Human NLRP1 is a sensor for double-stranded RNA

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · see citing works

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996 · see citing works

Inflammasomes: mechanism of assembly, regulation and signalling

Broz, P., & Dixit, V. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.58 · Cited by 3,500 · see citing works

A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core

Zimmermann, L., Stephens, A., Nam, S.-Z., Rau, D., Kübler, J., Lozajic, M., Gabler, F., Söding, J., Lupas, A. N., & Alva, V. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.12.007 · Cited by 2,522 · see citing works

The gasdermins, a protein family executing cell death and inflammation

Broz, P., Pelegrín, P., & Shao, F. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0228-2 · Cited by 1,641 · see citing works

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

Kanneganti, T., Özören, N., Body–Malapel, M., Amer, A. O., Park, J., Franchi, L., Whitfield, J. R., Barchet, W., Colonna, M., Vandenabeele, P., et al. (2006) · Nature · doi:10.1038/nature04517 · Cited by 1,149 · see citing works

Human Keratinocytes That Express hTERT and Also Bypass a p16 ^INK4a -Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics

Dickson, M. A., Hahn, W. C., Ino, Y., Ronfard, V., Wu, J. Y., Weinberg, R. A., Louis, D. N., Li, F. P., & Rheinwald, J. G. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.4.1436-1447.2000 · Cited by 1,104 · see citing works

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

Coll, R. C., Hill, J. R., Day, C. J., Zamoshnikova, A., Boucher, D., Massey, N. L., Chitty, J. L., Fraser, J. A., Jennings, M. P., Robertson, A. A. B., et al. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0277-7 · Cited by 1,041 · see citing works

Structural mechanism of cytosolic DNA sensing by cGAS

Çivril, F., Deimling, T., Mann, C. C. D. O., Ablasser, A., Moldt, M., Witte, G., Hornung, V., & Hopfner, K. (2013) · Nature · doi:10.1038/nature12305 · Cited by 888 · see citing works

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

Schlee, M., Roth, A. H. F. J., Hornung, V., Hagmann, C. A., Wimmenauer, V., Barchet, W., Coch, C., Janke, M., Mihailovic, A., Wardle, G. S., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.008 · Cited by 792 · see citing works

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

Gaidt, M. M., Ebert, T. S., Chauhan, D., Ramshorn, K., Pinci, F., Zuber, S., O’Duill, F., Schmid-Burgk, J. L., Hoss, F., Buhmann, R., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.039 · Cited by 638 · see citing works

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

Wu, B., Peisley, A., Richards, C., Yao, H., Zeng, X., Lin, C., Feixia Chu, C., Walz, T., & Hur, S. (2012) · Cell · doi:10.1016/j.cell.2012.11.048 · Cited by 572 · see citing works

Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

Duncan, J. A., Bergstralh, D. T., Wang, Y., Willingham, S. B., Ye, Z., Zimmermann, A. G., & Ting, J. P.-Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611496104 · Cited by 503 · see citing works

Homeostasis-altering molecular processes as mechanisms of inflammasome activation

Liston, A., & Masters, S. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.151 · Cited by 459 · see citing works

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

Zhong, F. L., Mamaï, O., Sborgi, L., Boussofara, L., Hopkins, R., Robinson, K., Szeverényi, I., Takeichi, T., Balaji, R., Lau, A., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.001 · Cited by 440 · see citing works

Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism

Hu, Z., Yan, C., Liu, P., Huang, Z., Ma, R., Zhang, C., Wang, R., Zhang, Y., Martinon, F., Miao, D., et al. (2013) · Science · doi:10.1126/science.1236381 · Cited by 401 · see citing works

Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

Sandstrom, A., Mitchell, P. S., Goers, L., Mu, E. W., Lesser, C. F., & Vance, R. E. (2019) · Science · doi:10.1126/science.aau1330 · Cited by 377 · see citing works

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

Johnson, D. C., Taabazuing, C. Y., Okondo, M. C., Chui, A. J., Rao, S. D., Brown, F. C., Reed, C., Peguero, E., de Stanchina, E., Kentsis, A., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0082-y · Cited by 342 · see citing works

ASC Speck Formation as a Readout for Inflammasome Activation

Stutz, A., Horvath, G. L., Monks, B. G., & Latz, E. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-523-1_8 · Cited by 335 · see citing works

Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

Peisley, A., Lin, C., Wu, B., Orme-Johnson, M., Liu, M., Walz, T., & Hur, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113651108 · Cited by 312 · see citing works

N-terminal degradation activates the NLRP1B inflammasome

Chui, A. J., Okondo, M. C., Rao, S. D., Gai, K., Griswold, A. R., Johnson, D. C., Ball, D. P., Taabazuing, C. Y., Orth-He, E. L., Vittimberga, B. A., et al. (2019) · Science · doi:10.1126/science.aau1208 · Cited by 300 · see citing works

Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci

Lilue, J., Doran, A. G., Fiddes, I. T., Abrudan, M., Armstrong, J., Bennett, R., Chow, W., Collins, J., Collins, S., Czechanski, A., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0223-8 · Cited by 267 · see citing works

In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-α and ribavirin combination

Briolant, S., Garín, D., Scaramozzino, N., Jouan, A., & Crance, J. (2003) · Antiviral Research · doi:10.1016/j.antiviral.2003.09.005 · Cited by 253 · see citing works

Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding

Zhong, F. L., Robinson, K. S., Teo, D. E. T., Tan, K. Y., Lim, C., Harapas, C. R., Yu, C., Xie, W. H., Sobota, R. M., Au, B. V., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004350 · Cited by 236 · see citing works

Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia

Robinson, K. S., Teo, D. E. T., Tan, K. S., Toh, G. A., Ong, H. H., Lim, C., Lay, K., Au, B. V., Lew, T. S., Chu, J. J. H., et al. (2020) · Science · doi:10.1126/science.aay2002 · Cited by 222 · see citing works

Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome

Okondo, M. C., Rao, S. D., Taabazuing, C. Y., Chui, A. J., Poplawski, S. E., Johnson, D. C., & Bachovchin, D. A. (2018) · Cell chemical biology · doi:10.1016/j.chembiol.2017.12.013 · Cited by 198 · see citing works

CARD8 inflammasome activation triggers pyroptosis in human T cells

Linder, A., Bauernfried, S., Cheng, Y., Albanese, M., Jung, C., Keppler, O. T., & Hornung, V. (2020) · The EMBO Journal · doi:10.15252/embj.2020105071 · Cited by 177 · see citing works

The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries

Mitchell, P. S., Sandstrom, A., & Vance, R. E. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2019.04.015 · Cited by 175 · see citing works

Rapid Mutagenesis and Purification of Phage RNA Polymerases

He, B., Rong, M., Lyakhov, D. L., Gartenstein, H., Díaz, G. A., Castagna, R., McAllister, W. T., & Durbin, R. K. (1997) · Protein Expression and Purification · doi:10.1006/prep.1996.0663 · Cited by 137 · see citing works

Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation

Chavarría‐Smith, J., Mitchell, P. S., Ho, A. M., Daugherty, M. D., & Vance, R. E. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1006052 · Cited by 135 · see citing works

Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosis

Drutman, S., Haerynck, F., Zhong, F., Hum, D., Hernandez, N., Belkaya, S., Rapaport, F., de Jong, S. J., Creytens, D., Tavernier, S., et al. (2019) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1906184116 · Cited by 98 · see citing works

DPP8/9 inhibitors are universal activators of functional NLRP1 alleles

Gai, K., Okondo, M. C., Rao, S. D., Chui, A. J., Ball, D. P., Johnson, D. C., & Bachovchin, D. A. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1817-5 · Cited by 91 · see citing works

Trans genomic capture and sequencing of primate exomes reveals new targets of positive selectionPreprint

George, R. D., McVicker, G., Diederich, R., Ng, S. B. H., MacKenzie, A. P., Swanson, W. J., Shendure, J., & Thomas, J. H. (2011) · Genome Research · doi:10.1101/gr.121327.111 · Cited by 89 · see citing works

Immunoblotting for Active Caspase-1

Jakobs, C., Bartok, E., Kubarenko, A., Bauernfeind, F. G., & Hornung, V. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-523-1_9 · Cited by 74 · see citing works

Establishing the role of ATP for the function of the RIG-I innate immune sensor

Rawling, D., Fitzgerald, M. E., & Pyle, A. M. (2015) · eLife · doi:10.7554/elife.09391 · Cited by 63 · see citing works

