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Ethanol and brain damage
Abstract
It is now well established that even uncomplicated alcoholics who have no specific neurological or hepatic problems show signs of regional brain damage and cognitive dysfunction. Improvements in neuroimaging technology, magnetic resonance imaging, magnetic resonance spectroscopy and positron emission tomography have contributed significantly, revealing alcoholic-specific changes in the CNS associated with neuropsychological abnormalities. Although greater efforts are needed, a human brain bank specifically targeting alcohol cases is now able to provide fresh and frozen tissue for alcohol researchers. These tissues can be used to test hypotheses developed using animal models and/or in vitro studies. The aim is to delineate mechanisms underlying alcohol-related brain damage in humans. The development of high-throughput, non-hypothesis-driven approaches using DNA microarrays and proteomics might also provide clues to this important problem.
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“Prolonged alcohol exposure also produces neurotoxic effects, including structural impairments in the prefrontal cortex and hippocampus – two regions essential for behavioral inhibition and emotional reasoning - thereby compounding the disinhibitory effects of acute intoxication (Harper And Matsumoto 2005; Oscar-Berman And Marinković 2007).”
From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Harper And Matsumoto 2005
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Metadata
- Authors
- Harper, C., & Matsumoto, I.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Harper, Clive
- Matsumoto, Izuru
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 5
- Issue
- 1
- Pages
- 73-78
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2149927155
- Cited by
- 342
- References
- 55
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 12 · 2021: 10 · 2020: 9 · 2019: 12 · 2018: 12 · 2017: 10 · 2016: 17 · 2015: 28 · 2014: 26 · 2013: 22 · 2012: 24
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA012725)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- ethanol, alcohol-related brain damage, alcoholic brain damage, cognitive impairment, brain banks, human brain tissue, neuroimaging, magnetic resonance spectroscopy, positron emission tomography, animal models of alcoholism, DNA microarrays, proteomics, neuropsychological abnormalities
- MeSH terms
- Aged, Ethanol, Alcoholism, Brain, Central Nervous System Depressants, Cognition Disorders, Female, Humans, Male
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