Role of Endoplasmic Reticulum Stress and c-Jun NH2-Terminal Kinase Pathways in Inflammation and Origin of Obesity and Diabetes

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works

Increased oxidative stress in obesity and its impact on metabolic syndrome

Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works

Insulin signalling and the regulation of glucose and lipid metabolism

Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works

C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus

Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433 · see citing works

Toll-like receptors and innate immunity

Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308 · see citing works

Signal transduction by the JNK group of MAP kinases

Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237 · see citing works

Inflammation, stress, and diabetes

Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143 · see citing works

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844 · see citing works

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543 · see citing works

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359 · see citing works

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630 · see citing works

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245 · see citing works

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234 · see citing works

Inflammation: the link between insulin resistance, obesity and diabetes

Dandona, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.10.013 · Cited by 2,170 · see citing works

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of <i>Ikkβ</i>

Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884 · see citing works

IKK-β links inflammation to obesity-induced insulin resistance

Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773 · see citing works

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

Yin, M.-J., Yamamoto, Y., & Gaynor, R. B. (1998) · Nature · doi:10.1038/23948 · Cited by 1,596 · see citing works

The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307

Aguirre, V., Uchida, T., Yenush, L., Davis, R., & White, M. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.9047 · Cited by 1,487 · see citing works

Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes

Pickup, J. C. (2004) · Diabetes Care · doi:10.2337/diacare.27.3.813 · Cited by 1,414 · see citing works

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305 · see citing works

ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism

Berg, A. H., Combs, T. P., & Scherer, P. E. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00524-0 · Cited by 1,211 · see citing works

Cloning and Characterization of the cDNA Encoding a Novel Human pre-B-Cell Colony-enhancing Factor

Samal, B. B., Sun, Y., Stearns, G., Xie, C., Suggs, S. V., & McNiece, I. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.2.1431 · Cited by 1,025 · see citing works

Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action

Aguirre, V., Werner, E. D., Giraud, J., Lee, Y. H., Shoelson, S. E., & White, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m101521200 · Cited by 1,010 · see citing works

Explaining How “High-Grade” Systemic Inflammation Accelerates Vascular Risk in Rheumatoid Arthritis

Sattar, N. A., McCarey, D. W., Capell, H. A., & McInnes, I. B. (2003) · Circulation · doi:10.1161/01.cir.0000099844.31524.05 · Cited by 932 · see citing works

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

Feng, B., Yao, P. M., Li, Y., Devlin, C. M., Zhang, D., Harding, H. P., Sweeney, M., Rong, J. X., Kuriakose, G., Fisher, E. A. A., et al. (2003) · Nature Cell Biology · doi:10.1038/ncb1035 · Cited by 886 · see citing works

Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex

Gao, Z., Hwang, D. H., Bataille, F., Lefevre, M., York, D. A., Quon, M. J., & Ye, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209459200 · Cited by 777 · see citing works

The expression of TNF alpha by human muscle. Relationship to insulin resistance.

Saghizadeh, M., Ong, J. M., Garvey, W. T., Henry, R. R., & Kern, P. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118504 · Cited by 717 · see citing works

Diabetes mellitus : a fundamental and clinical text

LeRoith, D., Taylor, S. I., & Olefsky, J. M. (2004) · Cited by 702 · see citing works

Insulin signaling pathways in time and space

Saltiel, A. R., & Pessin, J. E. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02207-3 · Cited by 628 · see citing works

The unfolded protein response in nutrient sensing and differentiation

Kaufman, R. J., Scheuner, D. L., Schröder, M., Shen, X., Lee, K., Liu, C. Y., & Arnold, S. M. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm829 · Cited by 607 · see citing works

The insulin signalling system and the IRS proteins

White, M. F. (1997) · Diabetologia · doi:10.1007/s001250051387 · Cited by 581 · see citing works

Cell-Permeable Peptide Inhibitors of JNK

Bonny, C., Oberson, A., Negri, S., Sauser, C., & Schorderet, D. F. (2001) · Diabetes · doi:10.2337/diabetes.50.1.77 · Cited by 571 · see citing works

Increased Activation of the Mammalian Target of Rapamycin Pathway in Liver and Skeletal Muscle of Obese Rats: Possible Involvement in Obesity-Linked Insulin Resistance