Detection of ASC Speck Formation by Flow Cytometry and Chemical Cross-linking

Hoß, F., Rolfes, V., Davanso, M. R., Braga, T. T., & Franklin, B. S. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7519-8_10 · Cited by 30 · see citing works

Quantification of absolute Ras-GDP/GTP levels by HPLC separation of Ras-bound [32P]-labelled nucleotides

Rubio, I., Pusch, R., & Wetzker, R. (2003) · Journal of Biochemical and Biophysical Methods · doi:10.1016/j.jbbm.2003.07.001 · Cited by 22 · see citing works

High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome

Harris, P. A., Duraiswami, C., Fisher, D. T., Fornwald, J. A., Hoffman, S. J., Hofmann, G. A., Jiang, M., Lehr, R. V., McCormick, P. M., Nickels, L., et al. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.05.032 · Cited by 19 · see citing works

Investigating the molecular basis of human NLRP1 inflammasome activation

Moecking, J. (2019) · Minerva Access (University of Melbourne) · Cited by 1 · see citing works

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

Bertheloot, D., Latz, E., & Franklin, B. S. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00630-3 · Cited by 2,198 · see citing works

SARS-CoV-2 pathogenesis

Lamers, M. M., & Haagmans, B. L. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00713-0 · Cited by 986 · see citing works

Role of pyroptosis in inflammation and cancer

Xiang, W. D., Xie, F., Zhou, X., Wu, Y., Yan, H., Liu, T., Huang, J. S., Wang, F., Zhou, F., & Zhang, L. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00905-x · Cited by 715 · see citing works

FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation

Junqueira, C., Crespo, Â. C., Ranjbar, S., de Lacerda, L., Lewandrowski, M., Ingber, J., Parry, B. A., Ravid, S., Clark, S. A., Schrimpf, M. R., et al. (2022) · Nature · doi:10.1038/s41586-022-04702-4 · Cited by 669 · see citing works

A 360° view of the inflammasome: Mechanisms of activation, cell death, and diseases

Barnett, K. C., Li, S., Liang, K., & Ting, J. P.-Y. (2023) · Cell · doi:10.1016/j.cell.2023.04.025 · Cited by 458 · see citing works

Cellular origins of dsRNA, their recognition and consequences

Chen, Y. G., & Hur, S. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00430-1 · Cited by 430 · see citing works

COVID-19 mRNA vaccines: Platforms and current developments

Szabó, G. T., Mahiny, A. J., & Vlatkovic, I. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.02.016 · Cited by 308 · see citing works

Prokaryotic innate immunity through pattern recognition of conserved viral proteins

Gao, L. A., Wilkinson, M. E., Strecker, J. G., Makarova, K. S., Macrae, R. K., Koonin, E. V., & Zhang, F. (2022) · Science · doi:10.1126/science.abm4096 · Cited by 233 · see citing works

The NLR gene family: from discovery to present day

Chou, W.-C., Jha, S., Linhoff, M. W., & Ting, J. P. ‐. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00849-x · Cited by 221 · see citing works

Mechanistic insights from inflammasome structures

Fu, J., Schroder, K., & Wu, H. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-00995-w · Cited by 215 · see citing works

The NLR family of innate immune and cell death sensors

Sundaram, B., Tweedell, R. E., Kumar, S. P., & Kanneganti, T. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.012 · Cited by 213 · see citing works

Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment

Zhu, P., Ke, Z.-R., Chen, J.-X., Li, S., Ma, T., & Fan, X.-L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1120034 · Cited by 194 · see citing works

Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis

Oh, S., Lee, J., Oh, J.-E., Yu, G., Ryu, H., Kim, D., & Lee, S. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01107-9 · Cited by 188 · see citing works

Cell biology of inflammasome activation

Pandey, A., Shen, C. X., Feng, S., & Man, S. M. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.06.010 · Cited by 179 · see citing works

ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome

Robinson, K. S., Toh, G. A., Rozario, P., Chua, R., Bauernfried, S., Sun, Z., Firdaus, M. J., Bayat, S., Nadkarni, R., Poh, Z. S., et al. (2022) · Science · doi:10.1126/science.abl6324 · Cited by 178 · see citing works

