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Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation
Abstract
Insulin receptor substrates (IRS) serine phosphorylation is a time-controlled physiological feedback mechanism in insulin signaling that is hijacked by metabolic and inflammatory stresses to promote insulin resistance. Kinases, including IKKbeta, JNK, ERK, mTOR, and S6K, activated by the inducers of insulin resistance induce uncontrolled IRS serine phosphorylation. Studies with genetically modified mice reveal that these kinases integrate signals from metabolic and inflammatory stresses in adipose tissue, liver, and hypothalamus leading to peripheral and central insulin resistance. Moreover, IKKbeta/NF-kappaB and JNK1 pathways in myeloid cells represent a core mechanism involved in inflammation linked to obesity. These kinases are thus potential drug targets against insulin resistance and the targeting of the IKKbeta/NF-kappaB or the JNK pathway may evolve into future diabetes medication.
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“Increased stress kinase activity also has been implicated in contribute to the serine phosphorylation of IRS-1 and subsequent impairment tyrosine phosphorylation [177, 178].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [177]
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Metadata
- Authors
- Tanti, J.-F., & Jager, J.
- Affiliations
- Inserm (FR)
- Corresponding author
- Tanti, Jean-François
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 9
- Issue
- 6
- Pages
- 753-762
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2001649002
- Cited by
- 430
- References
- 74
- Citations by year
- 2026: 19 · 2025: 14 · 2024: 8 · 2023: 17 · 2022: 29 · 2021: 24 · 2020: 17 · 2019: 20 · 2018: 23 · 2017: 28 · 2016: 32 · 2015: 36 · 2014: 41 · 2013: 41 · 2012: 38
- FWCI
- 18.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- insulin resistance, insulin receptor substrate, serine phosphorylation, insulin signaling, IKKβ, NF-κB, JNK, ERK, mTOR, S6K, inflammation, obesity, adipose tissue, liver, hypothalamus, myeloid cells
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Humans, Inflammation, Insulin Resistance, Models, Biological, Phosphorylation, Signal Transduction, NF-kappa B, Drug Delivery Systems, Protein Serine-Threonine Kinases, Mice, Knockout, Intracellular Signaling Peptides and Proteins, Mice, I-kappa B Kinase, Insulin Receptor Substrate Proteins, TOR Serine-Threonine Kinases
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