In vivo application of mAb directed against the γδ TCR does not deplete but generates “invisible” γδ T cells
Open accessAbstract
mAb targeting the γδ TCR have been used for γδ T‐cell depletion with varying success. Although the depletion‐capacity of the anti‐γδ TCR mAb clone GL3 has been disputed repeatedly, many groups continue to use γδ T‐cell depletion protocols involving the mAb clone UC7‐13D5 and find significant biological effects. We show here that treatment with both GL3 and UC7‐13D5 antibodies does not deplete γδ T cells in vivo, but rather leads to TCR internalization and thereby generates “invisible” γδ T cells. We addressed this issue using anti‐γδ TCR mAb injections into WT mice as well as into reporter TCR delta locus‐histone 2B enhanced GFP knock‐in mice, in which γδ T cells can be detected based on an intrinsic green fluorescence. Importantly, the use of TCR delta locus‐histone 2B enhanced GFP mice provided here for the first time direct evidence that the “depleted” γδ T cells were actually still present. Our results show further that GL3 and UC7‐13D5 mAb are in part cross‐competing for the same epitope. Assessed by activation markers, we observed in vitro and in vivo activation of γδ T cells through mAb. We conclude that γδ T‐cell depletion experiments must be evaluated with caution and discuss the implications for future studies on the physiological functions of γδ T cells.
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Antibodies and tracers injected into the CSF reach meningeal spaces.
“it has been previously demonstrated that antibodies and tracers injected into the CSF reach meningeal spaces16.”
From Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons (2020) · cites this paper as [16]
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Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17
Stark, M. A., Huo, Y., Burcin, T. L., MORRIS, M. A., Olson, T. S., & Ley, K. F. (2005) · Immunity · doi:10.1016/j.immuni.2005.01.011 · Cited by 945 · see citing works
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
Romani, L., Fallarino, F., De Luca, A., Montagnoli, C., D’Angelo, C., Zelante, T., Vacca, C., Bistoni, F., Fioretti, M. C., Grohmann, U., et al. (2008) · Nature · doi:10.1038/nature06471 · Cited by 535 · see citing works
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells
Lochner, M., Peduto, L., Cherrier, M., Sawa, S., Vives, F. L., Varona, R., Riethmacher, D., Si‐Tahar, M., Santo, J. P. D., & Eberl, G. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080034 · Cited by 533 · see citing works
Itohara, S., Mombaerts, P., Lafaille, J. J., Iacomini, J., Nelson, A., Clarke, A. R., Hooper, M., Farr, A. G., & Tonegawa, S. (1993) · Cell · doi:10.1016/0092-8674(93)90112-4 · Cited by 526 · see citing works
Shibata, K., Yamada, H., Hara, H., Kishihara, K., & Yoshikai, Y. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4466 · Cited by 481 · see citing works
Jensen, K. D. C., Su, X., Shin, S., Li, L., Youssef, S., Yamasaki, S., Steinman, L., Saito, T., Locksley, R. M., Davis, M. M., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.022 · Cited by 480 · see citing works
Immunoregulation in the tissues by γδ T cells
Hayday, A., & Tigelaar, R. E. (2003) · Nature reviews. Immunology · doi:10.1038/nri1030 · Cited by 414 · see citing works
Goodman, T., & Lefrançois, L. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.5.1569 · Cited by 350 · see citing works
γδ T cells: an important source of IL-17
Roark, C. L., Simonian, P. L., Fontenot, A. P., Born, W. K., & O’Brien, R. L. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.03.006 · Cited by 325 · see citing works
Itohara, S., Nakanishi, N., Kanagawa, O., Kubo, R. T., & Tonegawa, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.13.5094 · Cited by 252 · see citing works