Diverse viral proteases activate the NLRP1 inflammasome

Tsu, B. V., Beierschmitt, C., Ryan, A. P., Agarwal, R., Mitchell, P. S., & Daugherty, M. D. (2021) · eLife · doi:10.7554/elife.60609 · Cited by 175 · see citing works

DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways

Huang, Y., Jiang, W., & Zhou, R. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01027-3 · Cited by 189 · see citing works

Targeting the Inflammasome in Cardiovascular Disease

Olsen, M. B., Gregersen, I., Sandanger, Ø., Yang, K., Sokolova, M., Halvorsen, B. L., Gullestad, L. L., Broch, K., Aukrust, P., & Louwe, M. C. (2021) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2021.08.006 · Cited by 170 · see citing works

Inflammasome components as new therapeutic targets in inflammatory disease

Coll, R. C., & Schroder, K. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01075-9 · Cited by 168 · see citing works

CARD8 is an inflammasome sensor for HIV-1 protease activity

Wang, Q., Gao, H., Clark, K. M., Mugisha, C. S., Davis, K., Tang, J. P., Harlan, G. H., DeSelm, C. J., Presti, R. M., Kutluay, S. B., et al. (2021) · Science · doi:10.1126/science.abe1707 · Cited by 162 · see citing works

The role of NOD-like receptors in innate immunity

Almeida-da-Silva, C. L. C., Savio, L. E. B., Coutinho‐Silva, R., & Ojcius, D. M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1122586 · Cited by 160 · see citing works

Organellar homeostasis and innate immune sensing

Harapas, C. R., Idiiatullina, E., Al‐Azab, M., Hrovat-Schaale, K., Reygaerts, T., Steiner, A., Laohamonthonkul, P., Davidson, S., Yu, C., Booty, L. M., et al. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00682-8 · Cited by 151 · see citing works

Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells

Planès, R., Pinilla, M., Santoni, K., Hessel, A., Passemar, C., Lay, K., Paillette, P., Valadão, A. L. C., Robinson, K. S., Bastard, P., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.04.033 · Cited by 150 · see citing works

Triggers for the onset and recurrence of psoriasis: a review and update

Liu, S., He, M. L., Jiang, J. W., Duan, X., Chai, B., Zhang, J., Tao, Q., & Chen, H. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01381-0 · Cited by 153 · see citing works

The immunostimulatory nature of mRNA lipid nanoparticles

Sharma, P., Hoorn, D., Aitha, A., Breier, D., & Peer, D. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115175 · Cited by 132 · see citing works

The gasdermin family: emerging therapeutic targets in diseases

Zhu, C., Xu, S., Jiang, R., Yu, Y., Bian, J., & Zou, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01801-8 · Cited by 139 · see citing works

Innate Sensors Trigger Regulated Cell Death to Combat Intracellular Infection

Nozaki, K., Li, L., & Miao, E. A. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-011235 · Cited by 119 · see citing works

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

Jenster, L., Lange, K.-E., Normann, S., Hemdt, A. V., Wuerth, J. D., Schiffelers, L. D. J., Tesfamariam, Y. M., Gohr, F. N., Klein, L., Kaltheuner, I. H., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220837 · Cited by 113 · see citing works

NLRP inflammasomes in health and disease

Xu, Z., Kombe, A. J. K., Deng, S., Zhang, H., Wu, S., Ruan, J., Zhou, Y. Y., & Jin, T. (2024) · Molecular Biomedicine · doi:10.1186/s43556-024-00179-x · Cited by 120 · see citing works

Non-immunotherapy application of LNP-mRNA: Maximizing efficacy and safety

Vlatkovic, I. (2021) · Biomedicines · doi:10.3390/biomedicines9050530 · Cited by 112 · see citing works

Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment

Sharif, H., Hollingsworth, L. R., Griswold, A. R., Hsiao, J. C., Wang, Q., Bachovchin, D. A., & Wu, H. (2021) · Immunity · doi:10.1016/j.immuni.2021.04.024 · Cited by 96 · see citing works

PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field

Nguyen, L. N., & Kanneganti, T. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167249 · Cited by 98 · see citing works

The evolution of regulated cell death pathways in animals and their evasion by pathogens

