Growth of dendritic spines: a continuing story
Abstract
Dendritic spines, which are present at the vast majority of excitatory synapses in the central nervous system, have a specialized cytoskeleton of dynamic actin filaments that makes them capable of rapid morphological plasticity. During development, structural remodeling of nascent spines is an important factor in experience-dependent shaping of neuronal circuits, whereas in the adult brain spines maintain a balance between morphological stability and plasticity.
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Synaptic Ca2+ influx through NMDA receptors during long-term potentiation induction triggers Rho GTPase-mediated actin polymerization, resulting in AMPA-R trafficking to synapses.
“It has been suggested that synaptic Ca 2 + influx through NMDA receptors during long-term potentiation induction triggers Rho GTPase-meditated actin polymerization, resulting in AMPA-R trafficking to synapses (28).”
From AMPA receptor and GEF-H1/Lfc complex regulates dendritic spine development through RhoA signaling cascade (2009) · cites this paper as [28]
Cites
AMPA Receptor Trafficking and Synaptic Plasticity
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Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,500 · see citing works
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · see citing works
Long-term dendritic spine stability in the adult cortex
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Rapid Actin-Based Plasticity in Dendritic Spines
Fischer, M., Kaech, S., Knutti, D., & Matus, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80467-5 · Cited by 905 · see citing works
Self-citationDevelopmental regulation of spine motility in the mammalian central nervous system
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Bilousova, T. V., Dansie, L., Ngo, M., Aye, J., Charles, J. R., Ethell, D. W., & Ethell, I. M. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.061796 · Cited by 465 · see citing works
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Dendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease
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Rapid functional maturation of nascent dendritic spines
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Impaired Spine Stability Underlies Plaque-Related Spine Loss in an Alzheimer's Disease Mouse Model
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- Authors
- Matus, A.
- Affiliations
- Friedrich Miescher Institute (CH)
- Corresponding author
- Matus, Andrew
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 15
- Issue
- 1
- Pages
- 67-72
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2147276634
- Cited by
- 123
- References
- 9
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 6 · 2015: 2 · 2014: 6 · 2013: 6 · 2012: 5
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- dendritic spines, spine morphogenesis, actin cytoskeleton, synaptic plasticity, excitatory synapses, neuronal development, spinal stability
- MeSH terms
- Animals, Cell Differentiation, Humans, Neuronal Plasticity, Dendritic Spines
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