The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Inflammatory Cytokines Provide a Third Signal for Activation of Naive CD4+ and CD8+ T Cells
Abstract
The effects of inflammatory cytokines on naive T cells have been studied using MHC protein/peptide complexes on microspheres, thus avoiding the use of APCs whose functions may be affected by the cytokines. IL-1, but not IL-12, increased proliferation of CD4+ T cells in response to Ag and IL-2, which is consistent with effects on in vivo priming of CD4+ cells. In contrast, proliferation of CD8+ T cells to Ag and IL-2 required IL-12, and IL-12 replaced adjuvant in stimulating an in vivo response to peptide. These results support a model in which distinct inflammatory cytokines act directly on naive CD4+ and CD8+ T cells to provide a third signal, along with Ag and IL-2, to optimally activate differentiation and clonal expansion.
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2 retracted
RETRACTED: Role of Interleukin 12 and Costimulators in T Cell Anergy In Vivo
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CD28/B7 SYSTEM OF T CELL COSTIMULATION
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Redefining Chronic Viral Infection
Virgin, H. W., Wherry, E. J., & Ahmed, R. (2009) · Cell · doi:10.1016/j.cell.2009.06.036 · Cited by 1,031
Biomaterials: Foreign Bodies or Tuners for the Immune Response?
Mariani, E., Lisignoli, G., Borzì, R. M., & Pulsatelli, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030636 · Cited by 706
Signals required for programming effector and memory development by CD8+ T cells
Mescher, M. F., Curtsinger, J. M., Agarwal, P., Casey, K. A., Gerner, M., Hammerbeck, C. D., Popescu, F., & Xiao, Z. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00382.x · Cited by 601
Self-citationShaping and reshaping CD8+ T-cell memory
Harty, J. T., & Badovinac, V. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2251 · Cited by 555
Aluminum Hydroxide Adjuvants Activate Caspase-1 and Induce IL-1β and IL-18 Release
Li, H., Nookala, S., & Re, F. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5271 · Cited by 332
Metadata
- Authors
- Curtsinger, J. M., Schmidt, C. S., Mondino, A., Lins, D. C., Kedl, R. M., Jenkins, M. K., & Mescher, M. F.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03
- Volume
- 162
- Issue
- 6
- Pages
- 3256-3262
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2105382508
- Cited by
- 616
- References
- 42
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Inflammatory Cytokines Provide a Third Signal for Activation of Naive CD4+ and CD8+ T Cells. https://app.cochat.ai/papers/10.4049/jimmunol.162.6.3256
- The paper
- Curtsinger, J. M., Schmidt, C. S., Mondino, A., Lins, D. C., Kedl, R. M., Jenkins, M. K., & Mescher, M. F. (1999). Inflammatory Cytokines Provide a Third Signal for Activation of Naive CD4+ and CD8+ T Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.162.6.3256
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
