The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.
Safety aspects of next generation probiotics
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Computational tools can be applied to mitigate risks associated with NGPs by enabling whole-genome sequence analysis, early detection of antibiotic resistance genes, virulence-related traits, the potential for horizontal gene transfer, and other potentially negative metabolic characteristics, thus speeding up strain selection and regulatory assessment [140,161].”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [140]
In the citing paper
“Another class of probiotics, NGPs (e.g., specifically commensal gut bacteria such as Bacteroides, Clostridium, and Akkermansia), require greater safety consideration than traditional probiotics because they lack a “safe use history” and have a more “ambiguous” potential to cause infectious diseases [140].”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [140]
Citations
Cites
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511
Bacteroides : the Good, the Bad, and the Nitty-Gritty
Wexler, H. M. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00008-07 · Cited by 2,388
Plovier, H., Everard, A., Druart, C., Depommier, C., Van Hul, M., Geurts, L., Chilloux, J., Ottman, N., Duparc, T., Lichtenstein, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4236 · Cited by 2,204
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094
Akkermansia muciniphila and its role in regulating host functions
Derrien, M., Belzer, C., & de Vos, W. M. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.005 · Cited by 1,044
Next-generation probiotics: the spectrum from probiotics to live biotherapeutics
O’Toole, P. W., Marchesi, J. R., & Hill, C. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.57 · Cited by 971
Shoemaker, N. B., Vlamakis, H. C., Hayes, K., & Salyers, A. A. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.2.561-568.2001 · Cited by 529
Hansen, C. H. F., Krych, Ł., Nielsen, D. S., Vogensen, F. K., Hansen, L. H., Sørensen, S. J., Buschard, K., & Hansen, A. K. (2012) · Diabetologia · doi:10.1007/s00125-012-2564-7 · Cited by 507
van Passel, M. W. J., Kant, R., Zoetendal, E. G., Plugge, C. M., Derrien, M., Malfatti, S., Chain, P., Woyke, T., Palva, A., de Vos, W. M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016876 · Cited by 430
Martín, R., Miquel, S., Benevides, L., Bridonneau, C., Robert, V., Hudault, S., Chain, F., Berteau, O., Azevedo, V., Chatel, J. M., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01226 · Cited by 398
Flagged first, then by citations
1 of the 51 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Turck, 2016, Guidance on the preparation and presentation of an application for authorisation of a novel food in the context of Regulation (EU) 5/2283 EFSA, EFSA J, 14, 4594
- Chang, 2016, Modulation of host immune response by Bacteroides fragilis polysaccharides: a review of recent observation, J Biomed Lab Sci, 28, 1
Cited by
Sorted by citations
Items 101–119 of 119
Colorectal cancer: risk factors and potential of dietary probiotics in its prevention
Arora, R., Sharma, S., & Kumar, B. (2022) · Proceedings of the Indian National Science Academy · doi:10.1007/s43538-022-00083-4 · Cited by 2
“2019, Satokari 2019; Saarela 2019) but their relationship with cancer needs to be investigated.”
BackgroundMicrobiota and fatty liver disease: Potential candidate for therapeutic intervention
Eslami, M., Naderian, R., Tarahomi, M., Babaeizad, A., Amini, P., & Pouya, P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27370-4.00026-3 · Cited by 1
Enhancement of Gut Microbial Homeostasis by a Post-NGP Phocaeicola vulgatus
Shuvo, M. S. H., Kim, S., Jo, S., Ahmed, I., Aziz, M. T., Yoon, Y., Sarafraz, F., Oh, S., Nam, G. T., Lee, J.-H., et al. (2026) · Nutrients · doi:10.3390/nu18142355 · Cited by 1
“Nevertheless, current NGP approaches remain focused on a limited set of taxa and are insufficient to fully capture the ecological complexity and functional interactions inherent to the gut microbiome [50].”
