The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Features of responding T cells in cancer and chronic infection
Open accessAbstract
Summary Ever since T cell exhaustion was initially characterized and thoroughly analyzed in the murine LCMV model, such a functional impairment has been validated in other chronic viral infections such as HIV, HCV, and HBV. In tumor immunology, it has always been postulated that tumor-reactive T cells could also become functionally exhausted due to the high tumor-antigen load and accompanying inhibitory mechanisms. However, the empirical evidences for this hypothesis have not been as extensive as in chronic infection perhaps because much of the focus on T cell dysfunction in tumor immunology has been, and appropriately so, on breaking or bypassing immune tolerance and anergy to tumor/self antigens. Based on recent reports, it is becoming clear that T cell exhaustion also plays a critical role in the impairment of antitumor immunity. In this review, we will comparatively evaluate the T cell responses in cancer and chronic infection, and the therapeutic strategies and interventions for both diseases.
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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
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Background
Cited by
A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974
T-cell exhaustion in the tumor microenvironment
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Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients
Baitsch, L., Baumgaertner, P., Devêvre, E., Raghav, S. K., Legat, A., Barba, L., Wieckowski, S., Bouzourene, H., Deplancke, B., Romero, P., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46102 · Cited by 845
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Immunity, inflammation, and cancer: an eternal fight between good and evil
Shalapour, S., & Karin, M. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80007 · Cited by 698
Metadata
- Authors
- Kim, P. S., & Ahmed, R.
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 22
- Issue
- 2
- Pages
- 223-230
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2076111644
- Cited by
- 297
- References
- 12
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- green
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