Skeletal muscle autophagy and its role in sarcopenia and organismal aging

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FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

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Autophagy maintains stemness by preventing senescence

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Autophagy is required to maintain muscle mass.

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The Role of Inflammation in Age-Related Sarcopenia

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Sarcopenia – Molecular mechanisms and open questions

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Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators

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The effect of fasting or calorie restriction on autophagy induction: A review of the literature

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Hallmarks of Aging: An Autophagic Perspective

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The effects of metformin on autophagy

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Triptolide prevents LPS‐induced skeletal muscle atrophy via inhibiting NF‐κB/TNF‐α and regulating protein synthesis/degradation pathway

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Rheumatoid sarcopenia: loss of skeletal muscle strength and mass in rheumatoid arthritis

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Sarcopenia: Etiology, Nutritional Approaches, and miRNAs

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An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy

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Determining a multimodal aging clock in a cohort of Chinese women

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Chronic inflammation and sarcopenia: A regenerative cell therapy perspective

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The Effects of Calorie Restriction on Autophagy: Role on Aging Intervention

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Mesenchymal stromal cells ameliorate diabetes‐induced muscle atrophy through exosomes by enhancing AMPK/ULK1‐mediated autophagy

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The involvement of stress granules in aging and aging‐associated diseases

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Muscle-to-Brain Signaling Via Myokines and Myometabolites

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Autophagic lysosome reformation in health and disease

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Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles

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Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging

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Autophagy, apoptosis, and mitochondria: molecular integration and physiological relevance in skeletal muscle

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Oxidative Stress and Pathways of Molecular Hydrogen Effects in Medicine

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Lifelong Aerobic Exercise Alleviates Sarcopenia by Activating Autophagy and Inhibiting Protein Degradation via the AMPK/PGC-1α Signaling Pathway

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Rapamycin Induced Autophagy Inhibits Inflammation-Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells

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Potential harms of supplementation with high doses of antioxidants in athletes

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Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans

Aspernig, H., Heimbucher, T., Qi, W., Gangurde, D., Curic, S., Yan, Y., von Gromoff, E. D., Baumeister, R., & Thien, A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.072 · Cited by 75

Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging

Hunt, L. C., Schadeberg, B., Stover, J., Haugen, B., Pagala, V., Wang, Y., Puglise, J. M., Barton, E. R., Peng, J., & Demontis, F. (2021) · Nature Communications · doi:10.1038/s41467-021-21738-8 · Cited by 78

Contribution of muscle satellite cells to sarcopenia

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Contribution of proteases to the hallmarks of aging and to age-related neurodegeneration

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Oxidative muscles have better mitochondrial homeostasis than glycolytic muscles throughout life and maintain mitochondrial function during aging

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Integrated genomic and proteomic analyses identify stimulus-dependent molecular changes associated with distinct modes of skeletal muscle atrophy

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Nutritional and lifestyle management of the aging journey: A narrative review

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Senolytic treatment rescues blunted muscle hypertrophy in old mice

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Is inflammatory signaling involved in disease-related muscle wasting? Evidence from osteoarthritis, chronic obstructive pulmonary disease and type II diabetes

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GWENA: gene co-expression networks analysis and extended modules characterization in a single Bioconductor package

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Impacts of Green Tea on Joint and Skeletal Muscle Health: Prospects of Translational Nutrition

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Puerarin ameliorates skeletal muscle wasting and fiber type transformation in STZ-induced type 1 diabetic rats

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Docosahexaenoic Acid, a Potential Treatment for Sarcopenia, Modulates the Ubiquitin–Proteasome and the Autophagy–Lysosome Systems

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Cancer-Associated Muscle Wasting—Candidate Mechanisms and Molecular Pathways

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SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets

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Aerobic Exercise Improves Mitochondrial Function in Sarcopenia Mice Through Sestrin2 in an AMPKα2-Dependent Manner

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Reversible mitophagy drives metabolic suppression in diapausing beetles

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Molecular mechanisms and therapeutic interventions in sarcopenia

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Lnc-ORA interacts with microRNA-532-3p and IGF2BP2 to inhibit skeletal muscle myogenesis

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Acute Sarcopenia: Mechanisms and Management

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Muscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets

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Mitochondrial dysfunction in age-related sarcopenia: mechanistic insights, diagnostic advances, and therapeutic prospects

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Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease

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Analysis of proteostasis during aging with western blot of detergent-soluble and insoluble protein fractions

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Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populationsPreprint

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Exercise-induced AMPK activation is involved in delay of skeletal muscle senescence

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Enhanced autophagy in Becn1F121A/F121A knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction

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Nrf2 deficiency promotes the increasing trend of autophagy during aging in skeletal muscle: a potential mechanism for the development of sarcopenia

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The Current Landscape of Pharmacotherapies for Sarcopenia

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Proteomics-based identification of different training adaptations of aged skeletal muscle following long-term high-intensity interval and moderate-intensity continuous training in aged rats

