Enteroendocrine hormone mimetics for the treatment of obesity and diabetes
Abstract
The utilisation of gastrointestinal-derived hormones as treatment options for obesity-diabetes has been well publicised. This has been fuelled by the synthesis of longer-acting peptide forms and beneficial altered secretion of gut hormones following certain gastric bypass surgeries. The aim of this review is to highlight the potential of glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), cholecystokinin (CCK) and oxyntomodulin (OXM) as treatments for obesity-diabetes. To date, long-acting GLP-1 receptor mimetics have achieved clinical utility for diabetes. GIP, CCK and OXM molecules appear to offer promising new classes of drugs. Furthermore, recent observations suggest significant potential for concurrent modulation of numerous receptor sub-families in the treatment of obesity-diabetes. Thus, gut hormones offer an expanding family of druggable targets for obesity-diabetes.
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Potentiators of insulin release include Ach, VIP, GLP-1, GIP, opioids, PACAP and bombesin.
“Potentiators of insulin release include (but are not limited to) Ach, VIP, GLP-1, GIP, opioids, PACAP and bombesin (303).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [303]
Cites
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Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works
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- Authors
- Irwin, N., & Flatt, P. R.
- Affiliations
- University of Ulster (GB)
- Corresponding author
- Irwin, Nigel
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 13
- Issue
- 6
- Pages
- 989-995
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W1993607264
- Cited by
- 41
- References
- 9
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 10
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- enteroendocrine hormones, gastrointestinal hormones, obesity, diabetes mellitus, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1, cholecystokinin, oxyntomodulin, GLP-1 receptor agonists, gastric bypass, receptor modulation, druggable targets
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Animals, Diabetes Mellitus, Gastrointestinal Hormones, Humans, Obesity, Receptors, Glucagon, Enteroendocrine Cells
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