Tummers, B., & Green, D. R. (2021) · Physiological Reviews · doi:10.1152/physrev.00002.2021 · Cited by 95 · see citing works

Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns

Dubey, S. R., Turnbull, C., Pandey, A., Zhao, A., Kurera, M., Al-Zidan, R. N., Shen, C. X., Gautam, M., Mahajan, S., Jadhav, P. S., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01354-y · Cited by 97 · see citing works

SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”

Sievers, B. L., Cheng, M. T. K., Csiba, K., Meng, B., & Gupta, R. K. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01104-y · Cited by 85 · see citing works

Viral-mediated activation and inhibition of programmed cell death

Verburg, S. G., Lelievre, R. M., Westerveld, M. J., Inkol, J. M., Sun, Y. L., & Workenhe, S. T. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010718 · Cited by 85 · see citing works

Role of the inflammasome in insulin resistance and type 2 diabetes mellitus

Lu, S., Li, Y., Qian, Z., Zhao, T., Feng, Z., Weng, X., & Yu, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1052756 · Cited by 83 · see citing works

The human inflammasomes

Paerewijck, O., & Lamkanfi, M. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101100 · Cited by 84 · see citing works

Pyroptosis and respiratory diseases: A review of current knowledge

Sun, J., & Li, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.920464 · Cited by 82 · see citing works

Viral manipulation of host cell necroptosis and pyroptosis

Verdonck, S., Nemegeer, J., Vandenabeele, P., & Maelfait, J. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.11.011 · Cited by 76 · see citing works

Fantastic voyage: The journey of NLRP3 inflammasome activation

Que, X., Zheng, S., Song, Q., Pei, H., & Zhang, P. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.01.009 · Cited by 85 · see citing works

Involvement of inflammasomes in tumor microenvironment and tumor therapies

Zhang, Z., Li, X., Wang, Y., Wei, Y., & Wei, X. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01407-7 · Cited by 79 · see citing works

Molecular mechanisms of phenotypic variability in monogenic autoinflammatory diseases

Aksentijevich, I. A., & Schnappauf, O. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00614-1 · Cited by 75 · see citing works

NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity

Alijagić, A., Hedbrant, A., Persson, A., Larsson, M., Engwall, M., & Särndahl, E. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1178434 · Cited by 78 · see citing works

Inflammasomes: Mechanisms of Action and Involvement in Human Diseases

Bulté, D., Rigamonti, C., Romano, A., & Mortellaro, A. (2023) · Cells · doi:10.3390/cells12131766 · Cited by 82 · see citing works

Innate immune responses to RNA: sensing and signaling

Luan, X., Wang, L., Song, G., & Zhou, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1287940 · Cited by 79 · see citing works

NLRP7: From inflammasome regulation to human disease

Carrière, J., Dorfleutner, A., & Stehlik, C. (2021) · Immunology · doi:10.1111/imm.13372 · Cited by 71 · see citing works

Inflammasome activation in traumatic brain injury and Alzheimer's disease

Johnson, N. H., Vaccari, J. P. D. R., Bramlett, H. M., Keane, R. W., & Dietrich, W. D. (2022) · Translational research · doi:10.1016/j.trsl.2022.08.014 · Cited by 73 · see citing works

Human NLRP1: From the shadows to center stage

Bauernfried, S., & Hornung, V. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20211405 · Cited by 70 · see citing works

dsRNA-induced condensation of antiviral proteins modulates PKR activity

Corbet, G. A., Burke, J. M., Bublitz, G. R., Tay, J. W., & Parker, R. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204235119 · Cited by 70 · see citing works

ATP-binding and hydrolysis of human NLRP3

Brinkschulte, R., Fußhöller, D. M., Hoß, F., Rodríguez-Alcázar, J. F., Lauterbach, M. A. R., Kolbe, C., Rauen, M., Ince, S., Herrmann, C., Latz, E., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04120-2 · Cited by 70 · see citing works

Novel insights into double-stranded RNA-mediated immunopathology

de Reuver, R., & Maelfait, J. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00940-3 · Cited by 66 · see citing works

SARS-CoV-2 Envelope (E) Protein Binds and Activates TLR2 Pathway: A Novel Molecular Target for COVID-19 Interventions

Planès, R., Bert, J.-B., Tairi, S., BenMohamed, L., & Bahraoui, E. (2022) · Viruses · doi:10.3390/v14050999 · Cited by 64 · see citing works

