Heat-shock proteins and the host-pathogen interaction during bacterial infection.
Abstract
Heat-shock proteins (HSPs) are expressed at high levels by bacterial pathogens during adaptation to intracellular survival. Both host and pathogen heat-shock proteins contribute to immunity by receptor-mediated activation of the innate immune response and by participation in the presentation of antigens for the adaptive immune response. Manipulation of these interactions presents a potential route to improved control of infection by vaccination or immunotherapy.
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Heat-shock proteins are immunodominant antigens for the recognition of many pathogens and play a central role in mediating both innate and adaptive immune responses.
“Consistent with this thinking, heat-shock proteins are immunodominant antigens for the recognition of many pathogens and play a central role in mediating both innate and adaptive immune responses [54],[55].”
From Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin (2009) · cites this paper as [55]
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“Consistent with this thinking, heat-shock proteins are immunodominant antigens for the recognition of many pathogens and play a central role in mediating both innate and adaptive immune responses [54,55].”
Background
- Authors
- Stewart, G. R., & Young, D. B.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Stewart, Graham R
- ORCID
- Stewart, Graham R
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 16
- Issue
- 4
- Pages
- 506-510
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2002353839
- Cited by
- 79
- References
- 47
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 7
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Keywords
- heat shock proteins, host-pathogen interaction, bacterial infection, intracellular survival, innate immunity, antigen presentation, adaptive immunity, vaccination, immunotherapy
- MeSH terms
- Animals, Antigen-Presenting Cells, Autoimmune Diseases, Bacteria, Bacterial Infections, Heat-Shock Proteins, Humans, Lymphocyte Activation, Membrane Glycoproteins, Receptors, Cell Surface, T-Lymphocytes, Antigens, CD, Antigen Presentation, Toll-Like Receptors, Mice
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