Cytokines and growth factors in airway remodeling in asthma

Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases

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A Critical Role for Eosinophils in Allergic Airways Remodeling

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Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics

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Interleukin‐13 in asthma pathogenesis

Wills‐Karp, M. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00215.x · Cited by 683

Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung

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The mechanisms, diagnosis, and management of severe asthma in adults

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Inhibition of airway remodeling in IL-5–deficient mice

Cho, J. Y., Miller, M., Baek, K. J., Han, J. W., Nayar, J., Lee, S. Y., McElwain, K., McElwain, S., Friedman, S., & Broide, D. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19133 · Cited by 388

Airway remodeling contributes to the progressive loss of lung function in asthma: An overview

Pascual, R. M., & Peters, S. P. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.07.011 · Cited by 360

Mast cells can promote the development of multiple features of chronic asthma in mice

Yu, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25702 · Cited by 281

Manipulation of Allergen-Induced Airway Remodeling by Treatment with Anti-TGF-β Antibody: Effect on the Smad Signaling Pathway

McMillan, S. J., Xanthou, G., & Lloyd, C. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5774 · Cited by 247

A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation

Fulkerson, P. C., Fischetti, C. A., McBride, M. L., Hassman, L. M., Hogan, S. P., & Rothenberg, M. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607863103 · Cited by 213

Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology

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Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling

Yang, G., Volk, A. P. D., Petley, T., Emmell, E., Giles-Komar, J. M., Shang, X., Li, J., Das, A., Shealy, D., Griswold, D. E., et al. (2004) · Cytokine · doi:10.1016/j.cyto.2004.08.007 · Cited by 190

Increased expression of ADAM33 and ADAM8 with disease progression in asthma

Foley, S. C., Mogas, A. K., Olivenstein, R., Fiset, P., Chakir, J., Bourbeau, J., Ernst, P., Lemière, C., Martin, J. G., & Hamid, Q. A. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.12.665 · Cited by 148

Allergen-induced peribronchial fibrosis and mucus production mediated by IκB kinase β-dependent genes in airway epithelium

Broide, D. H., Lawrence, T., Doherty, T. A., Cho, J. Y., Miller, M., McElwain, K., McElwain, S., & Karin, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509235102 · Cited by 144

Inhibition of Allergen-Induced Airway Remodeling in Smad 3-Deficient Mice

Le, A. V., Cho, J. Y., Miller, M., McElwain, S., Golgotiu, K., & Broide, D. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.7310 · Cited by 124

Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factor-β

Xie, S., Sukkar, M. B., Issa, R., Khorasani, N. M., & Chung, K. F. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00068.2007 · Cited by 113

Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung

Bhandari, V., Choo-Wing, R., Chapoval, S. P., Lee, C. G., Tang, C., Kim, Y. K., Ma, B., Bałuk, P., Lin, M. I., McDonald, D. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601057103 · Cited by 110

IL-13 Mediates In Vivo IL-9 Activities on Lung Epithelial Cells but Not on Hematopoietic Cells

Steenwinckel, V., Louahed, J., Orabona, C., Huaux, F., Warnier, G., McKenzie, A., Lison, D., Levitt, R., & Renauld, J.-C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.3244 · Cited by 108

Persistent Effects Induced by IL-13 in the Lung

Fulkerson, P. C., Fischetti, C. A., Hassman, L. M., Nikolaidis, N. M., & Rothenberg, M. E. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0474oc · Cited by 104

The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts

Puxeddu, I., Bader, R., Piliponsky, A. M., Reich, R., Levi‐Schaffer, F., & Berkman, N. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.08.057 · Cited by 100

IL-4 Receptor Signaling in Clara Cells Is Required for Allergen-Induced Mucus Production

Kuperman, D. A., Huang, X., Nguyenvu, L. T., Hölscher, C., Brombacher, F., & Erle, D. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.3746 · Cited by 99

