Coaxial electrospinning multicomponent functional controlled-release vascular graft: Optimization of graft properties
Abstract
Small diameter vascular grafts possessing desirable biocompatibility and suitable mechanical properties have become an urgent clinic demand. Herein, heparin loaded fibrous grafts of collagen/chitosan/poly(l-lactic acid-co-ε-caprolactone) (PLCL) were successfully fabricated via coaxial electrospinning. By controlling the concentration of heparin and the ratio of collagen/chitosan/PLCL, most grafts had the heparin encapsulation efficiency higher than 70%, and the heparin presented sustained release for more than 45 days. Particularly, such multicomponent grafts had relative low initial burst release, and after heparin releasing for 3 weeks, the grafts still showed good anti-platelet adhesion ability. In addition, along with the excellent cell biocompatibility, the fabricated grafts possessed suitable mechanical properties including good tensile strength, suture retention strength, burst pressure and compliance which could well match the native blood vessels. Thus, the optimized graft properties could be properly addressed for vascular tissue application via coaxial electrospinning.
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Adding heparin to PLCL vascular stents enhances anticoagulant performance.
“most studies choose to add heparin to PLCL vascular stents to enhance the anticoagulant performance of the stents [156–158].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [158]
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Cited by
Sorted by citations
Application of PLCL as a biodegradable polymer in biomedical engineering
Zhao, Y., & Liu, H. (2026) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-026-07016-3 · Cited by 7 · see citing works
“In order to solve this problem, most studies choose to add heparin to PLCL vascular stents to enhance the anticoagulant performance of the stents [156 – 158].”
- Authors
- Yin, A., Luo, R., Li, J., Mo, X., Wang, Y., & Zhang, X.
- Affiliations
- Sichuan University (CN)
- Donghua University (CN)
- Corresponding author
- Yin, Anlin
- Mo, Xiumei
- Wang, Yunbing
- Venue
- Colloids and Surfaces B: Biointerfaces
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 152
- Pages
- 432-439
- ISSN
- 0927-7765 (ISSN-L)
- OpenAlex
- W2580556381
- Cited by
- 45
- References
- 27
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 3
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Colloids and Surfaces B Biointerfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31500784)
- China Postdoctoral Science Foundation Funded Project (2015M580790)
- Post-doctoral Special Fund of Sichuan University
- Program of Introducing Talents of Discipline to Universities (B16033)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- coaxial electrospinning, vascular grafts, heparin, controlled release, collagen, chitosan, PLCL, biocompatibility, mechanical properties, suture retention strength, burst pressure, compliance, tensile strength
- MeSH terms
- Animals, Biocompatible Materials, Blood Vessel Prosthesis, Collagen, Delayed-Action Preparations, Humans, Materials Testing, Polyesters, Tensile Strength, Tissue Engineering, Chitosan
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