The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Single-cell mass cytometry for analysis of immune system functional states
Open accessAbstract
Single cell mass cytometry facilitates high-dimensional, quantitative analysis of the effects of bioactive molecules on cell populations at single-cell resolution. Datasets are generated with antibody panels (upwards of 40) in which each antibody is conjugated to a polymer chelated with a stable metal isotope, usually in the Lanthanide series of the periodic table. Isotope labelled antibodies recognize surface markers to delineate cell types and intracellular signaling molecules to provide a measure of the network state—and thereby demarcating multiple cell state functions such as apoptosis, DNA damage and cell cycle. By measuring all these parameters simultaneously, the signaling state of an individual cell can be measured at its network state. This review will cover the basics of mass cytometry as well as outline steps already taken to allow it to stand aside traditional fluorescence based cytometry in the immunologist’s analytical arsenal in their study of immune states during infection.
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Cites
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Self-citationExtracting a cellular hierarchy from high-dimensional cytometry data with SPADE
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Self-citationMultiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators
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Cited by
Cytokines: From Clinical Significance to Quantification
Liu, C., Chu, D., Kalantar‐Zadeh, K., George, J., Young, H. A., & Liu, G. (2021) · Advanced Science · doi:10.1002/advs.202004433 · Cited by 940
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Single-Cell Mass Cytometry Analysis of Human Tonsil T Cell Remodeling by Varicella Zoster Virus
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“Single cell mass cytometry is a recently developed technique to study complex biological systems using quantitative, high-dimensional analysis of the simultaneous expression of more than 40 proteins per cell, detected with metal-isotope labeled antibodies (Bjornson et al., 2013).”
BackgroundSelf-citationTargeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer
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Metadata
- Authors
- Bjornson, Z. B., Nolan, G. P., & Fantl, W. J.
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 25
- Issue
- 4
- Pages
- 484-494
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2061729626
- Cited by
- 224
- References
- 10
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- green
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