Ca2+ and insulin-mediated glucose uptake
Abstract
Insulin stimulates glucose uptake in striated muscle and fat via a complex cascade of signaling events. Insulin resistance in these tissues and type 2 diabetes constitute major and rapidly increasing health problems in society. Recent research implicates an important role of Ca(2+) in insulin-mediated glucose uptake. Maneuvers that increase or decrease Ca(2+) influx also increase or decrease insulin-mediated glucose uptake both in normal and insulin-resistant cells. Ca(2+) appears to act on late steps in the insulin-signaling cascade, that is, the docking and fusion of glucose transporter 4 (GLUT4) vesicles with the plasma membrane. No Ca(2+) sensor in this process has yet been explicitly identified but recent studies point at synaptotagmin VII and the motor protein Myo1c as possible candidates.
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Additional mechanisms potentially linking impaired mitochondrial oxidative function to insulin resistance include reduced ATP synthesis for energy-requiring functions, abnormalities in calcium homeostasis, and reduced ATP production during exercise.
“Additional mechanisms potentially linking impaired mitochondrial oxidative function to insulin resistance include: 1) reduced ATP synthesis for energyrequiring functions such as insulin-stimulated glucose uptake; 2) abnormalities in calcium homeostasis (necessary for exercise-induced glucose uptake) (103-105); and 3) reduced ATP production during exercise (106), potentially contributing to reduced”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [103]
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- Authors
- LANNER, J., BRUTON, J., KATZ, A., & WESTERBLAD, H.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- LANNER, J
- BRUTON, J
- KATZ, A
- WESTERBLAD, H
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 8
- Issue
- 3
- Pages
- 339-345
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W1986467292
- Cited by
- 60
- References
- 54
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 3 · 2017: 4 · 2016: 3 · 2014: 6 · 2013: 2 · 2012: 8
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Karolinska Institutet
- Vetenskapsrådet
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- insulin signaling, glucose uptake, calcium, insulin resistance, type 2 diabetes, synaptotagmin VII, Myo1c, striated muscle, adipocytes, calcium influx
- MeSH terms
- Animals, Biological Transport, Calcium, Cell Membrane, Diglycerides, Exocytosis, Glucose, Humans, Insulin, Muscle, Skeletal, Protein Transport, Myocytes, Cardiac, Glucose Transporter Type 4
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