Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

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A central role for JNK in obesity and insulin resistance

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Molecular mechanisms of mTOR-mediated translational control

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Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

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Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

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Obesity, Inflammation, and Insulin Resistance

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IKK-β links inflammation to obesity-induced insulin resistance

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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The IKK NF-κB system: a treasure trove for drug development

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Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

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The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

Harrington, L. S., Findlay, G. M., Gray, A., Толкачева, Т. А., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N. R., Cheng, S., Shepherd, P. R., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403069 · Cited by 1,123

A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways

Nguyen, M. T. A., Favelyukis, S., Nguyen, A.-K., Reichart, D., Scott, P. A., Jenn, A., Liu-Bryan, R., Glass, C. K., Neels, J. G., & Olefsky, J. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706762200 · Cited by 1,035

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

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Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies

Shah, O. J., Wang, Z., & Hunter, T. R. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.026 · Cited by 800

Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex

Gao, Z., Hwang, D. H., Bataille, F., Lefevre, M., York, D. A., Quon, M. J., & Ye, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209459200 · Cited by 777

Interleukin-1β-Induced Insulin Resistance in Adipocytes through Down-Regulation of Insulin Receptor Substrate-1 Expression

Jager, J., Grémeaux, T., Cormont, M., MARCHAND‐BRUSTEL, Y. L., & Tanti, J. (2006) · Endocrinology · doi:10.1210/en.2006-0692 · Cited by 727

FROM MICE TO MEN: Insights into the Insulin Resistance Syndromes

Biddinger, S. B., & Kahn, C. R. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.124723 · Cited by 714

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

Bentzinger, C. F., Romanino, K., Cloëtta, D., Lin, S., Mascarenhas, J. B., Oliveri, F., Xia, J., Casanova, E., Costa, C. F., Brink, M., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.002 · Cited by 640

IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway

Lee, D., Kuo, H.-P., Chen, C., Hsu, J.-M., Chou, C., Wei, Y., Sun, H., Li, L., Ping, B., Huang, W., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.058 · Cited by 639

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

Sabio, G., Das, M., Mora, A., Zhang, Z., Jun, J. Y., Ko, H. J., Barrett, T., Kim, J. K., & Davis, R. J. (2008) · Science · doi:10.1126/science.1160794 · Cited by 604

Phosphorylation of IRS proteins, insulin action, and insulin resistance

Boura-Halfon, S., & Zick, Y. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90437.2008 · Cited by 598

The role of MAPKs in adipocyte differentiation and obesity

Bost, F., Aouadi, M., Caron, L., & Binétruy, B. (2004) · Biochimie · doi:10.1016/j.biochi.2004.10.018 · Cited by 583

Increased Activation of the Mammalian Target of Rapamycin Pathway in Liver and Skeletal Muscle of Obese Rats: Possible Involvement in Obesity-Linked Insulin Resistance

Khamzina, L., Veilleux, A., Bergeron, S., & Marette, A. (2005) · Endocrinology · doi:10.1210/en.2004-0921 · Cited by 562

JNK1 in Hematopoietically Derived Cells Contributes to Diet-Induced Inflammation and Insulin Resistance without Affecting Obesity

Solinas, G., Vilcu, C., Neels, J. G., Bandyopadhyay, G. K., Luo, J.-L., Naugler, W., Grivennikov, S., Wynshaw-Boris, A., Scadeng, M., Olefsky, J. M., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.011 · Cited by 513

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

Polak, P., Cybulski, N., Feige, J. N., Auwerx, J., Rüegg, M. A., & Hall, M. N. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.003 · Cited by 480

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

Tremblay, F., Brûlé, S., Hee Um, S., Li, Y., Masuda, K., Roden, M., Sun, X. J., Krebs, M., Polakiewicz, R. D., Thomas, G., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706517104 · Cited by 465

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

Özcan, U., Özcan, L., Yılmaz, E., Düvel, K., Şahin, M., Manning, B. D., & Hotamışlıgil, G. S. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.023 · Cited by 449

Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.

