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Cytokines and growth factors in airway remodeling in asthma
Abstract
Airway remodeling in asthma is defined by several structural changes including epithelial cell mucus metaplasia, an increase in peribronchial smooth muscle mass, subepithelial fibrosis, and angiogenesis. Cytokines, chemokines, and growth factors released from inflammatory and structural cells in the airway are considered to play a pivotal role in the development of remodeling. Studies of allergen induced airway remodeling in transgenic mice suggest an important role for TGF-beta, VEGF, Th2 cytokines (IL-5, IL-9, IL-13), and epithelial derived NF-kappaB regulated chemokines in airway remodeling. Although studies of bronchial biopsies from human asthmatics also demonstrate expression of TGF-beta, VEGF, IL-5, IL-9, IL-13, and NF-kappaB regulated chemokines, further human intervention studies are required in which individual cytokines or chemokines are neutralized to define their role in airway remodeling.
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“and by leading to excessive production of fibroblast growth factor basic (FGF-β) and EGF (51).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [51]
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Additional file 1 of Correlation between sestrin2 expression and airway remodeling in COPD
Zhang, D.-W., Wei, Y.-Y., Ji, S., & Fei, G. (2020) · Figshare · doi:10.6084/m9.figshare.13245343
Additional file 2 of Correlation between sestrin2 expression and airway remodeling in COPD
Zhang, D.-W., Wei, Y.-Y., Ji, S., & Fei, G. (2020) · Figshare · doi:10.6084/m9.figshare.13245346
Additional file 3 of Correlation between sestrin2 expression and airway remodeling in COPD
Zhang, D.-W., Wei, Y.-Y., Ji, S., & Fei, G. (2020) · Figshare · doi:10.6084/m9.figshare.13245355
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Metadata
- Authors
- Doherty, T., & Broide, D.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Doherty, Taylor
- Broide, David
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 19
- Issue
- 6
- Pages
- 676-680
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W1983403805
- Cited by
- 198
- References
- 32
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 7 · 2018: 8 · 2017: 14 · 2016: 6 · 2015: 11 · 2014: 12 · 2013: 11 · 2012: 13
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R37AI038425, R01AI072115, U19AI070535)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- airway remodeling, asthma, cytokines, growth factors, chemokines, TGF-beta, vascular endothelial growth factor, IL-5, IL-9, IL-13, Th2 cytokines, NF-κB, mucus metaplasia, subepithelial fibrosis, angiogenesis, transgenic mouse model
- MeSH terms
- Animals, Asthma, Eosinophils, Humans, Interleukins, CD4-Positive T-Lymphocytes, Transforming Growth Factor beta, Th2 Cells, Chemokines, Vascular Endothelial Growth Factor A, Metalloproteases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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