Interrogating the repertoire: broadening the scope of peptide–MHC multimer analysis
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Labelling antigen-specific T cells with peptide-MHC multimers has provided an invaluable way to monitor T cell-mediated immune responses. A number of recent developments in this technology have made these multimers much easier to make and use in large numbers. Furthermore, enrichment techniques have provided a greatly increased sensitivity that allows the analysis of the naive T cell repertoire directly. Thus, we can expect a flood of new information to emerge in the coming years.
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Peptide-MHC class-I or class-II multimers can estimate the extent of CMV 'obsession' by identifying antigen-specific cells.
“Studies can estimate the extent of CMV “obsession” by identifying antigen-specific cells using peptide-MHC class-I or class-II multimers (Altman et al. 1996; Davis et al. 2011).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Davis et al. 2011
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- Authors
- Davis, M. M., Altman, J. D., & Newell, E. W.
- Affiliations
- Howard Hughes Medical Institute (US)
- Emory University (US)
- Stanford Medicine (US)
- Corresponding author
- Davis, Mark M.
- Altman, John D.
- Venue
- Nature Reviews Immunology
- Published
- 2011-07-15
- Volume
- 11
- Issue
- 8
- Pages
- 551-558
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC3699324
- OpenAlex
- W1994359525
- Cited by
- 124
- References
- 95
- Citations by year
- 2026: 10 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 4 · 2021: 9 · 2020: 5 · 2019: 10 · 2018: 7 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 16 · 2012: 15
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- American Cancer Society
- Bill and Melinda Gates Foundation (U19AI057229)
- Emory University (P30AI050409)
- National Institutes of Health (AI050409)
- U.S. Public Health Service (N01A125456M0D13)
- Center for AIDS Research, University of Washington (P30 AI050409)
- National Institute of Allergy and Infectious Diseases (U19AI090019, P30AI050409, U19AI057229)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- T cell receptor repertoire, T cell specificity, antigen-specific T cells, T cell immunity, naive T cells, T cell enrichment, T cell therapy
- MeSH terms
- Animals, Immunotoxins, Communicable Diseases, Flow Cytometry, Humans, Immunologic Techniques, Major Histocompatibility Complex, Peptides, Receptors, Antigen, T-Cell, Mass Spectrometry, T-Lymphocytes, Vaccines, T-Lymphocyte Subsets, Immunotherapy, Adoptive, Epitope Mapping, Epitopes, T-Lymphocyte, Cancer Vaccines, Mice, Cell Tracking
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