Zabolotny, J. M., Kim, Y.-B., Welsh, L. A., Kershaw, E. E., Neel, B. G., & Kahn, B. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800061200 · Cited by 404

mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

Fraenkel, M., Ketzinel‐Gilad, M., Ariav, Y., Pappo, O., Karaca, M., Castel, J., Berthault, M., Magnan, C., Cerasi, E., Kaiser, N., et al. (2008) · Diabetes · doi:10.2337/db07-0922 · Cited by 386

Role of Endoplasmic Reticulum Stress and c-Jun NH2-Terminal Kinase Pathways in Inflammation and Origin of Obesity and Diabetes

Hotamisligil, G. S. (2005) · Diabetes · doi:10.2337/diabetes.54.suppl_2.s73 · Cited by 352

The Extracellular Signal–Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis

Bost, F., Aouadi, M., Caron, L., Even, P. C., Belmonte, N., Prot, M., Dani, C., Hofman, P. M., Pagès, G., Pouysségur, J., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.2.402 · Cited by 351

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

Tuncman, G., Hirosumi, J., Solinas, G., Chang, L., Karin, M., & Hotamisligil, G. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603509103 · Cited by 350

Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2

Bacquer, O. L., Petroulakis, E., Paglialunga, S., Poulin, F., Richard, D., Cianflone, K., & Sonenberg, N. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29528 · Cited by 348

Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults

Fleischman, A., Shoelson, S. E., Bernier, R., & Goldfine, A. B. (2008) · Diabetes Care · doi:10.2337/dc07-1338 · Cited by 346

S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2

Zhang, J., Gao, Z., Yin, J., Quon, M. J., & Ye, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806480200 · Cited by 304

Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes

Goldfine, A. B., Silver, R., Aldhahi, W., Cai, D., Tatro, E., Lee, J., & Shoelson, S. E. (2008) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2008.00026.x · Cited by 293

Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62

Rodriguez, A., Durán, A., Selloum, M., Champy, M.-F., Diez-Guerra, F. J., Flores, J. M., Serrano, M., Auwerx, J., Diaz-Meco, M. T., & Moscat, J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.011 · Cited by 290

Modulation of insulin action

Pirola, L., Johnston, A., & OBBERGHEN, E. V. (2004) · Diabetologia · doi:10.1007/s00125-003-1313-3 · Cited by 286

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

Solinas, G., Naugler, W., Galimi, F., Lee, M.-S., & Karin, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607626103 · Cited by 284

Hypoxia decreases insulin signaling pathways in adipocytes.

Regazzetti, C., Peraldi, P., Grémeaux, T., Najem-Lendom, R., Ben-Sahra, I., Cormont, M., Bost, F., Le Marchand-Brustel, Y., Tanti, J.-F., & Giorgetti-Peraldi, S. (2009) · Diabetes · doi:10.2337/db08-0457 · Cited by 281

The Mammalian Target of Rapamycin Pathway Regulates Nutrient-Sensitive Glucose Uptake in Man

Krebs, M., Brunmair, B., Brehm, A., Artwohl, M., Szendroedi, J., Nowotny, P., Roth, E., Fürnsinn, C., Promintzer, M., Anderwald, C., et al. (2007) · Diabetes · doi:10.2337/db06-1016 · Cited by 230

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance†

Singh, R., Wang, Y., Xiang, Y., Tanaka, K. E., Gaarde, W. A., & Czaja, M. J. (2008) · Hepatology · doi:10.1002/hep.22578 · Cited by 228

Disruption of Tsc2 in pancreatic β cells induces β cell mass expansion and improved glucose tolerance in a TORC1-dependent manner

Rachdi, L., Balcázar, N., Osorio-Duque, F., Elghazi, L., Weiss, A., Gould, A. P., Chang-Chen, K. J., Gambello, M. J., & Bernal‐Mizrachi, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803047105 · Cited by 217

TOR regulation of AGC kinases in yeast and mammals

Jacinto, E., & Lorberg, A. (2008) · Biochemical Journal · doi:10.1042/bj20071518 · Cited by 203

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

Stebbins, J. L., De, S. K., Machleidt, T., Becattini, B., Vazquez, J., Kuntzen, C., Chen, L.-H., Cellitti, J. F., Riel-Mehan, M., Emdadi, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805677105 · Cited by 186

Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats

Ono, H., Pocai, A., Wang, Y., Sakoda, H., Asano, T., Backer, J., Schwartz, G. J., & Rossetti, L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34277 · Cited by 183

Regulation of Interleukin-6-induced Hepatic Insulin Resistance by Mammalian Target of Rapamycin through the STAT3-SOCS3 Pathway

Kim, J.-H., Kim, J. E., Liu, H.-Y., Cao, W., & Chen, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708568200 · Cited by 154

Control of Metabolic Homeostasis by Stress Signaling Is Mediated by the Lipocalin NLaz