Vinderola, G., & Burns, P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819662-5.00014-8 · Cited by 1
X-BIÓTICOS: TENDÊNCIAS NA FUNCIONALIZAÇÃO DE PRODUTOS CÁRNEOS
Manassi, C. F., de Souza, S. S., Malaghini, C. M. E., Ferreira, B. C. F., Pierezan, M. D., & Verruck, S. (2022) · Editora Científica Digital eBooks · doi:10.37885/220207575 · Cited by 1
Probiotics for diabetes mellitus: prevention and treatment
Moreno‐Indias, I., & Tinahones, F. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89908-6.00001-7 · Cited by 1
Camelo‐Silva, C., Verruck, S., Luccio, M. D., Pimentel, T. C., Silva, M. C., Esmerino, E. A., & da Cruz, A. G. (2023) · Wiley eBooks · doi:10.1002/9781119776406.ch4 · Cited by 1
Winter, K. A., Osbelt, L., Lesker, T. R., Wende, M., Almási, É. D. H., Eisenhard, L., Knegendorf, L., Abt, B., Overmann, J., Hogardt, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.29.676038 · Cited by 1
“Controlled experiments in mammals would allow systematic assessment of carbohydrate availability, probiotic dosing and safety 95,96 , and timing to optimize suppression of In conclusion, our study underscores the central role of carbohydrate metabolism in shaping competitive interactions between…”
Hillman, T. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.10.455802
Probiyotik Bakterilerin Stress Koşullarının Azaltılmasında Alternatif Proses Teknolojileri
Aksöz, D., & Özcan, T. (2023) · Turkish Journal of Agriculture - Food Science and Technology · doi:10.24925/turjaf.v11i5.905-919.5830
Advantages of multi-strain probiotics in the treatment of infectious diseases in children
Alagova, M. V., Ratnikov, V. A., Silav, K. V., Ермоленко, К. Д., Potapova, T. V., & Константиновна, Р. А. (2025) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2025-101
Lobzin, Y. V., Gorelov, A. V., Гриценко, В. А., Migacheva, N. B., Usenko, D. V., & Ермоленко, К. Д. (2025) · Allergology and Immunology in Pediatrics · doi:10.53529/2500-1175-2025-3-6-16
Postbiotics and Mental Health: A New Frontier in Mood Disorders
Rad, A. H., Houshyar, J., Alikhah, H., Moghadam, S. K., Daneshfard, B., & Asghari, A. (2026) · Natural Product Communications · doi:10.1177/1934578x261433104
“58,59 These NGPs, unlike traditional probiotics, offer disease-speci fi c bene-fi ts and warrant further clinical trials to validate their SCFA production in human neuropsychiatric interventions.”
Zakharova, I. N., Berezhnaya, I. V., Churilova, V. D., & Anisimova, P. D. (2026) · Pediatrics Consilium Medicum · doi:10.26442/26586630.2026.2.203717
Khan, N., Nasir, M. M., Aziz, U., Manzoor, H., Raziq, M. F., Hussain, Z., Jabeen, I., & Kayani, M. U. R. (2026) · PLoS ONE · doi:10.1371/journal.pone.0340748
“Furthermore, previous studies have also demonstrated that B. uniformis, B. vulgatus, and E. rectale exhibit a significant positive association with healthy controls compared to CD and UC phenotypes [32], thus indicating their beneficial role in gut homeostasis.”
Tavassol, Z. H., Hosseini, F., & Ejtahed, H.-S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29835-6.00007-1
Kaur, M., & Mishra, A. K. (2026) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-026-05300-6
“Safety considerations are crucial in the creation and utiliza - tion of NGPs, as these treatments involve introducing live or bioactive microbial components into the human digestive system (Saarela 2019 ).”
Probiyotik Bacillus Suşlarının Güvenliği, Dayanıklılığı ve Endüstriyel Uygulamaları
Ataki, T., & Dikici, A. (2026) · Uşak Üniversitesi Fen ve Doğa Bilimleri Dergisi · doi:10.47137/usufedbid.1988852
Metadata
- Authors
- Saarela, M. H.
- Affiliations
- VTT Technical Research Centre of Finland (FI)
- Corresponding author
- Saarela, Maria H
- ORCID
- Saarela, Maria H
- Venue
- Current Opinion in Food Science
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 30
- Pages
- 8-13
- ISSN
- 2214-7993 (ISSN-L)
- OpenAlex
- W2889616411
- Cited by
- 118
- References
- 51
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 18 · 2023: 18 · 2022: 22 · 2021: 19 · 2020: 11 · 2019: 7
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Food Science (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- next-generation probiotics, probiotic safety assessment, gut microbiota, Bacteroides, Clostridium, Faecalibacterium, Akkermansia, antibiotic resistance genes, probiotic supplements, health-promoting properties
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