Li, F., Sun, L., Wu, D.-S., Gao, H.-E., & Zhu, M. (2019) · Aging · doi:10.18632/aging.102044 · Cited by 36

Molecular Mechanisms Underlying Muscle Wasting in Huntington’s Disease

Bozzi, M., & Sciandra, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218314 · Cited by 38

Regulatory role of exercise-induced autophagy for sarcopenia

Liang, J., Zeng, Z., Zhang, Y., & Chen, N. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2019.110789 · Cited by 33

Micro(RNA)-managing muscle wasting

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Taurine Attenuates Catabolic Processes Related to the Onset of Sarcopenia

Barbiera, A., Sorrentino, S., Lepore, E., Carfì, A., Sica, G., Dobrowolny, G., & Scicchitano, B. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228865 · Cited by 34

Role of Macroautophagy in Mammalian Male Reproductive Physiology

Kirat, D., Alahwany, A. M., Arisha, A. H., Abdelkhalek, A., & Miyasho, T. (2023) · Cells · doi:10.3390/cells12091322 · Cited by 34

(Pro)renin receptor accelerates development of sarcopenia via activation of Wnt/YAP signaling axis

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SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity

Lim, C.-Y., Lin, H.-T., Kumsta, C., Lu, T., Wang, F., Kang, Y.-H., Hansen, M., Ching, T., & Hsu, A. (2022) · Autophagy · doi:10.1080/15548627.2022.2068267 · Cited by 30

Sp1-Mediated circRNA circHipk2 Regulates Myogenesis by Targeting Ribosomal Protein Rpl7

Yan, J., Yang, Y., Fan, X., Tang, Y., & Tang, Z. (2021) · Genes · doi:10.3390/genes12050696 · Cited by 31

Exercise intervention mitigates zebrafish age‐related sarcopenia via alleviating mitochondrial dysfunction

Sun, C., Yang, D. K., Chen, Z., Xiao, J., Xiao, Q., Li, C., Zhou, Z., Peng, X., Tang, C., & Zheng, L. (2022) · FEBS Journal · doi:10.1111/febs.16637 · Cited by 34

Regulation of autophagy as a therapy for immunosenescence‐driven cancer and neurodegenerative diseases: The role of exercise

Batatinha, H., Diniz, T. A., Teixeira, A. A. D. S., Krüger, K., & Neto, J. C. R. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28318 · Cited by 29

Age-related impairment of autophagy in cervical motor neurons

Pareja‐Cajiao, M., Gransee, H. M., Stowe, J. M., Rana, S. D., Sieck, G. C., & Mantilla, C. B. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111193 · Cited by 29

TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1

Overå, K. S., Garcia‐Garcia, J., Bhujabal, Z., Jain, A., Øvervatn, A., Larsen, K. B., Deretic, V. P., Johansen, T., Lamark, T., & Sjøttem, E. (2019) · Journal of Cell Science · doi:10.1242/jcs.236596 · Cited by 30

Skeletal Muscle Gene Expression in Long-Term Endurance and Resistance Trained Elderly

Bolotta, A., Filardo, G., Abruzzo, P. M., Astolfi, A., Sanctis, P. D., Martino, A. D., Höfer, C., Indio, V., Kern, H., Löfler, S., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113988 · Cited by 30

Metabolic and Molecular Basis of Sarcopenia: Implications in the Management of Urothelial Carcinoma

Fukushima, H., Fujii, Y., & Koga, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030760 · Cited by 28

CACNA1H downregulation induces skeletal muscle atrophy involving endoplasmic reticulum stress activation and autophagy flux blockade

Li, S., Hao, M.-L., Li, B., Chen, M., Chen, J., Tang, J., Hong, S., Min, J., Hu, M., & Li, H. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2484-2 · Cited by 29

Mechanisms of the NAD+ salvage pathway in enhancing skeletal muscle function

Su, M., Qiu, F., Li, Y., Che, T., Li, N., & Zhang, S. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1464815 · Cited by 27

Arsenic Toxicity on Metabolism and Autophagy in Adipose and Muscle Tissues

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Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging

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Hippo pathway effectors YAP and TAZ and their association with skeletal muscle ageing

Setiawan, I., Sanjaya, A., Lesmana, R., Yen, P. M., & Goenawan, H. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00787-z · Cited by 25

Role of SIRT2 in regulating the dexamethasone-activated autophagy pathway in skeletal muscle atrophy

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SGK1, autophagy and cancer: an overview

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Skeletal Muscle Fiber Size and Gene Expression in the Oldest-Old With Differing Degrees of Mobility

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Dextran Sodium Sulfate-induced Colitis as a Model for Sarcopenia in Mice

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Exercise Training Attenuates Ubiquitin-Proteasome Pathway and Increases the Genes Related to Autophagy on the Skeletal Muscle of Patients With Inflammatory Myopathies

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