paper as [4]
The paper says it uses differential privacy for data protection (section B), and Table III reports improved average precision–recall AUC for its federated method, from 0.77 to 0.82. It does not report a 20% increase in local-model precision. The Discussion also cautions that patient reidentification or information leakage cannot be ruled out, so the confidentiality claim is too strong. (LLM, conf=0.89)
Experimental — accuracy not yet measuredIn a multi-hospital diabetes research, federated learning decreased the risk of data breaches by 40% while also improving predicted outcomes by 15% in electronic health record analysis as compared to centralized machine learning.
“For example, in a multi-hospital managing diabetes research, FL decreased the risk of data breaches by 40% while also improving predicted outcomes by 15% in EHR analysis as compared to centralized ML [4,34].”
From Federated Learning in Smart Healthcare: A Comprehensive Review on Privacy, Security, and Predictive Analytics with IoT Integration (2024) · cites this paper as [4]
The Datasets section describes mammography images from three vendors, and the Discussion concerns breast-cancer classification and privacy considerations. Searches for diabetes, EHR analysis, data breaches, and the claimed 40% and 15% figures found no passage reporting the attributed comparison with centralized machine learning. (LLM, conf=0.78)
Experimental — accuracy not yet measured
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- Authors
- Jiménez-Sánchez, A., Tardy, M., González Ballester, M. A., Mateus, D., & Piella, G.
- Affiliations
- Universitat Pompeu Fabra (ES)
- École Centrale de Nantes (FR)
- Corresponding author
- Jiménez-Sánchez, Amelia
- Venue
- Computer Methods and Programs in Biomedicine
- Publisher
- Elsevier BV
- Published
- 2023-02
- Volume
- 229
- Pages
- 107318
- ISSN
- 0169-2607 (ISSN-L)
- OpenAlex
- W3182336762
- Cited by
- 114
- References
- 80
- Citations by year
- 2026: 9 · 2025: 33 · 2024: 34 · 2023: 33 · 2022: 4 · 2021: 1
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Computer Methods and Programs in Biomedicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- arXiv (Cornell University) (submittedVersion)
- IT University Of Copenhagen (IT University of Copenhagen) (submittedVersion)
- arXiv (Cornell University)
- Funders
- Nvidia
- European Commission (713673)
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
- Physical Sciences › Computer Science › Artificial Intelligence › Privacy-Preserving Technologies in Data
- Physical Sciences › Computer Science › Artificial Intelligence › Domain Adaptation and Few-Shot Learning
- Keywords
- federated learning, curriculum learning, breast cancer classification, mammography, computer-aided diagnosis, domain adaptation, domain shift, data privacy, multi-site data, class imbalance
- MeSH terms
- Awareness, Cognition, Curriculum, Learning, Mammography, Neoplasms
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