The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries
Open accessAbstract
Nucleotide-binding domain, leucine-rich repeat (NLR) proteins constitute a diverse class of innate immune sensors that detect pathogens or stress-associated stimuli in plants and animals. Some NLRs are activated upon direct binding to pathogen-derived ligands. In contrast, we focus here on a vertebrate NLR called NLRP1 that responds to the enzymatic activities of pathogen effectors. We discuss a newly proposed ‘functional degradation’ mechanism that explains activation and assembly of NLRP1 into an oligomeric complex called an inflammasome. We also discuss how NLRP1 is activated by non-pathogen-associated triggers such as the anti- cancer drug Val-boroPro, or by human disease-associated mutations. Finally, we discuss how research on NLRP1 has led to additional biological insights, including the unexpected discovery of a new CARD8 inflammasome.
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Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
N-degron and C-degron pathways of protein degradation
Varshavsky, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816596116 · Cited by 544
Kummer, J. A., Broekhuizen, R., Everett, H., Agostini, L., Kuijk, L., Martinon, F., Bruggen, R. V., & Tschopp, J. (2007) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.6a7101.2006 · Cited by 531
Rules of engagement: molecular insights from host–virus arms races
Daugherty, M. D., & Malik, H. S. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155522 · Cited by 515
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Pyroptosis in inflammatory diseases and cancer
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Role of pyroptosis in inflammation and cancer
Wei, X., Xie, F., Zhou, X., Wu, Y., Yan, H., Liu, T., Huang, J., Wang, F., Zhou, F., & Zhang, L. (2022) · Cellular & Molecular Immunology · doi:10.1038/s41423-022-00905-x · Cited by 699
Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
Deng, W., Bai, Y., Deng, F., Pan, Y., Mei, S., Zheng, Z., Min, R., Wu, Z., Li, W., Miao, R., et al. (2022) · Nature · doi:10.1038/s41586-021-04384-4 · Cited by 348
Human NLRP1 is a sensor for double-stranded RNA
Bauernfried, S., Scherr, M. J., Pichlmair, A., Duderstadt, K. E., & Hornung, V. (2021) · Science · doi:10.1126/science.abd0811 · Cited by 304
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Metadata
- Authors
- Mitchell, P. S., Sandstrom, A., & Vance, R. E.
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 60
- Pages
- 37-45
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2945675033
- Cited by
- 179
- References
- 5
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- green
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