Cited by 79Heat shock proteins researchImmune Response and InflammationEscherichia coli research studies

Heat-shock proteins and the host-pathogen interaction during bacterial infection.

Stewart, Graham R, Young, Douglas B·2004·Current Opinion in Immunology

Abstract

Heat-shock proteins (HSPs) are expressed at high levels by bacterial pathogens during adaptation to intracellular survival. Both host and pathogen heat-shock proteins contribute to immunity by receptor-mediated activation of the innate immune response and by participation in the presentation of antigens for the adaptive immune response. Manipulation of these interactions presents a potential route to improved control of infection by vaccination or immunotherapy.

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Crossref · 10.1016/j.coi.2004.05.007

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  • Heat-shock proteins are immunodominant antigens for the recognition of many pathogens and play a central role in mediating both innate and adaptive immune responses.

    “Consistent with this thinking, heat-shock proteins are immunodominant antigens for the recognition of many pathogens and play a central role in mediating both innate and adaptive immune responses [54],[55].”

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Authors
Stewart, G. R., & Young, D. B.
Affiliations
Imperial College London (GB)
Corresponding author
Stewart, Graham R
Venue
Current Opinion in Immunology
Publisher
Elsevier BV
Published
2004-08
Volume
16
Issue
4
Pages
506-510
ISSN
0952-7915 (ISSN-L)
OpenAlex
W2002353839
Cited by
79
References
47
Citations by year
2026: 3 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 7
FWCI
0.41
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Open Research (University of Surrey) (submittedVersion)
  • Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Keywords
heat shock proteins, host-pathogen interaction, bacterial infection, intracellular survival, innate immunity, antigen presentation, adaptive immunity, vaccination, immunotherapy
MeSH terms
Animals, Antigen-Presenting Cells, Autoimmune Diseases, Bacteria, Bacterial Infections, Heat-Shock Proteins, Humans, Lymphocyte Activation, Membrane Glycoproteins, Receptors, Cell Surface, T-Lymphocytes, Antigens, CD, Antigen Presentation, Toll-Like Receptors, Mice

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