Khamzina, L., Veilleux, A., Bergeron, S., & Marette, A. (2005) · Endocrinology · doi:10.1210/en.2004-0921 · Cited by 562 · see citing works

A Molecular Basis for Insulin Resistance

Paz, K., Hemi, R., LeRoith, D., Karasik, A., Elhanany, E., Kanety, H., & Zick, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.47.29911 · Cited by 553 · see citing works

Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle

Perreault, M., & Marette, A. (2001) · Nature Medicine · doi:10.1038/nm1001-1138 · Cited by 540 · see citing works

An Inflammatory Cascade Leading to Hyperresistinemia in Humans

Lehrke, M., Reilly, M. P., Millington, S. C., Iqbal, N., Rader, D. J., & Lazar, M. A. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010045 · Cited by 523 · see citing works

The Hyperglycemia-induced Inflammatory Response in Adipocytes

Lin, Y., Berg, A. H., Iyengar, P., Lam, T. K. T., Giacca, A., Combs, T. P., Rajala, M. W., Du, X., Rollman, B., Li, W., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411863200 · Cited by 497 · see citing works

Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes

Maeda, K., Cao, H., Kono, K., Görgün, C. Z., Furuhashi, M., Uysal, K. T., Cao, Q., Atsumi, G., Malone, H., Krishnan, B. S., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.008 · Cited by 478 · see citing works

Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance

Shoelson, S. E., Lee, J., & Yuan, M. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802501 · Cited by 474 · see citing works

Endoplasmic Reticulum Stress and the Development of Diabetes

Harding, H. P., & Ron, D. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s455 · Cited by 465 · see citing works

Involvement of Endoplasmic Reticulum Stress in Insulin Resistance and Diabetes

Nakatani, Y., Kaneto, H., Kawamori, D., Yoshiuchi, K., Hatazaki, M., Matsuoka, T., Ozawa, K., Ogawa, S., Hori, M., Yamasaki, Y., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411860200 · Cited by 462 · see citing works

SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice

Emanuelli, B., Peraldi, P., Filloux, C., Carine Chavey, A., Freidinger, K., Hilton, D. J., Hotamışlıgil, G. S., & OBBERGHEN, E. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104602200 · Cited by 449 · see citing works

Distinct Roles for JNK1 and JNK2 in Regulating JNK Activity and c-Jun-Dependent Cell Proliferation

Sabapathy, K., Hochedlinger, K., Nam, S. Y., Bauer, A., Karin, M., & Wagner, E. F. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.028 · Cited by 397 · see citing works

The current biology of resistin

Steppan, C. M., & Lazar, M. A. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01306.x · Cited by 371 · see citing works

PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis

Li, A. C., & Glass, C. K. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400010-jlr200 · Cited by 357 · see citing works

Involvement of c-Jun N-terminal Kinase in Oxidative Stress-mediated Suppression of Insulin Gene Expression

Kaneto, H., Xu, G., FUJII, N. L., Kim, S., Bonner‐Weir, S., & Weir, G. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202066200 · Cited by 349 · see citing works

Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity.

Alessi, M. C., Bastelica, D., Morange, P., Berthet, B., Leduc, I., Verdier, M., Geel, O., & Juhan-Vague, I. (2000) · Diabetes · doi:10.2337/diabetes.49.8.1374 · Cited by 344 · see citing works

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

Kaneto, H., Nakatani, Y., Miyatsuka, T., Kawamori, D., Matsuoka, T., Matsuhisa, M., Kajimoto, Y., Ichijo, H., Yamasaki, Y., & Hori, M. (2004) · Nature Medicine · doi:10.1038/nm1111 · Cited by 337 · see citing works

Inhibition of Insulin Sensitivity by Free Fatty Acids Requires Activation of Multiple Serine Kinases in 3T3-L1 Adipocytes

Gao, Z., Zhang, X., Zuberi, A. R., Hwang, D. H., Quon, M. J., Lefevre, M., & Ye, J. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0383 · Cited by 335 · see citing works

Fatty Acid Binding Proteins—The Evolutionary Crossroads of Inflammatory and Metabolic Responses

Makowski, L., & Hotamışlıgil, G. S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.9.2464s · Cited by 308 · see citing works

