The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Angiotensin-converting enzyme 2 in lung diseases
Open accessAbstract
The renin-angiotensin system (RAS) plays a key role in maintaining blood pressure homeostasis, as well as fluid and salt balance. Angiotensin II, a key effector peptide of the system, causes vasoconstriction and exerts multiple biological functions. Angiotensin-converting enzyme (ACE) plays a central role in generating angiotensin II from angiotensin I, and capillary blood vessels in the lung are one of the major sites of ACE expression and angiotensin II production in the human body. The RAS has been implicated in the pathogenesis of pulmonary hypertension and pulmonary fibrosis, both commonly seen in chronic lung diseases such as chronic obstructive lung disease. Recent studies indicate that the RAS also plays a critical role in acute lung diseases, especially acute respiratory distress syndrome (ARDS). ACE2, a close homologue of ACE, functions as a negative regulator of the angiotensin system and was identified as a key receptor for SARS (severe acute respiratory syndrome) coronavirus infections. In the lung, ACE2 protects against acute lung injury in several animal models of ARDS. Thus, the RAS appears to play a critical role in the pathogenesis of acute lung injury. Indeed, increasing ACE2 activity might be a novel approach for the treatment of acute lung failure in several diseases.
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Angiotensin-converting enzyme 2 is an essential regulator of heart function
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Metadata
- Authors
- KUBA, K., IMAI, Y., & PENNINGER, J.
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 6
- Issue
- 3
- Pages
- 271-276
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2171671715
- Cited by
- 401
- References
- 57
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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