γδ T cells: an important source of IL-17
Open accessAbstract
IL-17 is a cytokine that plays an important role in orchestrating innate immune function. In addition, IL-17 has been shown to exacerbate autoimmune diseases. CD4(+) alphabeta T cells, gammadelta T cells, and NK cells all produce IL-17. Th17 cells are a newly defined alphabeta(+) T cell lineage characterized by IL-17 production. However, gammadelta T cells are often the major source of this cytokine. Their response can be very rapid during bacterial infections and has been shown to be protective, but IL-17-producing gammadelta T cells have also been found to exacerbate collagen-induced arthritis. Interestingly, some gammadelta T cells produce IL-17 in response to IL-23 alone, even in naïve animals, suggesting they are already differentiated and may develop differently than CD4(+) alphabeta Th17 cells.
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γδ T cells can secrete IFNγ and IL-17 in response to TCR stimulation.
“Previous reports have demonstrated that γδ T cells can secrete IFNγ and IL-17 in response to TCR stimulation [20]–[22]”
From The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis (2011) · cites this paper as [21]
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- Authors
- Roark, C. L., Simonian, P. L., Fontenot, A. P., Born, W. K., & O’Brien, R. L.
- Affiliations
- National Jewish Health (US)
- University of Colorado Denver (US)
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 20
- Issue
- 3
- Pages
- 353-357
- ISSN
- 0952-7915 (ISSN-L)
- PMC
- PMC2601685
- OpenAlex
- W2091180924
- Cited by
- 325
- References
- 4
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 4 · 2023: 12 · 2022: 6 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 9 · 2017: 20 · 2016: 14 · 2015: 18 · 2014: 26 · 2013: 17 · 2012: 30
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL062410, HL089766, R01HL065410, 2R01 HL65410, R01HL062410, K08HL089766)
- National Institute of Allergy and Infectious Diseases (R01AI044920)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- γδ T cells, IL-17, Th17 cells, innate immunity, autoimmune disease, collagen-induced arthritis, IL-23, bacterial infection, T cell differentiation, natural killer cells
- MeSH terms
- Animals, Autoimmune Diseases, T-Lymphocytes, T-Lymphocyte Subsets, Receptors, Antigen, T-Cell, gamma-delta, Interleukin-17, Mice
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