The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools
Open accessAbstract
Currently there is no effective antiviral therapy for SARS-CoV-2 infection, which frequently leads to fatal inflammatory responses and acute lung injury. Here, we discuss the various mechanisms of SARS-CoV-mediated inflammation. We also assume that SARS-CoV-2 likely shares similar inflammatory responses. Potential therapeutic tools to reduce SARS-CoV-2-induced inflammatory responses include various methods to block FcR activation. In the absence of a proven clinical FcR blocker, the use of intravenous immunoglobulin to block FcR activation may be a viable option for the urgent treatment of pulmonary inflammation to prevent severe lung injury. Such treatment may also be combined with systemic anti-inflammatory drugs or corticosteroids. However, these strategies, as proposed here, remain to be clinically tested for effectiveness.
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Metadata
- Authors
- Fu, Y., Cheng, Y., & Wu, Y.
- Venue
- Virologica Sinica
- Publisher
- Elsevier BV
- Published
- 2020-03-03
- Volume
- 35
- Issue
- 3
- Pages
- 266-271
- ISSN
- 1995-820X (ISSN-L)
- 1674-0769
- OpenAlex
- W3006390878
- Cited by
- 788
- References
- 37
- FWCI
- 22.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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