Reduced peribronchial fibrosis in allergen-challenged MMP-9-deficient mice

Lim, D. H., Cho, J. Y., Miller, M., McElwain, K., McElwain, S., & Broide, D. H. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00305.2005 · Cited by 92

Effects of a Low-Molecular-Weight CCR-3 Antagonist on Chronic Experimental Asthma

Wegmann, M., Göggel, R., Sel, S., Sel, S., Erb, K. J., Kalkbrenner, F., Renz, H. E., & Garn, H. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0188oc · Cited by 89

Corticosteroids prevent myofibroblast accumulation and airway remodeling in mice

Miller, M., Cho, J. Y., McElwain, K., McElwain, S., Shim, J. Y., Manni, M., Baek, J. S., & Broide, D. H. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00252.2005 · Cited by 88

Reversal of airway inflammation and remodeling in asthma by a bispecific antibody fragment linking CCR3 to CD300a

Munitz, A., Bachelet, I., & Levi‐Schaffer, F. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.07.041 · Cited by 86

Eosinophils and CCR3 Regulate Interleukin-13 Transgene-Induced Pulmonary Remodeling

Fulkerson, P. C., Fischetti, C. A., & Rothenberg, M. E. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060617 · Cited by 86

Chronic exposure to TNF-α increases airway mucus gene expression in vivo

Busse, P. J., Zhang, T., Srivastava, K. D., Lin, B. P., Schofield, B., Sealfon, S. C., & LI, X. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.08.059 · Cited by 76

ADAM33 Is Not Essential for Growth and Development and Does Not Modulate Allergic Asthma in Mice

Chen, C., Huang, X., & Sheppard, D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00646-06 · Cited by 66

Therapeutic administration of Budesonide ameliorates allergen‐induced airway remodelling

McMillan, S. J., Xanthou, G., & Lloyd, C. M. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.02193.x · Cited by 60

Immunostimulatory DNA inhibits allergen-induced peribronchial angiogenesis in mice

Lee, S. Y., Cho, J. Y., Miller, M., McElwain, K., McElwain, S., Sriramarao, P., Raz, E., & Broide, D. H. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.11.008 · Cited by 31

The development of allergic inflammation

Galli, S. J., Tsai, M., & Piliponsky, A. M. (2008) · Nature · doi:10.1038/nature07204 · Cited by 1,839

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

Monticelli, L. A., Sonnenberg, G. F., Abt, M. C., Alenghat, T., Ziegler, C. G. K., Doering, T. A., Angelosanto, J., Laidlaw, B. J., Yang, C. Y., Sathaliyawala, T., et al. (2011) · Nature Immunology · doi:10.1038/ni.2131 · Cited by 1,327

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

Monticelli (2011) · PubMed · doi:10.1031/ni.2131 · Cited by 1,286

The airway epithelium: soldier in the fight against respiratory viruses

Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655

Commonality of the IL-4/IL-13 pathway in atopic diseases

Gandhi, N. A., Pirozzi, G., & Graham, N. M. H. (2017) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2017.1298443 · Cited by 493

Immunologic and inflammatory mechanisms that drive asthma progression to remodeling

Broide, D. H. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.01.031 · Cited by 244

Structural aspects of airway remodeling in asthma

Siddiqui, S., & Martin, J. G. (2008) · Current Allergy and Asthma Reports · doi:10.1007/s11882-008-0098-3 · Cited by 49

Bronchial cytokines and growth factors augment fibroblast-induced airway remodeling in adult asthmatics

Lewis, C. C., Tucker, A., Bowen, R., Mason, G., Martin, R., & Kraft, M. (2002) · doi:10.25675/3.025697

Role of Transforming Growth Factor–β in Airway Remodeling in Asthma

Halwani, R., Al‐Muhsen, S., Al-Jahdali, H. H., & Hamid, Q. A. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0027tr · Cited by 404

Reasearch progress of airway remodeling in bronchial asthma

Luan, Y.-M., Song, X., & Wang, C. (2013) · Chinese Journal of Asthma · doi:10.3760/cma.j.issn.1673-436x.2013.005.011