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Multi-dimensional modeling of nanoparticles transportation from capillary bed into the tumor microenvironment

Jafari-Matanagh, Sina, Razavi, Seyed Esmail, Ehghaghi Bonab, Mir Biuk, Omidian, Hossein, Omidi, Yadollah·2023·Computers in Biology and Medicine
DOI 10.1016/j.compbiomed.2022.106477
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Abstract

In this study, we examined the extravasation of pharmaceutical inorganic nanoparticles (NPs) with a new approach from the leaky endothelium of tumor microvasculature (TMV) into the tumor microenvironment (TME) multi-dimensionally. We proposed a combination of prevailing macroscopic and microscopic methods and addressed the effect of interstitial fluid (IF) retention in solid tumor as an imperative parameter in drug delivery modeling. The Navier-Stokes equations and Darcy's law were utilized for blood flow and porous media, and the Starling's law was brought in for coupling effect. The blood flow was simulated as a non-Newtonian fluid alongside the Newtonian IF. We applied the Galerkin finite element method for the simulations. Our parametric study includes examining the effect of IF retention and TMV pressure on the distribution of tumor interstitial fluid pressure (TIFP), NPs concentration, and diameter on the penetration process, together with the time effect, on two-dimensional (2D) delivery of NPs. Our findings indicate that the IF retention in tumor cells increases TIFP depending on the amount of TMV pressure and IF retained. In addition to doubling pressure in the tumor necrotic region rather than the rest of TME, it enhances the TIFP which is an important parameter in drug delivery to solid tumors. By decreasing pressure drop within the TMV, pressure distribution within the TME becomes more uniform, creating a better condition for homogeneous penetration of NPs. Increa…

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Metadata

Authors
Jafari-Matanagh, S., Razavi, S. E., Ehghaghi Bonab, M. B., Omidian, H., & Omidi, Y.
Venue
Computers in Biology and Medicine
Publisher
Elsevier BV
Published
2023-01
Volume
152
Pages
106477
ISSN
0010-4825
DOI
10.1016/j.compbiomed.2022.106477
Cited by
6
References
2
Language
en
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