Cloning and Characterization of the cDNA Encoding a Novel Human pre-B-Cell Colony-enhancing Factor

Samal, B. B., Sun, Y., Stearns, G., et al. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.2.1431-1437.1994 · Cited by 264 · see citing works

Cellular mechanism of insulin resistance: potential links with inflammation

Perseghin, G., Petersen, K. F., & Shulman, G. I. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802491 · Cited by 257 · see citing works

Aspirin Inhibits Serine Phosphorylation of Insulin Receptor Substrate 1 in Tumor Necrosis Factor-treated Cells through Targeting Multiple Serine Kinases

Gao, Z., Zuberi, A. R., Quon, M. J., Dong, Z., & Ye, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300423200 · Cited by 257 · see citing works

Modulation of the JNK Pathway in Liver Affects Insulin Resistance Status

Nakatani, Y., Kaneto, H., Kawamori, D., Hatazaki, M., Miyatsuka, T., Matsuoka, T., Kajimoto, Y., Matsuhisa, M., Yamasaki, Y., & Hori, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406963200 · Cited by 230 · see citing works

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells.

Ammendrup, A., Maillard, A., Nielsen, K., Andersen, N. A., Serup, P., Madsen, O. D., Mandrup-Poulsen, T. R., & Bonny, C. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1468 · Cited by 212 · see citing works

The Endoplasmic Reticulum Chaperone Improves Insulin Resistance in Type 2 Diabetes

Ozawa, K., Miyazaki, M., Matsuhisa, M., Takano, K., Nakatani, Y., Hatazaki, M., Tamatani, T., Yamagata, K., Miyagawa, J.-I., Kitao, Y., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.3.657 · Cited by 209 · see citing works

The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

Waeber, G., Delplanque, J., Bonny, C., Mooser, V., Steinmann, M., Widmann, C., Maillard, A. M., Judith Miklossy, A., Christian Dina, C., Hani, E. H., et al. (2000) · Nature Genetics · doi:10.1038/73523 · Cited by 182 · see citing works

Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure

Abdelli, S., Ansite, J. D., Roduit, R., Borsello, T., Matsumoto, I., Sawada, T., Allaman-Pillet, N., Henry, H., Beckmann, J. S., Hering, B. J., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.11.2815 · Cited by 176 · see citing works

Sphingomyelinase and Ceramide Suppress Insulin-induced Tyrosine Phosphorylation of the Insulin Receptor Substrate-1

Kanety, H., Hemi, R., Papa, M. Z., & Karasik, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.9895 · Cited by 153 · see citing works

JNK: a new therapeutic target for diabetes

Bennett, B. L. (2003) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(03)00068-7 · Cited by 151 · see citing works

Tumor Necrosis Factor–α–Induced Insulin Resistance May Mediate The Hepatitis C Virus–Diabetes Association

Knobler, H., Zhornicky, T., Sandler, A., Haran, N., Ashur, Y., & Schattner, A. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.08728.x · Cited by 148 · see citing works

Elevated C-Reactive Protein Is a Risk Factor for the Development of Type 2 Diabetes in Japanese Americans

Nakanishi, S., Yamane, K., Kamei, N., Okubo, M., & Kohno, N. (2003) · Diabetes Care · doi:10.2337/diacare.26.10.2754 · Cited by 145 · see citing works

An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue

Jaeschke, A., Czech, M. P., & Davis, R. J. (2004) · Genes &amp; Development · doi:10.1101/gad.1216504 · Cited by 121 · see citing works

Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes

Jaeschke, A., Rincón, M., Doran, B., Reilly, J., Neuberg, D. S., Greiner, D. L., Shultz, L. D., Rossini, A. A., Flavell, R. A., & Davis, R. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502143102 · Cited by 96 · see citing works

When Translation Meets Metabolism: Multiple Links to Diabetes

Shi, Y., Taylor, S. I., Tan, S., & Sonenberg, N. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0018 · Cited by 89 · see citing works

Association of diabetes and hepatitis C infection: Epidemiologic evidence and pathophysiologic insights

Bahtiyar, G., Shin, J., Aytaman, A., Sowers, J. R., & McFarlane, S. I. (2004) · Current Diabetes Reports · doi:10.1007/s11892-004-0023-7 · Cited by 83 · see citing works