Hull‐Thompson, J., Muffat, J., Sánchez, D., Walker, D. W., Benzer, S., Ganfornina, M. D., & Jasper, H. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000460 · Cited by 152

MAP kinases and mTOR mediate insulin-induced phosphorylation of Insulin Receptor Substrate-1 on serine residues 307, 612 and 632

Gual, P., Grémeaux, T., Gonzalez, T., MARCHAND‐BRUSTEL, Y. L., & Tanti, J. (2003) · Diabetologia · doi:10.1007/s00125-003-1223-4 · Cited by 144

Serum Retinol-Binding Protein: A Link Between Obesity, Insulin Resistance, and Type 2 Diabetes

Wolf, G. (2007) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00302.x · Cited by 131

Inhibitors of c-Jun N-terminal kinases—JuNK no more?

Bogoyevitch, M. A., & Arthur, P. G. (2007) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2007.09.013 · Cited by 129

Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle

Morino, K., Neschen, S., Bilz, S., Sono, S., Tsirigotis, D., Reznick, R. M., Moore, I., Nagai, Y., Samuel, V., Sebastian, D., et al. (2008) · Diabetes · doi:10.2337/db06-0454 · Cited by 125

Mitogen-Activated Protein Kinases, Inhibitory-κB Kinase, and Insulin Signaling in Human Omental Versus Subcutaneous Adipose Tissue in Obesity

Bashan, N., Dorfman, K., Tarnovscki, T., Harman‐Boehm, I., Liberty, I. F., Blüher, M., Ovadia, S., Maymon-Zilberstein, T., Potashnik, R., Stümvoll, M., et al. (2007) · Endocrinology · doi:10.1210/en.2006-1369 · Cited by 123

The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study

Koška, J., Ortega, E., Bunt, J. C., Gasser, A., Impson, J., Hanson, R. L., Forbes, J. M., de Courten, B. V., & Krakoff, J. A. (2008) · Diabetologia · doi:10.1007/s00125-008-1239-x · Cited by 122

Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance

Emanuelli, B., Eberlé, D., Suzuki, R., & Kahn, C. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712275105 · Cited by 114

Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis

Wunderlich, F. T., Luedde, T., Singer, S., Schmidt‐Supprian, M., Baumgartl, J., Schirmacher, P., Pasparakis, M., & Brüning, J. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707849104 · Cited by 112

A Predominant Role for Parenchymal c-Jun Amino Terminal Kinase (JNK) in the Regulation of Systemic Insulin Sensitivity

Vallerie, S. N., Furuhashi, M., Fucho, R., & Hotamışlıgil, G. S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003151 · Cited by 110

Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance

Röhl, M., Pasparakis, M., Baudler, S., Baumgartl, J., Gautam, D., Huth, M., Lorenzi, R. D., Krone, W., Rajewsky, K., & Brüning, J. C. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18712 · Cited by 103

Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic β-Cells Leads to Increased β-Cell Mass and Prevention of Hyperglycemia

Hamada, S., Hara, K., Hamada, T., Yasuda, H., Moriyama, H., Nakayama, R., Nagata, M., & Yokono, K. (2009) · Diabetes · doi:10.2337/db08-0519 · Cited by 94

Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors

Zhao, H., Serby, M. D., Xin, Z., Szczepankiewicz, B. G., Liu, M., Kosogof, C., Liu, B., Nelson, L. T. J., Johnson, E. F., Wang, S., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060465l · Cited by 76

Involvement of TNF-α in abnormal adipocyte and muscle sortilin expression in obese mice and humans

Kaddai, V., Jager, J., Gonzalez, T., Najem-Lendom, R., Bonnafous, S., Tran, A., MARCHAND‐BRUSTEL, Y. L., Gual, P., Tanti, J., & Cormont, M. (2009) · Diabetologia · doi:10.1007/s00125-009-1273-3 · Cited by 73

IKKβ suppression of TSC1 function links the mTOR pathway with insulin resistance

Hung (1998) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000065 · Cited by 73

Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling

Sharfi, H., & Eldar-Finkelman, H. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00534.2007 · Cited by 69

Interplay and Effects of Temporal Changes in the Phosphorylation State of Serine-302, -307, and -318 of Insulin Receptor Substrate-1 on Insulin Action in Skeletal Muscle Cells