Perspectives of γδ T Cells in Tumor Immunology
Kabelitz, D., Wesch, D., & He, W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3069 · Cited by 251 · see citing works
Gamma delta T lymphocytes regulate the induction and maintenance of oral tolerance
Ke, Y., PEARCE, K. M., Lake, J. P., Ziegler, H., & Kapp, J. A. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.8.3610 · Cited by 220 · see citing works
Visualization of the earliest steps of γδ T cell development in the adult thymus
Prinz, I., Sansoni, A., Kissenpfennig, A., Ardouin, L., Malissen, M., & MALISSEN, B. (2006) · Nature Immunology · doi:10.1038/ni1371 · Cited by 201 · see citing works
Self-citationLahn, M., Kanehiro, A., Takeda, K., Joetham, A., Schwarze, J., Köhler, G., O’Brien, R. L., Gelfand, E. W., & Born, W. K. (1999) · Nature Medicine · doi:10.1038/13476 · Cited by 177 · see citing works
Jameson, J., Cauvi, G., Witherden, D. A., & Havran, W. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3573 · Cited by 152 · see citing works
Hahn, Y., Taube, C., Jin, N., Sharp, L., Wands, J. M., Aydintug, M. K., Lahn, M., Huber, S. A., O’Brien, R. L., Gelfand, E. W., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2894 · Cited by 137 · see citing works
Kaufmann, S. H. E., Blum, C., & Yamamoto, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9620 · Cited by 114 · see citing works
γδ T Cells Facilitate Adaptive Immunity against West Nile Virus Infection in Mice
Wang, T., Gao, Y., Scully, E. P., Davis, C. T., Anderson, J. F., Welte, T., Ledizet, M., Koski, R. A., Madri, J. A., Barrett, A. D. T., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1825 · Cited by 95 · see citing works
Kühl, A. A., Pawlowski, N. N., Grollich, K., Loddenkemper, C., Zeitz, M., & Hoffmann, J. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1105696 · Cited by 93 · see citing works
Critical role of host γδ T cells in experimental acute graft-versus-host disease
Maeda, Y., Reddy, P. R., Lowler, K. P., Liu, C., Bishop, D. K., & Ferrara, J. L. M. (2005) · Blood · doi:10.1182/blood-2004-10-4087 · Cited by 73 · see citing works
Odyniec, A., Szczepanik, M., Mycko, M. P., Stasiołek, M., Raine, C. S., & Selmaj, K. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.682 · Cited by 66 · see citing works
Fujiura, Y., Kawaguchi, M., Kondo, Y., Obana, S., Yamamoto, H., Nanno, M., & Ishikawa, H. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.8.2710 · Cited by 64 · see citing works
Chien, Y., & Bonneville, M. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6020-z · Cited by 64 · see citing works
Depletion of γδ T Cells Exacerbates Murine Adriamycin Nephropathy
Wu, H., Wang, Y. M., Wang, Y., Hu, M., Zhang, G. Y., Knight, J. F., Harris, D. C. H., & Alexander, S. I. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006060622 · Cited by 52 · see citing works
A TCR Cell Recognizing a Novel TL-encoded Gene ProductPreprint
Houlden, B. A., Matis, L. A., Cron, R. Q., Widacki, S. M., Brown, G., Pampeno, C. L., Meruelo, D., & Bluestone, J. A. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.006 · Cited by 50 · see citing works
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 982 · see citing works
T cells in multiple sclerosis and experimental autoimmune encephalomyelitis
Fletcher, J. M., Lalor, S. J., Sweeney, C. M., Tubridy, N. J., & Mills, K. H. G. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04143.x · Cited by 937 · see citing works
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works
Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons
Alves de Lima, K., Rustenhoven, J., Da Mesquita, S., Wall, M., Salvador, A. F., Smirnov, I., Martelossi Cebinelli, G., Mamuladze, T., Baker, W., Papadopoulos, Z., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0776-4 · Cited by 416 · see citing works
