The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Inflammatory cytokines as a third signal for T cell activation
Open accessAbstract
Summary CD8 T cells require a third signal, along with Ag and costimulation, to make a productive response and avoid death and/or tolerance induction. Recent studies indicate that IL-12 and Type I IFN (IFNα/β) are the major sources of signal 3 in a variety of responses, and that the two cytokines stimulate a common regulatory program involving altered expression of about 350 genes. Signal 3-driven chromatin remodeling is likely to play a major role in this regulation. Although less well studied, there is emerging evidence that CD4 T cells may also require a ‘third signal’ for a productive response and that IL-1 can provide this signal. Signal 3 cytokines can replace adjuvants in supporting in vivo T cell responses to peptide and protein antigens, and a better understanding of their activities and mechanisms should contribute to more rational design of vaccines.
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Distinct Effects of T-bet in T H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells
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Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin
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Inflammatory Cytokines Provide a Third Signal for Activation of Naive CD4+ and CD8+ T Cells
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Signals required for programming effector and memory development by CD8+ T cells
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Borst, J., Ahrends, T., Bąbała, N., Melief, C. J. M., & Kastenmüller, W. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0044-0 · Cited by 1,585
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Biomaterials: Foreign Bodies or Tuners for the Immune Response?
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Metadata
- Authors
- Curtsinger, J. M., & Mescher, M. F.
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 22
- Issue
- 3
- Pages
- 333-340
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2118613671
- Cited by
- 615
- References
- 44
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- green
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