Biorefineries for the production of top building block chemicals and their derivatives
Abstract
Due to the growing concerns on the climate change and sustainability on petrochemical resources, DOE selected and announced the bio-based top 12 building blocks and discussed the needs for developing biorefinery technologies to replace the current petroleum based industry in 2004. Over the last 10 years after its announcement, many studies have been performed for the development of efficient technologies for the bio-based production of these chemicals and derivatives. Now, ten chemicals among these top 12 chemicals, excluding the l-aspartic acid and 3-hydroxybutyrolactone, have already been commercialized or are close to commercialization. In this paper, we review the current status of biorefinery development for the production of these platform chemicals and their derivatives. In addition, current technological advances on industrial strain development for the production of platform chemicals using micro-organisms will be covered in detail with case studies on succinic acid and 3-hydroxypropionic acid as examples.
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Based on the status of the 12 chemicals listed in 2004 and a further revision in 2010, most of these building blocks have been commercialized or are on their way to commercialization.
“Based on the status of the 12 chemicals listed in 2004 (Choi et al., 2015), and considering a further revision that took place in 2010 (Bozell and Petersen, 2010), it is a fact that most of these building blocks have been commercialized or are on their way to commercialization.”
From Biorefineries: Achievements and challenges for a bio-based economy (2022) · cites this paper as Choi et al., 2015
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- Authors
- Choi, S., Song, C. W., Shin, J. H., & Lee, S. Y.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Corresponding author
- Lee, Sang Yup
- Venue
- Metabolic Engineering
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 28
- Pages
- 223-239
- ISSN
- 1096-7176 (ISSN-L)
- OpenAlex
- W2067596362
- Cited by
- 516
- References
- 90
- Citations by year
- 2026: 20 · 2025: 28 · 2024: 35 · 2023: 26 · 2022: 53 · 2021: 52 · 2020: 45 · 2019: 59 · 2018: 65 · 2017: 53 · 2016: 59 · 2015: 21
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolic Engineering (publishedVersion)
- PubMed (publishedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- Funders
- Ministry of Science, ICT and Future Planning (MSIP)
- National Research Foundation (NRF) of Korea (NRF-2012-C1AAA001-2012M1A2A2026556)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Physical Sciences › Engineering › Biomedical Engineering › Catalysis for Biomass Conversion
- Keywords
- biorefinery, bio-based building blocks, platform chemicals, succinic acid, 3-hydroxypropionic acid, microbial production
- MeSH terms
- Lactic Acid, Succinic Acid, Metabolic Engineering
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