The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Cytokines and growth factors in airway remodeling in asthma
Abstract
Airway remodeling in asthma is defined by several structural changes including epithelial cell mucus metaplasia, an increase in peribronchial smooth muscle mass, subepithelial fibrosis, and angiogenesis. Cytokines, chemokines, and growth factors released from inflammatory and structural cells in the airway are considered to play a pivotal role in the development of remodeling. Studies of allergen induced airway remodeling in transgenic mice suggest an important role for TGF-beta, VEGF, Th2 cytokines (IL-5, IL-9, IL-13), and epithelial derived NF-kappaB regulated chemokines in airway remodeling. Although studies of bronchial biopsies from human asthmatics also demonstrate expression of TGF-beta, VEGF, IL-5, IL-9, IL-13, and NF-kappaB regulated chemokines, further human intervention studies are required in which individual cytokines or chemokines are neutralized to define their role in airway remodeling.
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“and by leading to excessive production of fibroblast growth factor basic (FGF-β) and EGF (51).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [51]
Citations
Cites
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
Wynn, T. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31487 · Cited by 1,487
A Critical Role for Eosinophils in Allergic Airways Remodeling
Humbles, A. A., Lloyd, C. M., McMillan, S. J., Friend, D. S., Xanthou, G., McKenna, E. E., Ghiran, S., Gerard, N. P., Yu, C., Orkin, S. H., et al. (2004) · Science · doi:10.1126/science.1100283 · Cited by 856
Flood-Page, P. T., Menzies-Gow, A. N., Phipps, S., Sun, Y., Wangoo, A., Ludwig, M. S., Barnes, N. C., Robinson, D. S., & Kay, A. B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17974 · Cited by 843
Interleukin‐13 in asthma pathogenesis
Wills‐Karp, M. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00215.x · Cited by 683
Lee, C. G., Link, H., Bałuk, P., Homer, R., Chapoval, S. P., Bhandari, V., Kang, M., Cohn, L. E., Kim, Y. K., McDonald, D. M., et al. (2004) · Nature Medicine · doi:10.1038/nm1105 · Cited by 586
The mechanisms, diagnosis, and management of severe asthma in adults
Holgate, S. T., & Polosa, R. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69288-x · Cited by 407
Inhibition of airway remodeling in IL-5–deficient mice
Cho, J. Y., Miller, M., Baek, K. J., Han, J. W., Nayar, J., Lee, S. Y., McElwain, K., McElwain, S., Friedman, S., & Broide, D. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19133 · Cited by 388
Self-citationAirway remodeling contributes to the progressive loss of lung function in asthma: An overview
Pascual, R. M., & Peters, S. P. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.07.011 · Cited by 360
Mast cells can promote the development of multiple features of chronic asthma in mice
Yu, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25702 · Cited by 281
McMillan, S. J., Xanthou, G., & Lloyd, C. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5774 · Cited by 247
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The development of allergic inflammation
Galli, S. J., Tsai, M., & Piliponsky, A. M. (2008) · Nature · doi:10.1038/nature07204 · Cited by 1,839
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Monticelli, L. A., Sonnenberg, G. F., Abt, M. C., Alenghat, T., Ziegler, C. G. K., Doering, T. A., Angelosanto, J., Laidlaw, B. J., Yang, C. Y., Sathaliyawala, T., et al. (2011) · Nature Immunology · doi:10.1038/ni.2131 · Cited by 1,327
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Monticelli (2011) · PubMed · doi:10.1031/ni.2131 · Cited by 1,286
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
Commonality of the IL-4/IL-13 pathway in atopic diseases
Gandhi, N. A., Pirozzi, G., & Graham, N. M. H. (2017) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2017.1298443 · Cited by 493
Metadata
- Authors
- Doherty, T., & Broide, D.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Doherty, Taylor
- Broide, David
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 19
- Issue
- 6
- Pages
- 676-680
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W1983403805
- Cited by
- 198
- References
- 32
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 7 · 2018: 8 · 2017: 14 · 2016: 6 · 2015: 11 · 2014: 12 · 2013: 11 · 2012: 13
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R37AI038425, R01AI072115, U19AI070535)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- airway remodeling, asthma, cytokines, growth factors, chemokines, TGF-beta, vascular endothelial growth factor, IL-5, IL-9, IL-13, Th2 cytokines, NF-κB, mucus metaplasia, subepithelial fibrosis, angiogenesis, transgenic mouse model
- MeSH terms
- Animals, Asthma, Eosinophils, Humans, Interleukins, CD4-Positive T-Lymphocytes, Transforming Growth Factor beta, Th2 Cells, Chemokines, Vascular Endothelial Growth Factor A, Metalloproteases
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