CCR6 and NK1.1 distinguish between IL‐17A and IFN‐γ‐producing γδ effector T cells
Haas, J. D., González, F. H. M., Schmitz, S., Chennupati, V., Föhse, L., Kremmer, E., Förster, R., & Prinz, I. (2009) · European Journal of Immunology · doi:10.1002/eji.200939922 · Cited by 266 · see citing works
Self-citationγδ T Cells Exhibit Multifunctional and Protective Memory in Intestinal Tissues
Sheridan, B. S., Romagnoli, P. A., Pham, Q.-M., Fu, H.-H., Alonzo, F., Schubert, W., Freitag, N. E., & Lefrançois, L. (2013) · Immunity · doi:10.1016/j.immuni.2013.06.015 · Cited by 209 · see citing works
Wunderlich, C. M., Ackermann, P., Ostermann, A. L., Adams‐Quack, P., Vogt, M. C., Tran, M.-L., Nikolajev, A., Waisman, A., Garbers, C., Theurich, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03773-0 · Cited by 178 · see citing works
Tripodo, C., D, E. I. M., Florena, A. M., Pucillo, C. E. M., Piccaluga, P. P., Franco, V., & Pileri, S. A. (2009) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.169 · Cited by 164 · see citing works
Genetic models reveal origin, persistence and non-redundant functions of IL-17–producing γδ T cells
Sandrock, I., Reinhardt, A., Ravens, S., Binz, C., Wilharm, A., Barros‐Martins, J., Oberdörfer, L., Tan, L., Lienenklaus, S., Zhang, B., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20181439 · Cited by 141 · see citing works
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Sun, G., Yang, S., Cao, G., Wang, Q., Hao, J., Wen, Q., Li, Z., So, K., Liu, Z., Zhou, S., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170686 · Cited by 128 · see citing works
Akitsu, A., Ishigame, H., Kakuta, S., Chung, S.-H., Ikeda, S., Shimizu, K., Kubo, S., Liu, Y., Umemura, M., Matsuzaki, G., et al. (2015) · Nature Communications · doi:10.1038/ncomms8464 · Cited by 121 · see citing works
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Papotto, P. H., Reinhardt, A., Prinz, I., & Silva‐Santos, B. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.11.006 · Cited by 120 · see citing works
Self-citationZaidi, I., Diallo, H., Conteh, S., Robbins, Y. L., Kolasny, J., Orr-Gonzalez, S., Carter, D., Butler, B., Lambert, L., Brickley, E. B., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700314 · Cited by 110 · see citing works
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Hartwig, T., Pantelyushin, S., Croxford, A. L., Kulig, P., & Becher, B. (2015) · European Journal of Immunology · doi:10.1002/eji.201545883 · Cited by 107 · see citing works
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Mehta, P., Nuotio-Antar, A. M., & Smith, C. W. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0414-211rr · Cited by 107 · see citing works
Mamedov, M. R., Scholzen, A., Nair, R. V., Cumnock, K., Kenkel, J. A., Oliveira, J. H. M., Trujillo, D. L., Saligrama, N., Zhang, Y., Rubelt, F., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.009 · Cited by 100 · see citing works
Murdoch, J. R., & Lloyd, C. M. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200911-1775oc · Cited by 99 · see citing works
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Han, Y., Mora, J., Huard, A., da Silva, P., Wiechmann, S., Putyrski, M., Schuster, C., Elwakeel, E., Lang, G.-P., Scholz, A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2019.03.082 · Cited by 100 · see citing works
IL-17A Production by Renal γδ T Cells Promotes Kidney Injury in Crescentic GN
Turner, J., Krebs, C. F., Tittel, A. P., Paust, H., Meyer‐Schwesinger, C., Bennstein, S. B., Steinmetz, O. M., Prinz, I., Magnus, T. U., Korn, T., et al. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012010040 · Cited by 94 · see citing works
