Cited by 124T-cell and B-cell ImmunologyImmunotherapy and Immune Responsesvaccines and immunoinformatics approaches

Interrogating the repertoire: broadening the scope of peptide–MHC multimer analysis

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Davis, Mark M., Altman, John D., Newell, Evan W.·2011·Nature Reviews Immunology

Abstract

Labelling antigen-specific T cells with peptide-MHC multimers has provided an invaluable way to monitor T cell-mediated immune responses. A number of recent developments in this technology have made these multimers much easier to make and use in large numbers. Furthermore, enrichment techniques have provided a greatly increased sensitivity that allows the analysis of the naive T cell repertoire directly. Thus, we can expect a flood of new information to emerge in the coming years.

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  • Peptide-MHC class-I or class-II multimers can estimate the extent of CMV 'obsession' by identifying antigen-specific cells.

    “Studies can estimate the extent of CMV “obsession” by identifying antigen-specific cells using peptide-MHC class-I or class-II multimers (Altman et al. 1996; Davis et al. 2011).”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Davis et al. 2011

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Authors
Davis, M. M., Altman, J. D., & Newell, E. W.
Affiliations
  • Howard Hughes Medical Institute (US)
  • Emory University (US)
  • Stanford Medicine (US)
Corresponding author
  • Davis, Mark M.
  • Altman, John D.
Venue
Nature Reviews Immunology
Published
2011-07-15
Volume
11
Issue
8
Pages
551-558
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W1994359525
Cited by
124
References
95
Citations by year
2026: 10 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 4 · 2021: 9 · 2020: 5 · 2019: 10 · 2018: 7 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 16 · 2012: 15
FWCI
1.15
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • American Cancer Society
  • Bill and Melinda Gates Foundation (U19AI057229)
  • Emory University (P30AI050409)
  • National Institutes of Health (AI050409)
  • U.S. Public Health Service (N01A125456M0D13)
  • Center for AIDS Research, University of Washington (P30 AI050409)
  • National Institute of Allergy and Infectious Diseases (U19AI090019, P30AI050409, U19AI057229)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
Keywords
T cell receptor repertoire, T cell specificity, antigen-specific T cells, T cell immunity, naive T cells, T cell enrichment, T cell therapy
MeSH terms
Animals, Immunotoxins, Communicable Diseases, Flow Cytometry, Humans, Immunologic Techniques, Major Histocompatibility Complex, Peptides, Receptors, Antigen, T-Cell, Mass Spectrometry, T-Lymphocytes, Vaccines, T-Lymphocyte Subsets, Immunotherapy, Adoptive, Epitope Mapping, Epitopes, T-Lymphocyte, Cancer Vaccines, Mice, Cell Tracking

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