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

Buzzetti, E., Pinzani, M., & Tsochatzis, E. A. (2016) · Metabolism · doi:10.1016/j.metabol.2015.12.012 · Cited by 3,119 · see citing works

Trans fatty acids and cardiovascular disease

Mozaffarian, D., Katan, M. B., Ascherio, A., Stampfer, M. J., & Willett, W. C. (2006) · New England Journal of Medicine · doi:10.1056/nejmra054035 · Cited by 1,752 · see citing works

Lipid-induced insulin resistance: unravelling the mechanism

Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60408-4 · Cited by 1,189 · see citing works

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

Eizirik, D. L., Cardozo, A. K., & Cnop, M. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0015 · Cited by 1,173 · see citing works

The inflammation highway: metabolism accelerates inflammatory traffic in obesity

Johnson, A. R., Justin Milner, J., & Makowski, L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01151.x · Cited by 603 · see citing works

Phosphorylation of IRS proteins, insulin action, and insulin resistance

Boura-Halfon, S., & Zick, Y. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90437.2008 · Cited by 598 · see citing works

Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

Tanti, J.-F., & Jager, J. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.07.004 · Cited by 430 · see citing works

Functional <i>in vivo</i> interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

Tuncman, G., Hirosumi, J., Solinas, G., Chang, L., Karin, M., & Hotamisligil, G. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603509103 · Cited by 350 · see citing works

Fatty acid—induced inflammation and insulin resistance in skeletal muscle and liver

Boden, G. (2006) · Current Diabetes Reports · doi:10.1007/s11892-006-0031-x · Cited by 276 · see citing works

What is lipotoxicity?

Engin, A. B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_8 · Cited by 260 · see citing works

Omega-3 Fatty Acids and Insulin Resistance: Focus on the Regulation of Mitochondria and Endoplasmic Reticulum Stress

Lepretti, M., Martucciello, S., Burgos Aceves, M., Putti, R., & Lionetti, L. (2018) · Nutrients · doi:10.3390/nu10030350 · Cited by 232 · see citing works

Impact of er stress-regulated atf4/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy

Liu, J., Yang, J.-R., Chen, X.-M., Cai, G.-Y., Lin, L.-R., & He, Y.-N. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00096.2014 · Cited by 117 · see citing works

Whole body overexpression of PGC-1α has opposite effects on hepatic and muscle insulin sensitivity

Liang, H., Balas, B., Tantiwong, P., Dube, J., Goodpaster, B. H., O'Doherty, R. M., DeFronzo, R. A., Richardson, A., Musi, N., & Ward, W. F. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90292.2008 · Cited by 81 · see citing works

Pathways leading to muscle insulin resistance – The muscle – fat connection

Sell, H., Eckel, J., & Dietze-Schroeder, D. (2006) · Archives of Physiology and Biochemistry · doi:10.1080/13813450600711540 · Cited by 61 · see citing works

Brain insulin, insulin‐like growth factor 1 and glucagon‐like peptide 1 signalling in Alzheimer’s disease

Ferreira, S. T. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12959 · Cited by 59 · see citing works

Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice

Yoshiuchi, K., Kaneto, H., Matsuoka, T.-A., Kohno, K., Iwawaki, T., Nakatani, Y., Yamasaki, Y., Hori, M., & Matsuhisa, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.11.182 · Cited by 41 · see citing works

LCN2 null mice are sensitive to endoplasmic reticulum stress and unfolded protein responses

Borkham‐Kamphorst, E., de Leur, E. V., Haas, U., et al. (2019) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0038-1677061

Endoplasmic Reticulum Stress in Hearing Loss

Wang, Y., Liu, X., & Xu, Z. (2017) · Journal of Otorhinolaryngology Hearing and Balance Medicine · doi:10.3390/ohbm1010003 · Cited by 3 · see citing works

Endoplasmic reticulum stress in health and disease

Zhao, L., & Ackerman, S. L. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.06.005 · Cited by 440 · see citing works

Endoplasmic reticulum stress and pancreatic β-cell death

Fonseca, S. G., Gromada, J., & Urano, F. (2011) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2011.02.008 · Cited by 384 · see citing works

Endoplasmic reticulum and unfolded protein response

Wang, H. (2010) · Zhonghua zhongliu fangzhi zazhi