Self-citationChennupati, V., Worbs, T., Liu, X., Malinarich, F. H., Schmitz, S., Haas, J. D., Malissen, B., Förster, R., & Prinz, I. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001652 · Cited by 84 · see citing works
Self-citationTissue-Resident Lymphocytes in the Kidney
Turner, J., Becker, M., Mittrücker, H., & Panzer, U. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017060599 · Cited by 86 · see citing works
Interleukin 17–Producing γδT Cells Promote Hepatic Regeneration in Mice
Rao, R., Graffeo, C. S., Gulati, R., Jamal, M., Narayan, S., Zambirinis, C. P., Barilla, R., Deutsch, M., Greco, S. H., Ochi, A., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.04.042 · Cited by 81 · see citing works
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Chen, Y.-S., Chen, I.-B. D., Pham, G. H., Shao, T., Bangar, H., Way, S. S., & Haslam, D. B. (2020) · Journal of Clinical Investigation · doi:10.1172/jci127242 · Cited by 76 · see citing works
Klemann, C., Schröder, A., Dreier, A., Möhn, N., Dippel, S., Winterberg, T., Wilde, A., Yu, Y., Thorenz, A., Gueler, F., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.09.008 · Cited by 70 · see citing works
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Blink, S. E., Caldis, M. W., Goings, G. E., Harp, C. T., MALISSEN, B., Prinz, I., Xu, D., & Miller, S. D. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.04.013 · Cited by 69 · see citing works
Self-citationMalik, S., Want, M. Y., & Awasthi, A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00014 · Cited by 62 · see citing works
Beck, B. H., Kim, H., Kim, H., Samuel, S. L., Liu, Z., Shrestha, R., Haines, H. L., Zinn, K. R., & Lopez, R. D. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0527-6 · Cited by 64 · see citing works
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Korn, T., & Petermann, F. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06355.x · Cited by 64 · see citing works
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Rampoldi, F., Ullrich, L., & Prinz, I. (2020) · Cells · doi:10.3390/cells9030743 · Cited by 62 · see citing works
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Skyberg, J. A., Thornburg, T., Rollins, M. F., Huarte, E., Jutila, M. A., & Pascual, D. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021978 · Cited by 57 · see citing works
Li, Y., Wang, Y., Zhou, L., Liu, M., Liang, G., Yan, R., Jiang, Y., Hao, J., Zhang, X., Hu, X., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00240 · Cited by 53 · see citing works
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Kaminski, H., Couzi, L., & Eberl, M. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00466-8 · Cited by 53 · see citing works
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Wu, Q., Gupta, P. K., Suzuki, H., Wagner, S. R., Zhang, C., Cummings, O. W., Fan, L., Kaplan, M. H., Wilkes, D. S., & Shilling, R. A. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13215 · Cited by 51 · see citing works
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Bol‐Schoenmakers, M., Rezende, M. M., Bleumink, R., Boon, L., Man, S., Hassing, I., Fiechter, D., Pieters, R. H. H., & Smit, J. J. (2010) · Allergy · doi:10.1111/j.1398-9995.2010.02479.x · Cited by 50 · see citing works
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Li, Y., Wu, J., Luo, G., & He, W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01099 · Cited by 50 · see citing works
Nakada, E. M., Shan, J., Kinyanjui, M. W., & Fixman, E. D. (2014) · Respiratory Research · doi:10.1186/s12931-014-0090-5 · Cited by 48 · see citing works
Hu, M. D., Golovchenko, N. B., Burns, G. L., Nair, P. M., Kelly, T. J., Agos, J., Irani, M. Z., Soh, W. S., Zeglinski, M. R., Lemenze, A. D., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.11.028 · Cited by 48 · see citing works