Inflammasome activation: from molecular mechanisms to autoinflammation

Reyna, S. J. L., Caseley, E. A., Topping, J., Rodrigues, F., Jimenez-Macias, J. L., Lawler, S. E., & McDermott, M. (2022) · Clinical & Translational Immunology · doi:10.1002/cti2.1404 · Cited by 64 · see citing works

Activation and regulation mechanisms of NOD-like receptors based on structural biology

Ohto, U. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.953530 · Cited by 63 · see citing works

NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise

Barry, K. T., Murphy, C., & Mansell, A. S. (2023) · Communications Biology · doi:10.1038/s42003-023-05684-3 · Cited by 63 · see citing works

Structures and functions of the inflammasome engine

Wang, L., Sharif, H., Vora, S. M., Zheng, Y., & Wu, H. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.04.018 · Cited by 61 · see citing works

Understanding the impact of in vitro transcription byproducts and contaminants

Lenk, R., Kleindienst, W., Szabó, G. T., Baiersdörfer, M., Boros, G., Keller, J. M., Mahiny, A. J., & Vlatkovic, I. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1426129 · Cited by 63 · see citing works

DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling

Harapas, C. R., Robinson, K. S., Lay, K., Wong, J., Traspas, R. M., Nabavizadeh, N., Raas‐Rothschild, A., Boisson, B., Drutman, S. B., Laohamonthonkul, P., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abi4611 · Cited by 57 · see citing works

Role of the NLRP1 inflammasome in skin cancer and inflammatory skin diseases

Calabrese, L., Fiocco, Z., Mellett, M., Aoki, R., Rubegni, P., French, L. E., & Satoh, T. K. (2023) · British Journal of Dermatology · doi:10.1093/bjd/ljad421 · Cited by 56 · see citing works

Inflammasomes in Cancer Progression and Anti-Tumor Immunity

Lillo, S., & Saleh, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.839041 · Cited by 53 · see citing works

Oxidized thioredoxin-1 restrains the NLRP1 inflammasome

(2022) · doi:10.1126/sciimmunol.abm7200 · Cited by 53 · see citing works

The crosstalk between immune cells and tumor pyroptosis: advancing cancer immunotherapy strategies

Hu, M., Deng, F., Song, X., Zhao, H., & Yan, F. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03115-7 · Cited by 53 · see citing works

Dysregulated Inflammation During Obesity: Driving Disease Severity in Influenza Virus and SARS-CoV-2 Infections

Hulme, K. D., Noye, E. C., Short, K. R., & Labzin, L. I. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.770066 · Cited by 51 · see citing works

Origins and diversification of animal innate immune responses against viral infections

Iwama, R. E., & Moran, Y. (2023) · Nature Ecology & Evolution · doi:10.1038/s41559-022-01951-4 · Cited by 51 · see citing works

Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome

Zhang, Z., Shibata, T., Fujimura, A., Kitaura, J., Miyake, K., Ohto, U., & Shimizu, T. (2023) · Nature · doi:10.1038/s41586-023-06532-4 · Cited by 52 · see citing works

Targeting inflammasomes and pyroptosis in retinal diseases—molecular mechanisms and future perspectives

Sun, Y., Li, F., Liu, Y., Qiao, D., Yao, X., Liu, G., Li, D., Xiao, C., Wang, T., & Chi, W. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101263 · Cited by 51 · see citing works

Regulation of antiviral innate immunity by chemical modification of viral RNA

Li, N., & Rana, T. M. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1720 · Cited by 44 · see citing works

Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity

Bharadwaj, R., Lusi, C. F., Mashayekh, S., Nagar, A., Subbarao, M., Kane, G. I., Wodzanowski, K. A., Brown, A. R., Okuda, K., Monahan, A., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.04.001 · Cited by 48 · see citing works

Viral proteases activate the CARD8 inflammasome in the human cardiovascular system

Nadkarni, R., Chu, W., Lee, C. Q. E., Mohamud, Y., Yap, L., Toh, G. A., Beh, S., Lim, R., Fan, Y. M., Zhang, Y. L., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20212117 · Cited by 48 · see citing works

