Cited by 60Metabolism, Diabetes, and CancerPancreatic function and diabetesCellular transport and secretion

Ca2+ and insulin-mediated glucose uptake

LANNER, J, BRUTON, J, KATZ, A, WESTERBLAD, H·2008·Current Opinion in Pharmacology

Abstract

Insulin stimulates glucose uptake in striated muscle and fat via a complex cascade of signaling events. Insulin resistance in these tissues and type 2 diabetes constitute major and rapidly increasing health problems in society. Recent research implicates an important role of Ca(2+) in insulin-mediated glucose uptake. Maneuvers that increase or decrease Ca(2+) influx also increase or decrease insulin-mediated glucose uptake both in normal and insulin-resistant cells. Ca(2+) appears to act on late steps in the insulin-signaling cascade, that is, the docking and fusion of glucose transporter 4 (GLUT4) vesicles with the plasma membrane. No Ca(2+) sensor in this process has yet been explicitly identified but recent studies point at synaptotagmin VII and the motor protein Myo1c as possible candidates.

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Crossref · 10.1016/j.coph.2008.01.006

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  • Additional mechanisms potentially linking impaired mitochondrial oxidative function to insulin resistance include reduced ATP synthesis for energy-requiring functions, abnormalities in calcium homeostasis, and reduced ATP production during exercise.

    “Additional mechanisms potentially linking impaired mitochondrial oxidative function to insulin resistance include: 1) reduced ATP synthesis for energyrequiring functions such as insulin-stimulated glucose uptake; 2) abnormalities in calcium homeostasis (necessary for exercise-induced glucose uptake) (103-105); and 3) reduced ATP production during exercise (106), potentially contributing to reduced”

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Authors
LANNER, J., BRUTON, J., KATZ, A., & WESTERBLAD, H.
Affiliations
Karolinska Institutet (SE)
Corresponding author
  • LANNER, J
  • BRUTON, J
  • KATZ, A
  • WESTERBLAD, H
Venue
Current Opinion in Pharmacology
Publisher
Elsevier BV
Published
2008-06
Volume
8
Issue
3
Pages
339-345
ISSN
1471-4892 (ISSN-L)
OpenAlex
W1986467292
Cited by
60
References
54
Citations by year
2026: 1 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 3 · 2017: 4 · 2016: 3 · 2014: 6 · 2013: 2 · 2012: 8
FWCI
2.74
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Karolinska Institutet
  • Vetenskapsrådet
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
insulin signaling, glucose uptake, calcium, insulin resistance, type 2 diabetes, synaptotagmin VII, Myo1c, striated muscle, adipocytes, calcium influx
MeSH terms
Animals, Biological Transport, Calcium, Cell Membrane, Diglycerides, Exocytosis, Glucose, Humans, Insulin, Muscle, Skeletal, Protein Transport, Myocytes, Cardiac, Glucose Transporter Type 4

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