Production of succinic acid by metabolically engineered microorganisms

Production of succinic acid by bacterial fermentation

Song, H., & Lee, S. Y. (2006) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2005.11.043 · Cited by 815

Systems strategies for developing industrial microbial strains

Lee, S. Y., & Kim, H. U. (2015) · Nature Biotechnology · doi:10.1038/nbt.3365 · Cited by 589

Biorefineries for the production of top building block chemicals and their derivatives

Choi, S., Song, C. W., Shin, J. H., & Lee, S. Y. (2015) · Metabolic Engineering · doi:10.1016/j.ymben.2014.12.007 · Cited by 516

Combining metabolic engineering and metabolic evolution to develop nonrecombinant strains of Escherichia coli C that produce succinate and malate

Jantama, K., Haupt, M. J., Svoronos, S. A., Zhang, X., Moore, J. C., Shanmugam, K. T., & Ingram, L. O. (2008) · Biotechnology and Bioengineering · doi:10.1002/bit.21694 · Cited by 330

Metabolic Analysis of Corynebacterium glutamicum during Lactate and Succinate Productions under Oxygen Deprivation Conditions

Inui, M., Murakami, S., Okino, S., Kawaguchi, H., Vertès, A. A., & Yukawa, H. (2004) · Microbial Physiology · doi:10.1159/000079827 · Cited by 326

Isolation and characterization of a new succinic acid-producing bacterium, Mannheimia succiniciproducens MBEL55E, from bovine rumen

Lee, S. L. (2002) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-002-0935-6 · Cited by 317

Environmental and physiological factors affecting the succinate product ratio during carbohydrate fermentation by Actinobacillus sp. 130Z

der Werf, M. J. V., Guettler, M. V., Jain, M. K., & Zeikus, J. G. (1997) · Archives of Microbiology · doi:10.1007/s002030050452 · Cited by 316

Metabolic Engineering of Escherichia coli for Enhanced Production of Succinic Acid, Based on Genome Comparison and In Silico Gene Knockout Simulation

Lee, S. J., Lee, D.-Y., Kim, T. Y., Kim, B. H., Lee, J., & Lee, S. Y. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.7880-7887.2005 · Cited by 309

Succinic acid production derived from carbohydrates: An energy and greenhouse gas assessment of a platform chemical toward a bio‐based economy

Cok, B., Tsiropoulos, I., Roes, A. L., & Patel, M. K. (2014) · Biofuels, Bioproducts and Biorefining · doi:10.1002/bbb.1427 · Cited by 306

Genome-Based Metabolic Engineering of Mannheimia succiniciproducens for Succinic Acid Production

Lee, S. J., Song, H., & Lee, S. Y. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.3.1939-1948.2006 · Cited by 278

Succinate production in dual-phase Escherichia coli fermentations depends on the time of transition from aerobic to anaerobic conditions

Vemuri, G. N., Eiteman, M. A., & Altman, E. (2002) · Journal of Industrial Microbiology and Biotechnology · doi:10.1038/sj.jim.7000250 · Cited by 272

Metabolic engineering of Saccharomyces cerevisiae for the biotechnological production of succinic acid

Raab, A. M., Gebhardt, G., Bolotina, N., Weuster-Botz, D., & Lang, C. (2010) · Metabolic Engineering · doi:10.1016/j.ymben.2010.08.005 · Cited by 225

Towards large scale fermentative production of succinic acid

Jansen, M. L., & van Gulik, W. M. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.07.003 · Cited by 223

Toward Homosuccinate Fermentation: Metabolic Engineering of Corynebacterium glutamicum for Anaerobic Production of Succinate from Glucose and Formate

Litsanov, B., Brocker, M., & Bott, M. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.07790-11 · Cited by 223

Mutation of the ptsG Gene Results in Increased Production of Succinate in Fermentation of Glucose by Escherichia coli

Chatterjee, R., Millard, C. S., Champion, K., Clark, D. P., & Donnelly, M. I. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.1.148-154.2001 · Cited by 216

The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens

Hong, S. H., Kim, J. S., Lee, S. Y., In, Y. H., Choi, S. S., Rih, J.-K., Kim, C. H., Jeong, H., Hur, C. G., & Kim, J. J. (2004) · Nature Biotechnology · doi:10.1038/nbt1010 · Cited by 198

Sustainability metrics for succinic acid production: A comparison between biomass-based and petrochemical routes

Pinazo, J. M., Domine, M. E., Parvulescu, V., & Petru, F. (2015) · Catalysis Today · doi:10.1016/j.cattod.2014.05.035 · Cited by 177

Industrial Systems Biology of Saccharomyces cerevisiae Enables Novel Succinic Acid Cell Factory

Otero, J. M., Cimini, D., Patil, K. R., Poulsen, S. G., Olsson, L., & Nielsen, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054144 · Cited by 170

Construction of reductive pathway in Saccharomyces cerevisiae for effective succinic acid fermentation at low pH value

Yan, D., Wang, C., Zhou, J., Liu, Y., Yang, M., & Xing, J. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.01.053 · Cited by 149