The roles of inflammasomes in cancer

Deng, Z., Lu, L., Li, B., Shi, X., Jin, H., & Hu, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1195572 · Cited by 51 · see citing works

Innate immune sensing by epithelial barriers

Constant, D. A., Nice, T. J., & Rauch, I. (2021) · Current Opinion in Immunology · doi:10.1016/j.coi.2021.07.014 · Cited by 46 · see citing works

Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing

Matico, R., Yu, X., Miller, R., Somani, S., Ricketts, M. D., Kumar, N., Steele, R. A., Medley, Q. G., Berger, S. B., Faustin, B., et al. (2024) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-01143-z · Cited by 45 · see citing works

Shaping the Innate Immune Response Through Post-Transcriptional Regulation of Gene Expression Mediated by RNA-Binding Proteins

Guillemin, A., Kumar, A., Wencker, M., & Ricci, E. P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.796012 · Cited by 44 · see citing works

The role of pyroptosis in hepatocellular carcinoma

Zou, Z., Zhao, M., Yang, Y., Xie, Y., Li, Z., Zhou, L., Shang, R., & Zhou, P. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00787-9 · Cited by 44 · see citing works

EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption

Pinilla, M., Mazars, R., Vergé, R., Gorse, L., Paradis, M., Suire, B., Santoni, K., Robinson, K. S., Toh, G. A., Prouvensier, L., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20230104 · Cited by 46 · see citing works

KSHV-encoded ORF45 activates human NLRP1 inflammasome

Yang, X., Zhou, J., Liu, C., Qu, Y., Wang, W., Xiao, M. Z. X., Zhu, F., Liu, Z., & Liang, Q. (2022) · Nature Immunology · doi:10.1038/s41590-022-01199-x · Cited by 44 · see citing works

Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT)

Zhou, J. Y., Sarkar, M. K., Okamura, K., Harris, J. E., Gudjonsson, J. E., & Fitzgerald, K. A. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2213777120 · Cited by 43 · see citing works

Inflammasomes and SARS-CoV-2 Infection

Kaivola, J., Nyman, T., & Matikainen, S. (2021) · Viruses · doi:10.3390/v13122513 · Cited by 44 · see citing works

Pyroptosis and Sarcopenia: Frontier Perspective of Disease Mechanism

Jin, H., Xie, W., He, M., Li, H., Xiao, W., & Li, Y. (2022) · Cells · doi:10.3390/cells11071078 · Cited by 43 · see citing works

Pyroptosis and inflammasomes in cancer and inflammation

Wang, J., Hua, S., Bao, H., Yuan, J., Zhao, Y., & Chen, S. (2023) · MedComm · doi:10.1002/mco2.374 · Cited by 40 · see citing works

A Novel Self‐Amplifying mRNA with Decreased Cytotoxicity and Enhanced Protein Expression by Macrodomain Mutations

Gong, Y., Yong, D., Liu, G., Xu, J., Ding, J., & Jia, W. W.-G. (2024) · Advanced Science · doi:10.1002/advs.202402936 · Cited by 45 · see citing works

The NLRP1 Inflammasome Induces Pyroptosis in Human Corneal Epithelial Cells

Griswold, A. R., Huang, H., & Bachovchin, D. A. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.3.2 · Cited by 40 · see citing works

Tricks and threats of RNA viruses – towards understanding the fate of viral RNA

Markiewicz, Ł., Drążkowska, K., & Sikorski, P. J. (2021) · RNA Biology · doi:10.1080/15476286.2021.1875680 · Cited by 38 · see citing works

Epithelial Pyroptosis in Host Defense

Churchill, M. J., Mitchell, P. S., & Rauch, I. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167278 · Cited by 38 · see citing works

Cytoplasmic RNA sensors and their interplay with RNA-binding partners in innate antiviral response: theme and variations

Chan, C., & Jin, D. (2022) · RNA · doi:10.1261/rna.079016.121 · Cited by 36 · see citing works

Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity

Wu, X., Yang, Z., Wu, J., & Han, J. (2023) · Immunity · doi:10.1016/j.immuni.2023.02.014 · Cited by 38 · see citing works

Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy

Chen, Z., Behrendt, R., Wild, L., Schlee, M., & Bode, C. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02174-2 · Cited by 38 · see citing works

