The IKK NF-κB system: a treasure trove for drug development

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

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Phosphorylation meets ubiquitination: the control of NF-κB activity

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Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

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Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

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Missing Pieces in the NF-κB Puzzle

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The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

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Protein Oxidation in Aging, Disease, and Oxidative Stress

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NF-κB at the crossroads of life and death

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Inhibition of NF-κB by Sodium Salicylate and Aspirin

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The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

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Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

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Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase

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Inducible cyclooxygenase may have anti-inflammatory properties

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Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

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15-Deoxy-Δ 12,14 -prostaglandin J 2 inhibits multiple steps in the NF-κB signaling pathway

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Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

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IKK-γ is an essential regulatory subunit of the IκB kinase complex

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The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitroPreprint

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The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

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The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

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NF-κB as a Therapeutic Target in Multiple Myeloma

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Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

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Possible new role for NF-κB in the resolution of inflammation

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Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B

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Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex

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Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications

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Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression

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BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice

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An F‐box protein, FWD1, mediates ubiquitin‐dependent proteolysis of β‐catenin

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A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression

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NF‐κB inhibits TNF‐induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

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Sulindac Inhibits Activation of the NF-κB Pathway

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In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation

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The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion

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IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development

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Inhibition of NF-κB Activity by Thalidomide through Suppression of IκB Kinase Activity

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Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IκB kinase

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Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

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TAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB Pathway

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Female Mice Heterozygous for IKKγ/NEMO Deficiencies Develop a Dermatopathy Similar to the Human X-Linked Disorder Incontinentia Pigmenti

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Evidence that reactive oxygen species do not mediate NF‐κB activation

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15-deoxy Δ^ -PGJ2 inhibits multiple steps in the NF-kappaB signaling pathway

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IKKα controls formation of the epidermis independently of NF-κB

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Vitamin C Inhibits NF-κB Activation by TNF Via the Activation of p38 Mitogen-Activated Protein Kinase

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Salicylates inhibit I kappa B-α phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration

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Retroviral oncoprotein Tax induces processing of NF‐κB2/p100 in T cells: evidence for the involvement of IKKα

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Vitamin C Suppresses TNFα-Induced NFκB Activation by Inhibiting IκBα Phosphorylation

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Rel/NF-kappaB/IkappaB proteins and cancer.

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A Selective IKK-2 Inhibitor Blocks NF-κB-dependent Gene Expression in Interleukin-1β-stimulated Synovial Fibroblasts

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Novel IKK inhibitors: β-carbolines

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RelB Cellular Regulation and Transcriptional Activity Are Regulated by p100

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Cytokine Gene Transcription By NF‐κB Family Members in Patients with Inflammatory Bowel Disease

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A highly selective inhibitor of IκB kinase, BMS‐345541, blocks both joint inflammation and destruction in collagen‐induced arthritis in mice

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Inhibition of Interleukin-1-stimulated NF-κB RelA/p65 Phosphorylation by Mesalamine Is Accompanied by Decreased Transcriptional Activity

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HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IκB and β-catenin

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Discovery of novel and selective IKK-β serine-threonine protein kinase inhibitors. Part 1

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Thalidomide Suppresses NF-κB Activation Induced by TNF and H2O2, But Not That Activated by Ceramide, Lipopolysaccharides, or Phorbol Ester

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Clinical update: proteasome inhibitors in solid tumors

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Rel/NF-κB and IκB factors in oncogenesis

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NF-κB: arresting a major culprit in cancer

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CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo.

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Aminosalicylic Acid Inhibits IκB Kinase α Phosphorylation of IκBα in Mouse Intestinal Epithelial Cells

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Suppression of TNF?-mediated NF?b activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells

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Sulindac enhances tumor necrosis factor-alpha-mediated apoptosis of lung cancer cell lines by inhibition of nuclear factor-kappaB.

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Novel cyanoguanidines with potent oral antitumour activity

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Structure–Activity Relationship Studies of Ethyl 2-[(3-Methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate: An Inhibitor of AP-1 and NF-κB Mediated Gene Expression

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Thalidomide analogs as emerging anti-cancer drugs

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Combination of tumor necrosis factor‐α with sulindac augments its apoptotic potential and suppresses tumor growth of human carcinoma cells in nude mice

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A regulator branches out

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The combination of the antitumoural pyridyl cyanoguanidine CHS 828 and etoposide in vitro–from cytotoxic synergy to complete inhibition of apoptosis

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Signaling to NF-κB

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Nuclear factor-κB in cancer development and progression

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Integrating cell-signalling pathways with NF-κB and IKK function

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IKK-β links inflammation to obesity-induced insulin resistance

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The Immunomodulatory and Anti-Inflammatory Role of Polyphenols

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Liver regeneration

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Muscle wasting in disease: molecular mechanisms and promising therapies

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SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

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Natural polyphenols: An overview

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Inhibiting NF-κB activation by small molecules as a therapeutic strategy

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The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression

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NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

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Resolution of Inflammation: What Controls Its Onset?

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NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ

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Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor-κB Pathway in Rat Liver

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Good cop, bad cop: the different faces of NF-κB

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Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

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Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance

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What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion?

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Signal transduction of inflammatory cytokines and tumor development

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From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?

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