Weigert, C., Kron, M., Kalbacher, H., Pohl, A. K., Runge, H., Häring, H., Schleicher, E. D., & Lehmann, R. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0102 · Cited by 68

Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle

Yi, Z., Langlais, P. R., Filippis, E. A. D., Luo, M., Flynn, C. R., Schroeder, S., Weintraub, S. T., Mapes, R., & Mandarino, L. J. (2007) · Diabetes · doi:10.2337/db06-1355 · Cited by 65

Phosphorylation of Human Insulin Receptor Substrate-1 at Serine 629 Plays a Positive Role in Insulin Signaling

Luo, M., Langlais, P. R., Yi, Z., Lefort, N., Filippis, E. A. D., Hwang, H., Christ-Roberts, C. Y., & Mandarino, L. J. (2007) · Endocrinology · doi:10.1210/en.2007-0049 · Cited by 63

Identification of Insulin Receptor Substrate 1 Serine/Threonine Phosphorylation Sites Using Mass Spectrometry Analysis: Regulatory Role of Serine 1223

Luo, M., Reyna, S. M., Wang, L., Yi, Z.-P., Carroll, C. A., Dong, L., Langlais, P. R., Weintraub, S. T., & Mandarino, L. J. (2005) · Endocrinology · doi:10.1210/en.2005-0260 · Cited by 59

Identification of small-molecule inhibitors of the JIP–JNK interaction

Chen, T. X., Kablaoui, N. M., Little, J., Timofeevski, S. L., Tschantz, W. R., Chen, P., Feng, J., Charlton, M. E., Stanton, R. V., & Bauer, P. H. (2009) · Biochemical Journal · doi:10.1042/bj20081899 · Cited by 55

The Phosphorylation of Ser318 of Insulin Receptor Substrate 1 Is Not per se Inhibitory in Skeletal Muscle Cells but Is Necessary to Trigger the Attenuation of the Insulin-stimulated Signal

Weigert, C., Hennige, A. M., Brischmann, T., Beck, A., Moeschel, K., Schaüble, M., Brodbeck, K., Häring, H.-U., Schleicher, E. D., & Lehmann, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506134200 · Cited by 50

Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles ofob/obmice

Miller, A. M., Brestoff, J. R., Phelps, C. B., Berk, E. Z., & Reynolds, T. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90428.2008 · Cited by 35

Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice

Koketsu, Y., Sakoda, H., Fujishiro, M., Kushiyama, A., Fukushima, Y., Ono, H., Anai, M., Kikuchi, T., Fukuda, T., Kamata, H., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00253.2007 · Cited by 32

JNK1 deficiency does not enhance muscle glucose metabolism in lean mice

Witczak, C. A., Hirshman, M. F., Jessen, N., FUJII, N. L., Seifert, M. M., Brandauer, J., Hotamışlıgil, G. S., & Goodyear, L. J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.158 · Cited by 24

Pharmacological characterization of a small molecule inhibitor of c-Jun kinase

Cho, H. K., Black, S. C., Looper, D., Shi, M., Kelly-Sullivan, D., Timofeevski, S. L., Siegel, K., Yu, X., McDonnell, S. R. P., Chen, P., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90298.2008 · Cited by 23

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Talbot, K., Wang, H.-Y., Kazi, H., Han, L.-Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59903 · Cited by 1,871

ERK1/2 MAP kinases: Structure, function, and regulation

Roskoski, R. J. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.04.005 · Cited by 1,719

Diabetes mellitus: The epidemic of the century

Kharroubi, A. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i6.850 · Cited by 1,352

The insulin and insulin-like growth factor receptor family in neoplasia: an update

Pollak, M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3215 · Cited by 1,116

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.

Copps, K. D., & White, M. F. (2012) · Diabetologia · doi:10.1007/s00125-012-2644-8 · Cited by 1,017

Molecular Mechanism of Insulin Resistance

Yin, L. (2014) · Medical Recapitulate

Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex

Gao, Z., Hwang, D. H., Bataille, F., Lefevre, M., York, D. A., Quon, M. J., & Ye, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209459200 · Cited by 777

Ser/Thr Phosphorylation of IRS Proteins: A Molecular Basis for Insulin Resistance

Zick, Y. (2005) · Science s STKE · doi:10.1126/stke.2682005pe4 · Cited by 326

Withdrawal: Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance.

Herschkovitz, A., Liu, Y., Ilan, E., Ronen, D., Boura‐Halfon, S., & Zick, Y. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.w118.003468 · Cited by 1

Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance

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