Self-citationWang, X., Lin, X., Zheng, Z., Lu, B., Jun, W., Tan, A. H., Zhao, M., Loh, J. T., Ng, S. W., Chen, Q., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22242-9 · Cited by 46 · see citing works
Abou‐El‐Hassan, H., Rezende, R. M., Izzy, S., Gabriely, G., Yahya, T., Tatematsu, B. K., Habashy, K. J., Lopes, J. R., de Oliveira, G. L. V., Maghzi, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39857-9 · Cited by 45 · see citing works
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Guo, J., Chowdhury, R. R., Mallajosyula, V. V. A., Xie, J., Dubey, M., Liu, Y., Li, J., Wei, Y.-L., Palanski, B. A., Wang, C., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2315592121 · Cited by 39 · see citing works
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Nian, H., Shao, H., Zhang, G., Born, W. K., O’Brien, R. L., Kaplan, H. J., & Sun, D. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-5045 · Cited by 40 · see citing works
Chen, Z., Dragan, M., Sun, P., Haensel, D., Vu, R., Cui, L., Zhu, P., Yang, N., Shi, Y., & Dai, X. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01264-z · Cited by 39 · see citing works
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Victor, J. R., Lezmi, G., & Leite‐de‐Moraes, M. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08784-8 · Cited by 38 · see citing works
Bai, H., Gao, X., Zhao, L., Peng, Y., Yang, J., Qiao, S., Zhao, H., Wang, S., Fan, Y., Joyee, A. G., et al. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2016.53 · Cited by 36 · see citing works
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Fischer, M., Golovchenko, N. B., & Edelblum, K. L. (2020) · Immunological Reviews · doi:10.1111/imr.12915 · Cited by 34 · see citing works
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Self-citationNguyen, C. T., Furuya, H., Das, D., Marusina, A. I., Merleev, A. A., Ravindran, R. K., Jalali, Z., Khan, I. H., Maverakis, E. M., & Adamopoulos, I. E. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42124 · Cited by 32 · see citing works
Malinarich, F. H., Grabski, E., Worbs, T., Chennupati, V., Haas, J. D., Schmitz, S., Candia, E., Quera, R., Malissen, B., Förster, R., et al. (2010) · European Journal of Immunology · doi:10.1002/eji.201040727 · Cited by 29 · see citing works
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Funken, D., Yu, Y., Feng, X., Imvised, T., Gueler, F., Prinz, I., Madadi‐Sanjani, O., Ure, B. M., Kuebler, J. F., & Klemann, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-96525-y · Cited by 19 · see citing works
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Dutta, I., Postovit, L.-M. M., & Siegers, G. M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00776 · Cited by 17 · see citing works
Khairallah, C. F., Bettke, J. A., Gorbatsevych, O., Qiu, Z., Zhang, Y., Cho, K., Kim, K. S., Chu, T. H., Imperato, J. N., Hatano, S., et al. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00447-x · Cited by 15 · see citing works
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Dragan, M., Chen, Z., Li, Y., Le, J., Sun, P., Haensel, D., Sureshchandra, S., Pham, A., Lu, E., Pham, K. T., et al. (2023) · EMBO Reports · doi:10.15252/embr.202256214 · Cited by 12 · see citing works
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Xu, W., Golovchenko, N. B., Martínez-Vargas, I. U., Fong, A., Rout, P., Achi, S. C., Bucar, E. B., Hsieh, J. J., Vidmar, K. J., Zhang, L., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adk7429 · Cited by 15 · see citing works
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de Sousa, T. R., & Victor, J. R. (2020) · Vaccines · doi:10.3390/vaccines8030436 · Cited by 14 · see citing works
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Contreras, A. V., & Wiest, D. L. (2020) · F1000Research · doi:10.12688/f1000research.22161.1 · Cited by 14 · see citing works