Evaluation of succinic acid continuous and repeat-batch biofilm fermentation by Actinobacillus succinogenes using plastic composite support bioreactors

Urbance, S. E., Pometto, A. L., DiSpirito, A. A., et al. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-004-1634-2 · Cited by 136

Fed‐batch culture of a metabolically engineered Escherichia coli strain designed for high‐level succinate production and yield under aerobic conditions

Lin, H. C., Bennett, G. N., & San, K. (2005) · Biotechnology and Bioengineering · doi:10.1002/bit.20458 · Cited by 132

Oxygen dependence of metabolic fluxes and energy generation of Saccharomyces cerevisiae CEN.PK113-1A

Jouhten, P., Rintala, E., Huuskonen, A., Tamminen, A., Toivari, M., Wiebe, M., Ruohonen, L., Penttilä, M., & Maaheimo, H. (2008) · BMC Systems Biology · doi:10.1186/1752-0509-2-60 · Cited by 131

Systems‐wide analysis and engineering of metabolic pathway fluxes in bio‐succinate producing Basfia succiniciproducens

Becker, J., Reinefeld, J., Stellmacher, R., Schäfer, R., Lange, A., Meyer, H., Lalk, M., Zelder, O., von Abendroth, G., Schröder, H., et al. (2013) · Biotechnology and Bioengineering · doi:10.1002/bit.24963 · Cited by 114

Metabolic engineering of Escherichia coli to minimize byproduct formate and improving succinate productivity through increasing NADH availability by heterologous expression of NAD+-dependent formate dehydrogenase

Balzer, G. J., Thakker, C., Bennett, G. N., & San, K. (2013) · Metabolic Engineering · doi:10.1016/j.ymben.2013.07.005 · Cited by 111

Engineering glutathione biosynthesis of Saccharomyces cerevisiae increases robustness to inhibitors in pretreated lignocellulosic materials

Ask, M., Mapelli, V., Höck, H., Lisbeth Olsson, A., & Bettiga, M. (2013) · Microbial Cell Factories · doi:10.1186/1475-2859-12-87 · Cited by 105

Basfia succiniciproducens gen. nov., sp. nov., a new member of the family Pasteurellaceae isolated from bovine rumen

Kuhnert, P., Scholten, E., Haefner, S., et al. (2009) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.011809-0 · Cited by 102

Genes restoring redox balance in fermentation-deficient E. coli NZN111

Singh, A., Lynch, M., & Gill, R. T. (2009) · Metabolic Engineering · doi:10.1016/j.ymben.2009.07.002 · Cited by 89

Genome-scale modeling enables metabolic engineering of Saccharomyces cerevisiae for succinic acid production

Ågren, R., Otero, J. M., & Nielsen, J. (2013) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-013-1269-3 · Cited by 83

Stable disruption of ethanol production by deletion of the genes encoding alcohol dehydrogenase isozymes in Saccharomyces cerevisiae

Ida, Y., Furusawa, C., Hirasawa, T., & Shimizu, H. (2011) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2011.09.019 · Cited by 62

Engineering of Acetate Recycling and Citrate Synthase to Improve Aerobic Succinate Production in Corynebacterium glutamicum

Zhu, N., Xia, H., Wang, Z., Zhao, X., & Chen, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060659 · Cited by 61

Metabolic engineering of Saccharomyces cerevisiae to improve succinic acid production based on metabolic profiling

Ito, Y., Hirasawa, T., & Shimizu, H. (2014) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2014.877816 · Cited by 59

Physiological role of soluble fumarate reductase in redox balancing during anaerobiosis in Saccharomyces cerevisiae

Enomoto, K., Arikawa, Y., & Muratsubaki, H. (2002) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2002.tb11377.x · Cited by 57

Effect of gene disruption of succinate dehydrogenase on succinate production in a sake yeast strain

Kubo, Y., Takagi, H., & Nakamori, S. (2000) · Journal of Bioscience and Bioengineering · doi:10.1016/s1389-1723(00)90006-9 · Cited by 48

Improved succinate production in Corynebacterium glutamicum by engineering glyoxylate pathway and succinate export system

Zhu, N., Xia, H., Yang, J., et al. (2013) · Biotechnology Letters · doi:10.1007/s10529-013-1376-2 · Cited by 47

Production of succinate by a pflB ldhA double mutant of Escherichia coli overexpressing malate dehydrogenase

Wang, W., Li, Z., Xie, J., & Ye, Q. (2009) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-009-0298-9 · Cited by 34

Saccharomyces cerevisiae: a potential host for carboxylic acid production from lignocellulosic feedstock?

Sandström, A. G., Almqvist, H., Portugal-Nunes, D. J., Neves, D., Lidén, G., & Gorwa‐Grauslund, M. F. (2014) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-014-5866-5 · Cited by 21

Enzymatic Conversion of CO2: From Natural to Artificial Utilization

Bierbaumer, S., Nattermann, M., Schulz, L., Zschoche, R., Erb, T. J., Winkler, C. K., Tinzl, M., & Glueck, S. M. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00581 · Cited by 279