1,25-Dihydroxyvitamin D3 attenuates IL-1β secretion by suppressing NLRP1 inflammasome activation by upregulating the NRF2-HO-1 pathway in epidermal keratinocytes

Nakajo, T., Katayoshi, T., Kitajima, N., & Tsuji, K. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102203 · Cited by 36 · see citing works

Brain alarm by self-extracellular nucleic acids: from neuroinflammation to neurodegeneration

Kunze, R., Fischer, S., Marti, H. H., & Preissner, K. T. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00954-y · Cited by 35 · see citing works

Skin Colonization with S. aureus Can Lead to Increased NLRP1 Inflammasome Activation in Patients with Atopic Dermatitis

Vaher, H., Kingo, K., Kolberg, P., Pook, M., Raam, L., Laanesoo, A., Remm, A., Tenson, T., Alasoo, K., Mrowietz, U., et al. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.01.013 · Cited by 34 · see citing works

Bacterial homologs of innate eukaryotic antiviral defenses with anti-phage activity highlight shared evolutionary roots of viral defenses

van den Berg, D. F., Costa, A. R., Esser, J. Q., Stanciu, I., Geissler, J. Q., Zoumaro-Djayoon, A. D., Haas, P., & Brouns, S. J. J. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.07.007 · Cited by 33 · see citing works

NLRP1 Inflammasome Activation in Keratinocytes: Increasing Evidence of Important Roles in Inflammatory Skin Diseases and Immunity

Fenini, G., Karakaya, T., Hennig, P., Filippo, M. D., Slaufova, M., & Beer, H. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.04.004 · Cited by 33 · see citing works

Inflammasomes as mediators of inflammation in HIV-1 infection

Min, A. K., Fortune, T., Rodriguez, N., Hedge, E., & Swartz, T. H. (2022) · Translational research · doi:10.1016/j.trsl.2022.07.008 · Cited by 34 · see citing works

Redox regulation of the NLRP3-mediated inflammation and pyroptosis

Rusetskaya, N. Y., Loginova, N. Y., Pokrovskaya, E. P., Chesovskikh, Y. S., & Titova, L. E. (2023) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20236906333 · Cited by 34 · see citing works

Inflammasome diversity: exploring novel frontiers in the innate immune response

Yu, G., Choi, Y. K., & Lee, S. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.02.004 · Cited by 32 · see citing works

The Wheel of p53 Helps to Drive the Immune System

Łasut-Szyszka, B., & Rusin, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087645 · Cited by 31 · see citing works

NLRP1: a jack of all trades, or a master of one?

Bachovchin, D. A. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.01.001 · Cited by 30 · see citing works

Role of inflammasomes in HIV-1 infection and treatment

Jin, X., Zhou, R., & Huang, Y. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.02.010 · Cited by 30 · see citing works

How Pyroptosis Contributes to Inflammation and Fibroblast-Macrophage Cross-Talk in Rheumatoid Arthritis

Demarco, B., Danielli, S., Fischer, F. A., & Bezbradica, J. S. (2022) · Cells · doi:10.3390/cells11081307 · Cited by 30 · see citing works

A dsRNA detector in the immune toolkit

Scanlon, S. T. (2021) · Science · doi:10.1126/science.371.6528.477-m

TAK1 integrates the NLRP1 inflammasome into the innate immune response to double-stranded RNAPreprint

Corley, M. R., Hyodo, A., Toyoda, H. C., Yonemitsu, M. A., Chantharath, A., Hyde, J., & Mitchell, P. S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.23.701331 · Cited by 2 · see citing works

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

Wang, X., Jiang, W., Yan, Y., Gong, T., Han, J., Tian, Z., & Zhou, R. (2014) · Nature Immunology · doi:10.1038/ni.3015 · Cited by 323 · see citing works

Epidermal keratinocytes sense ds RNA via the NLRP 3 inflammasome, mediating interleukin ( IL )‐1β and IL ‐18 release

Dai, X., Tohyama, M., Murakami, M., & Sayama, K. (2017) · Experimental Dermatology · doi:10.1111/exd.13334 · Cited by 50 · see citing works

Molecular Mechanisms of RNA Sensing in NLRP6 Inflammasome Signaling

Shen, C., Li, R., Negro, R., Flavell, R. A., Zhu, S., & Wu, H. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2019.11.1216