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Hartmann, S. B., Emnéus, J., Wolff, A., & Jungersen, G. (2016) · Journal of Immunological Methods · doi:10.1016/j.jim.2016.04.003 · Cited by 13 · see citing works
Häselbarth, L., Ouwens, D. M., Teichweyde, N., Hochrath, K., Merches, K., & Esser, C. (2020) · EXCLI journal · doi:10.17179/excli2020-1123 · Cited by 13 · see citing works
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Le, S., Dooley, N., Murphy, D., Liu, S., Gandolfo, L. C., Ge, Z., May, R., Cozijnsen, A. J., Burn, T. N., Jennison, C., et al. (2026) · Nature Immunology · doi:10.1038/s41590-025-02397-z · Cited by 11 · see citing works
Foyle, K. L., & Robertson, S. A. (2024) · Discovery Immunology · doi:10.1093/discim/kyae004 · Cited by 14 · see citing works
Datta, A., Truong, T., Lee, J. H., Horneman, H. F., Flandrin, O., Lee, J., Kumar, N. G., Caspi, R. R., Evans, D. J., & Fleiszig, S. M. J. (2023) · The Ocular Surface · doi:10.1016/j.jtos.2023.02.004 · Cited by 12 · see citing works
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Golomb, S. M., Guldner, I. H., Aleksandrovic, E., Fross, S. R., Liu, X., Diao, L., Liang, K., Wu, J., Wang, Q., Lopez, J. A., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115356 · Cited by 9 · see citing works
Möhn, N., Bruni, E., Schröder, A., Froemmel, S., Gueler, F., Vieten, G., Prinz, I., Kuebler, J. F., Petersen, C., & Klemann, C. (2020) · Liver International · doi:10.1111/liv.14639 · Cited by 9 · see citing works
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Vigeland, C. L., Collins, S. L., Chan‐Li, Y., Hughes, A. H., Oh, M. H., Powell, J. D., & Horton, M. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163288 · Cited by 8 · see citing works
Park, J. H., Kang, I., Kim, H. C., Lee, Y., Lee, S. K., & Lee, H. K. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111594 · Cited by 8 · see citing works
γδT cells in oral tissue immune surveillance and pathology
Chen, Y., Du, J., Liu, Y., Luo, Z., Guo, L., Xu, J., Lü, J., & Liu, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1050030 · Cited by 8 · see citing works
γδ T cells shape memory-phenotype αβ T cell populations in non-immunized mice
Phalke, S., Huang, Y., Rubtsova, K., Getahun, A., Sun, D., Reinhardt, R. L., O’Brien, R. L., & Born, W. K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218827 · Cited by 8 · see citing works
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Prinz, I. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0701-y · Cited by 8 · see citing works
Self-citationMahmoud, A., Caillon, A., Shokoples, B. G., Ferreira, N. S., Comeau, K., Hatano, S., Yoshikai, Y., Lewis, J. M., Tigelaar, R. E., Paradis, P., et al. (2024) · Journal of Hypertension · doi:10.1097/hjh.0000000000003871 · Cited by 7 · see citing works
Khairallah, C. F., Chu, T. H., Qiu, Z., Imperato, J. N., Yang, D., & Sheridan, B. S. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00275-y · Cited by 7 · see citing works
Merky, P., Batsalova, T., Bockermann, R., Dzhambazov, B. M., Sehnert, B., Burkhardt, H., & Bäcklund, J. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3108 · Cited by 7 · see citing works
The recent progress of γδ T cells and its targeted therapies in rheumatoid arthritis
Feng, X., & Xu, Y. (2024) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.15381 · Cited by 4 · see citing works
γδ T cells: A disappearing act with a big reveal
Jameson, J. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20181960 · Cited by 4 · see citing works
Witt, L. T., Greenfield, K. G., & Knoop, K. A. (2024) · iScience · doi:10.1016/j.isci.2024.109669 · Cited by 3 · see citing works
Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles
Contreras, A. V., & Wiest, D. L. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2740-2_4 · Cited by 3 · see citing works
γδ T cells in immune‐mediated kidney disease
Waterhölter, A., Krebs, C. F., & Panzer, U. (2024) · European Journal of Immunology · doi:10.1002/eji.202451069 · Cited by 3 · see citing works
Chen, Z., Dragan, M., Sun, P., Haensel, D., Vu, R., Cui, L., Shi, Y., & Dai, X. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.29.577821 · Cited by 3 · see citing works
Zaidi, I., & Duffy, P. E. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701799 · Cited by 2 · see citing works
Iraolagoitia, X. L. R., McFarlane, A. J., Laing, S., Corbyn, R., Arnott, L. W. G., Fercoq, F., McGarry, L., Secklehner, J., Donatis, M. D., Mackey, J. B. G., et al. (2026) · Science Advances · doi:10.1126/sciadv.adu8802 · Cited by 1 · see citing works
Innate immune sensing of Plasmodium sporozoite cell traversal drives protective T cell responses
Pohl, K. G., Gao, X., McGowan, J., Mukherjee, P., Le, S., Carreira, P. E., Ngo, C., Sutton, H. J., Brumhard, S., Hiller, A. L., et al. (2026) · Nature Microbiology · doi:10.1038/s41564-026-02460-x · Cited by 1 · see citing works
The Il-IL/23-17 Immune Pathway in Arthritis
Cornelissen, F. (2011) · RePub (Erasmus University Rotterdam)
Role of γ δ T Cells in Lung Inflammation
Born, W. K., Roark, C. L., Jin, N., Wands, J. M., Aydintug, M. K., Huang, Y., Chain, J. L., Hahn, Y., Simonian, P. L., Fontenot, A. P., et al. (2014) · The Open Immunology Journal · doi:10.2174/1874226200902010143
Immunotherapy of Cancer Employing γ δ-T Cells: New Challenges, New Opportunities
Lopez, R. D. (2014) · The Open Immunology Journal · doi:10.2174/1874226200902010156
The Role of the IL-23/TH17 Immune Pathway in the Pathogenesis of Arthritis
Lubberts, E. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9371-7_23
IL-1 and Innate Immunity in the Differentiation of TH17 Cells
Lalor, S. J., Sutton, C. E., & Mills, K. H. G. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9371-7_6
Khairallah, C. F., Chu, T. H., Qiu, Z., Imperato, J. N., Yang, D., & Sheridan, B. S. (2022) · Figshare · doi:10.6084/m9.figshare.19695863
Hepatic γδ NKT cells modulate liver-resident CD8+ T cells to attenuated malaria parasite vaccinesPreprint
Blyn, R. C., Kulkarni, A. V., Donlan, A. N., Krakauer, A. A., Jones, G., Nemphos, S. M., Stegman, N., Tanner, E. G., Hertoghs, N., Schwedhelm, K. V., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.21.746325
IL-17A-producing γδ T cells control pulmonary Mycobacterium abscessus infection in mice
Hu, X., Lin, S., Meng, W., Liu, H., Qin, Z., Wu, Z., Wan, Y., Ma, S., Yang, X., Yin, Z., et al. (2026) · Nature Microbiology · doi:10.1038/s41564-026-02466-5
- Authors
- Koenecke, C., Chennupati, V., Schmitz, S., Malissen, B., Förster, R., & Prinz, I.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Prinz, Immo
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2009-01-29
- Volume
- 39
- Issue
- 2
- Pages
- 372-379
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2096637604
- Cited by
- 100
- References
- 25
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 9 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 11 · 2019: 4 · 2018: 8 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 2 · 2012: 4
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- HAL AMU (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- γδ T cells, T cell depletion, epitope cross-reactivity, T cell activation
- MeSH terms
- Animals, Antibodies, Monoclonal, Lymphocyte Depletion, Lymphocyte Activation, Mice, Inbred C57BL, Mice, Transgenic, T-Lymphocytes, Receptors, Antigen, T-Cell, gamma-delta, Green Fluorescent Proteins, Mice, Gene Knock-In Techniques
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