Cited by 393RNA and protein synthesis mechanismsChemical Synthesis and AnalysisProtein Structure and Dynamics

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Non-canonical amino acids in protein engineering

Link, A James, Mock, Marissa L, Tirrell, David A·2003·Current Opinion in Biotechnology

DOI 10.1016/j.copbio.2003.10.011

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Abstract

Methods for engineering proteins that contain non-canonical amino acids have advanced rapidly in the past few years. Novel amino acids can be introduced into recombinant proteins in either a residue-specific or site-specific fashion. The methods are complementary: residue-specific incorporation allows engineering of the overall physical and chemical behavior of proteins and protein-like macromolecules, whereas site-specific methods allow mechanistic questions to be probed in atomistic detail. Challenges remain in the engineering of the translational apparatus and in the design of schemes that can be used to encode both canonical and non-canonical amino acids.

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Authors: Link, A. J., Mock, M. L., & Tirrell, D. A.
Affiliations: California Institute of Technology (US)
Corresponding author: Tirrell, David A
ORCID: Link, A James
Mock, Marissa L
Tirrell, David A
Venue: Current Opinion in Biotechnology
Publisher: Elsevier BV
Published: 2003-12
Volume: 14
Issue: 6
Pages: 603-609
ISSN: 0958-1669 (ISSN-L)
DOI: 10.1016/j.copbio.2003.10.011
OpenAlex: W2090897179
Cited by: 393
References: 57
Citations by year: 2026: 1 · 2025: 5 · 2024: 16 · 2023: 14 · 2022: 11 · 2021: 11 · 2020: 14 · 2019: 23 · 2018: 16 · 2017: 18 · 2016: 8 · 2015: 11 · 2014: 20 · 2013: 24 · 2012: 20
FWCI: 1.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Biotechnology (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Keywords: unnatural amino acids, protein engineering, site-specific incorporation, amino acid encoding, protein design
MeSH terms: Amino Acids, Escherichia coli, Models, Biological, Models, Chemical, Ribosomes, RNA, Transfer, Protein Engineering

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Non-canonical amino acids in protein engineering

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